Probing the Metabolic Network in Bloodstream-Form Trypanosoma brucei Using Untargeted Metabolomics with Stable Isotope Labelled Glucose

Phosphoenolpyruvate Carboxylase Identified as a Key Enzyme in Erythrocytic Plasmodium falciparum Carbon Metabolism

(2014) Janet Storm et al.   PLoS Pathogens

Metabolomics Guides Rational Development of a Simplified Cell Culture Medium for Drug Screening against Trypanosoma brucei

(2013) Darren J. Creek et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum

(2013) James I MacRae et al.   BMC BIOLOGY

Explicit consideration of topological and parameter uncertainty gives new insights into a well-established model of glycolysis

(2013) Fiona Achcar et al.   FEBS Journal

Pyrimidine Biosynthesis Is Not an Essential Function for Trypanosoma brucei Bloodstream Forms

(2013) Juma A. M. Ali et al.   PLoS One

Handling Uncertainty in Dynamic Models: The Pentose Phosphate Pathway in Trypanosoma brucei

(2013) Eduard J. Kerkhoven et al.   PLoS Computational Biology

Revisiting the Central Metabolism of the Bloodstream Forms of Trypanosoma brucei: Production of Acetate in the Mitochondrion Is Essential for Parasite Viability

(2013) Muriel Mazet et al.   PLoS Neglected Tropical Diseases

Bloodstream form pre-adaptation to the tsetse fly in Trypanosoma brucei

(2013) Eva Rico et al.   Frontiers in Cellular and Infection Microbiology

Stable Isotope-Assisted Metabolomics for Network-Wide Metabolic Pathway Elucidation

(2012) Darren J. Creek et al.   ANALYTICAL CHEMISTRY

mzMatch–ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data

(2012) Achuthanunni Chokkathukalam et al.   BIOINFORMATICS

IDEOM: an Excel interface for analysis of LC–MS-based metabolomics data

(2012) Darren J. Creek et al.   BIOINFORMATICS

Proteome remodelling during development from blood to insect-form Trypanosoma brucei quantified by SILAC and mass spectrometry

(2012) Kapila Gunasekera et al.   BMC GENOMICS

Mitochondrial Metabolism of Glucose and Glutamine Is Required for Intracellular Growth of Toxoplasma gondii

(2012) James I. MacRae et al.   Cell Host & Microbe

Proliferating bloodstream-form Trypanosoma brucei use a negligible part of consumed glucose for anabolic processes

(2012) Jurgen R. Haanstra et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

ATP Synthesis-coupled and -uncoupled Acetate Production from Acetyl-CoA by Mitochondrial Acetate:Succinate CoA-transferase and Acetyl-CoA Thioesterase inTrypanosoma

(2012) Yoann Millerioux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

myo-Inositol Uptake Is Essential for Bulk Inositol Phospholipid but Not Glycosylphosphatidylinositol Synthesis inTrypanosoma brucei

(2012) Amaia Gonzalez-Salgado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thede novoand salvage pathways of GDP-mannose biosynthesis are both sufficient for the growth of bloodstream-formTrypanosoma brucei

(2012) Sabine Kuettel et al.   MOLECULAR MICROBIOLOGY

Channel-Forming Activities in the Glycosomal Fraction from the Bloodstream Form of Trypanosoma brucei

(2012) Melisa Gualdron-López et al.   PLoS One

Dynamic Modelling under Uncertainty: The Case of Trypanosoma brucei Energy Metabolism

(2012) Fiona Achcar et al.   PLoS Computational Biology

PeakML/mzMatch: A File Format, Java Library, R Library, and Tool-Chain for Mass Spectrometry Data Analysis

(2011) Richard A. Scheltema et al.   ANALYTICAL CHEMISTRY

Toward Global Metabolomics Analysis with Hydrophilic Interaction Liquid Chromatography–Mass Spectrometry: Improved Metabolite Identification by Retention Time Prediction

(2011) Darren J. Creek et al.   ANALYTICAL CHEMISTRY

High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome

(2011) S. Alsford et al.   GENOME RESEARCH

Isotopomer Profiling ofLeishmania mexicanaPromastigotes Reveals Important Roles for Succinate Fermentation and Aspartate Uptake in Tricarboxylic Acid Cycle (TCA) Anaplerosis, Glutamate Synthesis, and Growth

(2011) Eleanor C. Saunders et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transketolase in Trypanosoma brucei

(2011) Sabine A. Stoffel et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Metabolomic analysis of trypanosomatid protozoa

(2011) Darren J. Creek et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Towards an unbiased metabolic profiling of protozoan parasites: optimisation of a Leishmania sampling protocol for HILIC-orbitrap analysis

(2010) Ruben t’Kindt et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Potential new drugs for human African trypanosomiasis: some progress at last

(2010) Michael P Barrett   CURRENT OPINION IN INFECTIOUS DISEASES

Identification, subcellular localization, biochemical properties, and high-resolution crystal structure of Trypanosoma brucei UDP-glucose pyrophosphorylase

(2010) K. Marino et al.   GLYCOBIOLOGY

Widespread variation in transcript abundance within and across developmental stages of Trypanosoma brucei

(2009) Bryan C Jensen et al.   BMC GENOMICS

Alanine aminotransferase of Trypanosoma brucei- a key role in proline metabolism in procyclic life forms

(2009) Diana Spitznagel et al.   FEBS Journal

Human African trypanosomiasis

(2009) Reto Brun et al.   LANCET

The Phosphoproteome of Bloodstream FormTrypanosoma brucei, Causative Agent of African Sleeping Sickness

(2009) Isabelle R. E. Nett et al.   MOLECULAR & CELLULAR PROTEOMICS

Acetate produced in the mitochondrion is the essential precursor for lipid biosynthesis in procyclic trypanosomes

(2009) L. Riviere et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly sensitive feature detection for high resolution LC/MS

(2008) Ralf Tautenhahn et al.   BMC BIOINFORMATICS

A comparative study of methylglyoxal metabolism in trypanosomatids

(2008) Neil Greig et al.   FEBS Journal

Glucose-induced Remodeling of Intermediary and Energy Metabolism in ProcyclicTrypanosoma brucei

(2008) Virginie Coustou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New surveyor tools for charting microbial metabolic maps

(2007) Rainer Breitling et al.   NATURE REVIEWS MICROBIOLOGY