Exploiting Fungal Virulence-Regulating Transcription Factors As Novel Antifungal Drug Targets

Model-driven mapping of transcriptional networks reveals the circuitry and dynamics of virulence regulation

(2015) Ezekiel J. Maier et al.   GENOME RESEARCH

Systematic functional profiling of transcription factor networks in Cryptococcus neoformans

(2015) Kwang-Woo Jung et al.   Nature Communications

p53 as a target for the treatment of cancer

(2014) Michael J. Duffy et al.   CANCER TREATMENT REVIEWS

Calcineurin-Crz1 Signaling in Lower Eukaryotes

(2014) S. Thewes   EUKARYOTIC CELL

Synthesis and Biological Evaluation of Potent Antifungal Agents

(2013) Athina Geronikaki et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Biosynthesis and pathway engineering of antifungal polyene macrolides in actinomycetes

(2013) Dekun Kong et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Cryptococcus neoformans Rim101 Is Associated with Cell Wall Remodeling and Evasion of the Host Immune Responses

(2013) T. R. O'Meara et al.   mBio

Genetic Control of Conventional and Pheromone-Stimulated Biofilm Formation in Candida albicans

(2013) Ching-Hsuan Lin et al.   PLoS Pathogens

Two cation transporters Ena1 and Nha1 cooperatively modulate ion homeostasis, antifungal drug resistance, and virulence of Cryptococcus neoformans via the HOG pathway

(2012) Kwang-Woo Jung et al.   FUNGAL GENETICS AND BIOLOGY

BRG1 and NRG1 form a novel feedback circuit regulating Candida albicans hypha formation and virulence

(2012) Ian A. Cleary et al.   MOLECULAR MICROBIOLOGY

Roles of Candida albicans Gat2, a GATA-Type Zinc Finger Transcription Factor, in Biofilm Formation, Filamentous Growth and Virulence

(2012) Han Du et al.   PLoS One

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

A GATA Transcription Factor Recruits Hda1 in Response to Reduced Tor1 Signaling to Establish a Hyphal Chromatin State in Candida albicans

(2012) Yang Lu et al.   PLoS Pathogens

A Major Role for Capsule-Independent Phagocytosis-Inhibitory Mechanisms in Mammalian Infection by Cryptococcus neoformans

(2011) Cheryl D. Chun et al.   Cell Host & Microbe

Zap1 Control of Cell-Cell Signaling in Candida albicans Biofilms

(2011) Shantanu Ganguly et al.   EUKARYOTIC CELL

Unique Evolution of the UPR Pathway with a Novel bZIP Transcription Factor, Hxl1, for Controlling Pathogenicity of Cryptococcus neoformans

(2011) Seon Ah Cheon et al.   PLoS Pathogens

A complex task? Direct modulation of transcription factors with small molecules

(2010) Angela N Koehler   CURRENT OPINION IN CHEMICAL BIOLOGY

Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity

(2010) Suzanne M Noble et al.   NATURE GENETICS

Interaction of Cryptococcus neoformans Rim101 and Protein Kinase A Regulates Capsule

(2010) Teresa R. O'Meara et al.   PLoS Pathogens

Echinocandins: a wealth of choice – how clinically different are they?

(2009) Aimee K Zaas   CURRENT OPINION IN INFECTIOUS DISEASES

A Phenotypic Profile of the Candida albicans Regulatory Network

(2009) Oliver R. Homann et al.   PLoS Genetics

Systematic Genetic Analysis of Virulence in the Human Fungal Pathogen Cryptococcus neoformans

(2008) Oliver W. Liu et al.   CELL

Candida albicanstranscription factor Rim101 mediates pathogenic interactions through cell wall functions

(2008) Clarissa J. Nobile et al.   CELLULAR MICROBIOLOGY

Inhibition of transcription factors with small organic molecules

(2008) Thorsten Berg   CURRENT OPINION IN CHEMICAL BIOLOGY