☆ 4.2 Article

Synthesis, characterization, DNA interaction studies and anticancer activity of platinum-clotrimazole complexes

TRANSITION METAL CHEMISTRY (2009)

期刊

TRANSITION METAL CHEMISTRY

卷 34, 期 8, 页码 869-875

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SPRINGER

DOI: 10.1007/s11243-009-9276-y

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Chemistry, Inorganic & Nuclear

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Mision Ciencia-Venezuela
[MC 2007000881]

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New trans-platinum complexes of clotrimazole (CTZ) have been prepared and characterized. Their interaction with DNA and activity against tumour cell lines were evaluated. [Pt (CTZ)(2)I-2] (1) was synthesized by the reaction of K2PtCl4, KI and CTZ, and [Pt(CTZ)(2)Cl-2] (2) by direct reaction of K2PtCl4 with CTZ. These complexes were characterized by a combination of elemental analysis, molar conductivity, UV-Vis, IR, and NMR spectroscopy in one and two dimensions. DNA-platinum complex interactions were studied by spectroscopic, thermal denaturation and viscosity titration measurements. Covalent interaction studies were also performed. From these results we suggest that complexes 1 and 2 interact with the minor groove of DNA. Both complexes showed growth inhibitory effects on four out of the six tumour cells lines with GI(50) (50% growth inhibition) values in the 5-25 mu M range, but there was no indication of cytotoxicity over the range of concentrations tested.

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