Review
Biochemistry & Molecular Biology
Sante Roperto
Summary: Bovine Deltapapillomavirus genus is highly pathogenic and commonly found in bladder tumors of adult cattle and water buffaloes. These viruses are associated with specific gene mutations that may lead to abnormal cell proliferation and differentiation, particularly in animals grazing on pastures rich in bracken fern.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Immunology
Francesca De Falco, Anna Cutarelli, Adriana Florinela Catoi, Barbara Degli Uberti, Bianca Cuccaro, Sante Roperto
Summary: Persistent infection and tumorigenesis by papillomaviruses require manipulation of cellular processes involved in innate immune responses. A study found that a pathway essential for innate immune sensing, the cGAS-STING pathway, is impaired in bovine papillomavirus (BPV) infection, leading to persistent viral infection and tumorigenesis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
R. Hoikhman, D. Molinkova, D. Pillarova, P. Linhart, A. Kopecka, P. Jahn
Summary: Equine sarcoids (ES) are the most common skin tumor in horses, affecting their economic value and welfare. Bovine papillomavirus (BPV) is the cause of this tumor, with the E5 protein downregulating MHC I to escape immune reaction and allow viral infected cells to proliferate into ES. By using an ELISA test, antibodies to the E5 oncoprotein were found in ES positive horses, indicating an immune response to this protein.
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2023)
Article
Infectious Diseases
Anna Cutarelli, Francesca De Falco, Valeria Uleri, Canio Buonavoglia, Sante Roperto
Summary: The present study used liquid biopsy to investigate highly pathogenic bovine deltapapillomavirus DNA in blood samples of goats, revealing varying infection rates and genotype distributions. The findings suggest that animal husbandry practices may contribute to cross-species transmission of BPVs.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Ethan L. Morgan, James A. Scarth, Molly R. Patterson, Christopher W. Wasson, Georgia C. Hemingway, Diego Barba-Moreno, Andrew Macdonald
Summary: The study identified activation of the JNK signaling pathway in cervical disease and cancer, with the HPV E6 oncogene inducing JNK1/2 phosphorylation. Blocking JNK signaling reduced cell proliferation and induced apoptosis, while promoting EGFR signaling. This positive feedback loop between EGFR signaling and HPV E6/E7 expression may offer a novel therapeutic target for cervical cancer treatment.
CELL DEATH AND DIFFERENTIATION
(2021)
Review
Agriculture, Dairy & Animal Science
Alfredo Cruz-Gregorio, Ana Karina Aranda-Rivera, Jose Pedraza-Chaverri
Summary: This article focuses on the similarities in pathology and biomarkers in canine, feline, and human cancers associated with PV, specifically the overexpression of oncoproteins E5, E6, and E7. The potential benefit of treatments targeting these oncoproteins is discussed, highlighting the potential for translational research in these three species.
Review
Biochemistry & Molecular Biology
Daria A. Hareza, Jacek R. Wilczynski, Edyta Paradowska
Summary: Human papillomaviruses (HPVs) are small nonenveloped DNA viruses associated with various cancers. HPVs can be classified into high-risk and low-risk types based on their genotypes. The oncogenic effects of HPV are mainly attributed to the activity of its E6 and E7 proteins, which interfere with the cell cycle and contribute to carcinogenesis. Additionally, the E5 protein may also play a significant role in tumor formation. The role of HPV in the pathogenesis of gynecological cancers is still not fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Feng Pang, Qinqin Long, Min Wei
Summary: This article provides an overview of how bovine viral diarrhea virus (BVDV) evades the host's immune response through various immune evasion strategies, thereby promoting the virus's survival and replication. Understanding BVDV's immune evasion strategies can enhance our knowledge of its pathogenesis and contribute to the development of more effective prevention, control, and eradication measures.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Veterinary Sciences
Beatriz Medeiros-Fonseca, Ana Lucia Abreu-Silva, Rui Medeiros, Paula A. Oliveira, Rui M. Gil da Costa
Summary: Bovine papillomavirus (BPV) is a global concern due to its ability to induce various benign and malignant diseases, with a high association with bracken fern toxins. Understanding the interactions between BPV and bracken chemical carcinogens is crucial for controlling livestock losses caused by these pathogens worldwide.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Genetics & Heredity
Sidharth V. Puram, Michael Mints, Ananya Pal, Zongtai Qi, Ashley Reeb, Kyla Gelev, Thomas F. Barrett, Sophie Gerndt, Ping Liu, Anuraag S. Parikh, Salma Ramadan, Travis Law, Edmund A. Mroz, James W. Rocco, Doug Adkins, Wade L. Thorstad, Hiram A. Gay, Li Ding, Randal C. Paniello, Patrik Pipkorn, Ryan S. Jackson, Xiaowei Wang, Angela Mazul, Rebecca Chernock, Jose P. Zevallos, Jessica Silva-Fisher, Itay Tirosh
Summary: Single-cell analysis reveals high levels of inter- and intratumoral heterogeneity in head and neck squamous cell carcinoma (HNSCC), specifically in human papillomavirus (HPV)-positive and HPV-negative oropharynx tumors. Divergent patterns of HPV gene expression within HPV-positive tumors have functional effects on treatment resistance.
