Article
Multidisciplinary Sciences
Oyetunde Timothy Oyeyemi, Camila Amormino Corsini, Gustavo Goncalves, William de Castro Borges, Rafaella Fortini Queiroz Grenfell
Summary: The study demonstrates the potential of using SCA as a diagnostic target for detecting anti-S. mansoni antibodies, with high sensitivity and specificity. The human IgG-specific response against SCA was significantly higher in S. mansoni infected individuals compared to non-infected population. The 10-12 kDa component of SCA could serve as a useful diagnostic tool for chronic schistosomiasis.
SCIENTIFIC REPORTS
(2021)
Article
Public, Environmental & Occupational Health
Rufin K. Assare, Mathieu Tra-Bi, Jean T. Coulibaly, Paul L. A. M. Corstjens, Mamadou Ouattara, Eveline Huerlimann, Govert J. van Dam, Juerg Utzinger, Eliezer K. N'Goran
Summary: This study assessed the accuracy of UCP-LF CAA and POC-CCA tests for diagnosing Schistosoma mansoni and found that UCP-LF CAA had higher sensitivity compared to POC-CCA and Kato-Katz thick smears. UCP-LF CAA was more accurate in detecting S. mansoni in low-endemicity settings.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Public, Environmental & Occupational Health
Pytsje T. Hoekstra, Marjan van Esbroeck, Claudia J. de Dood, Paul L. A. M. Corstjens, Lieselotte Cnops, Christel J. G. Van Zeijl-van der Ham, Linda J. Wammes, Govert J. van Dam, Jan Clerinx, Lisette van Lieshout
Summary: In this study, the diagnostic value of schistosome circulating anodic antigen (CAA) detection was evaluated in a cluster of 34 Belgian tourists. The UCP-LF CAA serum assay was found to be the most sensitive method for the diagnosis of early Schistosoma infections and post-treatment monitoring in travelers.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2021)
Review
Immunology
Emmanuella Driciru, Jan Pieter R. Koopman, Stephen Cose, Afzal A. Siddiqui, Maria Yazdanbakhsh, Alison M. Elliott, Meta Roestenberg
Summary: The development of schistosomiasis vaccines faces immunological challenges, with prior exposure impacting vaccine response. Factors such as age, exposure levels, and co-infections contribute to the complexity of vaccine responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Abdallah Zacharia, Twilumba Makene, Clemence Kinabo, George Ogweno, Faraja Lyamuya, Billy Ngasala
Summary: This study developed a simple and efficient method for the collection and detection of Schistosoma CCA using urine spotted onto filter paper. The optimal results were obtained when the procedure involved dissolving the filter paper containing urine spots in distilled water and incubating at room temperature for 24 hours.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Infectious Diseases
Pytsje T. Hoekstra, Miriam Casacuberta-Parta, Lisette van Lieshout, Paul L. A. M. Corstjens, Roula Tsonaka, Rufin K. Assare, Kigbafori D. Silue, Eliezer K. N'Goran, Yves K. N'Gbesso, Eric A. T. Brienen, Meta Roestenberg, Stefanie Knopp, Jurg Utzinger, Jean T. Coulibaly, Govert J. van Dam
Summary: This study found that the efficacy of praziquantel (PZQ) treatment for schistosomiasis was overestimated when using less sensitive diagnostic methods. The results highlight the importance of using accurate diagnostic tools to monitor different treatment strategies.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Microbiology
Abraham Degarege, Abebe Animut, Yohannes Negash, Berhanu Erko
Summary: The performance of urine reagent strips (URS) in detecting Schistosoma haematobium infection was evaluated using urine filtration microscopy as a reference standard. The study found that URS is good for rapid screening but may have lower sensitivity, particularly for light infections. The sensitivity increased with higher urine egg count and there was a significant association between urine egg count and the level of hematuria.
Article
Infectious Diseases
Hermine Boukeng Jatsa, Ulrich Membe Femoe, Calvine Noumedem Dongmo, Romuald Issiaka Ngassam Kamwa, Betrand Nono Fesuh, Louis-Albert Tchuem Tchuente, Pierre Kamtchouing
Summary: This study investigated the impact of Schistosoma haematobium or S. mansoni infection on the reproductive function of men in Cameroon. The results showed that infection with S. haematobium or S. mansoni is associated with low production of the reproductive hormone testosterone and may be a significant cause of male infertility.
