Article
Chemistry, Multidisciplinary
Lirui Wang, Chunlei Zhang, Yuping Hong, Xinhong Li, Tangan Li, Ang Gao, Shaojun Pan, Bin Liu, Han Jin, Daxiang Cui
Summary: The study developed a method of combinatorial delivery of epigenetic modulatory drugs through self-assembly, effectively regulating DNA methylation and histone deacetylation, ultimately inhibiting tumor cell proliferation and promoting cell apoptosis.
Article
Immunology
Maomao Sun, Jiaxin Li, Liangfeng Mao, Jie Wu, Zhiya Deng, Man He, Sheng An, Zhenhua Zeng, Qiaobing Huang, Zhongqing Chen
Summary: Recent studies have shown that upregulation of autophagy can attenuate sepsis-induced acute kidney injury (SAKI). The tumor suppressor protein p53 has been identified as a regulator of autophagy in various forms of acute kidney injury. Acetylation of p53 exacerbates AKI, but deacetylation can promote RTEC autophagy and alleviate SAKI.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Chaoming Huang, Shisheng Jiang, Shuhan Gao, Yuxin Wang, Xiaoting Cai, Junyan Fang, Tingdong Yan, Chunpeng (Craig) Wan, Yi Cai
Summary: The sirtuins family has shown significant protective effects in acute kidney injury (AKI), and their therapeutic role and molecular mechanisms in AKI have important research implications. Through anti-inflammation, antioxidation, anti-apoptotic, and maintenance of mitochondrial homeostasis, the sirtuins family regulates the development and progression of AKI. The molecular mechanisms involve the regulation of NF-kappa B, JNK/ERK, and AMPK/mTOR signaling pathways, as well as the modulation of various proteins and genes. Furthermore, natural compounds and synthetic inhibitors targeting sirtuins have shown potential in the prevention and treatment of AKI.
Review
Medicine, Research & Experimental
Baiyin Zhong, Qicheng Liao, Xin Wang, Xiaonong Wang, Jianhong Zhang
Summary: Cholangiocarcinoma (CCA) is a malignant tumor of bile duct epithelial cells with aggressiveness, difficult diagnosis, and poor prognosis. Genetic and epigenetic alterations, including histone modification, DNA methylation, and noncoding RNA modulation, play a role in the development of CCA. Alterations in epigenetic regulation can be potential therapeutic targets and diagnostic biomarkers for CCA.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Letter
Medicine, General & Internal
Dominique Vodovar, Bruno Megarbane, Stephane Gaudry, Didier Dreyfuss, Paul M. Palevsky
Summary: This article discusses the importance and effectiveness of using extracorporeal kidney-replacement therapy in poisonings, even in the absence of acute kidney injury, to rapidly remove toxicants and save lives.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Immunology
Shankun Zhao, Jian Liao, Maolei Shen, Xin Li, Mei Wu
Summary: Sepsis-induced acute kidney injury (SI-AKI) is a leading cause of global death, and autophagy has been identified as a key modulator in SI-AKI. This review summarizes the proposed roles of autophagy in SI-AKI, revealing that autophagy levels are often elevated during the progression of SI-AKI. Various signaling molecules and pathways are involved in the process of SI-AKI, affecting autophagy and subsequently impacting kidney function. Targeting autophagy-associated proteins and pathways may offer new treatment prospects for critically ill patients with SI-AKI, although further preclinical studies are needed to validate this hypothesis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Endocrinology & Metabolism
Jie Wang(a), Shudong Wang, Jie Wang(b), Mengjie Xiao, Yuanfang Guo, Yufeng Tang, Jingjing Zhang, Junlian Gu
Summary: SIRT1 plays a crucial role in diabetic complications by regulating transcription factors and epigenetic mechanisms to influence the development and progression of the disease.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Ajinath Kale, Himanshu Sankrityayan, Anil Bhanudas Gaikwad
Summary: This study aimed to explore the mechanisms of Klotho regulation in hyperglycemia augmented AKI and evaluate epigenetic ways to restore Klotho expression in AKI-diabetes comorbidity. The findings suggest that hyperglycemia exacerbates AKI, but inhibition of kidney-specific HDACs can protect the kidney by restoring endogenous Klotho loss, preventing inflammation and apoptosis.
