Article
Immunology
Sehee Shin, So Hui Park, Jong-Hyeon Park, Su-Mi Kim, Min Ja Lee
Summary: This study aimed to determine the optimal timing of vaccination for young animals against foot-and-mouth disease (FMD) and investigate the impact of maternally derived antibodies (MDAs) on vaccine-mediated active immunity. Through analyzing antibody levels and immunoglobulin subtypes, the study provided insights into the age-dependent characteristics of MDAs and their interference with vaccine responses. Additionally, the correlation between MDA-mediated passive immunity and vaccine-mediated active immunity was explored, shedding light on potential novel strategies and vaccine development.
Article
Biochemistry & Molecular Biology
Tingting Ren, Haotai Chen, Xinsheng Liu, Yanxue Wang, Aixia Fan, Linlin Qi, Li Pan, Wenlong Bai, Yongguang Zhang, Yuefeng Sun
Summary: The ID1 protein promotes the degradation of FOXO1, suppresses interferon production, and inhibits HDAC4, ultimately suppressing the replication of FDMV and potentially other viruses.
Article
Immunology
Fanos Tadesse Woldemariyam, Demessa Negessu, Tsion Bilata, Ayelech Muluneh, Dereje Shegu Gebreweld, Ibsa Teshome Ebisa, Jan Paeshuyse
Summary: This study aimed to quantify the immune response and evaluate the serological relationship of the vaccine strain with field strain isolates. The results showed that the vaccine induced a protective immune response and had a good serological relationship with circulating field strains in Ethiopia.
Article
Immunology
Long-Feng Lu, Can Zhang, Zhuo-Cong Li, Xiao-Yu Zhou, Jing-Yu Jiang, Dandan Chen, Yong-An Zhang, Shun Li
Summary: The study demonstrates that GCRV's 35-kDa VP35 protein inhibits host IFN production by degrading MAVS protein, making host cells more susceptible to virus infection. This suggests that GCRV may employ a strategy of impairing host immune response through the autophagy pathway.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Tatsuya Nishi, Katsuhiko Fukai, Kentaro Masujin, Rie Kawaguchi, Mitsutaka Ikezawa, Manabu Yamada, Nozomi Nakajima, Takashi Komeno, Yousuke Furuta, Hiromi Sugihara, Chie Kurosaki, Kenichi Sakamoto, Kazuki Morioka
Summary: This study found that the pyrazinecarboxamide derivative T-1105 has strong antiviral activity against foot-and-mouth disease virus (FMDV) and can effectively control the spread of FMDV in pigs.
ANTIVIRAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Christine Vazquez, Kellie A. Jurado
Summary: This review outlines the immune regulatory mechanisms in the central nervous system (CNS) and the strategies viruses use to bypass the blood-brain barrier. Future questions in this rapidly expanding field are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Kun Li, Guoqiang Zhu, Shasha Zhou, Pu Sun, Hengmei Wang, Huifang Bao, Yuanfang Fu, Pinghua Li, Xingwen Bai, Xueqing Ma, Jing Zhang, Dong Li, Yingli Chen, Zaixin Liu, Yimei Cao, Zengjun Lu
Summary: Pigs are susceptible to foot-and-mouth disease virus (FMDV), and the humoral immune response plays a crucial role in protection. Antibodies from pigs recognize conserved antigen epitopes on capsid protein VP2 and exhibit broad reactivity against both FMDV serotypes A and O. The study reveals a novel method for analyzing the antibody response against FMDV in pigs at the clonal level.
JOURNAL OF GENERAL VIROLOGY
(2021)
Review
Immunology
Yihan Liu, Yupei Yuan, Leiliang Zhang
Summary: This article focuses on the mechanisms employed by alphaviruses to evade host immune responses, which is crucial for understanding the pathogenesis of alphaviruses and developing effective strategies for infection control.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Yimei Cao, Kun Li, Xiangchuan Xing, Guoqiang Zhu, Yuanfang Fu, Huifang Bao, Xingwen Bai, Pu Sun, Pinghua Li, Jing Zhang, Xueqing Ma, Jian Wang, Zhixun Zhao, Dong Li, Zaixin Liu, Zengjun Lu
Summary: In this study, a bovine broadly neutralizing monoclonal antibody (W145) against FMDV serotype A was successfully produced using fluorescence-based single-B-cell antibody technology. A competitive enzyme-linked immunosorbent assay (NAC-ELISA) was developed for the detection of neutralizing antibodies against FMDV serotype A. The NAC-ELISA showed high specificity and sensitivity and could be used to evaluate protective immunity.
