Review
Microbiology
Hiroshi Kimura, Yusuke Okuno, Yoshitaka Sato, Takahiro Watanabe, Takayuki Murata
Summary: EBV, a double-stranded DNA virus, is associated with various types of lymphomas and lymphoproliferative disorders. The oncogenic mechanism, including EBV receptors on T/NK cells, relationship with host genes, and epigenetic regulation, remains unclear. However, the roles of host and viral non-coding RNAs in tumorigenesis have been elucidated.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Youmna Atieh, Thomas Wyatt, Ana Maria Zaske, George T. Eisenhoffer
Summary: The study revealed that cell extrusion is preceded by pulsatile actomyosin contractions, which are crucial for defining the behavioral differences between extruding and non-extruding cells. Local increases in tension are shown to drive cell pulsing, while damage to many cells leads to an overall decrease in the tensile state of the epithelium.
Article
Oncology
Simon Jasinski-Bergner, Juliane Bluemke, Marcus Bauer, Saskia Luise Skiebe, Ofer Mandelboim, Claudia Wickenhauser, Barbara Seliger
Summary: This study investigates the relationship between human Epstein-Barr virus (EBV) and various cancers, particularly the role of virus-encoded microRNAs (miRs) in the malignant transformation of infected cells and immune evasion. Through the analysis of experimental data and in vitro experiments, the authors identified genes associated with oncogenic properties, immune escape, and anti-tumoral immune responses, and predicted potential candidate EBV-miRs and their target genes. This integrated method helps to deepen our understanding of the functions of EBV-miRs and their eligibility as markers in different EBV-associated tissues.
Article
Genetics & Heredity
Yulia Biggar, W. Aline Ingelson-Filpula, Kenneth B. Storey
Summary: Xenopus ictevis, the African clawed frog, undergoes seasonal estivation to survive drought. During estivation, the frog loses up to 30% of its body water, which impairs blood flow and increases the risk of cell survival. A study found that certain pro-apoptotic miRNAs were upregulated in the liver and skeletal muscle of estivating frogs, while anti-apoptotic miRNAs showed differential regulation between the two tissues. These miRNAs play diverse roles, ranging from inhibiting cell proliferation to preventing muscle atrophy.
Article
Biochemistry & Molecular Biology
Xiru Zhao, Ke Fang, Xiaoxu Liu, Ruihuan Yao, Min Wang, Fanfan Li, Shaohua Hao, Jingjing He, Yan Wang, Menghan Fan, Wei Huang, Yiping Li, Chun Gao, Chengqi Lin, Zhuojuan Luo
Summary: QSER1 plays a general role in preventing apoptosis and is up-regulated in multiple cancers. It functions antagonistically with p53 to maintain the expression of pro-apoptotic genes and suppresses PUMA in a p53-dependent and -independent manner. Inhibition of QSER1 might be a potential therapeutic strategy to induce apoptosis in cancer cells.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Cell Biology
Kishore Vaddadi, Chaitanya Gandikota, Chaoqun Huang, Yurong Liang, Lin Liu
Summary: MicroRNAs (miRNAs) regulate viral replication and host tropism by interacting with the viral genome or modulating host factors. Experimental validation showed that miR-15a, miR-153, miR-298, miR-508, miR-1909, and miR-3130 can effectively reduce SARS-CoV-2 replication and S-protein levels, and these miRNAs target conserved regions in the viral RNA genome among variants.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Plant Sciences
Kejing Fan, Johanna Wong-Bajracharya, Xiao Lin, Meng Ni, Yee-Shan Ku, Man-Wah Li, Chang Fu Tian, Ting-Fung Chan, Hon-Ming Lam
Summary: miRNAs, especially MiR399b, play crucial roles in regulating symbiotic nitrogen fixation in soybean by enhancing Pi uptake, which leads to improved nitrogen fixation and soybean growth. This study identified high-confidence differentially expressed (DE) miRNAs from uninoculated roots, rhizobium-inoculated roots, and nodules of soybean, shedding light on the regulatory mechanisms of miRNAs in SNF.
Article
Agronomy
Xiaohua Yao, Yue Wang, Youhua Yao, Yixiong Bai, Kunlun Wu, Youming Qiao
Summary: The study compared miRNA profiles before and after barley leaf stripe (BLS) infection in BLS-sensitive ('Z1141') and tolerant ('Kunlun14') Tibetan hulless barley for the first time, identifying 36 conserved and 56 novel miRNAs. Gene ontology analysis revealed 10 candidate target genes, including functional genes and transcription factors, regulated by eight miRNAs, suggesting the potential for improving BLS resistance in Tibetan hulless barley through breeding or genetic engineering.