BMC INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Julie Hoermann, Esther Kuenzli, Carmen Schaefer, Daniel H. Paris, Silja Buehler, Peter Odermatt, Somphou Sayasone, Andreas Neumayr, Beatrice Nickel
Summary: This study evaluated the sensitivity and specificity of a rapid diagnostic test (Schistosoma ICT IgG-IgM) for the detection of specific IgG and IgM antibodies against Schistosoma spp. in serum. The test showed a sensitivity of 100% in patients with confirmed schistosomiasis, and a specificity of 100% in healthy individuals and patients with rheumatoid arthritis. However, some cross-reactivity was observed in serum samples of patients with other helminth infections, resulting in a specificity of 85%. The Schistosoma ICT IgG-IgM test is a suitable screening tool for Schistosoma specific antibodies, but confirmatory testing is necessary in populations at risk of co-infection with other tissue invasive parasites.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Multidisciplinary Sciences
Nima Sayyadi, Irene Justiniano, Yan Wang, Xianlin Zheng, Wei Zhang, Lianmei Jiang, Dmitry M. Polikarpov, Robert D. Willows, David Gillatt, Douglas Campbell, Bradley J. Walsh, Jingli Yuan, Yiqing Lu, Nicolle H. Packer, Yuling Wang, James A. Piper
Summary: Two molecular cytology approaches, TGiA and RiA, have been developed to detect prostate cancer cells. TGiA-OSAM showed single-cell PCa detection sensitivity, while RiA had a lower limit of detection. Both assays detected low abundance PCa cells in patient urine and showed correlation with clinical data.
SCIENTIFIC REPORTS
(2022)
Article
Biophysics
Xiawei Xu, Jie Lin, Yanhong Guo, Xiaoxia Wu, Yanping Xu, Dinghu Zhang, Xiangzhi Zhang, Xie Yujiao, Jing Wang, Chengyang Yao, Junlie Yao, Jie Xing, Yi Cao, Yanying Li, Wenzhi Ren, Tianxiang Chen, Yong Ren, Aiguo Wu
Summary: This study presents a novel method for in situ isolating and directly detecting circulating tumor cells (CTCs) from peripheral blood using black TiO2-based Surface-Enhanced Raman Scattering (SERS) bio-probe. The strategy showed high efficiency, reliability, and specificity in distinguishing CTCs from peripheral blood cells. It significantly reduced the detection time and improved the detection sensitivity, making it a potential tool for liquid biopsy.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biochemistry & Molecular Biology
Jaehoon Lee, Hee Seung Lee, Soo Been Park, Chanyang Kim, Kahee Kim, Dawoon E. Jung, Si Young Song
Summary: The study aimed to identify non-invasive miRNA markers for early pancreatic cancer diagnosis. A total of 39 miRNA markers were selected from blood serum samples to build a PC diagnosis model, which showed excellent performance in independent sample validation and differential expression in samples from PC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Miriam Casacuberta-Partal, Margreet Beenakker, Claudia de Dood, Pytsje Hoekstra, Lisa Kroon, Dieuwke Kornelis, Paul Corstjens, Cornelis H. Hokke, Govert van Dam, Meta Roestenberg, Lisette van Lieshout
Summary: This study examined the specificity of the POC-CCA urine strip test in a non-exposed population, revealing reduced specificity in pregnant women and infants under 9 months. Modifications to the buffers used in the test may eliminate false positivity.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Infectious Diseases
Roshell Muir, Talibah Metcalf, Slim Fourati, Yannic Bartsch, Jacqueline Kyosiimire-Lugemwa, Glenda Canderan, Galit Alter, Enoch Muyanja, Brenda Okech, Teddy Namatovu, Irene Namara, Annemarie Namuniina, Ali Ssetaala, Juliet Mpendo, Annet Nanvubya, Paul Kato Kitandwe, Bernard S. Bagaya, Noah Kiwanuka, Jacent Nassuna, Victoria Menya Biribawa, Alison M. Elliott, Claudia J. de Dood, William Senyonga, Priscilla Balungi, Pontiano Kaleebu, Yunia Mayanja, Matthew Odongo, Jennifer Connors, Pat Fast, Matt A. Price, Paul L. A. M. Corstjens, Govert J. van Dam, Anatoli Kamali, Rafick Pierre Sekaly, Elias K. Haddad
Summary: This study explores the impact of Schistosoma mansoni worm burden on Hepatitis B (HepB) vaccination response in a Ugandan fishing cohort. It is found that higher schistosome-specific antigen concentration pre-vaccination is associated with lower HepB antibody titers post-vaccination. Individuals with high worm burden show alterations in immune responses and increased levels of regulatory T cells.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Endocrinology & Metabolism
Thomas F. J. King, Yingjuan Mok, Lily Mae Dacay, Hang Siang Wong, Pon Poh Hsu, Alvin Tan, Kang Min Wong, Seyed Ehsan Saffari, Jacques W. M. Lenders, Troy H. Puar
Summary: This study evaluated the false-positive results of plasma and urinary metanephrines in OSA patients for the diagnosis of PPGL. The results showed that OSA patients had more false-positive urinary metanephrines compared to plasma metanephrines. Severe OSA, obesity, and family history of hypertension were predictors for false-positive urinary metanephrines in patients with suspected OSA.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Pediatrics
E. Estorninos, R. B. Lawenko, E. Palestroque, J. Lebumfacil, M. Marko, C. Cercamondi
Summary: This study evaluated the safety and efficacy of a MOS-supplemented infant formula. The results showed that MOS supplementation promoted softer stooling pattern and reduced difficulties in passing stool. Overall, the MOS-supplemented infant formula was safe and well-tolerated for healthy term infants.
