Article
Cardiac & Cardiovascular Systems
Mariann Tang, Hanne Berg Ravn, Jan Jesper Andreasen, Jacob Greisen, Sisse Thomassen, Anja Fabrin, Carl-Johan Jakobsen
Summary: Previous studies have shown that transfusion of allogeneic red blood cells (RBC) is associated with higher long-term mortality, while newer recommendations advocate for lower transfusion rates. However, the consequences of RBC transfusion in cardiac surgery remain unclear, as most studies focus on short-term outcomes and transfusion triggers. Limited reports exist on long-term complications after cardiac surgery.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Neurosciences
Peter G. Tickle, Paul W. Hendrickse, Andrew Weightman, M. Hakam Nazir, Hans Degens, Stuart Egginton
Summary: Capillary rarefaction is associated with impaired muscle fatigue resistance and microvascular impairment in cardiovascular disease. Aerobic exercise and mechanical overload can prevent and restore muscle function in the early stages of heart disease, highlighting the importance of optimal capillary diffusion for skeletal muscle performance. Pro-angiogenic therapies are effective in improving skeletal muscle function in chronic diseases.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Review
Anesthesiology
Aaron Stansbury Hess, Jagan Ramamoorthy, John Rider Hess
Summary: This article briefly reviews the best evidence for when and how an anesthesiologist should administer platelets.
Article
Surgery
Jacob Raphael, Xiaoke Feng, Matthew S. Shotwell, Michael A. Mazzeffi, Bruce A. Bollen, Ashish S. Shah, Miklos D. Kertai
Summary: This study aimed to determine whether intraoperative packed red blood cell transfusion was associated with a higher incidence of hospital-acquired venous thromboembolic complications and adverse outcomes after isolated coronary artery bypass grafting surgery. The results showed that intraoperative transfusion was associated with HA-VTE and adverse outcomes.
Article
Respiratory System
Xiaofeng Li, Tong Tan, Hongxiang Wu, Chongjian Zhang, Dandong Luo, Weizhong Zhu, Boyu Li, Jian Zhuang
Summary: This study analyzed the changes in microcirculatory parameters after CPB-assisted cardiac surgery and found that TVD and PSVD may be the most sensitive indicators. There was no consistency between microcirculation and macrocirculation until 24 hours following surgery. In addition, early controlled oxygen supply may be beneficial for patient resuscitation after CPB-assisted cardiac surgery.
JOURNAL OF THORACIC DISEASE
(2022)
Article
Multidisciplinary Sciences
Andreas Garcia-Bardon, Jens Kamuf, Alexander Ziebart, Tanghua Liu, Nadia Krebs, Bastian Duenges, Robert F. Kelm, Svenja Morsbach, Kristin Mohr, Axel Heimann, Erik K. Hartmann, Serge C. Thal
Summary: The study investigated the effects of levosimendan on hemodynamic parameters, cerebral perfusion, and oxygenation following cardiac arrest in juvenile male pigs. Levosimendan significantly increased brain PbtO(2) levels without affecting cardiac output or cerebral microcirculation, suggesting a local effect. This indicates that levosimendan may offer a promising therapeutic approach to rescue brain tissue at risk following cardiac arrest or ischemic events.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Athanasios Chalkias, Nikolaos Papagiannakis, Bernd Saugel, Moritz Flick, Konstantina Kolonia, Zacharoula Angelopoulou, Dimitrios Ragias, Dimitra Papaspyrou, Aikaterini Bouzia, Nicoletta Ntalarizou, Konstantinos Stamoulis, Aikaterini Kyriakaki, Jesper Eugen-Olsen, Eleni Laou, Eleni Arnaoutoglou
Summary: This study found that elevated preoperative plasma suPAR levels were associated with intraoperative impairment of sublingual microvascular perfusion in patients undergoing major non-cardiac surgery. Specifically, higher suPAR levels were correlated with lower De Backer score, Consensus PPV, and Consensus PPV (small) during surgery.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Justyna Fercho, Michal Krakowiak, Rami Yuser, Tomasz Szmuda, Piotr Zielinski, Dariusz Szarek, Grzegorz Miekisiak
Summary: Pediatric spinal surgery is a blood-intensive procedure, and it is important to identify the risk factors for transfusions in order to implement a rational blood management program. Analysis of a national database from January 2015 to July 2017 revealed that fusing four or more levels and spinal deformity were the most significant risk factors for transfusions. A new patient blood management program is necessary to improve the transfusion rate in pediatric spinal surgery.
Article
Medicine, General & Internal
Chantal A. Boly, Margot Venhuizen, Nicole A. M. Dekker, Alexander B. A. Vonk, Christa Boer, Charissa E. van den Brom
Summary: Cardiac surgery with cardiopulmonary bypass impairs microcirculatory perfusion equally in metabolically healthy obese patients and lean patients, with recovery observed in both groups within three days post-surgery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
John C. Greenwood, David H. Jang, Audrey E. Spelde, Jacob T. Gutsche, Jiri Horak, Michael A. Acker, Todd J. Kilbaugh, Frances S. Shofer, John G. T. Augoustides, Jan Bakker, Benjamin S. Abella
Summary: This study found that low perfused vessel density and high microcirculatory heterogeneity are associated with an increased intensity and duration of lactic acidosis after cardiac surgery with cardiopulmonary bypass.