Article
Agriculture, Dairy & Animal Science
Annamaria Pratelli, Maria Stella Lucente, Marco Cordisco, Stefano Ciccarelli, Roberta Di Fonte, Alessio Sposato, Viviana Mari, Paolo Capozza, Francesco Pellegrini, Grazia Carelli, Amalia Azzariti, Canio Buonavoglia
Summary: The study described the evolution of a bovine coronavirus (BCoV) natural infection in a calf persistently infected with bovine viral diarrhea virus (BVDV). The co-infection resulted in increased monocytes and CD8(+) subpopulations, as well as prolonged viral shedding and high antibody titers. It is suggested that BVDV may have exacerbated the BCoV infection and favored the development of genetic mutations, potentially influencing the viral excretion pattern and genetic variation.
Article
Virology
Biagio Santella, Maria T. Schettino, Gianluigi Franci, Pasquale De Franciscis, Nicola Colacurci, Antonio Schiattarella, Massimiliano Galdiero
Summary: The prevalence of HPV infection in the world population is estimated to be between 9% and 13%. Certain bacteria are associated with HPV infection and the development of cervical tumors. This study aims to investigate the impact of HPV infection on the composition of the cervical microbiota.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Oncology
Yayi Zhao, Rossybelle P. Amorrortu, Neil A. Fenske, Basil Cherpelis, Jane L. Messina, Vernon K. Sondak, Anna R. Giuliano, Michael J. Schell, Tim Waterboer, Michael Pawlita, Sandrine McKay-Chopin, Tarik Gheit, Massimo Tommasino, Dana E. Rollison
Summary: The study investigated the association between UV radiation and various cutaneous viral infections, finding a positive correlation between UV exposure and three markers of Beta-HPV infection.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Veterinary Sciences
Rui Yao, Yueren Xu, Lang Wang, Dawei Wang, Linchang Ren, Changling Ren, Cunyuan Li, Xiaoyue Li, Wei Ni, Yanhua He, Ruirui Hu, Tao Guo, Yaxin Li, Lei Li, Xiaokui Wang, Shengwei Hu
Summary: In this study, a sensitive, specific, and simple nucleic acid detection method based on CRISPR-Cas13a was developed for BVDV. The method has a detection limit of 10(3) pM and does not cross-react with other cell types. This provides a new detection strategy for early diagnosis of BVDV.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Immunology
Ang Su, Yuguang Fu, Jochen Meens, Wei Yang, Fandan Meng, Georg Herrler, Paul Becher
Summary: BVDV infects bovine airway epithelial cells efficiently, with the virus being released to the apical site irrespective of the infection site. The receptor for apical infection, CD46, is predominantly expressed on the apical membrane domain, while the receptor for basolateral infection remains unknown.
