期刊
TRANSFUSION AND APHERESIS SCIENCE
卷 50, 期 3, 页码 349-357出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.transci.2014.04.005
关键词
Extracorporeal photopheresis; Graft-versus-host disease
类别
Graft-versus-host disease (GvHD) is a serious complication of allogeneic hematopoietic cell transplantation causing significant morbidity and mortality. Corticosteroids are the established first-line treatment of GvHD. Patients not responding to corticosteroids have a dismal prognosis. Extracorporeal photopheresis (ECP) has objective activity in the treatment of both acute and chronic corticosteroid-refractory GvHD patients, has an excellent safety profile and is internationally well-established. ECP has been recommended by a significant number of renowned scientific organizations as an efficient treatment option for patients with GvHD. ECP has a proven corticosteroid-sparing effect and favourably impacts on survival and quality of life of responding patients. (C) 2014 Elsevier Ltd. All rights reserved.
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