Article
Anesthesiology
John K. Peel, Jacqueline Trudeau, Ruby Tano, Saudia Jadunandan, Jeannie Callum, Fuad Moussa, Yulia Lin
Summary: The study found that preoperative IV iron >600 mg and epoetin alfa >80,000 U were associated with significant increases in hemoglobin levels, as well as a lower likelihood of transfusion and fewer units of RBC transfused. The authors recommend using cumulative preoperative doses of IV iron >600 mg and epoetin alfa >80,000 U for the treatment of anemia before cardiac surgery.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2021)
Article
Cardiac & Cardiovascular Systems
Rafael Gonzalez Cortes, Javier Urbano Villaescusa, Maria J. Solana Garcia, Jorge Lopez Gonzalez, Sarah N. Fernandez Lafever, Blanca Ramirez Gomez, Jose R. Fuentes Moran, Irene Hidalgo Garcia, Ana Peleteiro Pensado, Ramon Perez-Caballero Martinez, Carlos A. Pardo Prado, Alejandro Rodriguez Ogando, Maria Lopez Blazquez, Jesus Lopez-Herce Cid
Summary: This study conducted a prospective, observational single-center analysis of pediatric patients undergoing congenital heart defect surgery, assessing sublingual microcirculation and clinical parameters at various time points. The study found that all microcirculatory parameters worsened during cardiopulmonary bypass but returned to baseline values after surgery. Additionally, body temperature was correlated with various microcirculation parameters, and patients with cyanotic disease exhibited distinct microvascular changes compared to other patients.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Nursing
Kayla C. Everhart, Sarah B. Donevant, Victor N. Iskersky, Michael D. Wirth, Robin B. Dail
Summary: This study analyzed the physiological stability of very preterm infants before, during, and after packed red blood cell (PRBC) transfusions. The findings showed that the infants' physiological variables remained within defined limits during the transfusion. PRBC transfusions are necessary for very preterm infants and can prevent complications.
Article
Peripheral Vascular Disease
John C. Greenwood, Fatima M. Talebi, David H. Jang, Audrey E. Spelde, Emily K. Gordon, Jiri Horak, Michael A. Acker, Todd J. Kilbaugh, Frances S. Shofer, John G. T. Augoustides, Jan Bakker, Jacob S. Brenner, Vladimir R. Muzykantov, Benjamin S. Abella
Summary: Microcirculatory dysfunction after cardiovascular surgery is associated with significant morbidity and worse clinical outcomes. Changes in plasma soluble endothelial cell adhesion molecules (VCAM-1, ICAM-1, and E-Selectin) may be useful biomarkers for identifying abnormal microcirculatory blood flow in patients with shock.
MICROVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Yiquan Huang, Huimin Zhou, Shaozhao Zhang, Xiangbin Zhong, Yifen Lin, Zhenyu Xiong, Menghui Liu, Aili Yimamu, Odong Christopher, Ziwei Zhou, Xiaodong Zhuang, Xinxue Liao
Summary: The study found that exposure to higher blood pressure levels, especially diastolic blood pressure, from midlife to late life is associated with narrower retinal vessel diameters in late life. Race also moderates the association between cumulative blood pressure exposure and retinal microvasculature.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Clinical Neurology
Haryadi Prasetya, Lucas A. Ramos, Thabiso Epema, Kilian M. Treurniet, Bart J. Emmer, Ido R. van den Wijngaard, Guang Zhang, Manon Kappelhof, Olvert A. Berkhemer, Albert J. Yoo, Yvo B. E. W. M. Roos, Robert J. van Oostenbrugge, Diederik W. J. Dippel, Wim H. van Zwam, Aad van der Lugt, Bas A. J. M. de Mol, Charles B. L. M. Majoie, Ed van Bavel, Henk A. Marquering
Summary: The study introduces a semi-automated quantitative reperfusion measure, qTICI, which provides a similar prognostic value for functional outcome compared to eTICI score. It was found that in adjusted regression analyses, both qTICI and eTICI were independently associated with functional outcome.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Cardiac & Cardiovascular Systems
Hatem Al-Farra, Ameen Abu-Hanna, Bas A. J. M. de Mol, W. J. ter Burg, Saskia Houterman, Jose P. S. Henriques, Anita C. J. Ravelli
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2020)
Review
Cardiac & Cardiovascular Systems
Eric Wierda, Cathelijne Dickhoff, Martin Louis Handoko, Liane Oosterom, Wouter Emmanuel Kok, Y. de Rover, B. A. J. M. de Mol, Loek van Heerebeek, Jutta Maria Schroeder-Tanka
Review
Cardiac & Cardiovascular Systems
E. Wierda, D. van Veghel, A. Hirsch, B. A. J. M. de Mol
NETHERLANDS HEART JOURNAL
(2020)
Article
Primary Health Care
Idar Mappangara, Andriany Qanitha, Cuno S. P. M. Uiterwaal, Jose P. S. Henriques, Bastianus A. J. M. de Mol
BMC FAMILY PRACTICE
(2020)
Article
Cardiac & Cardiovascular Systems
Theodor Fischlein, Bart Meuris, Thierry Folliguet, Kavous Hakim-Meibodi, Martin Misfeld, Thierry Carrel, Marian Zembala, Elisa Cerutti, Federico M. Asch, Axel Haverich
