Article
Food Science & Technology
Massimo Bortolotti, Stefania Maiello, Jose M. Ferreras, Rosario Iglesias, Letizia Polito, Andrea Bolognesi
Summary: Ribosome-inactivating proteins (RIPs) are plant toxins that damage ribosomes irreversibly, with type 2 RIPs being particularly cytotoxic due to the linkage of active A chains to lectin B chains. Kirkiin, a newly discovered type 2 RIP, not only inhibits protein synthesis and induces apoptosis in neuroblastoma cells at very low doses, but also shows potential for pharmacological applications in neurodegenerative studies and cancer therapy.
Article
Food Science & Technology
Simin Chen, Claudia Figueiredo Lossio, Isabel Verbeke, Joost Verduijn, Bogdan Parakhonskiy, Louis Van der Meeren, Pengyu Chen, Jeroen De Zaeytijd, Andre G. Skirtach, Els J. M. Van Damme
Summary: The study found that OsRIP1 can inhibit protein synthesis in a sustained manner, leading to reduced proliferation of HeLa cells with apoptotic-like changes in the cell membrane, but without causing DNA fragmentation. OsRIP1 also interacts with ASPP1 and IFITM3, causing changes in the transcription levels of important genes in the cells, inducing a caspase-independent cell death process in HeLa cells.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Anna Marei Grages, Nicole Verhaar, Christiane Pfarrer, Gerhard Breves, Marion Burmester, Stephan Neudeck, Sabine Kastner
Summary: This study compared two experimental models, low flow and no flow, to characterize the development of intestinal injury in horses. The results showed that the no flow model produced more consistent intestinal damage compared to the low flow model.
Article
Immunology
Ruera Carolina, Miculan Emanuel, Ducca Geronimo, Perez Federico, Iribarren Maria Luz, Carasi Paula, Chirdo Fernando Gabriel
Summary: This study found that specific inhibition of caspase-1 or NLRP3 can eliminate the damage caused by the gluten derived peptide p31-43. Blocking IL-1 beta with antibodies can inhibit the histological changes, apoptosis, and caspase-3 activation induced by p31-43. Understanding the role of IL-1 beta in sterile inflammation may help to understand chronic inflammatory pathological processes and design new intervention strategies.
IMMUNOLOGY LETTERS
(2022)
Article
Environmental Sciences
Haoran Zhang, Jiaqiang Huang, Jie Yang, Jingzeng Cai, Qi Liu, Xintong Zhang, Jun Bao, Ziwei Zhang
Summary: Cadmium (Cd) is an environmental contaminant known for its potential toxicity, particularly in accumulating in the liver and kidney and causing serious damage. In this study, Cd-induced intestinal damage in swine was investigated through in vivo and in vitro models. The research found that Cd treatment induced ileal apoptosis and autophagy in cells, activating the PI3K/Akt pathway, and altering expression levels of apoptosis and autophagy-related proteins. Furthermore, the study showed that treatment with a PI3K activator could mitigate the effects of Cd-induced apoptosis and autophagy.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Medicine, Research & Experimental
Ruochen Cong, Linlin Sun, Jushun Yang, Hengxiang Cui, Xin Ji, Jing Zhu, Jin-hua Gu, Bosheng He
Summary: Protein O-GlcNAcylation is a dynamic post-translational modification that regulates cellular functions and has protective effects on ischemia-related injuries. Pharmacological manipulation to increase O-GlcNAcylation levels enhances cell survival while reducing levels makes cells more susceptible to injury. Acute increases in O-GlcNAcylation can protect against intestinal ischemia insults, suggesting it could be a potential therapeutic target for intestinal ischemic disease.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Yingying Zheng, Bo Zhang, Haoyue Guan, Xing Jiao, Jie Yang, Jingzeng Cai, Qi Liu, Ziwei Zhang
Summary: This study investigated the mechanism by which selenium deficiency causes intestinal damage in swine, showing that selenium deficiency can induce ER stress, increase apoptosis, and ultimately lead to tissue damage in the small intestine. These results fill the gap in understanding how selenium deficiency induces intestinal injury in swine.
Article
Biology
Sophie Fouyet, Elodie Olivier, Pascale Leproux, Melody Dutot, Patrice Rat
Summary: The study found that Bisphenol A (BPA), Bisphenol F (BPF), and Bisphenol S (BPS) are all toxic to human placental cells, with the P2X7 receptor being a common key element. BPA and BPF induced more activation of the caspase pathway compared to BPS, and only BPF enhanced the activity of another pathway.
