Article
Biochemistry & Molecular Biology
Lele Song, Xinyi Yao, Hangpeng Li, Bo Peng, Alan P. Boka, Yiman Liu, Guochao Chen, Zhenyang Liu, Kaeli M. Mathias, Lingbo Xia, Qinglan Li, Mustafa Mir, Yuanyuan Li, Haitao Li, Liling Wan
Summary: Growing evidence suggests the presence of transcriptional condensates on chromatin, but their formation mechanisms and functional significance are still unclear. This study reveals that mutations in the histone acetylation reader ENL can lead to aberrant condensate formation, which drives oncogenic gene activation in human cancer.
Editorial Material
Endocrinology & Metabolism
Natalie Niemi
Summary: Previous studies suggested that acetylation of mitochondrial proteins occurs non-enzymatically, but a new research challenges this notion by demonstrating the involvement of a histone acetyltransferase in enhancing mitochondrial metabolism through acetylating a complex IV assembly factor.
Review
Biochemistry & Molecular Biology
Kwon Young Chou, Jun-Yeong Lee, Kee-Beom Kim, Eunjeong Kim, Hyun-Shik Lee, Hong-Yeoul Ryu
Summary: The budding yeast Saccharomyces cerevisiae is a widely used model system for studying histone modifications and chromatin states. Recent advances in biotechnology have allowed for the detection and quantification of protein post-translational modifications, leading to the identification of new modification sites in histones. Understanding the cellular functions of these new histone markers is crucial for unraveling epigenetic mechanisms and their impact on biological processes.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Multidisciplinary Sciences
Yusuke Fujiwara, Yuki Yamanashi, Akiko Fujimura, Yuko Sato, Tomoya Kujirai, Hitoshi Kurumizaka, Hiroshi Kimura, Kenzo Yamatsugu, Shigehiro A. Kawashima, Motomu Kanai
Summary: The study developed a chemical catalyst that can achieve histone acetylation in living cells without genetic manipulation, offering a new tool for studying epigenetic regulation. This chemical method competes with and suppresses normal chromatin function markers, providing insights into epigenetic mechanisms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biophysics
Yan Chen, Yunlei Zhou, Huanshun Yin
Summary: Histone acetylation, a crucial histone modification, is closely related to various diseases. Detection of HAT activity plays a significant role in disease discovery, prevention, and treatment, with recent research focusing on new methods combining different technologies.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Zhao-Jing Huang, Hao Li, Jia-Yi Luo, Shunxing Li, Fengjiao Liu
Summary: The rapid emergence of deep learning, such as deep convolutional neural networks (DCNNs), has revolutionized colorimetric determination. However, the data-hungry nature of DCNNs limits its application. To overcome this, few-shot learning (FSL) is achieved by combining the generative adversarial network (GAN). By using GAN to generate 13,500 antagonistic samples as the training set, the accuracy is increased from 51.26% to 85.00%. The image quality generated by GAN is also superior to the commonly used convolution self-encoder method.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Kairui Yue, Simin Sun, Geng Jia, Mengting Qin, Xiaohan Hou, C. James Chou, Chao Huang, Xiaoyang Li
Summary: This study reports the development of a highly selective HDAC6 inhibitor with hydrazide as the zinc-binding group (ZBG), which exhibits superior pharmacokinetic properties compared to current hydroxamic acid inhibitors. Structure-activity relationship analysis reveals that the presence of an ethyl group substituent in the hydrazide-based ZBG and a cap group with increased rigidity and volume enhance the HDAC6 selectivity of the designed compounds. The representative inhibitor 35m demonstrates potent HDAC6 inhibitory activity and improved pharmacokinetic properties compared to hydroxamic acid-based HDAC6 inhibitors Tubastatin A and ACY1215. Furthermore, low-dose 35m effectively decreases LPS-induced IL-1 beta release by blocking the activation of NLRP3, indicating its potential as an orally active therapeutic agent for NLRP3-related diseases.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Genetics & Heredity
Simeng Wang, Xinyu Zhang, Qinglian Wang, Rong Wang
Summary: This review summarizes the pathogenesis of podocyte injury in diabetic nephropathy (DN), focusing on the role of histone modification. It provides new insights for further molecular research, diagnosis, and treatment.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Review
Biochemistry & Molecular Biology
K. Gomathi, N. Akshaya, N. Srinaath, M. Rohini, N. Selvamurugan
Summary: Bone remodeling is a complex event crucial for maintaining bone homeostasis, with histone acetylation playing a key role in the process. Studies have shown that histone acetyltransferases are major promoters of acetylation, and noncoding RNAs are also involved in regulating acetylation. Understanding these regulatory mechanisms may offer new insights for epigenetic therapies of bone diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Xiaoyan Wang, Guanghui Cheng, Jingjie Zhao, Ping Gao, Haiting Mao, Chao Yuan, Jian Zhang
Summary: In this study, potential inhibitors for YEATS2 YEATS domain were identified using computational approaches, and their interaction with the domain was studied through molecular optimization and dynamics simulation. The study provides a foundation for the development of highly active and selective inhibitors for YEATS2 YEATS domain.