Article
Cell Biology
Jingru Huangfu, Caili Hao, Zongbo Wei, I. Michael Wormstone, Hong Yan, Xingjun Fan
Summary: The study reveals that cFLIP is a critical gene regulating lens epithelial cell survival, with an important impact on the response to TNF alpha stimulation.
CELL DEATH & DISEASE
(2021)
Article
Engineering, Biomedical
Guanglin Zhang, Haoyu Xue, Dazheng Sun, Shenyu Yang, Mei Tu, Rong Zeng
Summary: Soft D-PSLs can persistently bind to macrophage membranes and enhance the anti-inflammatory and pro-healing responses of macrophages, shedding new light on the design of therapeutic biomaterials based on regulating macrophages and providing a promising biomimetic nano-therapeutic approach for chronic inflammatory injury.
ACTA BIOMATERIALIA
(2021)
Article
Pharmacology & Pharmacy
Thikryat Neamatallah, Azizah M. M. Malebari, Abdulmohsin J. J. Alamoudi, Syed Nazreen, Mohammad Mahboob Alam, Hawazen H. H. Bin-Melaih, Osama A. A. Abuzinadah, Shaimaa M. M. Badr-Eldin, Gharam Alhassani, Lamar Makki, Mohammed Z. Z. Nasrullah
Summary: In this study, an optimized AG-PTMs formulation was prepared, which significantly inhibited the proliferation of liver cancer cells HepG2 through enhanced cellular uptake, cell cycle arrest and mitochondrial-dependent apoptosis.
Review
Dentistry, Oral Surgery & Medicine
Padacherri Vethil Jishnu, Sangeetha U. Shenoy, Mohit Sharma, Aditi Chopra, Raghu Radhakrishnan
Summary: This study aims to understand the role of experimentally validated microRNAs (miRNAs) in the acquisition of oncogenic phenotype in oral submucous fibrosis (OSF) through computational analysis. The study identifies 13 deregulated miRNAs in OSF and shows that 371 experimentally validated genes interact with OSF-associated miRNAs. The findings highlight the physiological importance of miRNAs in fibrosis.
Article
Dermatology
Mallory J. DiVincenzo, Emily Schwarz, Casey Ren, Zoe Barricklow, Maribelle Moufawad, Lianbo Yu, Paolo Fadda, Colin Angell, Steven Sun, J. Harrison Howard, Catherine Chung, Craig Slingluff, Alejandro A. Gru, Kari Kendra, William E. Carson
Summary: Ulcerated cutaneous melanoma has a poor prognosis, and the underlying biology driving its aggressive behavior remains largely unexplored. This study aimed to investigate the unique miRNA profile in ulcerated melanoma and its correlation with biologically important target genes. The expression of miRNAs and mRNAs in ulcerated and non-ulcerated melanomas was assessed, and pathway enrichment and functional annotations were determined. The results revealed differential expression of miRNAs and mRNAs in ulcerated melanoma, providing further insight into its molecular characteristics.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Cell Biology
Nicoline W. E. van den Berg, Makiri Kawasaki, Fransisca A. Nariswari, Benedetta Fabrizi, Jolien Neefs, Ingeborg van der Made, Robin Wesselink, Wim Jan P. van Boven, Antoine H. G. Driessen, Aldo Jongejan, Joris R. de Groot
Summary: This study aims to elucidate the regulatory role of miRNAs in the mRNA signature of atrial fibrillation (AF) and identify potential targets for future therapies. Through combined miRNA-mRNA sequencing, differentially expressed miRNAs and their target genes were discovered in atrial tissues of patients with and without AF. Downregulated miRNAs were associated with upregulated gene expression involved in cell migration and glycosaminoglycan biosynthesis. In vitro inhibition experiments confirmed the effects of miRNAs on predicted target genes. These identified miRNAs can be explored as potential targets for anti-fibrotic therapies in AF.
CELL AND TISSUE RESEARCH
(2023)
Review
Oncology
Patrizia Perri, Mirco Ponzoni, Maria Valeria Corrias, Isabella Ceccherini, Simona Candiani, Tiziana Bachetti
Summary: Neuroblastoma is a tumor originating from neural crest cells that undergo genetic alterations during development, resulting in disrupted regulatory networks that promote tumor formation. The interactions between transcription factors and microRNAs in neuroblastoma play a key role in the development of the tumor.
