Article
Chemistry, Analytical
Chen Deng, Hui Li, Sihua Qian, Pan Fu, Hualan Zhou, Jianping Zheng, Yuhui Wang
Summary: Fluorescence lateral flow assays (FLFAs) have gained significant attention due to their low cost, rapid screening, and on-site detection. The development of high-performance label probes is crucial for improving detection limits. In this study, fluorescent carbon nanobeads (FCNBs) were introduced as a new label probe for FLFAs. The FCNBs exhibited excellent properties such as water solubility, high emissivity, and easy surface functionalization. By modifying biomolecules onto the FCNBs, lateral flow test strips were constructed for the detection of foodborne toxins and pathogenic bacteria. The proposed FCNB-based FLFAs showed lower detection limits compared to most reported methods and were successfully applied for the quantitative and rapid screening of target analytes in food samples.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Chenglong Li, Huijuan Yang, Wenbo Yu, Xuezhi Yu, Kai Wen, Jianzhong Shen, Zhanhui Wang
Summary: The study successfully improved the tolerance of natural antibodies to organic solvents by using a highly stable humanized antibody for the first time. The engineered antibody showed significantly improved tolerance to acetonitrile and methanol, while retaining high affinity and class-specificity to sulfonamides, providing a general strategy to enhance antibody tolerance to organic solvents and benefiting the development of immunoassays.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Yuan Ding, Yue Huang, Wanlin Sun, Fangxuan Li, Shuguang Zhang, Song Fang, Minghua Wang, Xiude Hua
Summary: By synthesizing three novel quinclorac haptens, a better anti-quinclorac antibody was obtained, and a colloidal gold immunochromatographic assay (GICA) was developed for the detection of quinclorac, which showed high sensitivity and accuracy.
MICROCHEMICAL JOURNAL
(2022)
Article
Biochemical Research Methods
Salome Yakubu, Boyuan Jia, Yujia Guo, Yanmin Zou, Ninghui Song, Jianxuan Xiao, Kunlong Liang, Yuanqing Bu, Zhen Zhang
Summary: An indirect competitive immunosensor has been developed for TBBPA detection based on a signal amplification system. The Pd nanospheres used as the label for the secondary antibody and the MWCNTs/Au-TB platform for the immunosensor contributed to the improved sensitivity and stability of the sensor. Furthermore, the strategy showed promising results for analyzing emerging pollutants in real water samples with acceptable accuracy and recoveries.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Ekaterina Makhneva, Dorota Sklenarova, Julian C. Brandmeier, Antonin Hlavacek, Hans H. Gorris, Petr Skladal, Zdenek Farka
Summary: This study compares the effect of different labels and solid supports on the performance of heterogeneous immunoassays, and finds that the use of upconversion nanoparticles (UCNPs) and magnetic microbeads (MBs) can significantly improve the sensitivity and working range of biomarker detection.
ANALYTICAL CHEMISTRY
(2022)
Article
Biophysics
Xiaoyu Su, Huan Wang, Chengquan Wang, Xuan Zhou, Xiaobo Zou, Wen Zhang
Summary: In this study, a highly efficient PTM immunosensor is proposed, which amplifies its analytical advantages by introducing flexible fabrication techniques. By synthesizing MXene-Au probe, high sensitivity detection of PTM is achieved, and immunoreactions are improved by introducing dual electric fields. This method has shorter immune time and stronger detection signal, and can be used for PTM analysis in laboratory and natural samples.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Yanan Wang, Xiaofei Wang, Haitang Zhang, Jinqing Jiang, Hanna Fotina
Summary: Different synthesis methods for preparing ZEN immunogens successfully synthesized ZEN-BSA, which was used to prepare ZEN polyclonal antibodies with high specificity and broad specificity to ZEN and its analogs. These findings provide a foundation for immunoassay methods for ZEN residue detection.
INTERNATIONAL JOURNAL OF ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Abdulrahman A. Almehizia, Ahmed M. Naglah, Lamees S. Alrasheed, Mashael G. Alanazi, Abdel El-Galil E. Amr, Ayman H. Kamel
Summary: A robust, reliable, and affordable paper-based analytical apparatus for potentiometric sensing has been developed for the rapid identification of cardiovascular disorders, which is particularly important for point-of-care monitoring.
Article
Chemistry, Multidisciplinary
Rubing Chen, Yongqin Hu, Meizhu Chen, Jia An, Ying Lyu, Yufei Liu, Dongling Li
Summary: A method for detecting virus markers using modified polystyrene nanospheres (PSs) was successfully developed, achieving signal amplification and high sensitivity for naked-eye detection. The specific modification on nanospheres allowed for the capture and synthesis of gold nanoparticles, enabling color change observation with the naked eye and achieving a low limit of detection.
