Article
Parasitology
Ernesto Candela, Carolina Goizueta, M. Victoria Periago, Carla Munoz-Antoli
Summary: In an indigenous community in Argentina, the overall prevalence of intestinal parasites (IPs) was 92.7%, specifically 72.0% for hookworm. IPs were more prevalent in preschool- and school-age children, and lack of formal education, unimproved floors, and overcrowding were significantly associated with IP infection. Molecular characterization revealed zoonotic transmission of G. intestinalis and Blastocystis spp. by domestic animals.
PARASITES & VECTORS
(2021)
Article
Medicine, General & Internal
Aleksandra Lanocha, Natalia Lanocha-Arendarczyk, Dominika Wilczynska, Barbara Zdziarska, Danuta Kosik-Bogacka
Summary: This study aimed to evaluate the frequency of gastrointestinal protozoan infection in patients with hematological malignancies undergoing intensive treatment and to determine the biological factors influencing intestinal parasite infection. The results showed a higher prevalence of parasitic infections in patients with hematological malignancies undergoing treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Zhiqiang Li, Dimitra Peirasmaki, Staffan Svard, Magnus Abrink
Summary: The proteoglycan serglycin plays a regulatory role in intestinal immune responses by influencing the expression levels of chemokines and cytokines, leading to delayed weight gain in young SG(-/-) mice infected with Giardia intestinalis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Suthinee Sangkanu, Alok K. K. Paul, Julalak Chuprom, Watcharapong Mitsuwan, Rachasak Boonhok, Maria de Lourdes Pereira, Sonia Marlene Rodrigues Oliveira, Polrat Wilairatana, Mohammed Rahmatullah, Christophe Wiart, Muhammad Nawaz, Chea Sin, Sunil Kayesth, Veeranoot Nissapatorn
Summary: Giardia infection can cause diarrhea and is the third most common cause of diarrhea and death in children under five. Antimicrobial drugs are commonly used to treat giardiasis, but vaccination may be a potential means of control and protection against this parasitic disease outbreak.
Article
Parasitology
Min Sun, Zhiteng Zhao, Ying Li, Lili Cao, Jianhua Li, Xichen Zhang, Xin Li, Nan Zhang, Shuqin Cheng, Xiaocen Wang, Pengtao Gong
Summary: Giardia intestinalis parasite evades host immune responses through surface proteins called VSPs. This study found that VSPAS7 protein in Giardia inhibits activation of signaling pathways and pyroptosis in host macrophages, allowing Giardia to evade host immune responses.
PARASITES & VECTORS
(2023)
Article
Biochemistry & Molecular Biology
Jana Caudet, Maria Trelis, Susana Cifre, Gabriela Tapia, Jose M. Soriano, Regina Rodrigo, Juan F. Merino-Torres
Summary: The diagnosis of obesity and the development of insulin resistance and metabolic comorbidities are linked. Enteric eukaryotic unicellular parasites may play an important role in modulating the antioxidant defenses of an obese host, thus potentially beneficial in the development of systemic metabolic disorders.
Article
Nutrition & Dietetics
Miranda N. N. Mpaka-Mbatha, Pragalathan Naidoo, Md Mazharul Islam, Ravesh Singh, Zilungile L. L. Mkhize-Kwitshana
Summary: This study investigated the anaemia profiles and nutritional status of HIV and helminth coinfected adult South Africans. The coinfected group had a lower anaemia prevalence compared to the HIV-infected group and a higher prevalence compared to the helminth infected group. Coinfected adults may be prone to micronutrient deficiency and anaemia.
