Review
Endocrinology & Metabolism
Michael Yapanis, Steven James, Maria E. Craig, David O'Neal, Elif Ekinci
Summary: This review summarizes the relationship between continuous glucose monitoring (CGM)-derived metrics of glycemic variability and diabetes-related complications. The results show that glycemic variability and low time in range (TIR) are associated with microvascular and macrovascular complications of diabetes. Higher TIR is associated with reduced risk of various complications, while standard deviation of blood glucose levels (SD) and mean amplitude of glycemic excursions (MAGE) are associated with peripheral neuropathy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Caroline T. B. Juel, Thomas F. Dejgaard, Carsten P. Hansen, Jan H. Storkholm, Tina Vilsboll, Asger Lund, Filip K. Knop
Summary: The study evaluated glycemic variability in totally pancreatectomized patients and compared it with HbA(1c)-matched patients with long-standing type 1 diabetes. Results showed higher CONGA(60 min) and time spent above range in PX patients compared to T1D patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Sua Lee, Soyoung Lee, Kyeong Min Kim, Jong Ho Shin
Summary: This study aimed to determine the usefulness of continuous glucose monitoring (CGM) for glycemic control and glycemic variability stabilization in patients with diabetes undergoing hemodialysis. The results showed that continuous glucose monitoring could be a promising tool for individualizing treatment strategies.
FRONTIERS IN MEDICINE
(2023)
Article
Endocrinology & Metabolism
Rong Huang, Huiying Wang, Ziyang Shen, Tingting Cai, Yunting Zhou, Yuming Wang, Wenqing Xia, Bo Ding, Rengna Yan, Huiqin Li, Jindan Wu, Jianhua Ma
Summary: This study found that increased glycemic variability is associated with osteoporosis in patients with type 2 diabetes. Age, gender, BMI, LDL-C, and SUA were also identified as factors related to osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Huiying Wang, Yunting Zhou, Xiaofang Zhai, Bo Ding, Ting Jing, Xiaofei Su, Huiqin Li, Jianhua Ma
Summary: The study aimed to evaluate glycemic control in adults with controlled type 2 diabetes mellitus using continuous glucose monitoring system during Basalin or Lantus administration. Lantus-treated patients showed lower 24-hour MBG, MAGE, and SDBG compared to the Basalin group. Insulin glargine Lantus may be a better choice for T2DM patients with HbA1c <= 7%.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Yongwen Zhou, Xiaodong Mai, Hongrong Deng, Daizhi Yang, Mao Zheng, Bin Huang, Linlin Xu, Jianping Weng, Wen Xu, Jinhua Yan
Summary: This study explored the differences in glycemic metrics between FreeStyle Libre and iPro2 in adults with type 1 diabetes mellitus. The results showed that these two devices provided different estimations on time in range, coefficient of variation, and hypoglycemia-related parameters during the 14-day period of use.
JOURNAL OF DIABETES
(2022)
Article
Engineering, Biomedical
Diana G. Kulawiec, Tony Zhou, Jennifer L. Knopp, J. Geoffrey Chase
Summary: The study reveals that glycemic variability and glycemic response to carbohydrate intake of athletes increase after endurance exercise, while overnight glucose levels remain elevated. These metabolic effects can be quantified using commercially available CGM devices, encouraging further research on monitoring athletic recovery after intense exercise events.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2021)
Article
Endocrinology & Metabolism
Eslam Montaser, Chiara Fabris, Boris Kovatchev
Summary: This study aimed to identify the principal dimensions of glycemic control and found that the glycemic-metric space has a true dimensionality of 2. Principal component analysis confirmed two essential metrics, treatment efficacy and treatment safety, which explained most of the variance.
DIABETES TECHNOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Valeria Musso, Isabella Panfoli, Marcella Battaglini, Giorgia Brigati, Diego Minghetti, Chiara Andreato, Luca A. Ramenghi
Summary: Glycemic variability is common in preterm infants and can affect neurodevelopment. This study found that intermittent enteral feeding is better for glycemic control compared to continuous feeding. Optimizing nutritional management is crucial for the long-term health of preterm infants.