Article
Nutrition & Dietetics
Ewelina Cholewinska, Aleksandra Marzec, Przemyslaw Solek, Bartosz Fotschki, Piotr Listos, Katarzyna Ognik, Jerzy Juskiewicz
Summary: The aim of this study was to investigate the effects of different types of dietary fibre (cellulose, inulin, pectin, and psyllium) in combination with recommended or enhanced levels of CuNPs on selected biological parameters of intestinal integrity in rats. The results showed that replacing CuCO3 with CuNPs in the diet reduced lactic acid and apoptosis markers levels in the small intestine, but it also increased DNA oxidation. Inulin had the most beneficial effect on DNA repair mechanisms, while pectin had the highest ability to inhibit inflammatory processes and apoptotic cell death in the small intestine. These findings suggest that dietary fibre supplementation can protect the small intestine against oxidative effects of CuNPs by enhancing the intestinal barrier.
Article
Cell Biology
Yingbin Luo, Bo Zhang, Lili Xu, Minghua Li, Jianchun Wu, Yiyang Zhou, Yan Li
Summary: This study found that downregulation of KIF15 expression can inhibit the migration and invasion of NSCLC cells mediated by MMP2 and MMP9, induce apoptosis and cell cycle arrest in NSCLC cells, and inhibit the tumor growth of NSCLC. Furthermore, KIF15 knockdown can also inhibit the activation of the Raf/MEK/ERK signaling pathway in NSCLC. These findings provide insights into the diagnosis and treatment of NSCLC.
HISTOLOGY AND HISTOPATHOLOGY
(2022)
Article
Toxicology
Serena Benedetti, Simona Catalani, Barbara Canonico, Maria Gemma Nasoni, Francesca Luchetti, Stefano Papa, Lucia Potenza, Francesco Palma
Summary: The antiviral drug Acyclovir may induce anticancer effects by inhibiting cancer cell growth and inducing apoptosis, even without detecting human herpesviruses in the cells. Furthermore, the drug also causes mitochondrial damage and an increase in intracellular reactive oxygen species levels.
TOXICOLOGY IN VITRO
(2022)
Article
Oncology
Han Wang, Yilan Wu, Xiaoyan Lin
Summary: This study evaluated the effect and safety of crizotinib loaded polydopamine-polylactide-TPGS nanoparticles (CZT/pD-PT NPs) on non-small cell lung cancer (NSCLC). The results showed that CZT/pD-PT NPs had sustained-release effect and promoted the cellular uptake of CZT, leading to significant inhibition of NSCLC cell viability and promotion of cell apoptosis. Moreover, CZT/pD-PT NPs exhibited low hepatotoxicity. Therefore, CZT/pD-PT NPs may serve as a novel drug delivery system to improve the efficacy of chemotherapy for NSCLC.
Article
Cell Biology
Yinping Huo, Tangfeng Lv, Mingxiang Ye, Suhua Zhu, Jiaxin Liu, Hongbing Liu, Yong Song
Summary: The study demonstrates that F-circEA1 can regulate cell proliferation and apoptosis in non-small cell lung cancer by affecting the expression of the parental gene EML4-ALK1 and its downstream ALK signaling pathway. Further experiments also show that F-circEA1 has an impact on cell metastasis, invasion, and drug sensitivity.
Review
Health Care Sciences & Services
Quratulain Maqsood, Aleena Sumrin, Muhammada Mahnoor, Muhammad Waseem, Esha Ameen, Natasha Tabassum
Summary: Ribosome-Inactivating Proteins (RIPs) are enzymes that exhibit cytotoxic activity by inactivating protein synthesis through N-glycosidase activity in 28S ribosomal RNA. They have potential as cancer therapeutics due to their short plasma half-life, low antigenicity, and selective cytotoxicity. RIPs can function as target-specific carriers by conjugating with toxins.
