Article
Microbiology
Shih-Chia Yeh, Mayra Diosa-Toro, Wei-Lian Tan, Florian Rachenne, Arthur Hain, Celestia Pei Xuan Yeo, Ines Bribes, Benjamin Wong Wei Xiang, Gayathiri Sathiamoorthy Kannan, Menchie Casayuran Manuel, Dorothee Misse, Yu Keung Mok, Julien Pompon
Summary: This study successfully identified 14 RBPs in Aedes aegypti cells that interact with DENV 2 3'UTR, providing new insights into the pro- and anti-viral functions of these RBPs in mosquitoes. The findings have important implications for the design of novel therapeutic interventions against Dengue viruses and for studying the role of RBPs in virus-vector interactions.
Article
Pharmacology & Pharmacy
Guangyi Cui, Han Wang, Chongting Yang, Xiaoxiao Zhou, Junyi Wang, Tong Wang, Tonghui Ma
Summary: In this study, it was found that Berberine has potent inhibitory effects on EV71 replication and can significantly reduce mortality in a mouse model of EV71 infection. Berberine achieves these effects by regulating the Keap-Nrf2 axis and reducing ROS generation. This study provides a potential antiviral treatment for severe EV71 infection associated with neurological complications.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eva Konkolova, Katerina Krejcova, Ludek Eyer, Jan Hodek, Michala Zgarbova, Andrea Fortova, Michael Jirasek, Filip Teply, Paul E. Reyes-Gutierrez, Daniel Ruzek, Jan Weber, Evzen Boura
Summary: Positive-sense single-stranded RNA (+RNA) viruses are important pathogens that pose a significant threat to modern societies, as evidenced by the ongoing COVID-19 pandemic. This study presents a compound called PR673, which is a helquat-like compound that can inhibit the replication of SARS-CoV-2 and tick-borne encephalitis virus in cell culture. Using in vitro polymerase assays, the researchers demonstrate that PR673 inhibits RNA synthesis by viral RNA-dependent RNA polymerases (RdRps). This study suggests the feasibility of developing broad-spectrum non-nucleoside inhibitors of RdRps.
Article
Multidisciplinary Sciences
Jolien Van Cleemput, Willem van Snippenberg, Laurens Lambrechts, Amelie Dendooven, Valentino D'Onofrio, Liesbeth Couck, Wim Trypsteen, Jan Vanrusselt, Sebastiaan Theuns, Nick Vereecke, Thierry P. P. van den Bosch, Martin Lammens, Ann Driessen, Ruth Achten, Ken R. Bracke, Wim Van den Broeck, Jan Von der Thusen, Hans Nauwynck, Jo Van Dorpe, Sarah Gerlo, Piet Maes, Janneke Cox, Linos Vandekerckhove
Summary: A detailed virological analysis of thirteen postmortem COVID-19 cases revealed presence of replication-competent SARS-CoV-2 in extrapulmonary organs of immunocompromised patients and identified tissue-specific patterns of genome diversity. Key mutations were found across multiple organs with infectivity confirmed in cell culture. Disease progression was classified into two stages based on duration and viral loads in lungs and plasma.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Medicinal
Desaboini Nageswara Rao, Jacqueto Zephyr, Mina Henes, Elise T. Chan, Ashley N. Matthew, Adam K. Hedger, Hasahn L. Conway, Mohsan Saeed, Alicia Newton, Christos J. Petropoulos, Wei Huang, Nese Kurt Yilmaz, Celia A. Schiffer, Akbar Ali
Summary: By designing and synthesizing compounds with different chemical scaffolds at the P2 and P4 positions, researchers developed pan-genotypic HCV NS3/4A protease inhibitors with excellent antiviral activity and improved drug resistance profiles.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Virology
Dong Joo Seo, Changsun Choi
Summary: Bioactive compounds derived from mushrooms show antiviral activity against DNA and RNA viruses, particularly herpes simplex virus, influenza virus, and human immunodeficiency virus (HIV). Some mushroom compounds have antiviral effects comparable to antiviral drugs, suggesting their potential as candidates for treating viral infections.
Article
Nutrition & Dietetics
Tatsuki Kimizuka, Natsumi Seki, Genki Yamaguchi, Masahiro Akiyama, Seiichiro Higashi, Koji Hase, Yun-Gi Kim
Summary: The study showed that an amino acid-based diet protected mice from enteric pathogen infection by preventing dehydration caused by diarrhea, altering amino acid levels in the plasma and feces as well as changing gut microbiota composition.
