Article
Food Science & Technology
Consiglia Longobardi, Sara Damiano, Gianmarco Ferrara, Serena Montagnaro, Valentina Meucci, Luigi Intorre, Samanta Bacci, Luigi Esposito, Nadia Piscopo, Antonio Rubino, Antonio Raffaele, Salvatore Florio, Roberto Ciarcia
Summary: This study conducted the first assessment of the concentrations of ZEN and its metabolites in different tissues of wild boars in the Campania region of Italy. The results showed the presence of ZEN and alpha-Zearalenol in most of the samples, highlighting the importance of monitoring these mycoestrogens.
Article
Agriculture, Dairy & Animal Science
Rimvydas Falkauskas, Bronius Bakutis, Jurgita Jovaisiene, Gintare Vaiciuliene, Gediminas Gerulis, Sigita Kerziene, Ingrida Jaceviciene, Eugenijus Jacevicius, Violeta Baliukoniene
Summary: This study investigated the metabolites of ZEN in the biological fluids of cows and found that feeding cows a diet without mycotoxins can reduce the concentrations of ZEN in their biological fluids.
Article
Food Science & Technology
Paula Llorens Castello, Matteo Antonio Sacco, Isabella Aquila, Juan Carlos Molto Cortes, Cristina Juan Garcia
Summary: This study investigated the presence of estrogenic compounds zearalenone (ZON), zearalanone (ZAN), and their metabolites in alternative biological matrices such as liver samples from chicken, pig, and lamb. The results showed that the samples were contaminated with these compounds at varying levels, indicating exposure to mycotoxins. Continuous analysis and monitoring are necessary to control the presence of these mycotoxins in order to protect animal and human health.
Article
Food Science & Technology
Yaoyin Pan, Chendi Liu, Jiguo Yang, Yuqian Tang
Summary: This study developed a new degradation method for Zearalenone (ZEN) using specific microorganisms to produce less toxic target products, such as beta-Zearalenol (beta-ZOL), which has the potential for detoxification applications.
Article
Food Science & Technology
Magdalena Gajecka, Michal S. Majewski, Lukasz Zielonka, Waldemar Grzegorzewski, Ewa Onyszek, Sylwia Lisieska-Zolnierczyk, Jerzy Juskiewicz, Andrzej Babuchowski, Maciej T. Gajecki
Summary: The study reveals that the carry-over of ZEN and its metabolites to the myocardium is a highly individualized process, even occurring at very low concentrations. Different doses of ZEN have varying effects on the vascular response in porcine coronary arteries, with a dose of 5 μg/kg having no negative impact on the vascular system.
Review
Food Science & Technology
Paula Llorens, Marta Herrera, Ana Juan-Garcia, Juan Jose Paya, Juan Carlos Molto, Agustin Arino, Cristina Juan
Summary: This review provides the latest information on ZEN biomarkers in humans, animals, and cell line cultures, highlighting the importance of determining specific biomarkers for estimating dietary intake and characterizing severity of ZEN exposure. The study also reveals the cytotoxic effects of oc-ZEL and beta-ZEL, as well as the oxidative stress effect and membrane integrity changes caused by ZEN exposure.
Article
Chemistry, Analytical
Zhuqiang Wu, Xiangqiong Jiang, Yanqun Yang, Rui Shi, Guihua Ruan, Yipeng Huang
Summary: Amphiphilic polymers synthesized from carboxylated carbon nanotubes are shown to be effective in extracting zearalenone and zearalanone in an oil-water emulsion system. The adsorption capacities, based on optimal conditions, are 17.27 and 13.26 mg/g for zearalenone and zearalanone, respectively. The adsorption is driven by pi-pi interaction, hydrophobic interaction, and hydrogen-bonding interaction. The results demonstrate the high efficiency of these polymers for adsorption and separation in heterogeneous media.
JOURNAL OF SEPARATION SCIENCE
(2023)
Review
Food Science & Technology
Cristina Valeria Bulgaru, Daniela Eliza Marin, Gina Cecilia Pistol, Ionelia Taranu
Summary: ZEA is an estrogenic fusariotoxin that affects reproductive health and immune response. It can cause reproductive disorders and impact immune response, with studies showing effects on different types of immune cells and immune organs. Despite the increasing research on the mechanisms of ZEA in modulating immune response, data are currently insufficient and further investigation is needed.