Article
Food Science & Technology
Yanan Wang, Xiaofei Wang, Shuyun Wang, Hanna Fotina, Ziliang Wang
Summary: This study established a highly sensitive and specific ZEN monoclonal antibody (mAb) and an indirect competitive enzyme-linked immunosorbent assay (icELISA) for the detection of ZEN residues in food and feed. The icELISA showed high sensitivity, specificity, rapidity, and reliability in detecting ZEN, making it a valuable tool for ZEN detection.
Article
Chemistry, Analytical
Kenneth R. Wehmeyer, Ryan J. White, Peter T. Kissinger, Andwilliam R. Heineman
Summary: The development of electrochemical affinity assays and sensors allows for selective and sensitive detection of target analytes, with recent advancements focusing on improving sensitivity and user-friendly features.
ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 14, 2021
(2021)
Article
Biochemical Research Methods
Shuang Peng, Kai Li, Yi-xuan Wang, Lin Li, Yun-Hui Cheng, Zhou Xu
Summary: A novel Porphyrin NanoMoFs (NanoPCN-223(Fe)) was synthesized with excellent dispersion and peroxidase-like activity, and used to construct Ed-MOFLISA for sensitive detection of AFB1 in milk. The method displayed a broad quantitative range and low detection limit, with good recovery for spiked peanut and soy milk.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Chemistry, Analytical
Sergio Forcada, Adrian Sanchez-Visedo, Candela Melendreras, Mario Menendez-Miranda, Jose M. Costa-Fernandez, Luis J. Royo, Ana Soldado
Summary: In this study, a competitive phosphorescent immunosensor was developed for the quantification of AFM1 in milk. The immunosensor utilized Mn:ZnS quantum dots as photoluminescent labels and exhibited a low detection limit and good accuracy.
Article
Materials Science, Biomaterials
Kulrisa Kuntamung, Jaroon Jakmunee, Kontad Ounnunkad
Summary: The newly developed electrochemical immunosensor can simultaneously detect three early breast cancer biomarkers with high reliability, low detection limits, and high selectivity, making it suitable for tumor marker detection in human serum.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Biochemical Research Methods
Xue Zhang, Xiaoning Liao, Yongfa Wu, Wanming Xiong, Juan Du, Zhui Tu, Wuying Yang, Dan Wang
Summary: A label-free electrochemical immunosensor for small molecular AFB(1) detection was constructed using functionalized black phosphorene and anti-AFB(1) nanobody, showing a linear range from 1.0 pM to 5.0 nM and an ultralow detection limit of 0.27 pM under optimized conditions. The fabricated immunosensor exhibited satisfactory stability, specificity, and reproducibility, providing a reliable reference for label-free sensing of small molecules in food samples.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Analytical
Claudia Campanale, Silvia Galafassi, Francesca Di Pippo, Iulian Pojar, Carmine Massarelli, Vito Felice Uricchio
Summary: Biodegradable plastic mulches (BDMs) have the potential to be an eco-friendly alternative to conventional plastic mulches in agriculture. However, their long-term impacts on soil ecosystems are still uncertain, and further research is needed. Incorporating BDMs into the soil may stimulate microbial activity, but there is also a risk of incomplete degradation and release of residual microplastics and additives.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Xuechi Yin, Sijie Liu, Deepak Kukkar, Jianlong Wang, Daohong Zhang, Ki-Hyun Kim
Summary: The lateral flow immunoassay strip is a classic and dominant tool in point-of-care detection, known for its portability and simplicity. However, current colored nanomaterials used as signal labels in LFIA have limited sensing potential, leading to the recognition of composite nanoparticles as alternatives to enhance sensitivity, signal readout diversity, anti-matrix interference, and cost-effectiveness.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Yaxin Cao, Longyi Shao, Timothy P. Jones, Wenjing Deng, M. Santosh, Pengju Liu, Cheng-Xue Yang, Yaowei Li, Daizhou Zhang, Kelly Berube
Summary: The toxicity of fibrous particles in ambient air can be higher than other types of particles. Microfibers can be organic or inorganic and their presence in the atmosphere as a result of human activity raises concerns for environmental and public health. Accurate collection, identification, and understanding of the health hazards associated with these fibers are crucial for mitigation strategies and protection of public health.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Chenchen Xie, Chen Meng, Huilin Liu, Baoguo Sun
Summary: The development of food hazard factor (FHF) detection has been moving towards on-site inspection and mobile law enforcement, calling for simple, fast, and affordable analysis technology to ensure food safety and quality. This review comprehensively summarizes the progress in research on smartphone-assisted MIP optosensors, focusing on the key issues of accuracy and sensitivity.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Guillem Peris-Pastor, Cristian Azorin, Jose Grau, Juan L. Benede, Alberto Chisvert
Summary: Green Analytical Chemistry plays an important role in every stage of method development, including sample preparation. Extraction techniques have evolved from conventional ones to a variety of miniaturized techniques in order to enhance analytical performance and ensure safety for operators and the environment. Green metric tools are used to evaluate the impact and sustainability of methods, with AGREEprep selected as the most suitable tool for evaluating published methods in various applications. The miniaturization of sample preparation strategies has led to the use of less and safer solvents, reduced waste generation and energy consumption, and improved portability and throughput.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Helena Hruskova, Roman Reminek, Frantisek Foret