Article
Medicine, Research & Experimental
Haoteng Ke, Zexing Chen, Xuanbin Zhao, Chaobo Yang, Tao Luo, Wen Ou, Lizi Wang, Haiqiong Liu
Summary: Activation transcription factor 3 (ATF3), a member of the ATF/cyclic adenosine monophosphate response element binding family, has been shown to play multiple roles in the development and progression of cardiovascular diseases. It can have detrimental effects but also function as a cardioprotective molecule. This review aims to explore the protective effects and mechanisms of ATF3 on cardiac dysfunction, providing evidence for the prevention and cure of cardiovascular diseases.
Article
Pharmacology & Pharmacy
Xuewen Duan, Meiling Hu, Linshan Yang, Sheng Zhang, Bo Wang, Tong Li, Yong Tan, Yingke Li, Xingguang Liu, Zhenzhen Zhan
Summary: Acute myocardial infarction (MI) and chemotherapeutic drug administration can induce myocardial damage and cardiomyocyte cell death, and trigger the release of damage-associated molecular patterns (DAMPs) that initiate the aseptic inflammatory response. Immune responsive gene 1 (IRG1), which produces itaconate, has a critical protective role in suppressing inflammation and preventing cardiac dysfunction under ischemic or toxic injury conditions. The deficiency of IRG1 enhances cardiac tissue inflammation, myocardial fibrosis, and impairs cardiac function, while administration of 4-octyl itaconate (4-OI) reverses these effects and inhibits cardiac inflammation and fibrosis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Engineering, Environmental
Zhong-Gui Gong, Yuan Zhao, Zhen-Yong Wang, Rui-Feng Fan, Zong-Ping Liu, Lin Wang
Summary: The study demonstrates that BRD4 acts as a transcriptional repressor in mediating lysosomal dysfunction, autophagy blockade, and oxidative stress during Cd exposure, showing its potential as a therapeutic target for Cd-induced AKI.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Medicine, Research & Experimental
Fanbing Meng, Zheng Zhang, Chaojin Chen, Yue Liu, Dongdong Yuan, Ziqing Hei, Gangjian Luo
Summary: The study showed that activation of the PI3K/AKT signaling pathway can attenuate post-AOLT AKI by regulating the expression of apoptosis-related proteins and facilitating cell deacetylation to protect renal function.
Article
Chemistry, Multidisciplinary
Jiajia Li, Qijia Duan, Xiaona Wei, Jianping Wu, Qiongqiong Yang
Summary: This study developed a nanoparticle for targeted delivery of rosmarinic acid (RA) in the treatment of acute kidney injury (AKI). The nanoparticle showed excellent antioxidative and antiapoptotic effects, improved renal function, and repaired damaged renal tissue in vivo.
Article
Chemistry, Analytical
Jiahui Tan, Kai Yin, Zhirong Ouyang, Rongchen Wang, Hongming Pan, Zhijun Wang, Chuchang Zhao, Wei Guo, Xianfeng Gu
Summary: A new fluorescent nanoprobe has been developed for real-time imaging of kidney function, providing high resolution imaging in living mice and showing potential for early diagnosis of renal diseases such as AKI and CKD. The nanoprobe is sensitive and specific for detecting AKI and CKD, allowing for noninvasive detection of disease onset at least 32 hours earlier than existing assays.
ANALYTICAL CHEMISTRY
(2021)
Review
Medicine, Research & Experimental
Jun Zhang, Wanqian Pan, Yue Zhang, Mingyue Tan, Yunfei Yin, Yuanmei Li, Lei Zhang, Lianhua Han, Jiaxiang Bai, Tingbo Jiang, Hongxia Li
Summary: This article provides a comprehensive overview of the role and mechanism of Nrf2-related epigenetic modifications in ischemic-reperfusion injury (IRI) of various organs. It also summarizes potential agonists that target the epigenetic regulation of Nrf2.
