Article
Chemistry, Analytical
Marinos Louka, Efstathios Kaliviotis
Summary: This study characterizes blood coagulation by analyzing time-dependent structural properties of whole blood using a cost-effective design and robust processing approaches. It employs brightfield microscopy and image processing techniques on finger-prick blood samples, demonstrating good agreement with literature and great potential for robust characterization of blood coagulation.
Article
Biochemical Research Methods
Kaushik N. Shankar, Yiyuan Zhang, Talid Sinno, Scott L. Diamond
Summary: Modeling thrombus growth in pathological flows using a 3D multiscale framework allows evaluation of risk under patient-specific conditions. The framework includes modules for platelet signaling, platelet position tracking, agonist release and transport, and blood flow computation. The model accurately predicts the evolution and morphology of growing thrombi and enables simulations of important clinical situations.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Critical Care Medicine
Wataru Takayama, Akira Endo, Koji Morishita, Yasuhiro Otomo
Summary: The utility of dielectric blood coagulometry for early sepsis-induced disseminated intravascular coagulation diagnosis was evaluated in this study. The results showed that dielectric blood coagulometry was strongly correlated with thrombin levels and can be used to detect early-phase disseminated intravascular coagulation in patients with sepsis.
CRITICAL CARE MEDICINE
(2022)
Article
Hematology
Anke Adenaeuer, Eyiuche D. Ezigbo, Hanan Fawzy Nazir, Stefano Barco, Alice Trinchero, Dagmar Laubert-Reh, Konstantin Strauch, Philipp S. Wild, Karl J. Lackner, Bernhard Laemmle, Heidi Rossmann
Summary: Severe prekallikrein deficiency is a rare autosomal-recessive condition. A variant in the KLKB1 gene causing PK deficiency was found to be common in Africans (allele frequency 1.43%) but absent in Europeans. This highlights the higher prevalence of PK deficiency among people of African descent compared to Europeans.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Biochemistry & Molecular Biology
Xiuxiu Wang, Juan Zhao, Shengli Ding, Hongyan Zhang
Summary: Nanoplastics are a type of emerging environmental contaminant that can enter the bloodstream and pose a risk to human health. This study found that polystyrene (PS), PS-NH2, and PS-COOH nanoparticles disrupt the structure of human fibrinogen (HF) in a dose-dependent manner, potentially affecting protein structure and function and inducing biological effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Law
Da Lin, Lev Menand
Summary: This article discusses the power of the Federal Reserve to remove bankers from office, examines its usage and legislative design, and provides policy recommendations for overcoming obstacles in removing senior bank executives.
VIRGINIA LAW REVIEW
(2022)
Review
Engineering, Biomedical
Yong Kiel Sung, Dae Ryeong Lee, Dong June Chung
Summary: The development of medical hemostatic biological materials is crucial for preventing intravascular bleeding, but separation of blood clots from blood vessel walls can cause serious health issues. Current research focuses on cellulose-based hemostatic starch, polysaccharide hemostatic materials, biomimetic adhesive chitosan, and gelatin-microbial transglutaminase-based hemostatic agents, aiming to find the optimal system to promote and strengthen active platelet aggregation in bleeding sites, increase thrombin production, and amplify hemostasis through a strengthened fibrin biopolymer network.
BIOMATERIALS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Barbara Boczkowska-Radziwon, Piotr Jozef Olbromski, Anna Rogowska, Magdalena Bujno, Marta Mysliwiec, Agnieszka Zebrowska, Dariusz Sredzinski, Barbara Politynska, Marek Z. Wojtukiewicz, Piotr Radziwon
Summary: This study demonstrates that ozone treatment significantly increases the release of microparticles derived from blood and endothelial cells. Although there were statistically significant changes in some coagulation factors, they were mild and did not exceed normal levels.
Article
Hematology
Aidan P. G. Walsh, Eefang Yu, James D. McFadyen, Viktoria Bongcaron, Mitchell J. Moon, Angela Huang, Jane F. Arthur, Ineke L. Muir, Veronika Rayzman, Con Panousis, Xiaowei Wang, Karlheinz Peter
Summary: Current clinical imaging of thromboembolic diseases often relies on indirect detection of thrombi, which may delay diagnosis and treatment. The development of targeted molecular imaging tools for direct imaging of thrombi using molecular imaging is highly desired. FXIIa targeting has been shown to be suitable for specific detection of venous and arterial thrombi, allowing for early imaging and monitoring of antithrombotic treatment.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Hematology
Pierre H. Mangin, Keith B. Neeves, Wilbur A. Lam, Judith M. E. M. Cosemans, Netanel Korin, Steven W. Kerrigan, Mikhail A. Panteleev
Summary: In vitro flow-based assays play a vital role in studying hemostasis and thrombosis, by integrating various aspects of platelet function and coagulation regulation through blood flow. Challenges include mimicking hemostatic plug formation in healthy vessels, thrombus formation in diseased arteries, and reproducing various aspects of venous thrombosis. Future directions aim to enhance the physiological or pathophysiological relevance of current flow-based assays by incorporating new flow models and techniques.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
Chiara Ambaglio, Federica Zane, Maria Concetta Russo, Paola Stefania Preti, Luigia Scudeller, Catherine Klersy, Gabriella Gamba, Alessandro Squizzato
Summary: The study aimed to assess the usefulness of ISTH-BAT and laboratory screening tests in identifying mild undiagnosed bleeding disorders and predicting bleeding complications in selected surgical patients.
