Article
Multidisciplinary Sciences
Joy Sarkar, Yuncin Luo, Qiang Zhou, Evguenia Ivakhnitskaia, Daniel Lara, Eitan Katz, Michael G. Sun, Victor Guaiquil, Mark Rosenblatt
Summary: This study compared the interactions of VEGF receptors and ligands in neuronal cells and endothelial cells, revealing higher levels of VEGFR heterodimers in neuronal cells and higher levels of VEGFR homodimers in endothelial cells.
Review
Biochemistry & Molecular Biology
Mariam Ahmed Galal, Samhar Samer Alouch, Buthainah Saad Alsultan, Huda Dahman, Nouf Abdullah Alyabis, Sarah Ammar Alammar, Ahmad Aljada
Summary: This comprehensive review thoroughly explores the intricate involvement of insulin receptor isoforms and insulin-like growth factor receptors in the insulin and insulin-like growth factor signaling pathway, emphasizing their crucial roles in cancer development and resistance to anti-cancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Juliete A. F. Silva, Xiaoping Qi, Maria B. Grant, Michael E. Boulton
Summary: The study demonstrates that VEGF induces rapid translocation of VEGFRs to the nucleus, with distinct characteristics between VEGFR1 and VEGFR2 in different cell types and a key role of the endosomal pathway in this process.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Genevieve A. Secker, Natasha L. Harvey
Summary: The importance of lymphatic vessels in human diseases, the initiation of lymphatic vascular development during embryogenesis, and the role of VEGF/VEGFR signaling in driving the construction of lymphatic vessels were discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Dirk Schmidt-Arras, Stefan Rose-John
Summary: Interleukin-6 plays a key role in inflammatory processes and cancer, as well as metabolic regulation and neural activities. Its receptor complexes can signal from both the plasma membrane and endomembranes, with pathogenic GP130 variants interfering with spatial activation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Mengmeng Zheng, Chunpu Li, Mi Zhou, Ru Jia, Gang Cai, Fengyu She, Lulu Wei, Shaohui Wang, Jie Yu, Dingyan Wang, Laurent Calcul, Xingmin Sun, Xiaomin Luo, Feng Cheng, Qi Li, Yan Wang, Jianfeng Cai
Summary: A novel small molecule, M-2-5, was discovered to tightly bind to the extracellular domain of EGFR and effectively antagonize EGF-stimulated EGFR phosphorylation and downstream signal transduction. Furthermore, it showed remarkable resistance to proteolytic degradation, effectively inhibiting cell proliferation and migration in vitro and suppressing tumor growth in vivo.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Cell Biology
Jerry D. Monroe, Faiza Basheer, Yann Gibert
Summary: Studies on fish species like Xiphophorus hellerii and Xiphophorus maculatus have shown similarities in oncogenic signaling pathways between Xmrk and EGFR, suggesting potential for identifying new chemotherapeutic drugs by targeting PI3K and MEK. In hepatocellular carcinoma, both Xmrk and EGFR signaling pathways utilize similar mechanisms for cell proliferation regulation.
Article
Multidisciplinary Sciences
Ashley J. Mason, Austin B. Keeler, Farah Kabir, Bettina Winckler, Christopher Deppmann
Summary: Proper wiring of the peripheral nervous system relies on neurotrophic signaling via nerve growth factor, in which NGF secreted by target organs binds to the TrkA receptor on postganglionic neurons and promotes cell survival and postsynaptic maturation. This study investigates extracellular vesicles as a novel route of neurotrophic signaling and finds that TrkA derived from endosomes can be detected on EVs secreted from the somatodendritic domain. Inhibition of classic TrkA downstream pathways decreases TrkA packaging into EVs. These findings suggest a novel trafficking route for TrkA and raise questions about the functionality of TrkA(+) EVs.
