期刊
TOXICOLOGY MECHANISMS AND METHODS
卷 20, 期 6, 页码 279-286出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/15376516.2010.485227
关键词
Persistent organic pollutants; AhR pathway; toxicology mechanism; fish
类别
资金
- Chinese Academy of Sciences [KZCX2-YW-Q07-05, KZCX2-YW-Q07-04]
- Yantai municipal Science and technology development program [2007323]
- Science and technology bureau of Yantai city [2009164]
- Natural Science Foundation of Hainan Province [309010]
- Education Department of Hainan Province [Hj2009-21]
With the development of industry and agriculture, the cases of cancer and tumor have been increasing gradually in the last 30 years, and quite a few cases are caused by persistent organic pollutants (POPs), some of them belonging to environmental endocrine disruptors, and they have become ubiquitous in the environment, especially in the aquatic ecosystem; so this issue has aroused the extensive attention of the world. The mechanism of POPs toxicology is very complicated, but it is mainly mediated by the aryl hydrocarbon receptor (AhR) pathway in fish. In order to gain a comprehensive understanding of the AhR pathway, the present paper focuses on reviewing it from four major steps, including formation of cytosolic complex, translocation of AhR, heterodimerization of AhR, and induction of CYP1A. This study summarized the isoform numbers of AhR pathway genes and the expression patterns in the regulation process of POPs toxicology in zebrafish.
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