标题
Comprehensive Antigenic Map of a Cleaved Soluble HIV-1 Envelope Trimer
作者
关键词
Crystal structure, Enzyme-linked immunoassays, Antibodies, Binding analysis, HIV-1, Antigens, Viral structure, Stoichiometry
出版物
PLoS Pathogens
Volume 11, Issue 3, Pages e1004767
出版商
Public Library of Science (PLoS)
发表日期
2015-03-26
DOI
10.1371/journal.ppat.1004767
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env
- (2015) Miklos Guttman et al. Nature Communications
- Early development of broadly reactive HIV-1 neutralizing activity in elite neutralizers
- (2014) Tom L.G.M. van den Kerkhof et al. AIDS
- Cooperation of B Cell Lineages in Induction of HIV-1-Broadly Neutralizing Antibodies
- (2014) Feng Gao et al. CELL
- Broadly Neutralizing HIV Antibodies Define a Glycan-Dependent Epitope on the Prefusion Conformation of gp41 on Cleaved Envelope Trimers
- (2014) Emilia Falkowska et al. IMMUNITY
- Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers
- (2014) Claudia Blattner et al. IMMUNITY
- Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface
- (2014) Jinghe Huang et al. NATURE
- A stamp on the envelope
- (2014) Rogier W. Sanders et al. NATURE
- Structure and immune recognition of trimeric pre-fusion HIV-1 Env
- (2014) Marie Pancera et al. NATURE
- Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies
- (2014) Nicole A. Doria-Rose et al. NATURE
- Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits
- (2014) Anila Yasmeen et al. Retrovirology
- Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions
- (2014) J. B. Munro et al. SCIENCE
- Antibody 8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope Spike
- (2014) Louise Scharf et al. Cell Reports
- Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies
- (2013) Andrew T. McGuire et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Structural Characterization of Cleaved, Soluble HIV-1 Envelope Glycoprotein Trimers
- (2013) R. Khayat et al. JOURNAL OF VIROLOGY
- Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein
- (2013) P. J. Klasse et al. JOURNAL OF VIROLOGY
- Identification of an HIV-1 Clade A Envelope That Exhibits Broad Antigenicity and Neutralization Sensitivity and Elicits Antibodies Targeting Three Distinct Epitopes
- (2013) S. Hoffenberg et al. JOURNAL OF VIROLOGY
- Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120
- (2013) Leopold Kong et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The N276 Glycosylation Site Is Required for HIV-1 Neutralization by the CD4 Binding Site Specific HJ16 Monoclonal Antibody
- (2013) Sunita S. Balla-Jhagjhoorsingh et al. PLoS One
- Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation
- (2013) R. P. Ringe et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Computational analysis of anti-HIV-1 antibody neutralization panel data to identify potential functional epitope residues
- (2013) A. P. West et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9
- (2013) Jean-Philippe Julien et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer
- (2013) J.-P. Julien et al. SCIENCE
- Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer
- (2013) D. Lyumkis et al. SCIENCE
- Viral Escape from HIV-1 Neutralizing Antibodies Drives Increased Plasma Neutralization Breadth through Sequential Recognition of Multiple Epitopes and Immunotypes
- (2013) Constantinos Kurt Wibmer et al. PLoS Pathogens
- Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans
- (2013) Jean-Philippe Julien et al. PLoS Pathogens
- A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies
- (2013) Rogier W. Sanders et al. PLoS Pathogens
- Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein
- (2012) Florian Klein et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Broadly neutralizing antibodies against HIV-1: Templates for a vaccine
- (2012) Marit J. van Gils et al. VIROLOGY
- Structural Mechanism of Trimeric HIV-1 Envelope Glycoprotein Activation
- (2012) Erin E. H. Tran et al. PLoS Pathogens
- Three-Dimensional Structures of Soluble CD4-Bound States of Trimeric Simian Immunodeficiency Virus Envelope Glycoproteins Determined by Using Cryo-Electron Tomography
- (2011) T. A. White et al. JOURNAL OF VIROLOGY
- Mechanism of Neutralization by the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01
- (2011) Y. Li et al. JOURNAL OF VIROLOGY
- Broad neutralization coverage of HIV by multiple highly potent antibodies
- (2011) Laura M. Walker et al. NATURE
- Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding
- (2011) J. F. Scheid et al. SCIENCE
- A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield
- (2011) R. Pejchal et al. SCIENCE
- Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01
- (2010) T. Zhou et al. SCIENCE
- Appion: An integrated, database-driven pipeline to facilitate EM image processing
- (2009) Gabriel C. Lander et al. JOURNAL OF STRUCTURAL BIOLOGY
- DoG Picker and TiltPicker: Software tools to facilitate particle selection in single particle electron microscopy
- (2009) N.R. Voss et al. JOURNAL OF STRUCTURAL BIOLOGY
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