Article
Veterinary Sciences
Gennaro Altamura, Giusy Cardeti, Antonella Cersini, Claudia Eleni, Cristiano Cocumelli, Leticia E. B. Del Pino, Elisabetta Razzuoli, Manuela Martano, Paola Maiolino, Giuseppe Borzacchiello
VETERINARY AND COMPARATIVE ONCOLOGY
(2020)
Article
Microbiology
Manuela Martano, Gennaro Altamura, Karen Power, Brunella Restucci, Francesca Carella, Giuseppe Borzacchiello, Paola Maiolino
Article
Veterinary Sciences
Gennaro Altamura, Manuela Martano, Luca Licenziato, Paola Maiolino, Giuseppe Borzacchiello
FRONTIERS IN VETERINARY SCIENCE
(2020)
Editorial Material
Microbiology
Gennaro Altamura, Massimo Tommasino, Giuseppe Borzacchiello
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Veterinary Sciences
Gennaro Altamura, Barbara degli Uberti, Giorgio Galiero, Giovanna De Luca, Karen Power, Luca Licenziato, Paola Maiolino, Giuseppe Borzacchiello
Summary: BIBR1532 shows multiple anti-cancer activities in feline oral squamous cell carcinoma by inhibiting telomerase pathway and interfering with signaling routes involved in cell proliferation, cell survival, and invasion, paving the way for future translational studies.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Manuela Martano, Gennaro Altamura, Karen Power, Pierluigi Liguori, Brunella Restucci, Giuseppe Borzacchiello, Paola Maiolino
Summary: Equine sarcoids, caused by bovine papillomaviruses, exhibit an alteration of the autophagic process, leading to the survival of a specific population of fibroblasts that produce more and/or altered collagen in a hypoxic microenvironment.
Article
Veterinary Sciences
Gennaro Altamura, Giuseppe Borzacchiello
Summary: The study aims to assess the efficacy of Cetuximab in FOSCC and found that Cetuximab can inhibit the activation of EGFR, reduce cell proliferation and cell viability, and induce cell apoptosis. These results suggest potential anti-cancer activities of Cetuximab in the therapy of FOSCC.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Veterinary Sciences
Florentina Daraban Bocaneti, Gennaro Altamura, Annunziata Corteggio, Oana Irina Tanase, Mihaela Anca Dascalu, Sorin Aurelian Pasca, Ozana Hritcu, Mihai Mares, Giuseppe Borzacchiello
Summary: This study investigated the expression of MMP-1/-8/-13 and TIMP-3 in bovine cutaneous fibropapillomas. The results showed that MMP-8/-13 were overexpressed while MMP-1 was down-regulated in the tumors compared to normal skin samples, along with a decrease in TIMP-3 levels. These findings suggest that an imbalance between MMPs/TIMPs may contribute to increased collagenolytic activity and play a role in ECM changes and tumor development.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Veterinary Sciences
Florentina Daraban Bocaneti, Gennaro Altamura, Annunziata Corteggio, Oana Irina Tanase, Mihaela Anca Dascalu, Sorin Aurelian Pasca, Ozana Hritcu, Mihai Mares, Giuseppe Borzacchiello
Summary: This study conducted immunohistochemical and biochemical analysis on MMPs and TIMPs in BPV-2 positive bovine cutaneous fibropapillomas, revealing their significant role in tumor development and their unbalanced expression in tumor samples.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Infectious Diseases
Florentina Daraban Bocaneti, Larisa Maria Ivanescu, Liviu Miron, Oana Irina Tanase, Mihaela Anca Dascalu
Summary: Leishmaniasis, traditionally considered a nonendemic disease in Romania, has seen an increase in prevalence due to climate change creating optimal conditions for vector spread. Importation of the disease through travel of humans and dogs has made it a medical concern in the country.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Veterinary Sciences
Gennaro Altamura, Giuseppe Borzacchiello
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Veterinary Sciences
Gennaro Altamura, Manuela Martano, Anna Matrone, Annunziata Corteggio, Giuseppe Borzacchiello
Summary: Feline oral squamous cell carcinoma (FOSCC) is difficult to treat and new therapeutic strategies are needed. This study found that cetuximab, an anti-epidermal growth factor receptor monoclonal antibody, has inhibitory effects on invasion and metastasis in FOSCC by affecting MMPs and epithelial-mesenchymal transition pathways, potentially improving the management of the disease.
VETERINARY AND COMPARATIVE ONCOLOGY
(2023)
Article
Veterinary Sciences
Gennaro Altamura, Bianca Cuccaro, Claudia Eleni, Carina Strohmayer, Sabine Brandt, Giuseppe Borzacchiello
Summary: Recent evidence suggests a potential association of Felis catus papillomavirus type 2 (FcaPV-2) DNA with feline oral squamous cell carcinoma (FOSCC). This study detected viral DNA in a significant number of FOSCC samples collected in Italy and Austria using type-specific PCR targeting different genes of FcaPV-1/-2/-3/-4/-5/-6. The results confirmed the high prevalence of FcaPV-2 in FOSCC and highlighted potential differences in the circulation rates of FcaPVs among European countries.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2022)