NEW JOURNAL OF CHEMISTRY
(2023)
Review
Cell Biology
Kenya Bonitto, Kirthana Sarathy, Kaiser Atai, Mithun Mitra, Hilary A. Coller
Summary: This article discusses the epigenetic changes during cell entry into and exit from quiescence, examines the role of different histone marks during quiescence, and explores the possibility of a quiescence histone code.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Environmental
Chenwei Liang, Fenglian Fu, Bing Tang
Summary: The incorporation of Mn into ferrihydrite enhances the adsorption capacity for Cr(VI), inhibits its migration, and increases its retention in the environment.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Review
Polymer Science
Xiaoqing Yuan, Jingxia Li, Lin Luo, Zhenyu Zhong, Xiande Xie
Summary: This study reviewed the mostly investigated polymeric materials for removing Cr(VI), emphasizing the strategies of assembling functional groups, reducing self-aggregation, and enhancing stability and mechanical strength to improve the performance of polymeric adsorbents. The maximum adsorption capacities of these polymers towards Cr(VI) ranged from 3.2 to 1185 mg/g according to the Langmuir isotherm model. Various mechanisms, including complexation, chelation, reduction, electrostatic attraction, anion exchange, and hydrogen bonding, were involved in the removal of Cr(VI). Factors such as pH, initial concentration, temperature, anions, and cations affected the adsorption of Cr(VI) and the regeneration of the adsorbents. The study provides insights for developing more robust polymeric adsorbents and promoting the treatment of Cr(VI)-containing wastewater.
Article
Nutrition & Dietetics
Erik Elebring, Ville Wallenius, Anna Casselbrant, Neil G. Docherty, Carel W. le Roux, Hanns-Ulrich Marschall, Lars Fandriks
Summary: This study aimed to investigate the effects of diets enriched in fat or carbohydrates on glucose absorption in the healthy jejunum and the underlying mechanisms. The results showed that a fat-enriched diet decreased jejunal glucose absorption through a ketogenesis-induced alteration of histone acetylation. This research provides important insights into the metabolic effects of different diets.
