期刊
PROTEIN & CELL
卷 6, 期 11, 页码 804-813出版社
SPRINGER
DOI: 10.1007/s13238-015-0204-y
关键词
metabolic homeostasis; transcription factor; post-translational modification; type 2 diabetes mellitus
类别
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [NRF-2011-0030086, 2014R1A2A2A01004396, NRF-2013R1A1A2058302]
- National Research Foundation of Korea [2014R1A2A2A01004396] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Post-translational modifications (PTMs) of transcription factors play a crucial role in regulating metabolic homeostasis. These modifications include phosphorylation, methylation, acetylation, ubiquitination, SUMOylation, and O-GlcNAcylation. Recent studies have shed light on the importance of lysine acetylation at nonhistone proteins including transcription factors. Acetylation of transcription factors affects subcellular distribution, DNA affinity, stability, transcriptional activity, and current investigations are aiming to further expand our understanding of the role of lysine acetylation of transcription factors. In this review, we summarize recent studies that provide new insights into the role of protein lysine-acetylation in the transcriptional regulation of metabolic homeostasis.
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