期刊
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
卷 27, 期 9, 页码 749-761出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2008.07.003
关键词
Bead injection; Bioanalysis; Bioassay; Chemical-derivatization reaction; Detection; Environmental analysis; Flow-injection analysis; Preconcentration; Sample processing; Solid-phase extraction
资金
- Commission on Higher Education (Thailand)
- The Center of Excellence for Innovation in Chemistry (PERCH-CIC)
- Commission on Higher Education, Ministry of Education
- Thailand Research Fund
- Conselleria d'Economia, Hisenda i Innovacio del Govern de les Illes Balears (Spain)
Solid-phase extraction (SPE) is the most versatile sample-processing method for removal of interfering species and/or analyte enrichment. Although significant advances have been made over the past two decades in automating the entire analytical protocol involving SPE via flow-injection approaches, on-line SPE assays performed in permanent mode lack sufficient reliability as a consequence of progressively tighter packing of the bead reactor, contamination of the solid surfaces and potential leakage of functional moieties. This article overviews the current state-of-the-art of an appealing tool for overcoming the above shortcomings, so-called bead-injection (BI) analysis, based on automated renewal of the sorbent material per assay exploiting the various generations of flow-injection analysis. it addresses novel instrumental developments for implementing BI and a number of alternatives for on-line chemical-derivatization reactions, and it pinpoints the most common instrumental detection techniques utilized. We present and discuss in detail relevant environmental and bioanalytical applications reported in the past few years. (c) 2008 Elsevier Ltd. All rights reserved.
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