Article
Endocrinology & Metabolism
Akira Kurozumi, Yosuke Okada, Tomoya Mita, Satomi Wakasugi, Naoto Katakami, Hidenori Yoshii, Kazuko Kanda, Keiko Nishida, Shinichiro Mine, Yoshiya Tanaka, Masahiko Gosho, Iichiro Shimomura, Hirotaka Watada
Summary: This study aimed to investigate the relationship between TIR and HbA1c levels in patients with T2DM. The analysis of glycemic profile in Japanese patients revealed a predictive relationship between TIR and HbA1c. Patients with lower TIR tended to have additional diabetes-related complications and medication use. These findings provide valuable insights for the management of T2DM, but caution should be exercised when using different sensors.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Endocrinology & Metabolism
Yu-Shan Hsieh, Min-Chun Yeh, Yan-Yu Lin, Shuen-Fu Weng, Chung-Huei Hsu, Chen-Ling Huang, Yu-Pei Lin, A-Young Han
Summary: This study identifies the significance of serum lactate dehydrogenase (LDH) level in T2DM patients and investigates its relationship with other variables.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Hidenori Yoshii, Tomoya Mita, Naoto Katakami, Yosuke Okada, Takeshi Osonoi, Katsumi Aso, Akira Kurozumi, Satomi Wakasugi, Fumiya Sato, Ryota Ishii, Masahiko Gosho, Iichiro Shimomura, Hirotaka Watada
Summary: Higher HbA1c levels do not always protect against hypoglycemic episodes. Our data demonstrate that using CGM metrics to complement HbA1c monitoring is beneficial, especially in older people, users of insulin and/or sulfonylureas, and patients with chronic kidney disease.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Caroline Wuyts, Caroline Simoens, Silvia Pinto, Koenraad Philippaert, Rudi Vennekens
Summary: Research using continuous glucose monitoring has shown that mice develop glucose adaptations similar to pregnant women during the full pregnancy period. Continuous glucose monitoring is a feasible, accurate, and safe method to track blood glucose levels in conscious, unstressed mice, providing valuable insights into the mechanisms of gestational diabetes mellitus.
SCIENTIFIC REPORTS
(2021)
Article
Anesthesiology
Catherine E. Price, Jessica E. Fanelli, Joseph A. Aloi, Saskia C. Anzola, Susan R. Vishneski, Amit K. Saha, Christopher C. Woody, Scott Segal
Summary: Perioperative hyperglycemia is associated with adverse outcomes in surgical patients, and continuous glucose monitors (CGMs) have not been widely used in this population. This study evaluated the use of CGMs compared to standard practices in surgical patients with diabetes. CGMs provided more glycemic data and could potentially improve perioperative glycemic control.
JOURNAL OF CLINICAL ANESTHESIA
(2023)
Review
Endocrinology & Metabolism
Stacey Uhl, Anuja Choure, Benjamin Rouse, Aggee Loblack, Peter Reaven
Summary: In adults with type 2 diabetes mellitus, the use of continuous glucose monitors (CGMs) led to modest but statistically significant declines in HbA1c levels. The results were consistent for both real-time CGM and flash CGM, with trends favoring real-time CGM for other glucose metrics. However, longer term studies are needed to establish the impact of short-term glucose control improvements on important clinical outcomes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Obstetrics & Gynecology
Yoshifumi Kasuga, Kei Miyakoshi, Yoshifumi Saisho, Satoru Ikenoue, Daigo Ochiai, Mamoru Tanaka
Summary: This study investigated the clinical and metabolic features of underweight women with gestational diabetes (GDM). The results showed that impaired early phase insulin secretion was associated with GDM onset in underweight women.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Letter
Endocrinology & Metabolism
Kazutoshi Sugiyama, Yoshifumi Saisho
Article
Urology & Nephrology
Ayumi Matsui, Ayumi Yoshifuji, Junichiro Irie, Takaya Tajima, Kiyotaka Uchiyama, Tomoaki Itoh, Shu Wakino, Hiroshi Itoh
Summary: This study found that canagliflozin can increase colonic glucose concentration and the number of Lactobacillus bacteria, restore the expression of tight junction proteins in the colon, decrease serum uremic toxin concentrations, and ameliorate cardiac interstitial fibrosis in nephrectomized rats. These effects may be attributed to the inhibition of SGLT1 by canagliflozin, as similar effects were not observed in tofogliflozin-treated rats.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2023)
Article
Gastroenterology & Hepatology
Junki Miyamoto, Hidenori Shimizu, Keiko Hisa, Chiaki Matsuzaki, Shinsuke Inuki, Yuna Ando, Akari Nishida, Ayano Izumi, Mayu Yamano, Chihiro Ushiroda, Junichiro Irie, Takane Katayama, Hiroaki Ohno, Hiroshi Itoh, Kenji Yamamoto, Ikuo Kimura
Summary: Fermented foods have health benefits due to probiotic bacteria or microproducts produced by bacterial fermentation. Prebiotics associated with L. mesenteroides-produced exopolysaccharides (EPS) show significant metabolic benefits. EPS-derived gut microbial short-chain fatty acids improve glucose metabolism and energy homeostasis, and alter gut microbial composition.
