Review
Biochemistry & Molecular Biology
Giulia D. S. Ferretti, Julia Quarti, Gileno dos Santos, Luciana P. Rangel, Jerson L. Silva
Summary: p53 is a mutated tumor suppressor protein that often aggregates and promotes cancer growth. Studying new molecules and therapeutic targets that disrupt p53 aggregates is a promising strategy against cancer. This review classifies anticancer molecules into four categories and highlights the role of autophagy in degrading aggregated p53.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Sara A. Al-Shun, Fardous F. El-Senduny, Mohamed A. Ismail, Wael M. El-Sayed, Farid A. Badria, Magdy M. Youssef
Summary: The study investigated different monocationic arylthiophene derivatives as potential chemotherapeutic agents against HCC. Compound 2j showed the highest cytotoxicity among the tested compounds, with a selectivity index indicating safety to normal cells. It was found to inhibit HepG2 cell migration and division, induce apoptosis, and sensitize standard anticancer drugs.
Article
Multidisciplinary Sciences
Savinee Chanvijit, Suttinee Phuagkhaopong, Panupong Mahalapbutr, Methus Klaewkla, Warinthorn Chavasiri, Piyanuch Wonganan
Summary: The study found that Mansonone G (MG) and its derivatives exhibited concentration-dependent cytotoxicity on CRC cell lines, with allyl ether mansonone G (MG7) being the most toxic. MG7 induced ROS generation and apoptosis, and modulated protein expression and signaling pathways related to cell survival and proliferation. Molecular docking analysis revealed the potential binding of MG7 to ATP-binding pockets of AKT and ERK1 proteins.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
D. A. Skvortsov, M. A. Kalinina, I. V. Zhirkina, L. A. Vasilyeva, Y. A. Ivanenkov, P. V. Sergiev, O. A. Dontsova
Summary: The FCCT method provides a new approach to screening for selectively cytotoxic substances on cancer cells by co-cultivating tumor and non-tumor etiology cells. It is a non-disruptive and high-throughput compatible method that has shown promising results in identifying compounds selectively cytotoxic to cancer cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Analytical
Yanping Zhu, Qian Zhang, Jun Lu, Kai Wang, Ruina Zhang, Quan Yu
Summary: With its advantages of rapid analysis, high sensitivity, and multicomponent identification, mass spectrometry (MS) is an appealing choice for high-throughput screening (HTS) analysis. Over the last 2 decades, the development of miniature mass spectrometers has made great progress, providing not only the essential analytical performance, but also simple operation and HTS capability.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Madeline E. McCarthy, William B. Dodd, Xiaoming Lu, Daniel J. Pritko, Nishi D. Patel, Charlotte V. Haskell, Hugo Sanabria, Mark A. Blenner, Marc R. Birtwistle
Summary: We propose a theory for high-throughput genetic interaction screens, which extends the Multiplexing using Spectral Imaging and Combinatorics (MuSIC) approach to create 100,000 spectrally unique MuSIC barcodes. Experimental testing of this theory could revolutionize genetic perturbation technology and knowledge of genetic function. Additionally, a genome-scale spectral barcode library could have widespread applications in genetic screening and lineage tracing.
ACS SYNTHETIC BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Elisa Abas, Diego Aguirre-Ramirez, Mariano Laguna, Laura Grasa
Summary: Newly synthesized dithiocarbamate cycloaurated complexes exhibit good antitumor properties with excellent in vitro antiproliferative activity and selectivity. They also show good antimicrobial activity against various bacteria and fungi.
Article
Biochemical Research Methods
Hang Zhang, Mengjing Xu, Haofeng Li, Xiaohan Mai, Jiawei Sun, Lan Mi, Jiong Ma, Xiangdong Zhu, Yiyan Fei
Summary: This study presents a series of optimization methods that greatly reduce the scanning time of OI-RD microscope images, resulting in a 10 times increase in detection speed. This makes the OI-RD microscope suitable for ultra-high throughput screening applications.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Biochemistry & Molecular Biology
John E. La Marca, Brandon J. Aubrey, Bruce Yang, Catherine Chang, Zilu Wang, Andrew Kueh, Lin Tai, Stephen Wilcox, Liz Milla, Susanne Heinzel, David Vremec, Lauren Whelan, Christina Konig, Deeksha Kaloni, Anne K. Voss, Andreas Strasser, Sarah T. Diepstraten, Marco J. Herold, Gemma L. Kelly
Summary: Whole-genome screens using CRISPR technologies can identify novel tumour suppressors and factors affecting cancer cell response to anti-cancer drugs. In this study, a genome-wide screen on lymphoma cells found that the absence of ARRDC3 enhances the survival and competitiveness of MYC-driven lymphoma cells treated with TRP53-activating anti-cancer drugs. Deleting Arrdc3 in mice resulted in perinatal lethality and cardiac defects. The absence of ARRDC3 significantly accelerated MYC-driven lymphoma development, highlighting its role as a new mediator of TRP53-mediated tumour suppression.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Chemistry, Inorganic & Nuclear
Elisabetta Barresi, Iogann Tolbatov, Tiziano Marzo, Elisa Zappelli, Alessandro Marrone, Nazzareno Re, Alessandro Pratesi, Claudia Martini, Sabrina Taliani, Federico Da Settimo, Diego La Mendola
Summary: The nature of ligands in Ru-2(ii,iii) paddlewheel complexes significantly influences their anticancer properties, with [Ru-2(EB776)(4)Cl] showing higher activity against a glioblastoma model compared to its isomer [Ru-2(EB106)(4)Cl]. These differences are attributed to steric hindrance, allowed conformations of the complexes, and the presence of hydrophilic regions in [Ru-2(EB776)(4)Cl], resulting in lower steric protection.
