Type I Interferon Induced Epigenetic Regulation of Macrophages Suppresses Innate and Adaptive Immunity in Acute Respiratory Viral Infection

Targeted Prostaglandin E2 Inhibition Enhances Antiviral Immunity through Induction of Type I Interferon and Apoptosis in Macrophages

(2014) François Coulombe et al.   IMMUNITY

CCR2+ Monocyte-Derived Dendritic Cells and Exudate Macrophages Produce Influenza-Induced Pulmonary Immune Pathology and Mortality

(2014) K. L. Lin et al.   JOURNAL OF IMMUNOLOGY

Alveolar Macrophages Are Essential for Protection from Respiratory Failure and Associated Morbidity following Influenza Virus Infection

(2014) Christoph Schneider et al.   PLoS Pathogens

Depletion of Alveolar Macrophages during Influenza Infection Facilitates Bacterial Superinfections

(2013) H. E. Ghoneim et al.   JOURNAL OF IMMUNOLOGY

Autophagy-Inducing Protein Beclin-1 in Dendritic Cells Regulates CD4 T Cell Responses and Disease Severity during Respiratory Syncytial Virus Infection

(2013) M. Reed et al.   JOURNAL OF IMMUNOLOGY

Molecular Characterization of Mutant Mouse Strains Generated from the EUCOMM/KOMP-CSD ES Cell Resource

(2013) Edward Ryder et al.   MAMMALIAN GENOME

Harnessing alveolar macrophages for sustained mucosal T-cell recall confers long-term protection to mice against lethal influenza challenge without clinical disease

(2013) D C Macdonald et al.   Mucosal Immunology

Cytokine Induced Phenotypic and Epigenetic Signatures Are Key to Establishing Specific Macrophage Phenotypes

(2013) Nicolai A. Kittan et al.   PLoS One

Interferon-Inducible Protein Mx1 Inhibits Influenza Virus by Interfering with Functional Viral Ribonucleoprotein Complex Assembly

(2012) J. Verhelst et al.   JOURNAL OF VIROLOGY

Multifunctional CD4 Cells Expressing Gamma Interferon and Perforin Mediate Protection against Lethal Influenza Virus Infection

(2012) D. M. Brown et al.   JOURNAL OF VIROLOGY

Type I Interferon Induction during Influenza Virus Infection Increases Susceptibility to Secondary Streptococcus pneumoniae Infection by Negative Regulation of    T Cells

(2012) W. Li et al.   JOURNAL OF VIROLOGY

Suppression of the antiviral response by an influenza histone mimic

(2012) Ivan Marazzi et al.   NATURE

A FOXO3–IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses

(2012) Vladimir Litvak et al.   NATURE

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

(2012) Laurens Kruidenier et al.   NATURE

GM-CSF in the Lung Protects against Lethal Influenza Infection

(2011) Fang-Fang Huang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Synergistic stimulation of type I interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization in mice

(2011) Shigeki Nakamura et al.   JOURNAL OF CLINICAL INVESTIGATION

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

Pfizer's JAK inhibitor sails through phase 3 in rheumatoid arthritis

(2011) Ken Garber   NATURE BIOTECHNOLOGY

The Critical Role of Notch Ligand Delta-like 1 in the Pathogenesis of Influenza A Virus (H1N1) Infection

(2011) Toshihiro Ito et al.   PLoS Pathogens

Type I Interferon Signaling Regulates Ly6Chi Monocytes and Neutrophils during Acute Viral Pneumonia in Mice

(2011) Sang-Uk Seo et al.   PLoS Pathogens

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

An improved Flp deleter mouse in C57Bl/6 based on Flpo recombinase

(2010) Andrea Kranz et al.   GENESIS

Critical Role of Airway Macrophages in Modulating Disease Severity during Influenza Virus Infection of Mice

(2010) M. D. Tate et al.   JOURNAL OF VIROLOGY

Positive Regulation of Interferon Regulatory Factor 3 Activation by Herc5 via ISG15 Modification

(2010) H. X. Shi et al.   MOLECULAR AND CELLULAR BIOLOGY

Epigenetic regulation of the alternatively activated macrophage phenotype

(2009) M. Ishii et al.   BLOOD

Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice

(2009) Arash Shahangian et al.   JOURNAL OF CLINICAL INVESTIGATION

Alveolar Macrophages Transport Pathogens to Lung Draining Lymph Nodes

(2009) A. C. Kirby et al.   JOURNAL OF IMMUNOLOGY

Interferon-Induced ISG15 Conjugation Inhibits Influenza A Virus Gene Expression and Replication in Human Cells

(2009) T.-Y. Hsiang et al.   JOURNAL OF VIROLOGY

Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10

(2009) Jie Sun et al.   NATURE MEDICINE

Agouti C57BL/6N embryonic stem cells for mouse genetic resources

(2009) Stephen J Pettitt et al.   NATURE METHODS

Alveolar Macrophages Are Indispensable for Controlling Influenza Viruses in Lungs of Pigs

(2008) H. M. Kim et al.   JOURNAL OF VIROLOGY

Alveolar Macrophages Are a Major Determinant of Early Responses to Viral Lung Infection but Do Not Influence Subsequent Disease Development

(2008) P. K. Pribul et al.   JOURNAL OF VIROLOGY

Macrophage Turnover Kinetics in the Lungs of Mice Infected with Streptococcus pneumoniae

(2007) Katharina Taut et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY