期刊
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
卷 30, 期 10, 页码 1575-1586出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2011.07.007
关键词
Centrifugally-driven microextraction; Electrophoretic separation; Fractionation; Lab-on-a-disc; Microfluidic compact disc (mu-CD); Monolithic stationary phase; Packed stationary phase; Preconcentration; Purification; Sample extraction
资金
- Science Foundation Ireland [08/SRC/B1412]
Centrifugally-driven microfluidic compact discs (mu-CDs) have attracted significant interest within the analytical science community in the past decade, with the primary focus on the potential of such platforms for performing parallel and/or multiplex biological assays and further application in biomedical diagnostics. More recently, mu-CD-based devices were also applied to environmental analysis as platforms for multi-sample extraction and transportation, prior to off-disc analysis in the laboratory. This review critically summarizes recent developments in mu-CD platforms for sample extraction, preconcentration, fractionation and purification in bioanalytical and environmental applications. We also summarize the common methods employed in the fabrication of mu-CD platforms. Further, we discuss preparation of stationary phases in microfluidic channels embedded in mu-CDs, as applications of mu-CDs in sample extraction are generally based on enclosed series of extraction phases and microcolumns. (C) 2011 Elsevier Ltd. All rights reserved.
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