JOURNAL OF CLINICAL MICROBIOLOGY
(2022)
Article
Virology
Huisheng Liu, Qiao Xue, Zixiang Zhu, Fan Yang, Weijun Cao, Xiangtao Liu, Haixue Zheng
Summary: The study found that RIP2 inhibited the replication of foot-and-mouth disease virus (FMDV) and played an important role in the activation of the IFN-β and NF-κB signal pathways during FMDV infection. Specific regions of FMDV proteins were responsible for reducing RIP2 protein expression, with specific regions of 2B and 2C being crucial for this process.
Article
Multidisciplinary Sciences
Xinhai Chen, Olaf Schneewind, Dominique Missiakas
Summary: This study demonstrates that modifying the Fc gamma domain of therapeutic antibodies can enhance their half-life and opsonophagocytic killing, leading to improved antibody-based immunotherapy. Additionally, staphylococci are able to reduce antibody half-life by competing for FcRn binding.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Microbiology
Gyeongmin Lee, Hyo Rin Kang, Aro Kim, Jong-Hyeon Park, Min Ja Lee, Su-Mi Kim
Summary: This study found that quercetin has antiviral effects against FMDV by inducing interferon production and enhancing the immune system in animals. Therefore, quercetin could potentially be used as a novel and effective antiviral agent for controlling FMDV infection. However, further research on its application in livestock is needed.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Immunology
Michelle Felicia Lee, Guan Zhong Voon, Hui Xuan Lim, Mun Lok Chua, Chit Laa Poh
Summary: Dengue is a mosquito-borne disease that poses significant public health concerns in tropical and subtropical countries. The dengue virus has evolved various strategies to manipulate the host's immune responses, and miRNAs and DENV non-structural proteins (NS) are promising targets for anti-dengue therapeutics.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Immunology
Zhijie Jian, Rui Ma, Ling Zhu, Huidan Deng, Fengqin Li, Jun Zhao, Lishuang Deng, Siyuan Lai, Xiangang Sun, Huaqiao Tang, Zhiwen Xu
Summary: This article reviews the strategies used by Arteriviruses to antagonize IFN production and thwart IFN-activated antiviral signaling, emphasizing the significance of this research in understanding the pathogenesis of arthritis virus and developing vaccines.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Hyejin Kim, Ah-Young Kim, Jieun Choi, Sun Young Park, Sang Hyun Park, Jae-Seok Kim, Sim-In Lee, Jong-Hyeon Park, Choi-Kyu Park, Young-Joon Ko
Summary: During foot-and-mouth disease virus (FMDV) infection, inhibition of MDA5 protein expression is primarily caused by the non-structural proteins Lb(pro) and 3C(pro), with 3C(pro) directly interacting with MDA5 protein through its protease activity. This study sheds light on the pathogenesis of FMDV and may contribute to the development of novel vaccines or therapeutic agents.
Article
Immunology
Simon Welner, Nicolas Ruggli, Matthias Liniger, Artur Summerfield, Lars Erik Larsen, Gregers Jungersen
Summary: This study introduced virus replicon particles (VRPs) based on classical swine fever virus genome to express conserved PRRSV-2 cytotoxic T-cell epitopes. The pigs vaccinated with VRPs showed significantly lower virus load in the lung and higher interferon-gamma secreting cells after challenge compared to the control group. These results suggest a potential for developing effective PRRSV vaccines with a shapeable cell-mediated immune response.
Article
Neurosciences
Leticia Tavares-Gomes, Camille Monney, Geraldine Neuhaus, David Francisco, Diana Solis, Artur Summerfield, Daniel Erny, Vidhya Jagannathan, Anna Oevermann
Summary: Microglia and MDM play different roles in neuroinfections, with potential data from studies on bovine neuroinfections being applicable to human infections.
