期刊
TRAFFIC
卷 10, 期 3, 页码 268-274出版社
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1600-0854.2008.00869.x
关键词
adherens junctions; cadherins; focal adhesions; microtubules
类别
资金
- Netherlands Organization for Scientific Research
- National Health and Medical Research Council of Australia
- Human Frontiers Science Program
Cross-talk between microtubule networks and sites of cell-matrix and cell-cell adhesion has profound impact on these structures and is essential for proper cell organization, polarization and motility. Components of adhesion sites can interact directly with microtubules or with proteins that specifically associate with microtubule plus ends and minus ends and in this way capture, stabilize or destabilize microtubules. In their turn, microtubules can serve as routes for delivery of structural and regulatory factors that control adhesion site turnover. In addition, the microtubule lattice or growing microtubule plus ends can serve as diffusional sinks that accumulate and scaffold regulatory molecules, thereby affecting their activity in the vicinity of adhesions. Combination of these mechanisms underlies the functional co-operation between microtubules and adhesion sites and defines their dynamic behavior.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据