Summary: This study reports the midterm clinical outcomes of a self-expandable sutureless aortic valve. The results show that this technology is associated with low mortality and morbidity rates, and good hemodynamic performance.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Biology
Ricardo R. Lopes, Hidde Bleijendaal, Lucas A. Ramos, Tom E. Verstraelen, Ahmad S. Amin, Arthur A. M. Wilde, Yigal M. Pinto, Bas A. J. M. de Mol, Henk A. Marquering
Summary: This study utilized transfer learning for ECG-based detection of PLN gene mutation, demonstrating that this method can improve the accuracy and efficiency of rare disease detection models.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Medicine, General & Internal
Ben Swinkels, Jurrien ten Berg, Johannes Kelder, Freddy Vermeulen, Wim Jan van Boven, Bas de Mol
Summary: Impaired left ventricular function, severe prosthesis-patient mismatch, and increased aortic cross-clamp time were found to be independent predictors of decreased long-term survival after aortic valve replacement. Patients with a mechanical prosthesis had a higher risk of major bleeding events, and younger age did not protect patients with a mechanical prosthesis against major bleeding events.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Riccardo Cocchieri, Bertus van de Wetering, Marco Stijnen, Robert Riezebos, Bastian de Mol
Summary: The article highlights the importance of reducing procedure-related patient injury and discomfort in minimally invasive cardiac surgery (MICS) through innovation and collaboration across bio-medical engineering sub-specialties. It emphasizes the need for focused interaction between engineers, industry, and surgeons to address unmet patient or professional needs. Additionally, the use of training and simulation models is crucial for safe and effective use of novel techniques in MICS.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Sarah W. E. Baalman, Ricardo R. Lopes, Lucas A. Ramos, Jolien Neefs, Antoine H. G. Driessen, WimJan P. van Boven, Bas A. J. M. de Mol, Henk A. Marquering, Joris R. de Groot
Summary: Thoracoscopic surgical ablation for atrial fibrillation has been proven effective, and machine learning techniques were used in this study to investigate how baseline characteristics can predict AF recurrence. Multiple ML models were trained and variable selection significantly improved model performance, especially in predicting AF recurrence in younger patients.
Article
Cardiac & Cardiovascular Systems
Hatem Al-Farra, Anita C. J. Ravelli, Jose P. S. Henriques, Saskia Houterman, Bas A. J. M. de Mol, Ameen Abu-Hanna
Summary: A new mortality prediction model (MPM) for transcatheter aortic valve implantation (TAVI) was developed and validated in this study. The model showed good discrimination and calibration, outperforming the currently available models. It can provide valuable information for preprocedural risk assessment and patient counseling.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Marco Mamprin, Ricardo R. Lopes, Jo M. Zelis, Pim A. L. Tonino, Martijn S. van Mourik, Marije M. Vis, Svitlana Zinger, Bas A. J. M. de Mol, Peter H. N. de With
Summary: Machine learning models were used to improve risk stratification for TAVI patients, with a dedicated exchange protocol demonstrating the robustness of the models across different centers. The models developed with larger datasets showed similar or higher prediction accuracy during external validation, suggesting the potential for broader application in different clinical scenarios.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Hatem Al-Farra, Bas A. J. M. de Mol, Anita C. J. Ravelli, W. J. P. P. ter Burg, Saskia Houterman, Jose P. S. Henriques, Ameen Abu-Hanna
Summary: This study updated and internally validated the FRANCE-2 and ACC-TAVI models using a recent TAVI cohort from the Netherlands Heart Registration. The updated models showed improved performance, with internal validation results better than external validation studies, and ACC-TAVI outperformed FRANCE-2 in temporal validation.
IJC HEART & VASCULATURE
(2021)
Article
Medicine, Research & Experimental
Noemi Vanerio, Marco Stijnen, Bas A. J. M. de Mol, Linda M. Kock
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
(2020)
Article
Cardiac & Cardiovascular Systems
Ben M. Swinkels, Jurrien M. Ten Berg, Johannes C. Kelder, Freddy E. Vermeulen, Wim Jan Van Boven, Bas A. de Mol
Summary: This study found that longer aortic cross-clamp time was independently associated with decreased late survival in patients with severe aortic stenosis after isolated aortic valve replacement. Longer cardiopulmonary bypass time was not found to have a similar association.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2021)