期刊
TRAFFIC
卷 10, 期 12, 页码 1745-1752出版社
WILEY
DOI: 10.1111/j.1600-0854.2009.00979.x
关键词
antigen presentation; endocytosis; endoplasmic reticulum; membrane traffic; molecular chaperones; peptide loading complex; ubiquitylation
类别
资金
- Canadian Cancer Society
- Canadian Institutes of Health Research
- Intramural Research Program of the National Heart, Lung and Blood Institute, NIH
The presentation of antigenic peptides by class I molecules of the major histocompatibility complex begins in the endoplasmic reticulum (ER) where the co-ordinated action of molecular chaperones, folding enzymes and class I-specific factors ensures that class I molecules are loaded with high-affinity peptide ligands that will survive prolonged display at the cell surface. Once assembled, class I molecules are released from the quality-control machinery of the ER for export to the plasma membrane where they undergo dynamic endocytic cycling and turnover. We review recent progress in our understanding of class I assembly, anterograde transport and endocytosis and highlight some of the events targeted by viruses as a means to evade detection by cytotoxic T cells and natural killer cells.
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