Article
Pediatrics
Yu-Chao Hsiao, Jen-Hung Wang, Chia-Hsiang Chu, Yu-Hsun Chang, Jui-Shia Chen, Rong-Hwa Jan, Shang-Hsien Yang, Ming-Chun Chen, Wei-Chih Chou, Shao-Yin Chu, Pei-Chun Lai, Ching-Feng Cheng, Pin-Yun Chiu, Yu-Hsuan Liu, Yung-Chieh Chang
Summary: The study found that obesity in children aged 6-13 was associated with weight gain and height gain. Obese children had higher growth velocity than normal BMI groups between 6 and 9 years of age, but overweight and obese girls between 9 and 13 years had lower growth velocity than underweight girls.
FRONTIERS IN PEDIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Kuei-Ting Chang, Lee-Hsin Wang, Yu-Mei Lin, Ching-Feng Cheng, Guey-Shin Wang
Summary: Elevated CELF1 expression causes vascular rarefaction and may contribute to the progression of DCM, inducing hypoxic conditions. Vegfa mRNA levels are downregulated in DCM patients, with CELF1 potentially affecting cardiomyocyte function by regulating Vegfa mRNA stability.
Article
Medicine, Research & Experimental
Hui-Chen Ku, Tsai-Yun Chan, Jia-Fang Chung, Yung-Hsi Kao, Ching-Feng Cheng
Summary: The study found that the ATF3 inducer ST32db effectively reduced obesity by inhibiting adipogenesis, activating lipolysis and browning pathways, and reducing fat accumulation in adipocytes. This suggests the therapeutic potential of ST32db in combating obesity.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Editorial Material
Pediatrics
Ching-Feng Cheng, Yen-Hsuan Ni
FRONTIERS IN PEDIATRICS
(2021)
Article
Cell Biology
Dun-Jie Chuang, Subhashree Pethaperumal, Bijaya Siwakoti, Hung-Jen Chien, Ching-Feng Cheng, Shih-Che Hung, Te-Sheng Lien, Der-Shan Sun, Hsin-Hou Chang
Summary: Psychological stress increases the risk of gastrointestinal diseases, with the stress-responsive transcription factor ATF3 potentially being part of the native cellular protection pathway in the GI system.
Article
Medicine, Research & Experimental
Chia-Pei Chen, Tsung-Chen Su, Meei-Ju Yang, Wen-Ting Chen, An-Ci Siao, Ling-Ru Huang, Yen-Yue Lin, Yow-Chii Kuo, Jia-Fang Chung, Ching-Feng Cheng, Hui-Chen Ku, Yung-Hsi Kao
Summary: Green tea epigallocatechin gallate (EGCG) inhibits 3T3-L1 cell growth through the miR-143/MAPK7 pathway, indicating the crucial role of miR-143 in the regulation of fat cell proliferation by EGCG.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Pediatrics
Ping-Sheng Wu, Shi-Bing Wong, Ching-Feng Cheng, Chun-Hsien Yu
Summary: This study retrospectively reviewed the clinical features and outcomes of rhabdomyolysis in pediatric patients aged 0-18 years with COVID-19 at an epicenter in Taiwan. The study found that rhabdomyolysis is not rare in pediatric patients with omicron-SARS-CoV-2 infection and reassuring a good prognosis is important to alleviate family anxiety.