Article
Food Science & Technology
Po-Yen Lee, Ching-Chih Liu, Shu-Chi Wang, Kai-Yin Chen, Tzu-Chieh Lin, Po-Len Liu, Chien-Chih Chiu, I-Chen Chen, Yu-Hung Lai, Wei-Chung Cheng, Wei-Ju Chung, Hsin-Chih Yeh, Chi-Han Huang, Chia-Cheng Su, Shu-Pin Huang, Chia-Yang Li
Summary: ZEA suppresses macrophage-mediated innate immunity activated by LPS, attenuating the production of proinflammatory mediators and cytokines, inhibiting inflammatory signaling pathways, and repressing inflammasome activation. This suggests that ZEA-contaminated food intake may decrease innate immunity and increase adverse effects during infection.
Article
Engineering, Environmental
Fa-Li Zhang, Ke-Xin Zhu, Jing-Ya Wang, Min Zhang, Jia-Mao Yan, Qing-Chun Liu, Xiao-Yuan Zhang, Jia-Chen Guo, Xuan Liu, Qi-Cheng Sun, Wei Ge, Lan Li, Wei Shen
Summary: Zearalenone (ZEN) is a toxicant that can cause reproductive health risks and pose threats to global agricultural production and human health. This study used various analyses to investigate the damage caused by ZEN exposure on ovarian granulosa cells and found the disordered TNF-a-mediated MAP2K7/AKT2 axis as the main signaling pathway for ZEN-induced apoptosis. The findings provide new insights into the mechanism of ZEN toxicity and potential therapeutic targets for reproductive health issues caused by ZEN in livestock and humans.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Veterinary Sciences
Henrique Meiroz de Souza Almeida, Karina Sonalio, Marina Lopes Mechler-Dreibi, Fernando Antonio Moreira Petri, Gabriel Yuri Storino, Dominiek Maes, Luis Guilherme de Oliveira
Summary: Mycoplasma hyopneumoniae infection can alter the diversity of the lower respiratory microbiota and increase the susceptibility of pigs to respiratory infections.
VETERINARY SCIENCES
(2022)
Article
Immunology
Qiaohua Luo, Rendong Qian, Zongsheng Qiu, Fernando Y. Yamamoto, Yingying Du, Xiaowen Lin, Jianhua Zhao, Qiyou Xu
Summary: This study examined the damage to the intestine caused by glycinin and beta-conglycinin, as well as the alleviating effect of alpha-ketoglutarate. The results showed that intake of soybean protein had negative effects on the growth and immune system of fish, while alpha-ketoglutarate could mitigate the damage.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Quanhui Yan, Xiaodi Liu, Yawei Sun, Weijun Zeng, Yuwan Li, Feifan Zhao, Keke Wu, Shuangqi Fan, Mingqiu Zhao, Jinding Chen, Lin Yi
Summary: This review summarizes recent advances in autophagy, apoptosis, and innate immunity induced by swine enteric coronavirus (SeCoV) infection, emphasizing their relationship with viral replication and signaling pathway alterations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Fisheries
Mohsen Abdel-Tawwab, Riad H. Khalil, Amany M. Diab, Mohamed A. Khallaf, Nashwa Abdel-Razek, Hany M. R. Abdel-Latif, Eman Khalifa
Summary: The study evaluated the toxic effects of feed-born zearalenone (ZEN) on European seabass in terms of antioxidative status, immunity, and transcriptomic responses. It was found that ZEN intake led to adverse effects but dietary supplementation of garlic and chitosan can mitigate these effects, with combined supplementation showing better results.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Reproductive Biology
Ahmed E. Elweza, Mohamed A. Marey, Ibrahim F. Elesh, Mohammad A. Zinnah, Ihshan Akthar, Chihiro Kanno, Mitsuhiro Takagi, Akio Miyamoto
Summary: Zearalenone (ZEN) contamination negatively affects bovine reproduction. This study reveals that the presence of ZEN enhances the pro-inflammatory response triggered by sperm, leads to phagocytosis of sperm by PMNs, and reduces sperm motility.
REPRODUCTIVE TOXICOLOGY
(2022)
Article
Food Science & Technology
Laurentiu Mihai Palade, Madalina Ioana Dore, Daniela Eliza Marin, Mircea Catalin Rotar, Ionelia Taranu
Summary: This study found that grape seed meal (GSM) and seabuckthorn meal (SBM) exhibited the most promising binding capacity for AFB1 and ZEA among eight food-derived by-products investigated as biosorbent approaches. The optimal settings for experimental factors and different specificity for the binary-mycotoxin system were also determined. Overall, GSM showed higher binding capacity compared to SBM, suggesting that they are viable alternatives to commercial biosorbent products.
