期刊
TOXICOLOGY LETTERS
卷 225, 期 1, 页码 192-200出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2013.12.009
关键词
Glyphosate; Acute kidney injury; Kidney injury molecule-1; Cystatin-C; Creatinine; Roundup
类别
资金
- National Health and Medical Research Committee of Australia [1011772]
- Faculty of Development Fund, Faculty of Medicine, Chiang Mai University
- University of Queensland
Accidental or intentional ingestion of glyphosate surfactant-based herbicides, like Roundup (R), leads to nephrotoxicity as well as death. In this study, a panel of kidney injury biomarkers was evaluated in terms of suitability to detect acute kidney injury and dysfunction. The Roundup (R) intoxication model involved oral administration of glyphosate to rats at dose levels of 250, 500, 1200 and 2500 mg/kg. Urinary and plasma biomarker patterns were investigated at 8, 24 and 48 h after dosing. Biomarkers were quantified by absolute concentration; by normalising to urine creatinine; and by calculating the excretion rate. The diagnostic performances of each method in predicting of acute kidney injury were compared. By Receiver Operating Characteristic (ROC) analysis of the selected biomarkers, only urinary kidney injury molecule-1 (KIM-1) best predicted histological changes at 8 h (best cut-off point >0.00029 mu g/ml). Plasma creatinine performed better than other biomarkers at 24 h (best cut-off point > 0.21 mg/dl). Urinary KIM-1 was the best early biomarker of kidney injury in this glyphosate-induced nephrotoxicity model. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据