Article
Multidisciplinary Sciences
Kazuhiro Kashiwagi, Jun Inaishi, Shotaro Kinoshita, Yasuyo Wada, Sayaka Hanashiro, Kiko Shiga, Momoko Kitazawa, Shiori Tsutsumi, Hiroyuki Yamakawa, Junichiro Irie, Taishiro Kishimoto
Summary: This study found a correlation between body mass index (BMI), glycemic variability (GV), and life-related factors in healthy nondiabetic adults. Prediabetes and underweight individuals had higher GV, possibly due to irregular eating habits and low activity levels. On the other hand, overweight individuals had longer periods of elevated blood sugar, potentially due to dietary habits and lack of exercise.
Meeting Abstract
Peripheral Vascular Disease
Shunta Takebayashi, Junichiro Irie, Isao Kurihara, Sakiko Kobayashi, Kazutoshi Miyashita, Kenichiro Kinouchi, Toshifumi Nakamura, Hiroshi Itoh
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Shintaro Yamaguchi, Taichi Nagahisa, Shotaro Kosugi, Ken Nishioka, Yasuhiro Watanabe, Koichiro Homma, Kazutoshi Miyashita, Junichiro Irie, Jun Yoshino, Hiroshi Itoh
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Nobuko Goto, Motoko Kita, Junichiro Irie, Hiroshi Itoh
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Arata Itoh, Kazunari Yuki, Junichiro Irie, Hiroshi Itoh
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Akihide Iwahara, Kazutoshi Sugiyama, Tami Tsuchiya, Arata Itoh, Yuya Nakajima, Yoshifumi Saisho, Kenichiro Kinouchi, Sakiko Kobayashi, Kazutoshi Miyashita, Junichiro Irie, Shu Meguro, Satoru Ikenoue, Mamoru Tanaka, Hiroshi Itoh
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Shotaro Kosugi, Shintaro Yamaguchi, Koichiro Homma, Taichi Nagahisa, Ken Nishioka, Yasuhiro Watanabe, Kenichiro Kinouchi, Kaori Hayashi, Kazutoshi Miyasita, Takeshi Kanda, Junichiro Irie, Jun Yoshino, Hiroshi Ito
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Yuya Nakajima, Junichiro Irie, Toshifumi Nakamura, Yoshinaga Kawano, Arata Ito, Kenichiro Kinouchi, Sakiko Kobayashi, Shu Meguro, Hiroshi Itoh
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Yusuke Otomo, Junichiro Irie, Kazutoshi Miyashita, Sakiko Kobayashi, Kenichiro Kinouchi, Toshifumi Nakamura, Yusuke Kubota, Takeshi Nishimura, Hiroshi Itoh
JOURNAL OF HYPERTENSION
(2023)
Article
Endocrinology & Metabolism
Tami Tsuchiya, Yoshifumi Saisho, Jun Inaishi, Hironobu Sasaki, Midori Sato, Masaru Nishikawa, Yohei Masugi, Taketo Yamada, Hiroshi Itoh
Summary: Pancreatic cancer is associated with worsened glucose tolerance and changes in islet morphology. This study found that individuals with pancreatic cancer have an increased ratio of alpha to beta cell mass, which may contribute to the risk of worsening glucose metabolism.
Article
Endocrinology & Metabolism
Tami Tsuchiya, Yoshifumi Saisho, Jun Inaishi, Hironobu Sasaki, Midori Sato, Masaru Nishikawa, Yohei Masugi, Taketo Yamada, Hiroshi Itoh
Summary: The alpha to beta cell mass ratio is increased in patients with pancreatic cancer, which may contribute to worsened glucose metabolism. Further studies are needed to elucidate the mechanisms behind the increased alpha to beta cell mass in these patients.