Review
Microbiology
Jose Manuel Rojas, Miguel Avia, Veronica Martin, Noemi Sevilla
Summary: Bluetongue virus (BTV) is a prototypical orbivirus belonging to the Reoviridae family that infects ruminants, particularly sheep, and is transmitted by Culicoides spp. midges. Infection leads to reduced productivity and economic losses.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Daniel Rodriguez-Martin, Jose Manuel Rojas, Francesca Macchi, Valentina Franceschi, Luca Russo, Noemi Sevilla, Gaetano Donofrio, Veronica Martin
Summary: Utilizing a bovine herpesvirus-4 vector to deliver PPRV antigen, vaccination provided protection against virulent PPRV challenge in sheep and allowed for differentiation between infected and vaccinated animals. This study suggests that the new approach may be promising for PPRV eradication programs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Lorenz Ulrich, Nico Joel Halwe, Adriano Taddeo, Nadine Ebert, Jacob Schoen, Christelle Devisme, Bettina Salome Trueb, Bernd Hoffmann, Manon Wider, Xiaoyu Fan, Meriem Bekliz, Manel Essaidi-Laziosi, Marie Luisa Schmidt, Daniela Niemeyer, Victor Max Corman, Anna Kraft, Aurelie Godel, Laura Laloli, Jenna N. Kelly, Brenda M. Calderon, Angele Breithaupt, Claudia Wylezich, Ines Berenguer Veiga, Mitra Gultom, Sarah Osman, Bin Zhou, Kenneth Adea, Benjamin Meyer, Christiane S. Eberhardt, Lisa Thomann, Monika Gsell, Fabien Labroussaa, Joerg Jores, Artur Summerfield, Christian Drosten, Isabella Anne Eckerle, David E. Wentworth, Ronald Dijkman, Donata Hoffmann, Volker Thiel, Martin Beer, Charaf Benarafa
Summary: Experimental assessments of major VOCs show that Alpha and Beta variants have a higher affinity for the human ACE2 receptor compared to the progenitor variant. Competition experiments demonstrate that Alpha has a clear fitness advantage over wt-S-614G in ferrets and mouse models.
Article
Veterinary Sciences
S. Ruefenacht, S. Schellenberg, S. Borio, A. Summerfield, M. E. Ricklin
Summary: This study found that using oral prednisolone as a monotherapy for four weeks can effectively treat aural hematoma in dogs. The treatment led to at least 80% clinical improvement in most dogs and reduced the ear thickness by at least 50%.
SCHWEIZER ARCHIV FUR TIERHEILKUNDE
(2022)
Article
Immunology
Stephanie C. Talker, G. Tuba Barut, Heidi E. L. Lischer, Reto Rufener, Lilly von Munchow, Remy Bruggmann, Artur Summerfield
Summary: This study investigates the transcriptome profiles and functions of bovine monocytes. The findings reveal three subtypes of monocytes in bovine, each with distinct functional roles. Classical monocytes are involved in pro-inflammatory and antibacterial responses, while nonclassical and intermediate monocytes are specialized in regulatory/anti-inflammatory functions, tissue repair, antiviral responses, and T-cell immunomodulation. Furthermore, heterogeneity within classical monocytes is discovered, and intermediate monocytes are proposed as a transient differentiation stage between classical and nonclassical monocytes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Daniel Rodriguez-Martin, Isabel Garcia-Garcia, Veronica Martin, Jose Manuel Rojas, Noemi Sevilla
Summary: Viruses, including morbilliviruses, can impair immunity through various strategies. In this study, it was found that the highly contagious morbillivirus peste des petits ruminants virus (PPRV) can infect monocytes and dendritic cells (DC), leading to immunosuppression. PPRV infection compromised the differentiation and phagocytic ability of monocyte-derived DC, as well as their capacity to activate T cell responses. Furthermore, PPRV-infected DC exhibited an immunosuppressive profile. These findings contribute to our understanding of how morbilliviruses suppress the immune response.