Article
Pediatrics
Md Ridwan Islam, Sharika Nuzhat, Shah Mohammad Fahim, Parag Palit, Robin L. Flannery, David J. Kyle, Mustafa Mahfuz, M. Munirul Islam, Shafiqul Alam Sarker, Tahmeed Ahmed
Summary: The study highlights the prevalence of antibiotic use among infants aged 2-6 months, with non-severe acute malnutrition infants more likely to receive antibiotics. The findings suggest that antibiotic use increases with age.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Tanja E. Peters, Benno Kreuels, Marylyn M. Addo, Egbert Tannich, Camilla Rothe
Summary: This study analyzed 339 cases of returning travellers with confirmed giardiasis between 2007 and 2016 in Hamburg, Germany, finding a significantly higher risk of treatment failure with metronidazole for patients returning from South Asia. Second-line treatment regimens showed inconsistency and unsatisfactory results, suggesting a need for reevaluation of treatment strategies for giardiasis. Prospective trials are urgently needed to assess new first-line treatment options and improve second-line treatment strategies.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Vendula Horackova, Lubos Voleman, Kari D. Hagen, Marketa Petru, Martina Vinopalova, Filip Weisz, Natalia Janowicz, Lenka Markova, Alzbeta Motyckova, Vladimira Najdrova, Pavla Tumova, Scott C. Dawson, Pavel Dolezal
Summary: This study demonstrated successful genome editing of G. intestinalis using CRISPR/Cas9 technology, achieving effective gene knockout and providing important tools for further research on parasitic protists.
Article
Infectious Diseases
Shabab Hossain, S. M. Khodeza Nahar Begum, M. Masudur Rahman, Mashud Parvez, Ramendra Nath Mazumder, Shafiqul Alam Sarker, Mehedi Hasan, Shah Mohammad Fahim, Amran Gazi, Subhasish Das, Mustafa Mahfuz, Tahmeed Ahmed
Summary: The purpose of this study was to evaluate the intestinal histological characteristics of stunted children aged between 12-18 months with possible EED. The study found that more than 90% of children, regardless of their nutritional status, were diagnosed with chronic non-specific duodenitis. These results suggest that the prevalence of chronic non-specific duodenitis is high in Bangladeshi children, and these children have abnormal findings in intestinal histomorphology.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Biology
Abel Sana, Izadora Volpato Rossi, Bruna Sabatke, Leticia Bassani Bonato, Lia Carolina Soares Medeiros, Marcel Ivan Ramirez
Summary: This study aimed to enrich the large extracellular vesicles (LEVs) of G. intestinalis and better understand their role in the parasite's interaction with the host. The researchers modified their method and compared different centrifugation techniques to concentrate the EVs. They found that direct ultracentrifugation and longer centrifugation time were more effective in enriching the EVs.
Article
Microbiology
Malgorzata Smogula, Roland Wesolowski, Marta Pawlowska, Celestyna Mila-Kierzenkowska
Summary: Giardia intestinalis is a common food-borne protozoan, and 22 selected factors were found to have an impact on its survival assessment and detection. Microscopic method showed significant influence compared to real-time PCR. Prevention of infection is crucial, and further research and epidemiological observation are needed.
Article
Microbiology
Anne-Sophie Boucard, Myriam Thomas, Wilfried Lebon, Bruno Polack, Isabelle Florent, Philippe Langella, Luis G. Bermudez-Humaran
Summary: This study monitored naturally Giardia intestinalis-infected puppies for 3 months, revealing that the infection is associated with changes in the gut microbiota structure, immune health markers, and the establishment of chronic low-grade inflammation in the puppies. Further research is needed to determine if these alterations in the canine gut microbiota could lead to the development of dysbiosis-related diseases such as irritable bowel syndrome (IBS) or inflammatory bowel disease (IBD).
Article
Microbiology
Louise Basmaciyan, Alexandre Francois, Anne Vincent, Stephane Valot, Alain Bonnin, Damien Costa, Romy Razakandrainibe, Florent Morio, Loic Favennec, Frederic Dalle
Summary: This study evaluated the performance of four commercial SimpPCRa and three MultPCRa for detecting intestinal parasites in stool samples. The results showed that SimpPCRa had better sensitivity and specificity compared to the tested MultPCRa. Additionally, MultPCRa could be an interesting alternative for detecting protozoans in stool samples in certain clinical contexts.