PEDIATRIC RESEARCH
(2022)
Article
Nutrition & Dietetics
Roelinda Jongstra, Md Mokbul Hossain, Valeria Galetti, Andrew G. Hall, Roberta R. Holt, Colin Cercamondi, Sabina F. Rashid, Michael B. Zimmermann, Malay K. Mridha, Rita Wegmueller
Summary: Consumption of zinc-biofortified rice for 9 months did not significantly affect plasma zinc concentration, prevalence of zinc deficiency, or fatty acid desaturase activity in preschool-aged children in rural Bangladesh.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Philippe Alliet, Yvan Vandenplas, Paola Roggero, Sabine N. J. Jespers, Stefaan Peeters, Jean-Philippe Stalens, Guus A. M. Kortman, Mailis Amico, Bernard Berger, Norbert Sprenger, Colin I. Cercamondi, Giovanni Corsello
Summary: This study demonstrates that an infant formula containing 2'FL and L. reuteri supports age-appropriate growth, is well-tolerated, and may help regulate gut microbiota composition.
Article
Parasitology
Miriam Casacuberta-Partal, Lisette van Lieshout, Angela van Diepen, Jeroen C. Sijtsma, Arifa Ozir-Fazalalikhan, Jan Pieter R. Koopman, Claudia J. de Dood, Paul L. A. M. Corstjens, Govert J. van Dam, Cornelis H. Hokke, Meta Roestenberg
Summary: The study found that male parasites excrete more circulating antigens than females in both the mouse model and ex vivo, and in mixed infections, serum CAA levels correlate with the number of recovered worms. In mice infected with female worms only, no viable eggs and no inflammation were seen in the livers. Additionally, CAA levels were higher than CCA levels ex vivo.
Article
Infectious Diseases
Gebeyaw G. Mekonnen, Bemnet A. Tedla, Mark S. Pearson, Luke Becker, Matt Field, Abena S. Amoah, Govert van Dam, Paul L. A. M. Corstjens, Takafira Mduluza, Francisca Mutapi, Alex Loukas, Javier Sotillo
Summary: This study identified the anatomical sites of expression of six TSPs in Schistosoma haematobium and found differential expression of their mRNAs throughout the parasite's developmental stages. The potential diagnostic value of three Sh-TSPs was assessed in individuals' urine from an endemic area of Zimbabwe, showing promising results for immunological diagnosis of S. haematobium infection.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Pytsje T. Hoekstra, Afona Chernet, Claudia J. de Dood, Eric A. T. Brienen, Paul L. A. M. Corstjens, Niklaus D. Labhardt, Beatrice Nickel, Linda Wammes, Govert J. van Dam, Andreas Neumayr, Lisette van Lieshout
Summary: The study on asymptomatic refugees from Eritrea showed that the circulating anodic antigen (CAA) test is the most accurate method for screening and monitoring schistosomiasis infections, while traditional methods such as stool microscopy, serology, and urine point-of-care circulating cathodic antigen (POC-CCA) lack sensitivity.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Nutrition & Dietetics
Miroslava Bosheva, Istvan Tokodi, Aleksander Krasnow, Helle Krogh Pedersen, Oksana Lukjancenko, Aron C. Eklund, Dominik Grathwohl, Norbert Sprenger, Bernard Berger, Colin I. Cercamondi
Summary: This study investigated the effects of an infant formula containing five HMOs on gut maturation. The results showed that this formula can support the development of the intestinal immune system and gut barrier function, and shift the gut microbiome closer to that of breastfed infants.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Martin N. Mwangi, Dennis G. A. B. Oonincx, Marijke Hummel, Dessy A. Utami, Lidyawati Gunawan, Margot Veenenbos, Christophe Zeder, Colin Cercamondi, Michael B. Zimmermann, Joop J. A. van Loon, Marcel Dicke, Alida Melse-Boonstra
Summary: This study assessed the absorption of iron from edible crickets in humans. The results showed that iron absorption was lower from crickets consumed with refined maize porridge, possibly due to the presence of chitin and other inhibitors in the cricket biomass.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Parasitology
Khanh Pham, Gideon S. Mtalitinya, Christine Aristide, Efeose A. Airewele, Deborah K. Nyakaru, Paige McMahon, Gerald Mulaki Mulaki, Paul L. A. M. Corstjens, Claudia J. . de Dood, Govert J. van Dam, John M. Changalucha, Humphrey D. Mazigo, Myung Hee Lee, Hyasinta Jaka, Jennifer A. Downs
Summary: Schistosoma mansoni infection is associated with mild-to-moderate lower gastrointestinal mucosal abnormalities that are visible during sigmoidoscopy, and these abnormalities partially improve 6 months after effective praziquantel treatment.