DALTON TRANSACTIONS
(2021)
Article
Multidisciplinary Sciences
Cheok Wui Chee, Nor Hisam Zamakshshari, Vannajan Sanghiran Lee, Iskandar Abdullah, Rozana Othman, Yean Kee Lee, Najihah Mohd Hashim, Nurshamimi Nor Rashidid
Summary: This study aimed to identify potential anti-colorectal cancer compounds from the root bark of Morinda citrifolia and analyze their efficacy in vitro. The results showed that morindone and damnacanthal from this plant exhibited significant anti-colorectal cancer activity and selectivity.
Article
Biochemistry & Molecular Biology
Mine Sulak, Gurbet Celik Turgut, Alaattin Sen
Summary: In this study, cerium oxide nanoparticles (CONPs) were synthesized using fresh green walnut shell extract in a microwave environment. The morphology and structure of the CONPs were characterized, and their mechanism of action in breast cancer cell lines (MCF7) was evaluated. The CONPs showed cytotoxic effects, induced apoptosis, and affected gene expression in the cancer cells.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Multidisciplinary Sciences
Tarfah Al-Warhi, Matokah Abualnaja, Ola A. Abu Ali, Najiah M. Alyamani, Fahmy G. Elsaid, Ali A. Shati, Sarah Albogami, Eman Fayad, Ali H. Abu Almaaty, Khaled O. Mohamed, Wael M. Alamoudi, Islam Zaki
Summary: Z-configurated isomers are preferred molecules with significant applications in natural products, biologically active compounds, and organic synthesis. In this study, new thiazole analogs were synthesized and evaluated for their inhibitory activity against breast cancer cells and VEGFR-2. Compound 4d showed strong VEGFR-2 inhibitory activity and induced apoptosis through cell cycle arrest.
Article
Oncology
Hong-Chieh Tsai, Kuo-Chen Wei, Pin-Yuan Chen, Chiung-Yin Huang, Ko-Ting Chen, Ya-Jui Lin, Hsiao-Wei Cheng, Yi-Rou Chen, Hsiang-Tsui Wang
Summary: Combination treatment of TMZ and VPA in GBM patients can be beneficial for survival, depending on the p53 gene status. In cellular experiments, VPA enhances the antineoplastic effect of TMZ by promoting p53 activation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemical Research Methods
Bisan Samara, Muhammedin Deliorman, Pavithra Sukumar, Mohammad A. Qasaimeh
Summary: A method of creating cryopreservable high throughput arrays of 3D tumor models using a paper platform is presented, utilizing virtual microwells to facilitate cell aggregation and prevent mixing, allowing for extended storage and drug treatment studies.
Article
Audiology & Speech-Language Pathology
Stella Chin-Shaw Tsai, Frank Cheau-Feng Lin, Kuang-Hsi Chang, Min-Chih Li, Ruey-Hwang Chou, Mei-Yue Huang, Yen-Chung Chen, Chien-Yu Kao, Ching-Chang Cheng, Hung-Ching Lin, Yi-Chao Hsu
Summary: MSCs can be isolated from different tissue origins and have the potential to ameliorate ototoxicity-induced hearing loss. In this study, skin-derived MSCs were found to significantly reduce the hearing threshold of mice with cisplatin-induced hearing loss. Neuropathological gene analyses revealed the mechanisms through which SMSCs could alleviate cochlear damage and hearing loss induced by cisplatin.
Article
Biochemistry & Molecular Biology
Stella Chin-Shaw Tsai, Kuender D. Yang, Kuang-Hsi Chang, Frank Cheau-Feng Lin, Ruey-Hwang Chou, Min-Chih Li, Ching-Chang Cheng, Chien-Yu Kao, Chie-Pein Chen, Hung-Ching Lin, Yi-Chao Hsu
Summary: The study demonstrated that UCMSC exosomes have protective effects in treating ototoxicity-induced hearing loss by promoting tissue remodeling and repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Letter
Oncology
Jui-Hsuan Tsai, Chun-Hsiang Chang, Chih-Hsien Lee, Frank Cheau-Feng Lin, Stella Chin-Shaw Tsai
Editorial Material
Oncology
Jun-Liang Li, Tsai-Ling Hsieh, Ming-Che Ou, Frank Cheau-Feng Lin, Stella Chin-Shaw Tsai
Article
Oncology
Jin-Yang Huang, Stella Chin-Shaw Tsai, Tzu-Chin Wu, Frank Cheau-Feng Lin
Summary: Puncture frequency and male gender are associated with the development of iatrogenic pneumothorax in POCTGL, while angle difference affects the puncture frequency.