Review
Integrative & Complementary Medicine
Qiuju Huang, Muyang Wang, Min Wang, Yuhui Lu, Xiaohua Wang, Xin Chen, Xin Yang, Hongwei Guo, Rongrong He, Zhuo Luo
Summary: Viruses pose an escalating threat to human health as the leading cause of worldwide mortality, despite significant progress in therapies and vaccines. The need for effective antiviral interventions remains urgent due to the lack of effective vaccines, severe side effects of current drugs, and emergence of drug-resistant strains. Scutellaria baicalensis, a traditional Chinese medicine, has been extensively studied and shown efficacy in diverse therapeutic areas, making it a promising source of antiviral drugs.
CHINESE JOURNAL OF NATURAL MEDICINES
(2023)
Article
Virology
Denisa Bojkova, Marco Bechtel, Tamara Rothenburger, Joshua D. D. Kandler, Lauren Hayes, Ruth Olmer, Ulrich Martin, Danny Jonigk, Sandra Ciesek, Mark N. N. Wass, Martin Michaelis, Jindrich Cinatl Jr
Summary: Recent findings show that SARS-CoV-2 Omicron BA.1 induces a stronger interferon response compared to Delta. In this study, it was demonstrated that BA.1 and BA.5, but not Delta, induce an antiviral state in air-liquid interface cultures of primary human bronchial epithelial cells and primary human monocytes. Both Omicron subvariants trigger the production of biologically active interferons and protect cells from super-infection with influenza A viruses. These findings highlight the significance of Omicron in the immune response against viral infections.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Rashid Manzoor, Nao Eguchi, Reiko Yoshida, Hiroichi Ozaki, Tatsunari Kondoh, Kosuke Okuya, Hiroko Miyamoto, Ayato Takada
Summary: Protective immunity against influenza A viruses mainly relies on antibodies to hemagglutinin (HA), but the conserved M2 protein has been studied as a vaccine antigen for cross-protective immunity. This study reveals that an M2-specific antibody can interfere with the HA-M2 association, providing a novel mechanism for the antiviral activity of M2-specific antibodies.
JOURNAL OF VIROLOGY
(2021)
Review
Chemistry, Multidisciplinary
Yao Zhang, Wei Fan, Yanli Sun, Weichun Chen, Yifan Zhang
Summary: Research on antiviral textiles has gained significant attention due to the rise of new infectious diseases. Various antiviral materials and methods can effectively inhibit virus spread, reduce infection risks, and protect people's health and safety.
NANOTECHNOLOGY REVIEWS
(2021)
Article
Pharmacology & Pharmacy
Xinyu Wang, Lisanne Terrie, Guanghui Wu, Els J. M. Van Damme, Lieven Thorrez, Anthony R. Fooks, Ashley C. Banyard, Dirk Jochmans, Johan Neyts
Summary: Infection with the rabies virus is a deadly neurological disease, but post-exposure prophylaxis (PEP) with vaccination and anti-rabies immunoglobulins (RIGs) is 100% effective if administered early. This study found that Urtica dioica agglutinin (UDA), a specific lectin, can prevent the entry of the virus into host cells and effectively stop virus replication in a muscle model. UDA holds promise as a cheap and simple alternative for RIGs in PEP.
Article
Cell Biology
Min Lu, Shen Wang, Tao Wang, Sisi Hu, Brijesh Bhayana, Momoko Ishii, Yifei Kong, Yuchen Cai, Tianhong Dai, Wenguo Cui, Mei X. Wu
Summary: The combination therapy of blue light and phytochemical carvacrol was found to effectively kill a range of bacteria, including antibiotic-resistant strains, with significant efficacy against acute and established infections. This unique phototoxic reaction selectively targeted bacteria without adverse effects on mammalian cells or host DNA, providing a promising strategy to combat multidrug-resistant bacteria.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
William Dunker, Xiang Ye, Yang Zhao, Lanxi Liu, Antiana Richardson, John Karijolich
Summary: TDP-43 is shown to regulate the accumulation of immunostimulatory dsRNA, preventing interferon-mediated cell death. This study reveals an intricate relationship between the control of cellular gene expression and IFN-mediated cell death.