ANNALS OF MEDICAL AND HEALTH SCIENCES RESEARCH
(2021)
Review
Food Science & Technology
Elvira Franco, Veronica Garcia-Recio, Pilar Jimenez, Manuel Garrosa, Tomas Girbes, Manuel Cordoba-Diaz, Damian Cordoba-Diaz
Article
Allergy
Alicia Armentia, Sara Martin-Armentia, Rafael Alvarez-Nogal, Blanca Martin Armentia, Manuel Jose Gayoso, Delia Fernandez-Gonzalez
CLINICAL AND EXPERIMENTAL ALLERGY
(2019)
Article
Pharmacology & Pharmacy
Damian Cordoba Diaz, Marta Elena Losa Iglesias, Ricardo Becerro de Bengoa Vallejo, Manuel Cordoba Diaz
Review
Pharmacology & Pharmacy
Rafael G. Seoane, Veronica Garcia-Recio, Manuel Garrosa, Maria A. Rojo, Pilar Jimenez, Tomas Girbes, Manuel Cordoba-Diaz, Damian Cordoba-Diaz
CURRENT PHARMACEUTICAL DESIGN
(2020)
Article
Microscopy
Jorge Gayoso, Manuel Garrosa, Sara Gayoso, Carlos Alberto Rodriguez-Arias, Miguel Angel Martin-Ferrero, Manuel Jose Gayoso
Article
Chemistry, Multidisciplinary
Salvador Manzur-Valdespino, Esther Ramirez-Moreno, Jose Arias-Rico, Osmar Antonio Jaramillo-Morales, Zuli Guadalupe Calderon-Ramos, Luis Delgado-Olivares, Manuel Cordoba-Diaz, Damian Cordoba-Diaz, Nelly del Socorro Cruz-Cansino
APPLIED SCIENCES-BASEL
(2020)
Article
Food Science & Technology
M. Angeles Rojo, Manuel Garrosa, Pilar Jimenez, Tomas Girbes, Veronica Garcia-Recio, Manuel Cordoba-Diaz, Damian Cordoba-Diaz
Article
Pharmacology & Pharmacy
Ines Perez-Roman, Filip Kiekens, Damian Cordoba-Diaz, Juan Jose Garcia-Rodriguez, Manuel Cordoba-Diaz
Review
Food Science & Technology
Rosalia Marcano, M. Angeles Rojo, Damian Cordoba-Diaz, Manuel Garrosa
Summary: Periodontal disease is an inflammatory disease caused by infectious agents, with endotoxins playing a key role in triggering inflammation and destruction of supporting tissues. Endotoxins are released into tissues after cell lysis, inducing immune responses that may lead to systemic dissemination and diseases.
Article
Food Science & Technology
Raul Fraile-Fabero, Maria Ozcariz-Fermoselle, Juan A. Oria-de-Rueda-Salgueiro, Veronica Garcia-Recio, Damian Cordoba-Diaz, Maria Del P. Jimenez-Lopez, Tomas Girbes-Juan
Summary: The study found differences in nutritional composition and antioxidant content between Ganoderma lingzhi from China and cultivated Ganoderma lucidum from Spain. There were also differences in protein profile and digestibility, indicating potential differences in nutritional and industrial applications.
Article
Geochemistry & Geophysics
Camila Diez, Maria Angeles Rojo, Jesus Martin-Gil, Pablo Martin-Ramos, Manuel Garrosa, Damian Cordoba-Diaz
Summary: Teeth are unique and complex organs that provide important data about a person's health. This study used various techniques to analyze teeth and found that factors such as smoking, psychotherapeutic drugs, and biological age can affect tooth structure and mineralization. The ATR-FTIR technique showed promise for investigating changes in tooth structure and informing diagnostic strategies.
Article
Chemistry, Medicinal
Cristina Martin-Sabroso, Mario Alonso-Gonzalez, Ana Fernandez-Carballido, Juan Aparicio-Blanco, Damian Cordoba-Diaz, Federico Navarro-Garcia, Manuel Cordoba-Diaz, Ana I. Torres-Suarez
Summary: Cysteamine eye drops, commonly used for treating patients with cystinosis, have high instability in aqueous solution, which may compromise their clinical efficacy. This study analyzed the stability of different formulations of cysteamine eye drops and found that they had high degradation rates at the end of their shelf life.
Article
Cell Biology
Manuel Garrosa, Pilar Jimenez, Damian Cordoba-Diaz, Veronica Garcia-Recio, Sara Gayoso, Maria Angeles Rojo, Manuel J. Gayoso, Tomas Girbes
HISTOLOGY AND HISTOPATHOLOGY
(2018)
Article
Pharmacology & Pharmacy
Mohammadhossein Movassaghghazani, Nazanin Shabansalmani
Summary: The study revealed high levels of AFM1 in both breast milk and powdered milk samples in Tehran, with some samples exceeding the established limits. Therefore, monitoring and regulating toxin levels in these products is crucial for maternal and infant health.
Article
Pharmacology & Pharmacy
Defeng Wen, Wantong Han, Quan Chen, Guanhui Qi, Mengling Gao, Pu Guo, Yu Liu, Zhongyuan Wu, Shulin Fu, Qirong Lu, Yinsheng Qiu
Summary: Luteolin can inhibit FB1-induced intestinal inflammatory injury by inhibiting the activation of NF-kappa B and ERK signaling pathways, according to network pharmacology and in vitro experiments.