Summary: This review article summarizes the progress and recent studies in offline electromigration preparative techniques between 2018 and 2023. It covers various techniques including electrophoresis, free-flow electrophoresis, isoelectric focusing, and isotachophoresis, providing theoretical aspects, trends, and solutions to existing limitations in each technique.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Mayank Garg, Nicole Pamme
Summary: This review focuses on the removal strategies of templates from molecularly imprinted polymers (MIPs) used in diagnostic biosensors. Chemical-based and electrochemical-based template extraction approaches are summarized and evaluated, providing guidance for researchers in the fields of analytical chemistry, diagnostics, and materials science for the design of MIP-based sensors.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Ivneet Banga, Anirban Paul, Nathan Kodjo Mintah Churcher, Ruchita Mahesh Kumar, Sriram Muthukumar, Shalini Prasad
Summary: Breathomics is an emerging field that focuses on analyzing exhaled breath to diagnose and monitor respiratory diseases. Electrochemical sensors, with their high sensitivity, selectivity, and low cost, play a significant role in breathomics and can be integrated into portable devices for point-of-care diagnosis.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Fabjola Bilo, Paola Cirelli, Laura Borgese
Summary: This review explores the application of X-ray fluorescence (XRF) spectrometry for elemental analysis of particulate matter (PM) in air quality monitoring. It discusses the fundamentals of XRF, experimental configurations, PM sampling devices and substrate, sample preparation strategies, qualitative and quantitative analysis, as well as the challenges faced by XRF in becoming a reliable analytical technique for PM analysis.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Hakim Faraji
Summary: The dispersive liquid-liquid microextraction (DLLME) technique is widely popular in analytical chemistry due to its high efficiency, cost-effectiveness, and simplicity. Recent advancements have addressed the limitations of DLLME, incorporating greener solvents, innovative dispersion strategies, and simplified procedures. These changes have made DLLME a more sustainable and efficient technique.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Sherin F. Hammad, Inas A. Abdallah, Alaa Bedair, Reda M. Abdelhameed, Marcello Locatelli, Fotouh R. Mansour
Summary: Carbon nanomaterials (CNMs) have excellent capabilities in terms of adsorption, enhanced oxidation, and photocatalysis, attracting widespread attention in different fields. Metal-organic frameworks (MOFs) have been widely used due to their regular network structure, porous nature, and large specific surface area. However, the instability of MOFs in aqueous solutions limits their applications in chemical sensing. Recent studies have focused on increasing the stability of MOFs in water-based matrices through chemical modifications using CNMs.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Alexandra Pape, Oliver J. Schmitz
Summary: Low temperature plasmas based on dielectric barrier discharges have emerged as a recent development in ion source research. These ion sources are applicable to heat-sensitive analytes and can ionize a wide range of compounds. Despite intensive research on important parameters such as configuration, shape, size, and materials in the past two decades, the actual ionization mechanism for all plasma gases has not been fully elucidated. This review provides an overview of atmospheric pressure ion sources, with a focus on plasma and dielectric barrier discharge based ion sources, summarizing the reactions occurring in the plasma and discussing the applications developed by different research groups.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Hai Xiong, Fengli Li, Linyu Zeng, Qiyu Lei
Summary: This review provides an overview of the emerging trends in the use of functional COF nanomaterials as biosensors for DNA/RNA detection. It summarizes the construction of DNA/RNA hybridized COF nanoprobes and their potential applications in bioanalyte detection, biosensing, biomarker imaging, and clinical biomedicine.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Bing Yan
Summary: This article summarizes the recent progress in logic gate computing and operation based on multiple luminescence response and chemical sensing for lanthanide functionalized MOF hybrid systems. The article first describes multi-color luminescence and the subsequent multiple luminescence response. The basic concept of logic gate operation and the advantages of lanthanide-based hybrid materials are then introduced. Reports on logic gate operation using pure lanthanide MOFs are provided, followed by a detailed summary of logic gate operations using lanthanide functionalized MOF hybrid materials. Additionally, the article discusses the practical luminescent detection of analytes by correlating the luminescence responsive signals and the concentration of different analytes. Finally, the article concludes with a prospect for this topic.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Brij Mohan, Gurjaspreet Singh, Rakesh Kumar Gupta, Pawan Kumar Sharma, Alexander A. Solovev, Armando J. L. Pombeiro, Peng Ren
Summary: Porous materials, particularly hydrogen-bonded organic frameworks (HOFs), have gained significant attention due to their versatile applications and unique properties such as well-defined crystalline structure and easy regeneration processes. This article provides a comprehensive overview of HOFs, including synthesis methods, hydrogen bonding motifs, recent advancements, and potential applications, offering valuable guidance for further exploration in this dynamic field.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)