Article
Immunology
Nuha Milad Ashtiwi, Demba Sarr, Tamas Nagy, Z. Beau Reneer, Ralph A. Tripp, Balazs Rada
Summary: The combination treatment of OSCN- and AMT shows potential in curing lethal influenza virus infection. Monotherapy with OSCN- or AMT alone does not substantially improve survival outcomes, but the combination treatment significantly inhibits viral replication.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Xiaojing Pang, Xiaoping Xiao, Yang Liu, Rudian Zhang, Jianying Liu, Qiyong Liu, Penghua Wang, Gong Cheng
NATURE MICROBIOLOGY
(2016)
Review
Virology
Xiaojing Pang, Rudian Zhang, Gong Cheng
Article
Multidisciplinary Sciences
Yang Liu, Jianying Liu, Senyan Du, Chao Shan, Kaixiao Nie, Rudian Zhang, Xiao-Feng Li, Renli Zhang, Tao Wang, Cheng-Feng Qin, Penghua Wang, Pei-Yong Shi, Gong Cheng
Article
Multidisciplinary Sciences
Yibin Zhu, Rudian Zhang, Bei Zhang, Tongyan Zhao, Penghua Wang, Guodong Liang, Gong Cheng
NATURE COMMUNICATIONS
(2017)
Article
Microbiology
Xiaoping Xiao, Lijuan Yang, Xiaojing Pang, Rudian Zhang, Yibin Zhu, Penghua Wang, Guanjun Gao, Gong Cheng
NATURE MICROBIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Shu-ya Wang, Qi-jia Yu, Ru-dian Zhang, Bo Liu
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2011)
Article
Cell Biology
Fei Wang, Rudian Zhang, Wenzhi Feng, Dai Tsuchiya, Olivia Ballew, Jiajia Li, Vladimir Denic, Soni Lacefield
DEVELOPMENTAL CELL
(2020)
Editorial Material
Cell Biology
Rudian Zhang, Wenzhi Feng, Suhong Qian, Fei Wang
Summary: In Saccharomyces cerevisiae, autophagy plays a crucial role in meiotic processes. This study reveals that the meiosis-specific RNA-binding protein Rim4 forms a complex with the 14-3-3 proteins Bmh1 and Bmh2 to regulate the translation of specific meiotic transcripts. The interaction between Rim4 and Bmh1/Bmh2 expels mRNAs from Rim4's binding grip, and this interaction is controlled by the phosphorylation states at certain sites in Rim4. Furthermore, Rim4 is found to be a selective autophagy substrate, and after dissociation from mRNAs and Bmh1/Bmh2, it activates Atg1, a key protein in autophagy.
Article
Cell Biology
Rudian Zhang, Wenzhi Feng, Suhong Qian, Fei Wang
Summary: Autophagy plays an important role in regulating the meiosis-specific RNA-binding protein Rim4 and its associated transcripts in yeast meiosis. Rim4 enters the nucleus using a nuclear localization signal and loads its mRNA substrates before nuclear export. Active autophagy selectively spares the Rim4-mRNA complex in the cytoplasm, while degrading Rim4 during meiotic divisions in an Atg11-dependent manner, coinciding with the release of Rim4-bound mRNAs for translation. The conserved RNA recognition motifs (RRMs) of Rim4 are involved in stimulating Atg1 kinase and facilitating selective autophagy.
Article
Cell Biology
Rudian Zhang, Wenzhi Feng, Suhong Qian, Shunjin Li, Fei Wang
Summary: Meiotic gene expression in budding yeast is tightly controlled by RNA-binding proteins, and the Rim4 protein plays a key role in this process. This study reveals that the Rim4 protein is regulated by the 14-3-3 proteins Bmh1 and Bmh2, through the formation of a complex that expels mRNAs from Rim4 binding. The phosphorylation and dephosphorylation of serine/threonine residues in Rim4 by PKA kinase and Cdc14 phosphatase activities control the formation of the Rim4-Bmh1-Bmh2 complex, thus regulating Rim4's subcellular distribution, function, and stability.
Article
Medicine, Research & Experimental
Lei Yu, Ruoke Wang, Fei Gao, Min Li, Jianying Liu, Jian Wang, Wenxin Hong, Lingzhai Zhao, Yingfen Wen, Chibiao Yin, Hua Wang, Qi Zhang, Yangyang Li, Panpan Zhou, Rudian Zhang, Yang Liu, Xiaoping Tang, Yongjun Guan, Cheng-Feng Qin, Ling Chen, Xuanling Shi, Xia Jin, Gong Cheng, Fuchun Zhang, Linqi Zhang
Article
Immunology
Rudian Zhang, Yibin Zhu, Xiaojing Pang, Xiaoping Xiao, Renli Zhang, Gong Cheng
Frontiers in Cellular and Infection Microbiology
(2017)