Article
Food Science & Technology
Yi-Hsien Hsieh, Tung-Wei Hung, Yong-Syuan Chen, Yi-Ning Huang, Hui-Ling Chiou, Chu-Che Lee, Jen-Pi Tsai
Summary: Fraxetin has been shown to decrease renal dysfunction and reduce renal interstitial collagen fibers in a mouse model of renal fibrosis, while inhibiting the expression of key proteins involved in fibrosis. This suggests that fraxetin may be beneficial in slowing the progression of chronic kidney disease.
Article
Biochemistry & Molecular Biology
Nozomi Yabuuchi, Huixian Hou, Nao Gunda, Yuki Narita, Hirofumi Jono, Hideyuki Saito
Summary: SULT1A1 plays toxico-pathological roles in the progression of cisplatin-induced acute kidney injury, while the IS/AhR/ROS axis brings about oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
David S. Wishart, Eponine Oler, Harrison Peters, AnChi Guo, Sagan Girod, Scott Han, Sukanta Saha, Vicki W. Lui, Marcia LeVatte, Vasuk Gautam, Rima Kaddurah-Daouk, Naama Karu
Summary: The Human Microbial Metabolome Database (MiMeDB) is a comprehensive multi-omic microbiome resource that connects microorganisms, microbial genomes, microbial metabolites, the human exposome, and human health. It contains detailed taxonomic and microbiological data on human microbes, linked to genomic and proteomic sequence data. The database also includes information about metabolites, reactions, enzymes, and exposure sources, as well as health effects and protein targets. MiMeDB aims to enable comprehensive multi-omic integration and is designed to be easy to search, browse, and navigate.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Multidisciplinary Sciences
Ping-Hsun Wu, Yi-Ting Lin, Yi-Wen Chiu, Gabriel Baldanzi, Jiun-Chi Huang, Shih-Shin Liang, Su-Chu Lee, Szu-Chia Chen, Ya-Ling Hsu, Mei-Chuan Kuo, Shang-Jyh Hwang
Summary: Protein-bound uremic toxins (IS and PCS) are associated with various cardiovascular-related proteins, involved in endothelial barrier function, cell adhesion, phosphate homeostasis, and inflammation. Multiplex proteomics may be a promising approach to uncover novel pathophysiology of uremic toxins.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Chyou-Wei Wei, Tsai-Kun Wu, Shu-Cing Wu, Yi-Lin Chen, Ying-Ru Pan, Yi-Chung Chien, Jia-Yan Wu, Yung-Lung Yu, Giou-Teng Yiang
Summary: This study compared the different cytotoxic effects on renal cells between IS and PCS treatment, and found that PCS exerted a stronger anti-proliferative effect on renal tubular cells compared to IS treatment. In addition, the study demonstrated for the first time that curcumin enhanced PCS-induced cell cytotoxicity through caspase-dependent apoptotic pathway and cell cycle alteration.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Regiane Stafim da Cunha, Paulo Cezar Gregorio, Rayana Ariane Pereira Maciel, Giane Favretto, Celia Regina Cavichiolo Franco, Jenifer Pendiuk Goncalves, Marina Luise Viola de Azevedo, Roberto Pecoits-Filho, Andrea Emilia Marques Stinghen
Summary: Uremic toxins PCS and IS contribute to endothelial dysfunction in chronic kidney disease. This study found that CREB/ATF1 is activated by PCS, IS, and US in uremic conditions and may play a relevant role in endothelial dysfunction.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Critical Care Medicine
Selena Z. Kuo, Katja Dettmer, Medini K. Annavajhala, David H. Chong, Anne-Catrin Uhlemann, Julian A. Abrams, Peter J. Oefner, Daniel E. Freedberg
Summary: The study investigated the relationship between urinary 3-IS levels and patient outcomes in the ICU, finding that low 3-IS levels were associated with fewer ICU-free days and increased one-year mortality. Further research should explore urinary 3-IS as an ICU biomarker.
JOURNAL OF CRITICAL CARE
(2021)
Article
Microbiology
Stefanie Westermann, Christoph Schubart, Axel Dietschmann, Kirstin Castiglione, Daniel Radtke, David Voehringer
Summary: Gastrointestinal helminths are a major health threat worldwide. Alternatively activated macrophages (AAMs) have been shown to contribute to host protection during secondary helminth infections. However, the specific role of STAT6-regulated genes like Arginase-1 (Arg1) from AAMs or other cell types for host protection remains unclear.
Article
Biochemistry & Molecular Biology
Anna Pieniazek, Michal Kopera, Lukasz Gwozdzinski, Krzysztof Gwozdzinski
Summary: The study found that indoxyl sulfate (IS) can cause oxidative damage and impact the progression of chronic kidney disease (CKD). IS affects oxidative stress parameters and may shorten the lifespan of red blood cells in patients.
Article
Veterinary Sciences
Stacie Summers, Jessica Quimby, Jason Gagne, Michael Lappin
Summary: This study evaluated the effects of feeding healthy adult cats with variable protein concentrations on the fecal microbiome and serum concentrations of gut-derived toxins. The results showed that a high-protein diet increased the serum concentrations of p-cresol sulfate and decreased the relative abundance of Bifidobacterium in the gut. This suggests that dietary protein concentration can affect the gut microbial community and toxin production.
VETERINARY SCIENCES
(2023)
Article
Food Science & Technology
Nicolas Fabresse, Islam Amine Larabi, Emuri Abe, Elodie Lamy, Claire Rigothier, Ziad A. Massy, Jean-Claude Alvarez
Summary: The objective of this study was to investigate the correlation between saliva concentration and free serum concentration of 10 uremic toxins (UTs). Saliva and blood samples from 18 healthy volunteers were collected and analyzed using LC-MS/MS. The results showed a significant correlation between saliva and serum for six UTs, while the correlation for other substances was weak or not evident. This study is the first to report the saliva concentrations of TMAO, KYN, HA, PAGN, pCG, and 3-IAA.
Article
Chemistry, Multidisciplinary
Antonio Ruiz-Gonzalez, Adam J. Clancy, Kwang-Leong Choy
Summary: The developed hybrid material enables rapid and selective detection of toxins associated with early-stage chronic kidney disease within 5 minutes, with the ability to measure free and bound analytes separately and simultaneously at an ultra-low limit of detection. The processes used in this system are adaptable to any charged molecular analyte.
CHEMICAL COMMUNICATIONS
(2021)
Review
Immunology
Xuewei Ye, Haiyi Li, Komal Anjum, Xinye Zhong, Shuping Miao, Guowan Zheng, Wei Liu, Lanjuan Li
Summary: Indoles affect immune system function by activating AhR and PXR receptors, exhibiting anti-inflammatory activity to improve intestinal health and promote human health, but also have toxic effects.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Food Science & Technology
Vaibhav Maheshwari, Xia Tao, Stephan Thijssen, Peter Kotanko
Summary: The traditional dialysis method is insufficient for removing protein-bound uremic toxins (PBUTs). A novel approach of using binding competitors to enhance dialysis efficiency by increasing the free PBUT fraction has shown promising results in in silico, ex vivo, and in vivo studies. Further research is needed to identify ideal binding competitors for routine clinical use.
Article
Food Science & Technology
Alonso Jerez-Morales, Jose S. Merino, Sindy T. Diaz-Castillo, Carlos T. Smith, Jorge Fuentealba, Humberto Bernasconi, Gerson Echeverria, Apolinaria Garcia-Cancino
Summary: In a rat CKD model, the putative synbiotic reduced IS levels and slowed the progression of the disease, but did not provide protection for the heart.