Article
Food Science & Technology
Roua Gabriela Popescu, Cristina Bulgaru, Arabela Untea, Mihaela Vlassa, Miuta Filip, Anca Hermenean, Daniela Marin, Ionelia Taranu, Sergiu Emil Georgescu, Anca Dinischiotu
Summary: The study investigated the potential of a byproduct mixture from grapeseed and sea buckthorn oil industry in mitigating the harmful effects of ochratoxin A and aflatoxin B1 on hepatic and renal levels in weaned piglets. Results showed that the mycotoxins induced histomorphological alterations in liver and kidney, affecting the expression levels of specific cytochrome P450 genes. The byproduct mixture may offer protective benefits against mycotoxin-induced damage in piglets.
Article
Immunology
Lin Xu, Daniela Tudor, Morgane Bomsel
Summary: P1, a conserved region of HIV-1 gp41-envelope glycoprotein, exhibits various immunomodulatory properties, including inducing T cell proliferation, mucosal dendritic cell maturation, secretion of cytokines, and acting as an adjuvant to stimulate antigen-specific B cell responses in vitro.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Gina Cecilia Pistol, Cristina Valeria Bulgaru, Daniela Eliza Marin, Alexandra Gabriela Oancea, Ionelia Taranu
Summary: Dietary grape seed meal rich in bioactive compounds can effectively restore epithelial integrity, enhance mucosal barrier function, reduce pro-inflammatory markers, and suppress innate immune response in DSS-treated piglets, potentially attenuating the progression of chronic colitis to carcinogenesis.
Review
Food Science & Technology
Cristina Valeria Bulgaru, Daniela Eliza Marin, Gina Cecilia Pistol, Ionelia Taranu
Summary: ZEA is an estrogenic fusariotoxin that affects reproductive health and immune response. It can cause reproductive disorders and impact immune response, with studies showing effects on different types of immune cells and immune organs. Despite the increasing research on the mechanisms of ZEA in modulating immune response, data are currently insufficient and further investigation is needed.
Article
Food Science & Technology
Roua Gabriela Popescu, Sorin Avramescu, Daniela Eliza Marin, Ionelia Taranu, Sergiu Emil Georgescu, Anca Dinischiotu
Summary: This study aimed to investigate the combined effects of aflatoxin B1 and ochratoxin A on protein expression and enzyme activities in piglets, and the potential preventive effect of dietary antioxidants. The results indicated that the mixture of grape seed and sea buckthorn meal may help counteract the harmful effects of these mycotoxins on liver and kidney.
Article
Agronomy
Daniela Eliza Marin, Andrei Cristian Anghel, Cristina Valeria Bulgaru, Iulian Grosu, Gina Cecilia Pistol, Ana Elena Cismileanu, Ionelia Taranu
Summary: In conclusion, the nutritional intervention of using agro-industrial wastes rich in omega-3 PUFA can effectively improve piglets' gut health by reducing proinflammatory cytokines and increasing the expression of junction proteins. This eco-friendly approach can help counteract the negative effects of weaning stress on piglets.
Article
Biochemistry & Molecular Biology
Ionelia Taranu, Gina Cecilia Pistol, Andrei Cristian Anghel, Daniela Marin, Cristina Bulgaru
Summary: The present study investigated the potential of a fermented rapeseed meal extract to reduce medicinal ZnO and found that it could be a valuable alternative to zinc oxide in various applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Maria Julia Ruiz, Gabriel Siracusano, Andrea Cottignies-Calamarte, Daniela Tudor, Fernando Real, Aiwei Zhu, Claudia Pastori, Claude Capron, Arielle R. Rosenberg, Nigel Temperton, Diego Cantoni, Hanqing Liao, Nicola Ternette, Pierre Moine, Mathieu Godement, Guillaume Geri, Jean-Daniel Chiche, Djillali Annane, Elisabeth Cramer Borde, Lucia Lopalco, Morgane Bomsel
Summary: This study found that the mucosal IgG and IgA antibody response in the lungs plays a significant role in the outcome of COVID-19. These antibodies persist even after the virus is cleared. Fatal COVID-19 cases have higher levels of mucosal antibodies, but their neutralizing activity decreases over time.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Mihaela Vlassa, Miuta Filip, Ionelia Taranu, Daniela Marin, Arabela Elena Untea, Mariana Ropota, Catalin Dragomir, Mihaela Saracila
Summary: This study aimed to evaluate the changes in bioactive, nutritional and anti-nutritional factors in rapeseed meal fermented with Saccharomyces cerevisiae or Saccharomyces boulardii yeasts at different time periods for improving the nutritional characteristics in piglets' feeding. The results showed that fermentation reduced the content of anti-nutritional factors and increased the protein content of the rapeseed meal without major adverse effects on its overall nutritive value.