Article
Virology
Goran Gregorovic, Elizabeth A. Boulden, Rachel Bosshard, Claudio Elgueta Karstegl, Rebecca Skalsky, Bryan R. Cullen, Cornelia Gujer, Patrick Raemer, Christian Muenz, Paul J. Farrell
JOURNAL OF VIROLOGY
(2015)
Article
Virology
Rebecca L. Skalsky, Sarah A. Barr, Andrew J. Jeffery, Tiffany Blair, Ryan Estep, Scott W. Wong
JOURNAL OF VIROLOGY
(2016)
Article
Virology
Camille M. Skinner, Nikita S. Ivanov, Sarah A. Barr, Yan Chen, Rebecca L. Skalsky
JOURNAL OF VIROLOGY
(2017)
Article
Virology
Rebecca L. Skalsky, Dong Kang, Sarah D. Linnstaedt, Bryan R. Cullen
JOURNAL OF VIROLOGY
(2014)
Article
Virology
Hal P. Bogerd, Rebecca L. Skalsky, Edward M. Kennedy, Yuki Furuse, Adam W. Whisnant, Omar Flores, Kimberly L. W. Schultz, Nicole Putnam, Nicholas J. Barrows, Barbara Sherry, Frank Scholle, Mariano A. Garcia-Blanco, Diane E. Griffin, Bryan R. Cullen
JOURNAL OF VIROLOGY
(2014)
Article
Biochemical Research Methods
William H. Majoros, Parawee Lekprasert, Neelanjan Mukherjee, Rebecca L. Skalsky, David L. Corcoran, Bryan R. Cullen, Uwe Ohler
Article
Biochemistry & Molecular Biology
Omar Flores, Edward M. Kennedy, Rebecca L. Skalsky, Bryan R. Cullen
NUCLEIC ACIDS RESEARCH
(2014)
Letter
Multidisciplinary Sciences
Rebecca L. Skalsky, Ken E. Olson, CarolD. Blair, Mariano A. Garcia-Blanco, Bryan R. Cullen
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Article
Microbiology
Yan Chen, Devin Fachko, Nikita S. Ivanov, Camille M. Skinner, Rebecca L. Skalsky
Article
Immunology
Afam A. Okoye, Maren Q. DeGottardi, Yoshinori Fukazawa, Mukta Vaidya, Chike O. Abana, Audrie L. Konfe, Devin N. Fachko, Derick M. Duell, He Li, Richard Lum, Lina Gao, Byung S. Park, Rebecca L. Skalsky, Anne D. Lewis, Michael K. Axthelm, Jeffrey D. Lifson, Scott W. Wong, Louis J. Picker
JOURNAL OF IMMUNOLOGY
(2019)
Review
Microbiology
Nicole L. Diggins, Rebecca L. Skalsky, Meaghan H. Hancock
Summary: Human cytomegalovirus (HCMV) encodes 22 mature microRNAs that regulate various cellular processes, including vesicular trafficking, cell cycle progression, apoptosis, and immune evasion. Recent evidence suggests a critical role for HCMV microRNAs in mediating latency in CD34(+) hematopoietic progenitor cells by modulating cellular signaling pathways. Additionally, these microRNAs can interact with viral proteins to influence host cell functions.
Article
Microbiology
Mickael Bouvet, Stefanie Voigt, Takanobu Tagawa, Manuel Albanese, Yen-Fu Adam Chen, Yan Chen, N. Devin Fachko, Dagmar Pich, Christine Goebel, L. Rebecca Skalsky, Wolfgang Hammerschmidt
Summary: Research shows that multiple Epstein-Barr virus-encoded miRNAs play crucial roles in regulating type I IFN response in newly infected human B cells, while dampening the acute release of IFN-alpha in pDCs upon encounter with EBV.
Article
Microbiology
Yan Chen, Devin N. Fachko, Nikita S. Ivanov, Rebecca L. Skalsky
Summary: Recognition of antigens by the B cell receptor can lead to reactivation of Epstein-Barr virus and certain miRNAs, like miR-141, play a role in dampening this reactivation. Both host and viral miRNAs can modulate the lytic cycle of EBV, with targets including B cell transcription factors and regulators of immediate-early genes. The study identifies FOXO3 as a key player commonly suppressed by these miRNAs, impacting the progression of the lytic cycle.
Article
Virology
Rebecca L. Skalsky
Summary: This review discusses the roles of miRNAs in EBV infection and current advances in miRNA-based diagnostic and therapeutic strategies potentially applicable toward EBV-associated diseases.
CURRENT OPINION IN VIROLOGY
(2022)