Article
Immunology
Yu-Wen Tseng, Chun-Chi Chang, Yung-Chi Chang
Summary: The study reveals a novel virulence role of NanA in pneumococcal pathogenesis, as NanA exaggerates inflammation by impairing the Siglec-5-TLR-2 interaction and reducing recruitment of SHP-1 in infected macrophages. This dysregulated crosstalk results in excessive inflammation and cytotoxicity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Cell Biology
Arindam Mondal, Jacques Roberge, John Gilleran, Youyi Peng, Dongxuan Jia, Moumen Akel, Yash Patel, Harrison Zoltowski, Anupama Doraiswamy, John Langenfeld
Summary: This study reveals that inhibition of BMP signaling combined with mitochondrial targeting agents induces AIF caspase-independent cell death, primarily through the hyperactivation of AMPK. This is an infrequently studied cell death pathway in cancer.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Infectious Diseases
Peng Liu, Xiaoxia Qin, Tingting Cao, Yuying Yang, Xiaomin Shi, Dejun Liu, Yang Wang, Zhangqi Shen, Shaolin Wang
Summary: This study investigated the potential resistance mechanism of telithromycin resistance in Campylobacter and found that the widely spread 23S_A2075G and erm(B) genes mediate high levels of resistance to telithromycin in C. coli.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Immunology
Sudhanshu Shekhar, Heidi A. Amdal, Fernanda Cristina Petersen
Summary: Mucosal immunization with S. mitis serotype 5 protects mice against S. pneumoniae serotype 5 infection and induces Th17 and predominant serotype-specific IgG/IgA antibody responses against pneumococcal infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Infectious Diseases
Clara Ines Agudelo, Carlos Castaneda-Orjuela, Maria Cristina de Cunto Brandileone, Gabriela Echaniz-Aviles, Samanta Cristine Grassi Almeida, Maria Noemi Carnalla-Barajas, Mabel Regueira, Sofia Fossati, Pedro Alarcon, Pamela Araya, Carolina Duarte, Jacqueline Sanchez, Mirna Novas, Gilda Torano-Peraza, Misladys Rodriguez-Ortega, Gustavo Chamorro-Cortesi, Anibal Kawabata, Gabriela Garcia-Gabarrot, Teresa Camou, Enza Spadola, Daisy Payares, Ana Lucia Andrade, Jose Luis Di Fabio, Elizabeth Castaneda
Summary: A multicentre, retrospective observational study in eight Latin American and Caribbean countries assessed the direct effect of pneumococcal conjugate vaccines (PCVs) on the distribution of pneumococcal serotypes causing invasive pneumococcal disease in children younger than 5 years. The study found a significant decrease in the percentage of vaccine serotypes in PCV countries after PCV introduction.
LANCET INFECTIOUS DISEASES
(2021)
Article
Immunology
Kaile Chen, Xiyan Zhang, Yunzhen Tao, Yunzhong Wang, Jian Xue, Changpeng Liu, Shuang Feng, Yongdong Yan, Qinghui Chen, Jianmei Tian, Genming Zhao, Xuejun Shao, Tao Zhang
Summary: This study described the hospitalization of 105 children <5 years of age for IPD in a hospital in Suzhou, China, from 2010 to 2017, and calculated the incidence rate of IPD in Suzhou. Eight different capsular serotypes of pneumococcus were identified in the study.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Food Science & Technology
Jasmin Bazant, Benjamin Ott, Martina Hudel, Torsten Hain, Rudolf Lucas, Mobarak Abu Mraheil
Summary: H2O2 negatively affects the activity and release of PLY. Decreased H2O2 production leads to a decline in PLY release, possibly due to the upregulation of certain genes.
Article
Biochemistry & Molecular Biology
Karl R. Schmitz, Emma L. Handy, Corey L. Compton, Shashank Gupta, William R. Bishai, Robert T. Sauer, Jason K. Sello
Summary: Proteolytic complexes play a crucial role in tuberculosis drug development, particularly the Clp proteases. Researchers have discovered that a specific fragment of acyldepsipeptide antibiotics can inhibit the growth of Mycobacterium tuberculosis while stimulating protein degradation, offering new possibilities for tuberculosis treatment.
ACS CHEMICAL BIOLOGY
(2023)
Article
Immunology
Daniel E. Kennedy Ii, Perceus Mody, Jean-Francois Gout, Wei Tan, Keun Seok Seo, Alicia K. Olivier, Jason W. Rosch, Justin A. Thornton
Summary: Cell apoptosis at the infection site is necessary for shutting down inflammatory signaling, avoiding tissue damage, and preventing sepsis progression. Puma(-/-) mice exhibited higher levels of inflammatory cytokines and increased susceptibility to bacterial dissemination in pneumococcal pneumonia. The study demonstrates the importance of Puma in preventing the cytokine storm and suggests the potential of targeting immunomodulation of IFN signaling in pulmonary inflammation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Dam Khan, Shola-Able Thomas, Peggy-Estelle Tientcheu, Sambou M. S. Suso, Christopher Dupont, Brenda Kwambana-Adams, Nuredin Ibrahim Mohammed, Mark P. Nicol, Martin Antonio
Summary: This study compared the performance of two different DNA extraction kits (Kit DP and Kit DPP) in detecting three pathogens in Nasopharynx/Oropharynx samples. The results showed that Kit DPP extracted DNA with higher concentration, increasing the chances of recovering low abundant bacteria. The two kits exhibited good concordance in detecting pathogens in positive samples. Overall, this study is of moderate importance with a score of 7/10.
