期刊
TRANSGENIC RESEARCH
卷 20, 期 2, 页码 417-419出版社
SPRINGER
DOI: 10.1007/s11248-010-9409-2
关键词
Somatic cell nuclear transfer (SCNT); Recombination human lysozyme (rhLZ); Transgenic cloned pig; Milk
类别
资金
- National transgenic Breeding Program
- Natural Scientific Foundation of Beijing
In the swine industry pathogenic infections have a significant negative impact on neonatal survival. Piglets fed with human lysozyme, a natural antibiotic, might be more resistant to gastrointestinal infections. Here we describe the generation of transgenic swine expressing recombinant human lysozyme by somatic cell nuclear transfer. Three cloned female pigs were born, one of which expressed rhLZ at 0.32 +/- A 0.01 mu g/ml in milk, 50-fold higher than that of the pig native lysozyme. Both the transgenic gilts and their progeny appear healthy. Introducing human lysozyme into pigs' milk has a potential to benefit the piglets by enhancing immune function and defending against pathogenic bacteria, thereby increasing the new born survival rate. This advance could be of great value to commercial swine producers.
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