Article
Hematology
Qiao Cheng, Dong Wang, Xiaoxuan Lai, Yin Liu, Yibo Zuo, Wenli Zhang, Lei Lei, Jia Chen, Hong Liu, Ying Wang, Haiyan Liu, Hui Zheng, Depei Wu, Yang Xu
Summary: Disorders of the ubiquitin-proteasome system (UPS) have been found to affect the incidence and mortality of various diseases. This study uncovered a vital role of the deu-biquitinase OTUD1 in the regulation of acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The study revealed that OTUD1 interacts with Notch2-ICD (NICD), cleaves the ubiquitin of NICD, and promotes the accumulation of NICD protein in T cells, thereby amplifying the cascade of aGVHD. Moreover, the study identified dapagliflozin as an inhibitor of the OTUD1/NICD axis that significantly prolonged the survival of aGVHD mice.
Article
Multidisciplinary Sciences
Lu Wang, Dongmeng Li, Kezhen Yang, Xiaoyu Guo, Chao Bian, Takeshi Nishimura, Jie Le, Miyo Terao Morita, Dominique C. Bergmann, Juan Dong
Summary: Cell polarity is crucial for cell morphogenesis and organismal development. The BASL and PRAF proteins are identified as important players in establishing cell polarity in the Arabidopsis stomatal lineage. The interaction between PRAF and GNOM proteins in the plasma membrane and endosomal trafficking contribute to the intrinsic cell polarity.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Xiaonan Zheng, Hang Xu, Lina Gong, Dehong Cao, Tao Jin, Yan Wang, Jinkui Pi, Yang Yang, Xianyanling Yi, Dazhou Liao, Xi Jin, Qiang Wei, Lu Yang, Hong Li, Jianzhong Ai
Summary: This study evaluated the potential role of vinculin (VCL) in prostate cancer (PCa) progression through in vitro and in vivo experiments. The methylation level of the VCL promoter in PCa was found to be downregulated with age and nodal metastasis progression. Knockdown of VCL significantly changed cell morphology, inhibited migration, invasion, movement, and colony formation, as well as suppressed tumor growth in vivo. These findings suggest that VCL could be a potential target for PCa prognosis and treatment.
Article
Microbiology
Haley E. Adcox, Amanda L. Hatke, Shelby E. Andersen, Sarika Gupta, Nathan B. Otto, Mary M. Weber, Richard T. Marconi, Jason A. Carlyon
Summary: Orientia tsutsugamushi is an intracellular pathogen causing scrub typhus, with Ank13 being a key effector that enters the nucleus using RaDAR nuclear import mechanism. Ank13 dysregulates the expression of over 2,000 host genes, particularly those involved in transcriptional control and the inflammatory response, through a combination of nucleotropism and F-box-dependent mechanisms. This effector plays a crucial role in the pathogenesis of scrub typhus by reprogramming host cell transcription.
Article
Biochemistry & Molecular Biology
Olga Tsaplina, Ekaterina Lomert, Yuliya Berson
Summary: Bacteria use cell surface proteins to interact with host cells, and E-cadherin plays a crucial role in bacterial invasion. Full-length E-cadherin is involved in S. proteamaculans invasion, while both full-length and truncated E-cadherin can promote S. grimesii invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Joana Figueiredo, Rui M. Ferreira, Han Xu, Margarida Goncalves, Andre Barros-Carvalho, Janine Cravo, Andre F. Maia, Patricia Carneiro, Ceu Figueiredo, Michael L. Smith, Dimitrije Stamenovic, Eurico Morais-de-Sa, Raquel Seruca
Summary: Research has shown that mutations in E-cadherin lead to abnormal interactions of cells with specific ECM components, resulting in increased traction forces and activation of Integrin beta 1, which promotes cell scattering and invasion. This crosstalk between E-cadherin and Integrin beta 1 is validated in Drosophila models and human gastric carcinomas, where low E-cadherin and high Integrin beta 1 levels are associated with increased tumour grade and poor survival. Integrin beta 1 is identified as a key mediator of invasion in carcinomas with E-cadherin impairment and a biomarker of poor prognosis in gastric cancer.
Article
Chemistry, Multidisciplinary
Can Wang, Telmo O. Paiva, Chiara Motta, Pietro Speziale, Giampiero Pietrocola, Yves F. Dufrene
Summary: This study reveals that Staphylococcus aureus utilizes clumping factors to form extremely strong catch bonds with annexin A2, allowing efficient invasion of mammalian cells. These catch bonds can withstand high mechanical tension of 1500-1700 pN, providing insights into the mechanism of host cell attachment during S.aureus invasion and potentially guiding the development of new therapeutic strategies.