JOURNAL OF VIROLOGY
(2022)
Article
Microbiology
Emilia Radulovic, Kemal Mehinagic, Tsering Wuethrich, Markus Hilty, Horst Posthaus, Artur Summerfield, Nicolas Ruggli, Charaf Benarafa
Summary: In this study, the immunological profile of specific pathogen-free (SPF) and farm-raised Large White domestic pigs before and after African Swine Fever virus (ASFV) infection was compared. The results showed that SPF pigs had lower immune cell counts and basal inflammatory responses at steady state. When infected with a highly virulent virus strain, SPF pigs showed earlier and more severe clinical signs and pro-inflammatory cytokines, indicating a reduced ability to control early virus replication. In contrast, SPF pigs presented a milder and shorter disease course with full recovery when infected with an attenuated virus strain.
Article
Immunology
Jose M. Rojas, Carolina Mancho, Andres Louloudes-Lazaro, Daniel Rodriguez-Martin, Miguel Avia, Santiago Moreno, Noemi Sevilla, Veronica Martin
Summary: This study investigates the immunomodulatory properties of OX40L and CD70 on the immune response to OVA antigen. The results show that OaCD70 administration can enhance the adaptive immune response to OVA, including increased antibody titers and the number of antigen-specific IgG-secreting B cells. Additionally, OaCD70 also promotes the differentiation and long-term activity of CD8(+) T cell effectors.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Veterinary Sciences
Artur Summerfield, Heidi Gerber, Rebeka Schmitt, Matthias Liniger, Santina Grazioli, Emiliana Brocchi
Summary: This study demonstrates that monoclonal antibodies targeting FMDV O and A serotypes are able to opsonize the virus and induce cell death. Opsonization shows broader reactivity within the serotype and correlates better with vaccine dose compared to neutralization. Neutralization and opsonization titers are similarly predictive of protection.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Immunology
Pedro J. Alcolea, Jaime Larraga, Daniel Rodriguez-Martin, Ana Alonso, Francisco J. Loayza, Jose M. Rojas, Silvia Ruiz-Garcia, Andres Louloudes-Lazaro, Ana B. Carlon, Pedro J. Sanchez-Cordon, Pablo Nogales-Altozano, Natalia Redondo, Miguel Manzano, Daniel Lozano, Jesus Palomero, Maria Montoya, Maria Vallet-Regi, Veronica Martin, Noemi Sevilla, Vicente Larraga
Summary: Researchers presented a promising DNA vaccine candidate, pPAL-Sfs + pPAL-N, which demonstrated strong protective effects in mice, fully controlling viral replication and inducing potent humoral and cellular immune responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Gueliz Tuba Barut, Marco Kreuzer, Remy Bruggmann, Artur Summerfield, Stephanie C. Talker
Summary: Dendritic and monocytic cells work together to initiate and shape adaptive immune responses in secondary lymphoid tissue. By sequencing mononuclear phagocytes at the single-cell level in mesenteric lymph nodes of cows, researchers identified distinct clusters of dendritic cells and monocytes/macrophages with different transcriptomic profiles. They also discovered subsets of highly activated migratory dendritic cells and potential differentiation paths for certain cell types. Additionally, they found sub-clusters of monocytes and macrophages driven by pro- or anti-inflammatory gene expression signatures. This study provides valuable insight into the functional properties and differentiation trajectories of mononuclear phagocytes in the immune system.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Infectious Diseases
Patrick Thalmann, Simone Ehrhard, Artur Summerfield, Meret Elisabeth Ricklin
Summary: This retrospective study described patients presenting to the emergency department of a large university hospital in Switzerland with complaints of tick bite. The study found that although tick bites were not frequently seen in the emergency department, there were many patients with neurological symptoms following tick bites, indicating the need for a systematic assessment of vaccination status, virus serology, and further diagnostic evaluations.
INFECTIOUS DISEASE REPORTS
(2023)
Article
Veterinary Sciences
Roger-Junior Eloiflin, Llorenc Grau-Roma, Sylvie Python, Kemal Mehinagic, Aurelie Godel, Genevieve Libeau, Artur Summerfield, Arnaud Bataille, Obdulio Garcia-Nicolas
Summary: This study confirmed the difference in virulence between Peste des petits ruminants (PPR) virus strains and found that viral RNA can be detected in the tissues and serum samples of vaccinated animals.
VETERINARY RESEARCH
(2022)