SCIENTIFIC REPORTS
(2023)
Article
Plant Sciences
Jiuxiao Ruan, Huhui Chen, Tao Zhu, Yaoguang Yu, Yawen Lei, Liangbing Yuan, Jun Liu, Zhi-Yong Wang, Jian-Fei Kuang, Wang-Jin Lu, Shangzhi Huang, Chenlong Li
Summary: This study uncovered a molecular network triggered by the plant hormone brassinosteroid (BR) that inhibits the seed maturation program during the seed-to-seedling transition in Arabidopsis, working synergistically with the VAL1/2-mediated pathway to ensure full repression of the seed maturation program. This sheds light on how BR promotes seedling growth by suppressing the seed maturation program.
Article
Biochemistry & Molecular Biology
Aleksandra Marchwicka, Urszula Nowak, Anna Grembowska, Agnieszka Jakuszak, Piotr Poreba, Ewa Marcinkowska
Summary: It has been found that fibroblast growth factor receptors play a crucial role in regulating the vitamin D receptor gene and cell differentiation. Overexpression of fibroblast growth factor receptors in myeloid leukemia cells upregulates the expression of the vitamin D receptor gene and promotes cell differentiation, while it has no effect on the expression and activity of the vitamin D receptor gene in bone cells.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jacinta N. Conroy, Elizabeth J. Coulson
Summary: Neurotrophin signaling is crucial for normal nervous system development and function. Understanding the mechanism of high-affinity receptor generation will facilitate the development of pharmaceuticals for the treatment of nervous system disorders. Despite decades of research, the modulation mechanism of the high-affinity complex remains unclear.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Keiko Midorikawa, Keiji Numata, Yutaka Kodama
Summary: The size and shape of organelles can affect biochemical reactions in cells. This study found that the morphologies of peroxisomes varied with proximity to the nucleus, indicating the presence of a nucleus-peroxisome signal transduction cascade mediated by chloroplasts.
Article
Chemistry, Multidisciplinary
Momoko Akiyama, Ryosuke Ueki, Masataka Yanagawa, Mitsuhiro Abe, Michio Hiroshima, Yasushi Sako, Shinsuke Sando
Summary: In this study, a synthetic receptor agonist was designed using a DNA aptamer as a building block to fine-tune agonism. The developed synthetic partial agonist can regulate therapeutically relevant cellular activities by eliciting finely-tuned receptor signaling.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Cell Biology
Xiao-Wei Zhang, Lin Li, Wen-Qian Hu, Ming-Ning Hu, Yan Tao, Hui Hu, Xiao-Kang Miao, Wen-Le Yang, Qiong Zhu, Ling-Yun Mou
Summary: This study reveals that G protein-coupled receptor neurokinin-1 (NK1R) is significantly upregulated in lung cancer samples and is associated with advanced clinical stages and poor prognosis. NK1R co-expresses with epidermal growth factor receptor (EGFR) and interacts with it in tumor cells. Activation of NK1R promotes lung cancer cell proliferation and migration through EGFR signaling pathways. Inhibition of NK1R suppresses cell proliferation and migration, and knockdown of NK1R slows down tumor growth. The presence of a selective NK1R antagonist enhances the sensitivity of lung cancer cells to specific drugs.
CELL DEATH & DISEASE
(2022)
Article
Neurosciences
Lolita Dokshokova, Mauro Franzoso, Anna Di Bona, Nicola Moro, Jose Luis Sanchez Alonso, Valentina Prando, Michele Sandre, Cristina Basso, Giuseppe Faggian, Hugues Abriel, Oriano Marin, Julia Gorelik, Tania Zaglia, Marco Mongillo
Summary: Cardiomyocytes release nerve growth factor (NGF) to support innervating sympathetic neurons in the heart, with neuro-cardiac junctions (NCJ) playing a crucial role in supporting retrograde neurotrophic signaling. The direct link between sympathetic neuron survival and neurotrophin release by cardiomyocytes is essential for heart cellular homeostasis.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)