Supramolecular DNA origami nanostructures for use in bioanalytical applications

Bioanalytical chemistry is defined as the study of biological molecules and their related processes, and in the last two decades, it has advanced considerably due to the development of a variety of techniques and general nanotechnological progress. One technique for creating analytical nanodevices that has appeared recently is DNA origami, which uses DNA programmability to create nanostructures with high shape, size and actuation fidelity. Due to its versatility, this technique can be used to develop functional bioanalytical devices, and it is one of the keys to advancing analytical chemistry applications towards single-molecule studies. Herein, we briefly review the field of DNA nanotechnology and some reasons for the widespread attention to this topic from the scientific community. Later, perspectives and applications related to the field of analytical chemistry will be discussed, focusing principally on recent advances in the development of DNA devices for bioanalytical chemistry studies and DNA-based nanomachines. (c) 2018 Elsevier B.V. All rights reserved.