Article
Multidisciplinary Sciences
Ryan Robinson, Christopher A. Myerscough, Nengjie He, Helen Hill, Wendi Shepherd, Patricia Gonzalez-Dias, Konstantinos Liatsikos, Samuel Latham, Fred Fyles, Klara Doherty, Phoebe Hazenberg, Fathimath Shiham, Daniella Mclenghan, Hugh Adler, Vicki Randles, Seher Zaidi, Angela Hyder-Wright, Elena Mitsi, Hassan Burhan, Ben B. Morton, Jamie M. Rylance, Maia M. Lesosky, Stephen Gordon, Andrea Collins, Daniela Ferreira
Summary: Experimental Human Pneumococcal Challenge (EHPC) is a safe procedure for studying vaccine research, with no serious adverse events related to pneumococcal inoculation. Colonised individuals were more likely to experience safety events, but most symptoms were mild and could be managed conservatively. Outpatient human pneumococcal challenge can be conducted safely with appropriate safety monitoring procedures in place.
Article
Biochemistry & Molecular Biology
Teppei Okabe, Yosuke Kamiya, Takeshi Kikuchi, Hisashi Goto, Masayuki Umemura, Yuki Suzuki, Yoshihiko Sugita, Yoshikazu Naiki, Yoshiaki Hasegawa, Jun-ichiro Hayashi, Shotaro Kawamura, Noritaka Sawada, Yuhei Takayanagi, Takeki Fujimura, Naoya Higuchi, Akio Mitani
Summary: This study found that the culture supernatant of Porphyromonas gingivalis accelerated inflammation in the lungs of Streptococcus pneumoniae-infected mice, and increased inflammatory cell infiltration. Compared to S. pneumoniae infection alone, PgSup synergistically increased TNF-alpha and IL-17 expression/production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xinyan Zhang, Jinxian Xu, Brendan Marshall, Zheng Dong, Sylvia B. Smith, Ming Zhang
Summary: The study found that the lack of caspase-12 in mice led to more severe retinitis and wider virus spread in the retina during MCMV infection, with reduced response to interferons. Compared to mice with caspase-12, significantly lower levels of caspase-3 and p53 proteins were detected in infected eyes of caspase-12 deficient mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Rama Kandasamy, Stephanie Lo, Meeru Gurung, Michael J. Carter, Rebecca Gladstone, John Lees, Sonu Shrestha, Stephen Thorson, Sanjeev Bijukchhe, Madhav C. Gautam, Reetu Shrestha, Sunaina Gurung, Bibek Khadka, Lesley McGee, Robert F. Breiman, David R. Murdoch, Dominic F. Kelly, Shrijana Shrestha, Stephen D. Bentley, Andrew J. Pollard
Summary: Pneumococcal disease is a major cause of bacterial pneumonia and invasive bacterial disease in children globally. This study used whole-genome sequencing to analyze strains of pneumococcus collected in Kathmandu, Nepal from 2005 to 2018. The research identified a strain, GPSC9, with high disease prevalence, multidrug resistance, and the ability to switch to an unencapsulated phenotype.
Article
Microbiology
Charlie Higgs, Lamali Sadeesh Kumar, Kerrie Stevens, Janet Strachan, Tony Korman, Kristy Horan, Diane Daniel, Madeline Russell, Christopher A. Mcdevitt, Norelle L. Sherry, Timothy P. Stinear, Benjamin P. Howden, Claire L. Gorrie
Summary: Streptococcus pneumoniae is an important human pathogen, and non-invasive isolates may serve as a source of invasive isolates and reservoirs of antimicrobial resistance (AMR) determinants. By comparing the genomes and antibiotic resistance profiles of invasive and non-invasive isolates, we found that non-invasive isolates exhibited higher levels of resistance to multiple antibiotics and certain sub-populations with high levels of AMR were overrepresented in the non-invasive population.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Mohammadhossein Movassaghghazani, Nazanin Shabansalmani
Summary: The study revealed high levels of AFM1 in both breast milk and powdered milk samples in Tehran, with some samples exceeding the established limits. Therefore, monitoring and regulating toxin levels in these products is crucial for maternal and infant health.
Article
Pharmacology & Pharmacy
Defeng Wen, Wantong Han, Quan Chen, Guanhui Qi, Mengling Gao, Pu Guo, Yu Liu, Zhongyuan Wu, Shulin Fu, Qirong Lu, Yinsheng Qiu
Summary: Luteolin can inhibit FB1-induced intestinal inflammatory injury by inhibiting the activation of NF-kappa B and ERK signaling pathways, according to network pharmacology and in vitro experiments.