Article
Hematology
Amanda M. Marshall, Taylor M. Trussell, Addison M. Yee, Mathew P. Malone
Summary: The study revealed that over 20% of pediatric patients in intensive care units receiving enoxaparin for VTE prophylaxis had serum anti-Xa levels consistent with therapeutic anticoagulation, with 5% achieving supratherapeutic anticoagulation levels. There was no correlation between serum anti-Xa levels and dosing frequency, body mass index, or creatinine levels, but blood urea nitrogen levels were found to have a positive association with anti-Xa levels above 0.5 units/mL. Routine monitoring of anti-Xa levels during VTE prophylaxis may be warranted to prevent unintended therapeutic anticoagulation.
THROMBOSIS RESEARCH
(2021)
Article
Hematology
Laura B. Harrington, Alexa N. Ehlert, Evan L. Thacker, Nancy S. Jenny, Oscar Lopez, Mary Cushman, Annette Fitzpatrick, Kenneth J. Mukamal, Majken K. Jensen
Summary: This study aimed to explore the association between hemostatic factors and changes in cognition, revealing that levels of plasmin-alpha(2)-antiplasmin complex, tissue factor pathway inhibitor, and factor X were associated with cognitive decline.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Business, Finance
Utz Weitzel, Michael Kirchler
Summary: Financial misbehavior is addressed by the Dutch government through a mandatory banker's oath for employees in the financial sector. A study found that nudges reminding financial advisers of their oath can positively impact their service by prioritizing client interests. However, Dutch regulators' expectations of the oath's effectiveness were higher than the observed results.
JOURNAL OF BANKING & FINANCE
(2023)
Article
Medicine, General & Internal
Connor M. Bunch, Anthony Thomas, John E. Stillson, Laura Gillespie, Rashid Z. Khan, Nuha Zackariya, Faadil Shariff, Mahmoud Al-Fadhl, Nicolas Mjaess, Peter D. Miller, Michael T. McCurdy, Daniel H. Fulkerson, Joseph B. Miller, Hau C. Kwaan, Ernest E. Moore, Hunter B. Moore, Matthew D. Neal, Peter L. Martin, Mark L. Kricheff, Mark M. Walsh
Summary: This study highlights the importance of implementing a precision-based titration strategy for anticoagulation in hospitalized COVID-19 patients to prevent thrombotic and bleeding complications.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Troy C. Sarich, Jonathan H. Seltzer, Scott D. Berkowitz, James Costin, John T. Curnutte, C. Michael Gibson, Maureane Hoffman, Edvardas Kaminskas, Mitchell W. Krucoff, Jerrold H. Levy, Paul D. Mintz, Paul A. Reilly, Philip T. Sager, Daniel E. Singer, Norman Stockbridge, Jeffrey I. Weitz, Peter R. Kowey
AMERICAN HEART JOURNAL
(2015)
Article
Anesthesiology
Maureane Hoffman, Zoya Volovyk, Dougald M. Monroe
Meeting Abstract
Hematology
Anthony D. Sung, Richard Yen, Divino Deoliveira, Yiqun Jiao, Sadhna Piryani, Alyssa Bernanke, Sharon Hall, Keith Klemp, Sangwon Yun, Gowthami Arepally, Maureane R. Hoffman, Thomas L. Ortel, Nelson J. Chao, Benny J. Chen
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2015)
Article
Hematology
Maureane Hoffman
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2015)
Article
Hematology
Junjiang Sun, Baolai Hua, Eric W. Livingston, Sarah Taves, Peter B. Johansen, Maureane Hoffman, Mirella Ezban, Dougald M. Monroe, Ted A. Bateman, Paul E. Monahan
Article
Hematology
M. Hoffman, J. -Y. Chang, M. Ezban, D. M. Monroe
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2016)
Article
Hematology
A. M. Fager, K. R. Machlus, M. Ezban, M. Hoffman
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2018)
Editorial Material
Hematology
M. Hoffman
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2018)
Review
Hematology
Gerhard Dickneite, Maureane Hoffman
THROMBOSIS AND HAEMOSTASIS
(2014)
Article
Hematology
Maureane Hoffman, Rafal Pawlinski
THROMBOSIS RESEARCH
(2014)
Article
Hematology
Laura J. Sommerville, Kristen L. Gorman, Stacey A. Snyder, Dougald M. Monroe, Maureane Hoffman
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2019)
Editorial Material
Hematology
Dougald Monroe, Maureane Hoffman
Editorial Material
Hematology
Maureane Hoffman
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Orthopedics
Benjamin Andress, Maureane Hoffman, Amy L. McNulty
Summary: Orthopaedic research, like biomedical research in general, has made significant progress in developing treatments for previously untreatable conditions. However, there is a concern about the quality of published research. This commentary highlights the importance of analytical validation and quality control in orthopaedic research and proposes recommendations for implementing these practices to improve research rigor and reproducibility.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Review
Emergency Medicine
Maureane Hoffman, Joshua N. Goldstein, Jerrold H. Levy
INTERNATIONAL JOURNAL OF EMERGENCY MEDICINE
(2018)
