Human germ line editing—roles and responsibilities

Development of the adverse outcome pathway “alkylation of DNA in male premeiotic germ cells leading to heritable mutations” using the OECD's users' handbook supplement

(2015) Carole L. Yauk et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Regulate gene editing in wild animals

(2015) Jeantine Lunshof   NATURE

Don’t edit the human germ line

(2015) Edward Lanphier et al.   NATURE

Oversight of human inheritable genome modification

(2015) Rosario Isasi et al.   NATURE BIOTECHNOLOGY

Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining

(2015) Takeshi Maruyama et al.   NATURE BIOTECHNOLOGY

Small molecule–triggered Cas9 protein with improved genome-editing specificity

(2015) Kevin M Davis et al.   Nature Chemical Biology

A Novel Candidate Region for Genetic Adaptation to High Altitude in Andean Populations

(2015) Guido Valverde et al.   PLoS One

Safeguarding gene drive experiments in the laboratory

(2015) O. S. Akbari et al.   SCIENCE

CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes

(2015) Puping Liang et al.   Protein & Cell

In utero exposure to cigarette smoke dysregulates human fetal ovarian developmental signalling

(2014) P. A. Fowler et al.   HUMAN REPRODUCTION

Regulating gene drives

(2014) K. A. Oye et al.   SCIENCE

Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells

(2014) Luhan Yang et al.   Nature Communications

Improved Efficiency of Microsurgical Enucleated Tripronuclear Zygotes Development and Embryonic Stem Cell Derivation by Supplementing Epidermal Growth Factor, Brain-Derived Neurotrophic Factor, and Insulin-Like Growth Factor-1

(2013) Yong Fan et al.   STEM CELLS AND DEVELOPMENT

What is the evidence for heterozygote advantage selection?

(2012) Philip W. Hedrick   TRENDS IN ECOLOGY & EVOLUTION