Review
Immunology
Dan Huang, Jingjing Luo, Xuan OuYang, Lei Song
Summary: This article reviews how different species of Rickettsia utilize their arsenal of effector proteins to impact host cellular processes in order to promote their own replication or evade destruction.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Cell Biology
Kerry Woods, Carmen Perry, Francis Bruehlmann, Philipp Olias
Summary: Following invasion by Theileria sporozoites, one of the first events is the destruction of the host cell membrane and rapid association with host microtubules. Theileria species transform bovine cells by rewiring signaling pathways and controlling mitotic machinery. Theileria-encoded proteins can modify host gene expression, but their mode of action and secretion pathways are not well understood.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Microbiology
Allen G. Sanderlin, Ruth E. Hanna, Rebecca L. Lamason
Summary: This study reveals the importance of the ankyrin repeat protein RARP-1 in host cell invasion and growth in Rickettsia infection. Contrary to previous studies suggesting secretion of RARP-1 into the host cytoplasm, this study shows that RARP-1 in R. parkeri resides in the periplasm and plays a critical role in the rickettsial life cycle.
JOURNAL OF BACTERIOLOGY
(2022)
Review
Immunology
Guy Tran Van Nhieu, Patricia Latour-Lambert, Jost Enninga
Summary: Shigella's type III effector IpgD plays a key role in disrupting the cortical actin filaments of epithelial cells by decreasing PI4,5P(2) levels, facilitating bacterial invasion and cell migration. Additionally, IpgD also stimulates various signaling pathways and regulates endosomal trafficking and immune responses, making it a versatile bacterial enzyme.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Leia Colin, Raquel Martin-Arevalillo, Simone Bovio, Amelie Bauer, Teva Vernoux, Marie-Cecile Caillaud, Benoit Landrein, Yvon Jaillais
Summary: Biological imaging is an interdisciplinary field crucial in cell biology research, involving techniques, probe development, and image analysis. Recent advances in live imaging of plant cells include studies on cell structure, hormones, mechanical properties, etc. driving the field forward.
Article
Cell Biology
Okay Saydam, Nurten Saydam
Summary: Cancer metastasis and therapy resistance are major challenges in cancer treatment. A study showed that deficiency of Ku protein in cancer cells leads to a parasitic lifestyle, utilizing host cells for survival. This finding may provide new insights into cancer cell evolution and impact future cancer therapy protocols.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell & Tissue Engineering
Margit Rosner, Markus Hengstschlager
Summary: Clinicians and patients hope that stem cell-based therapies will be effective remedies for various diseases and injuries. However, the use of pluripotent stem cells is still hindered by their potential to cause immune reactions and tumor formation. In addition, stem cells can influence the behavior of nearby cells, which can have both beneficial and detrimental effects on therapeutic outcomes.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Xiaoling Liang, Xiaoxiao Qiu, Yana Ma, Wenzhi Xu, Sijia Chen, Peipei Zhang, Mengying Liu, Xiaona Lin
Summary: Female infertility is a global issue that affects the quality of life and well-being of couples. This study focuses on the molecular mechanism of embryo implantation and the role of KRT18 in trophoblast cells. The findings demonstrate that KRT18 plays a critical role in trophoblast migration, invasion, and adhesion by binding to E-cadherin.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Immunology