Article
Food Science & Technology
Wen-Ting Chen, Meei-Ju Yang, Yi-Wei Tsuei, Tsung-Chen Su, An-Ci Siao, Yow-Chii Kuo, Ling-Ru Huang, Yi Chen, Sy-Jou Chen, Po-Chuan Chen, Ching-Feng Cheng, Hui-Chen Ku, Yung-Hsi Kao
Summary: This study investigates the effect of epigallocatechin gallate (EGCG) on the growth of white and beige preadipocytes by modulating the miR-let-7a and HMGA2 pathways. The results show that EGCG inhibits the growth of 3T3-L1 and D12 preadipocytes, upregulates miR-let-7a expression, and downregulates HMGA2 mRNA and protein levels. Overexpression of miR-let-7a and HMGA2 antagonizes the inhibitory effects of EGCG on cell growth. Therefore, EGCG acts on preadipocytes through the miR-let-7a/HMGA2 pathway to inhibit their growth.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Bijaya Siwakoti, Te-Sheng Lien, You-Yen Lin, Subhashree Pethaperumal, Shih-Che Hung, Der-Shan Sun, Ching-Feng Cheng, Hsin-Hou Chang
Summary: Metformin, a commonly used drug for type 2 diabetes, has been found to have potential applications in anti-aging, cellular protection, and anti-inflammation. Research shows that metformin can protect the gastrointestinal tract from injury caused by psychological stress. This protection is regulated by the ATF3 gene.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chi-Cheng Li, Rina Munalisa, Hsuan-Yun Lee, Te-Sheng Lien, Hao Chan, Shih-Che Hung, Der-Shan Sun, Ching-Feng Cheng, Hsin-Hou Chang
Summary: Psychological stress is widely acknowledged as a major contributor to immunosuppression, rendering individuals more susceptible to various diseases. The complex interplay between the nervous, endocrine, and immune systems underlies stress-induced immunosuppression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Hui-Chen Ku, Ching-Feng Cheng
Summary: Prostate cancer (PC) and breast cancer (BC) are the most common cancers in developed countries. The prevalence of obesity and metabolic syndrome has contributed to the increased incidence of PC and BC. Adipose tissue plays a key role in the development and progression of PC and BC through paracrine and endocrine signaling. While the role of white adipose tissue (WAT) has been extensively studied, the influence of browning of WAT on PC and BC remains unclear. This review highlights the important role of adipose tissue in regulating the tumor microenvironment in PC and BC and discusses the potential of WAT browning as a therapeutic strategy.
TZU CHI MEDICAL JOURNAL
(2022)
Letter
Nutrition & Dietetics
Chun-Hsien Yu, Ya-Hsuan Lin, Ching-Feng Cheng, Chan-Yen Kuo
Summary: This article discusses recent investigations into complementary and alternative medicine as a means of preventing and treating liver fibrosis.
CURRENT TOPICS IN NUTRACEUTICAL RESEARCH
(2022)
Article
Nutrition & Dietetics
Yi-Cheng Hou, Jing-Hui Wu, Ching-Feng Cheng, Chan-Yen Kuo, I-Shiang Tzeng
Summary: A health belief model was used to evaluate people's beliefs about health problems and predict their engagement in health-promoting behaviors. A study was conducted in which 87 employees of Taipei Tzu Chi Hospital participated in a one-month program offering 500-calorie vegetarian meals. The study found that higher perceived susceptibility and higher perceived benefits/barriers were related to changes in weight, body fat, body water, and muscle mass. In the overweight or obese group, perceived barriers were significantly correlated with weight.
CURRENT TOPICS IN NUTRACEUTICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ken-Pen Weng, Ching-Feng Cheng, Kuang-Jen Chien, Luo-Ping Ger, Shih-Hui Huang, Kuo-Wang Tsai
Summary: In this study, dysregulated circulating microRNAs were identified as potential diagnostic biomarkers for Kawasaki disease (KD). Among them, miR-24-3p showed significantly higher expression levels in KD patients, suggesting its potential as a diagnostic biomarker. Pathway analysis revealed the involvement of these miRNAs in KD progression.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2021)
Article
Immunology
Wen-Lin Su, Chih-Pei Lin, Hui-Ching Hang, Ping-Sheng Wu, Ching-Feng Cheng, You-Chen Chao
Summary: Increased heme levels, anemia, and desaturation occur during infection. Heme and HO-1 enzyme levels significantly increased in the low SpO(2) group, but further studies are required.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)