Article
Agronomy
Daniela Eliza Marin, Gina Cecilia Pistol, Cristina Valeria Procudin, Ionelia Taranu
Summary: Food and feed safety is a major concern for both animal and human health, as contamination with pathogens can occur frequently. This study investigated the effects of simultaneous contamination with mycotoxins and bacterial toxins on cell viability, oxidative stress, and inflammation. The results showed significant additive/synergistic effects of co-exposure to fungal and bacterial toxins, suggesting that the concomitant contamination with bacteria and mycotoxins could lead to higher toxicity.
Article
Food Science & Technology
Iulian Alexandru Grosu, Cristina Valeria Bulgaru, Gina Cecilia Pistol, Ana Cismileanu, Daniela Eliza Marin, Ionelia Taranu
Summary: Pigs are highly sensitive to zearalenone (ZEN) contamination, especially after weaning, and it can have adverse effects on their health. There are no clear regulations regarding the maximum limit of ZEN in piglet feed, so further investigations are needed. This study examines the effects of different concentrations of ZEN on the microbiota, SCFA synthesis, and various markers in the colon of young pigs.
Article
Food Science & Technology
Roua Gabriela Popescu, George Catalin Marinescu, Andreea Luminita Radulescu, Daniela Eliza Marin, Ionelia Taranu, Anca Dinischiotu
Summary: This study investigates the proteomic effects of mycotoxins on piglets' liver and the potential compensatory effects of grape seed and sea buckthorn meal as dietary antioxidants. It found that mycotoxins affect metabolism, antioxidant capacity, and various metabolic pathways in piglets' liver, and antioxidants partially restore the expression of affected proteins. This research is of great significance for protecting the health of farm animals and the quality of meat consumed by humans.
Article
Food Science & Technology
Daniela Eliza Marin, Ionelia Taranu
Summary: In this study, an in silico working model based on online computational programs was used to predict the Phase I and II metabolites of alternariol and provide a detailed ADME/Tox profile. A total of 12 metabolites were identified corresponding to the metabolomic profile of alternariol. The ADME profile indicated moderate or high intestinal absorption probability but low probability to penetrate the blood-brain barrier. The computational model also predicted other toxicological endpoints for the compounds, such as vascular toxicity, haemato-toxicity, diarrhea, and nephrotoxicity.
Article
Agronomy
Valeria Cristina Bulgaru, Ana Maria Pertea, Iulian Alexandru Grosu, Andrei Cristian Anghel, Gina Cecilia Pistol, Daniela Eliza Marin, Anca Dinischiotu, Ionelia Taranu
Summary: Zearalenone (ZEN), a mycotoxin produced by Fusarium fungi, contaminates food and feed, causing health issues for humans and animals. Pigs, as major consumers of grains, are particularly sensitive to mycotoxins. This study observed the effects of ZEN at concentrations below and above the EU recommendation on oxidative and inflammatory responses in the colon of weaned piglets. Exposure to the lower concentration of ZEN (75 ppb) did not result in changes in stress and inflammation markers or associated signaling pathways.
Article
Pharmacology & Pharmacy
Mohammadhossein Movassaghghazani, Nazanin Shabansalmani
Summary: The study revealed high levels of AFM1 in both breast milk and powdered milk samples in Tehran, with some samples exceeding the established limits. Therefore, monitoring and regulating toxin levels in these products is crucial for maternal and infant health.
Article
Pharmacology & Pharmacy
Defeng Wen, Wantong Han, Quan Chen, Guanhui Qi, Mengling Gao, Pu Guo, Yu Liu, Zhongyuan Wu, Shulin Fu, Qirong Lu, Yinsheng Qiu
Summary: Luteolin can inhibit FB1-induced intestinal inflammatory injury by inhibiting the activation of NF-kappa B and ERK signaling pathways, according to network pharmacology and in vitro experiments.