Review
Biochemistry & Molecular Biology
Svetlana Demyanenko, Svetlana Sharifulina
Summary: HDAC and HAT play crucial roles in regulating cell functions through acetylating/deacetylating histones and non-histone proteins, impacting cell survival, death, and other processes. The effects of stroke on non-histone protein acetylation/deacetylation in brain cells are still poorly understood, but HDAC inhibitors have shown promise in protecting the brain from ischemic damage. The roles of different HDAC isoforms in brain cell survival and death after stroke remain controversial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
You-Jin Yi, Yu-sheng Li, Bo Xia, Wen-ping Li, Li Pang, Zhi-dan Tong
BIOLOGICAL CONTROL
(2015)
Article
Toxicology
Xiaohu Ren, Jie Li, Bo Xia, Wei Liu, Xifei Yang, Wen-Xu Hong, Peiwu Huang, Yong Wang, Shuiming Li, Fei Zou, Jianjun Liu
TOXICOLOGY MECHANISMS AND METHODS
(2015)
Article
Toxicology
Xiaohu Ren, Jie Li, Bo Xia, Wei Liu, Xifei Yang, Wen-Xu Hong, Peiwu Huang, Yong Wang, Shuiming Li, Fei Zou, Jianjun Liu
TOXICOLOGY MECHANISMS AND METHODS
(2015)
Article
Pharmacology & Pharmacy
Bo Xia, Lin-Qing Yang, Hai-Yan Huang, Li Pang, Xi-Fei Yang, You-Jin Yi, Xiao-Hu Ren, Jie Li, Zhi-Xiong Zhuang, Jian-Jun Liu
INTERNATIONAL JOURNAL OF TOXICOLOGY
(2016)
Article
Toxicology
Bo Xia, Li Pang, Zhi-xiong Zhuang, Jian-jun Liu
TOXICOLOGY LETTERS
(2016)
Article
Biochemistry & Molecular Biology
Haiyan Huang, Gonghua Hu, Jianfeng Cai, Bo Xia, Jianjun Liu, Xuan Li, Wei Gao, Jianqing Zhang, Yinpin Liu, Zhixiong Zhuang
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2014)
Article
Multidisciplinary Sciences
Wenqiang Feng, Juanjuan Guo, Haiyan Huang, Bo Xia, Hongya Liu, Jie Li, Shaolin Lin, Tiyuan Li, Jianjun Liu, Hui Li
Article
Food Science & Technology
Pao Li, Jing Xie, Hui Tang, Cong Shi, Yanhua Xie, Jing He, Yulun Zeng, Hongli Zhou, Bo Xia, Chunyan Zhang, Liwen Jiang
FOOD SCIENCE & NUTRITION
(2019)
Article
Food Science & Technology
Pao Li, Hui Tang, Cong Shi, Yanhua Xie, Hongli Zhou, Bo Xia, Chunyan Zhang, Lili Chen, Liwen Jiang
FOOD SCIENCE & NUTRITION
(2019)
Article
Environmental Sciences
Xiaohu Ren, Bo Xia, Zhihong Chen, Xiao Chen, Desheng Wu, Weixue Lu, Nuanyuan Luo, Li Zhou, Wei Liu, Xifei Yang, Jianjun Liu
Article
Food Science & Technology
Yi Chen, Pao Li, Weiwei He, Luyan Liao, Bo Xia, Liwen Jiang, Yang Liu
Summary: The study revealed the fluctuation characteristics of microbial diversity during the fermentation of Liuyang Douchi, with Staphylococcus and Petromyces being the dominant bacteria and fungi, respectively. Additionally, four non-aflatoxigenic Aspergillus flavus strains were isolated from Liuyang Douchi for the first time, displaying high cellulase and protease activities.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bo Xia, Minyi Luo, Li Pang, Xia Liu, Youjin Yi
Summary: The study used molecular docking to predict the binding of different lipopeptides to the RNA-dependent RNA polymerase nsp12 of SARS-CoV-2. Results showed that seven lipopeptides bound to nsp12, with iron-chelating ferrocin A having the highest binding affinity. This suggests that these lipopeptides could be promising drug candidates for anti-coronaviral treatments against SARS-CoV-2.
BIOMEDICAL JOURNAL
(2021)
Review
Environmental Sciences
Wen-Tao Yang, You-Jin Yi, Bo Xia
Summary: Pantoea dispersa is a versatile bacterium with potential applications in biotechnology, environmental protection, soil bioremediation, and plant growth stimulation. However, it can also be harmful to humans and plants. To fully harness its potential while minimizing harm, understanding its genetic makeup, ecological interactions, and underlying mechanisms is crucial.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Li Pang, Bo Xia, Xiubin Liu, Youjin Yi, Liwen Jiang, Chao Chen, Pao Li, Min Zhang, Xinbei Deng, Rencai Wang
Summary: This study optimized the culture conditions and medium components of the endophytic Bacillus amyloliquefaciens strain M9 isolated from kiwifruit, resulting in enhanced antifungal activity against the soft rot fungal pathogen Botryosphaeria dothidea. Postharvest experiments showed that M9 culture filtrate could improve disease resistance, delay fruit senescence, and maintain kiwifruit quality during storage. The presence of the C12-surfactin A lipopeptide was found to be associated with the antifungal activity of M9.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)