Kristen E. Rennoll-Bankert, M. Sayeedur Rahman, Mark L. Guillotte, Stephanie S. Lehman, Magda Beier-Sexton, Joseph J. Gillespie, Abdu F. Azad
INFECTION AND IMMUNITY
(2016)
Article
Multidisciplinary Sciences
Monika Gulia-Nuss, Andrew B. Nuss, Jason M. Meyer, Daniel E. Sonenshine, R. Michael Roe, Robert M. Waterhouse, David B. Sattelle, Jose de la Fuente, Jose M. Ribeiro, Karine Megy, Jyothi Thimmapuram, Jason R. Miller, Brian P. Walenz, Sergey Koren, Jessica B. Hostetler, Mathangi Thiagarajan, Vinita S. Joardar, Linda I. Hannick, Shelby Bidwell, Martin P. Hammond, Sarah Young, Qiandong Zeng, Jenica L. Abrudan, Francisca C. Almeida, Nieves Ayllon, Ketaki Bhide, Brooke W. Bissinger, Elena Bonzon-Kulichenko, Steven D. Buckingham, Daniel R. Caffrey, Melissa J. Caimano, Vincent Croset, Timothy Driscoll, Don Gilbert, Joseph J. Gillespie, Gloria I. Giraldo-Calderon, Jeffrey M. Grabowski, David Jiang, Sayed M. S. Khalil, Donghun Kim, Katherine M. Kocan, Juraj Koci, Richard J. Kuhn, Timothy J. Kurtti, Kristin Lees, Emma G. Lang, Ryan C. Kennedy, Hyeogsun Kwon, Rushika Perera, Yumin Qi, Justin D. Radolf, Joyce M. Sakamoto, Alejandro Sanchez-Gracia, Maiara S. Severo, Neal Silverman, Ladislav Simo, Marta Tojo, Cristian Tornador, Janice P. Van Zee, Jesus Vazquez, Filipe G. Vieira, Margarita Villar, Adam R. Wespiser, Yunlong Yang, Jiwei Zhu, Peter Arensburger, Patricia V. Pietrantonio, Stephen C. Barker, Renfu Shao, Evgeny M. Zdobnov, Frank Hauser, Cornelis J. P. Grimmelikhuijzen, Yoonseong Park, Julio Rozas, Richard Benton, Joao H. F. Pedra, David R. Nelson, Maria F. Unger, Jose M. C. Tubio, Zhijian Tu, Hugh M. Robertson, Martin Shumway, Granger Sutton, Jennifer R. Wortman, Daniel Lawson, Stephen K. Wikel, Vishvanath M. Nene, Claire M. Fraser, Frank H. Collins, Bruce Birren, Karen E. Nelson, Elisabet Caler, Catherine A. Hill
NATURE COMMUNICATIONS
(2016)
Article
Immunology
Joseph J. Gillespie, Isabelle Q. H. Phan, Timothy P. Driscoll, Mark L. Guillotte, Stephanie S. Lehman, Kristen E. Rennoll-Bankert, Sandhya Subramanian, Magda Beier-Sexton, Peter J. Myler, M. Sayeedur Rahman, Abdu F. Azad
PATHOGENS AND DISEASE
(2016)
Article
Microbiology
Timothy P. Driscoll, Victoria I. Verhoeve, Mark L. Guillotte, Stephanie S. Lehman, Sherri A. Rennoll, Magda Beier-Sexton, M. Sayeedur Rahman, Abdu F. Azad, Joseph J. Gillespie
Article
Microbiology
Mark L. Guillotte, Joseph J. Gillespie, Courtney E. Chandler, M. Sayeedur Rahman, Robert K. Ernst, Abdu F. Azad
JOURNAL OF BACTERIOLOGY
(2018)
Article
Microbiology
Stephanie S. Lehman, Nicholas F. Noriea, Karin Aistleitner, Tina R. Clark, Cheryl A. Dooley, Vinod Nair, Simran Jeet Kaur, M. Sayeedur Rahman, Joseph J. Gillespie, Abdu F. Azad, Ted Hackstadt
Article
Evolutionary Biology
Joseph J. Gillespie, Timothy P. Driscoll, Victoria Verhoeve, Mohammed Sayeedur Rahman, Kevin R. Macaluso, Abdu F. Azad
GENOME BIOLOGY AND EVOLUTION
(2018)
Article
Evolutionary Biology
Rachael Hagen, Victoria I. Verhoeve, Joseph J. Gillespie, Timothy P. Driscoll
GENOME BIOLOGY AND EVOLUTION
(2018)
Article
Microbiology
Mark L. Guillotte, Courtney E. Chandler, Victoria I. Verhoeve, Joseph J. Gillespie, Timothy P. Driscoll, M. Sayeedur Rahman, Robert K. Ernst, Abdu F. Azad
Summary: Species of Rickettsia are intracellular parasites of eukaryotes and can cause a variety of diseases. Our study focused on the structure of Rickettsia lipid A, revealing distinct characteristics that may impact disease manifestations.
Article
Immunology
Sherri A. Rennoll, Kristen E. Rennoll-Bankert, Mark L. Guillotte, Stephanie S. Lehman, Timothy P. Driscoll, Magda Beier-Sexton, M. Sayeedur Rahman, Joseph J. Gillespie, Abdu F. Azad
INFECTION AND IMMUNITY
(2018)