Article
Environmental Sciences
Shih-Wei Chen, Han-Jie Lin, Stella Chin-Shaw Tsai, Cheng-Li Lin, Chung Y. Hsu, Tsai-Ling Hsieh, Chuan-Mu Chen, Kuang-Hsi Chang
Summary: This study aims to investigate the association between air pollution and chronic rhinosinusitis (CRS). Using databases from Taiwan's National Health Insurance and Air Quality Monitoring, the study found that higher levels of air pollutants, such as PM2.5, NO2, and PM10, were significantly associated with increased CRS risk.
Article
Environmental Sciences
Kuang-Hsi Chang, Chieh-Lin Jerry Teng, Yi-Chao Hsu, Stella Chin-Shaw Tsai, Han-Jie Lin, Tsai-Ling Hsieh, Chih-Hsin Muo, Chung Y. Hsu, Ruey-Hwang Chou
Summary: This study assessed the environmental risk factors of benign brain tumors (BBT) by integrating patients' clinical data and daily air quality data. The results indicated that long-term exposure to air pollutants such as CO, NO2, and PM2.5 may be associated with an increased risk of BBT.
Article
Medicine, General & Internal
Jing-Yang Huang, Chuck Lin, Stella Chin-Shaw Tsai, Frank Cheau-Feng Lin
Summary: Despite the decreasing rate of smoking, there has been an increase in the incidence of lung cancer. The ratio of adenocarcinoma to squamous cell carcinoma and the ratio of women to men in lung cancer cases are still increasing. Human papillomavirus (HPV) has been found in lung cancer tissues and blood specimens, especially in Eastern countries, but its association with lung adenocarcinoma remains unclear.
FRONTIERS IN MEDICINE
(2022)
Correction
Medicine, General & Internal
Jing-Yang Huang, Chuck Lin, Stella Chin-Shaw Tsai, Frank Cheau-Feng Lin
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Chia-Chun Chang, Chung-Hsiung Chen, Tsai-Ling Hsieh, Kuang-Hsi Chang, Jing-Yang Huang, Frank Cheau-Feng Lin, Stella Chin-Shaw Tsai
Summary: This study compares the treatment outcomes of transoral robotic surgery (TORS) and traditional open surgery for oral cancer patients. The results show that TORS group had a higher negative resection margin rate, lower mortality risk, and better overall survival. TORS may offer better treatment outcomes for oral cancer.
Article
Oncology
Yu-Hsiang Wang, Stella Chin-Shaw Tsai, Frank Cheau-Feng Lin
Summary: This study aimed to investigate the surgical outcomes associated with Cavitron Ultrasonic Surgical Aspirator (CUSA) usage in thoracoscopic salvage pulmonary resections. The results showed that using CUSA can significantly reduce blood loss during the procedure, although it may result in a longer surgical time. Overall, the use of CUSA in salvage anatomic resections of centrally located lung cancer is crucial in minimizing blood loss.
Article
Oncology
Chuck Lin, Stella Chin-Shaw Tsai, Jing-Yang Huang, Frank Cheau-Feng Lin
Summary: The prevalence of breast cancer has increased globally, and there is evidence suggesting a correlation between HPV and breast cancer. A study in Taiwan found that HPV patients had a higher risk of developing breast cancer compared to non-HPV patients, and this risk was also influenced by age, insurance providers, and comorbidities.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Chiao-Yun Tsai, Stella Chin-Shaw Tsai, Guang-Qian Shen, Guan-Liang Robert Guo, Zhe-Luen Gerald Tsui, Ming-Yu Hsieh, Cadmus Yuan, Frank Cheau-Feng Lin
Summary: Postgraduate education and the use of LAGA in PNCL can improve confidence level, enhance PNCL ability, and optimize puncture angles. Pleural depth is associated with puncture frequency and procedure time, while experienced physicians and puncture towards the mediastinum can reduce frequency and time. There is no improvement in procedure performance with the learning curve.
Article
Environmental Sciences
Hueng-Chuen Fan, Chuan-Mu Chen, Jeng-Dau Tsai, Kuo-Liang Chiang, Stella Chin-Shaw Tsai, Ching-Ying Huang, Cheng-Li Lin, Chung Y. Hsu, Kuang-Hsi Chang
Summary: This study found a significant correlation between early-life exposure to particulate matter PM2.5 and PM10 and attention-deficit/hyperactivity disorder (ADHD).
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Ming-Feng Tseng, Chia-Chen Huang, Stella Chin-Shaw Tsai, Ming-Daw Tsay, Yu-Kang Chang, Chun-Lin Juan, Fang-Chi Hsu, Ruey-Hong Wong
Summary: This study evaluated the short-term and long-term effectiveness of workplace smoking cessation intervention implemented using the transtheoretical model. The results showed substantial short-term effectiveness, but weaker long-term effectiveness.
TOBACCO USE INSIGHTS
(2022)