Article
Pediatrics
Luca Lavalle, Nicolas Sauvageot, Colin Ivano Cercamondi, Delphine Egli, Ivana Jankovic, Yvan Vandenplas
Summary: This observational study found no significant difference in overall GI tolerance between formula-fed infants and breastfed infants. However, infants fed formula with pre- and/or probiotics showed better stooling and less infantile colic compared to those fed formula without any pre- and/or probiotics, and were more similar to breastfed infants.
Article
Infectious Diseases
Pytsje T. Hoekstra, Miriam Casacuberta-Parta, Lisette van Lieshout, Paul L. A. M. Corstjens, Roula Tsonaka, Rufin K. Assare, Kigbafori D. Silue, Eliezer K. N'Goran, Yves K. N'Gbesso, Eric A. T. Brienen, Meta Roestenberg, Stefanie Knopp, Jurg Utzinger, Jean T. Coulibaly, Govert J. van Dam
Summary: This study found that the efficacy of praziquantel (PZQ) treatment for schistosomiasis was overestimated when using less sensitive diagnostic methods. The results highlight the importance of using accurate diagnostic tools to monitor different treatment strategies.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Immunology
Justin R. Kingery, Andrea Chalem, Crispin Mukerebe, Peter S. Shigella, Donald Miyaye, Ruth G. Magawa, Maureen Ward, Samuel E. Kalluvya, Jason McCormick, Jane K. Maganga, Soledad Colombe, Christine Aristide, Paul L. A. M. Corstjens, Myung Hee Lee, John M. Changalucha, Jennifer A. Downs
Summary: This study characterized immune cell populations in cervical brushings of women with and without Schistosoma mansoni infection. The results showed lower frequencies of natural killer T cells and higher frequencies of CD14(+) monocytes in infected women.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Immunology
Amy S. Sturt, Emily L. Webb, Comfort R. Phiri, Joyce Mapani, Maina Mudenda, Lisa Himschoot, Eyrun F. Kjetland, Tobias Mweene, Bruno Levecke, Govert J. van Dam, Paul L. A. M. Corstjens, Helen Ayles, Richard J. Hayes, Suzanna C. Francis, Lisette van Lieshout, Piet Cools, Isaiah Hansingo, Amaya L. Bustinduy
Summary: This study found that Polymerase chain reaction-FGS, visual-FGS, and active Schistosoma infection were not associated with the presence of CVL hemoglobin. Further research is needed to establish accessible community-based FGS diagnostics.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Pytsje T. Hoekstra, Joule Madinga, Pascal Lutumba, Rebecca van Grootveld, Eric A. T. Brienen, Paul L. A. M. Corstjens, Govert J. van Dam, Katja Polman, Lisette van Lieshout
Summary: This study evaluated the use of alternative methods such as real-time PCR, POC-CCA, and UCP-LF CAA for detecting Schistosoma infections in the absence of microscopy. Results indicated that stool-based PCR and POC-CCA test are suitable for screening S. mansoni infections even without microscopy. However, a significant proportion of CAA-positive cases showed low antigen concentrations, suggesting underestimation of schistosome positives by PCR and POC-CCA.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Parasitology
Mariana Silva Sousa, Gdayllon Cavalcante Meneses, Govert Jan van Dam, Paul Leo Albert Maria Corstjens, Rosangela Lima de Freitas Galvao, Marta Cristhiany Cunha Pinheiro, Alice Maria Costa Martins, Elizabeth de Francesco Daher, Fernando Schemelzer de Moraes Bezerra
Summary: The study aimed to investigate the baseline levels of Schistosoma mansoni-Circulating Anodic Antigen (CAA) and their association with kidney biomarkers in individuals with long-term schistosomiasis follow-up after praziquantel treatment. The results showed that CAA-positive patients had increased baseline albuminuria and proteinuria, and their CAA levels were only correlated with Vascular Endothelial Growth Factor (VEGF) levels. However, no significant differences were observed in kidney biomarkers between the groups and different periods during the follow-up analysis.
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
(2023)