Article
Endocrinology & Metabolism
Martin Werdermann, Ilona Berger, Laura D. Scriba, Alice Santambrogio, Pia Schlinkert, Heike Brendel, Henning Morawietz, Andreas Schedl, Mirko Peitzsch, Aileen J. F. King, Cynthia L. Andoniadou, Stefan R. Bornstein, Charlotte Steenblock
Summary: This study investigated the impact of metabolic diseases on progenitor cells in the hypothalamic-pituitary-adrenal axis, showing that insulin enhances proliferation and differentiation of these cells, while chronic metabolic stress leads to hyperactivation of the axis. This suggests a potential link between early life stress and the development of metabolic syndrome in adulthood.
MOLECULAR METABOLISM
(2021)
Review
Endocrinology & Metabolism
Jody A. Rusch, Brian T. Layden, Lara R. Dugas
Summary: Cognitive function in humans relies on the complex interplay between multiple body systems, including the HPA axis. The gut microbiota, which outnumbers human cells and has a greater genetic potential, plays a crucial role through the MGB axis, a bidirectional communication pathway. Stress can affect the MGB axis through the HPA axis and other pathways, and animal research has contributed to a paradigm shift in understanding the influence of microbiota on human health and disease. Preclinical and human trials are currently investigating the applicability of these findings in humans.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Neurosciences
Svetlana Trifunovic, Ivana Stevanovic, Ana Milosevic, Natasa Ristic, Marija Janjic, Ivana Bjelobaba, Danijela Savic, Iva Bozic, Marija Jakovljevic, Katarina Tesovic, Danijela Laketa, Irena Lavrnja
Summary: This study investigated the inflammatory and oxidative stress status of the HPA axis during EAE, revealing upregulation of Pomc gene expression, increased levels of POMC and ACTH proteins in the pituitary, upregulation of prostaglandins, and activation of oxidative pathways. The results highlight the potential mechanisms and pharmacological modulation in MS, showing the impact of oxidative stress on HPA activation during EAE.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Psychology, Multidisciplinary
Isabel Crespo-Sanmiguel, Mariola Zapater-Fajari, Matias M. Pulopulos, Vanesa Hidalgo, Alicia Salvador
Summary: The study found that early life stress (ELS) is associated with perceived stress, but not with HPA axis functioning. Loneliness mediates the relationship between ELS and perceived stress, but not between ELS and HPA axis functioning.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Krisztina Csabafi, Katalin Eszter Ibos, Eva Bodnar, Kata Filkor, Julia Szakacs, Zsolt Bagosi
Summary: Intracerebroventricular administration of KP-13 induces anxiety-like behavior and activates the HPA axis in rats. The study found that KP-13 alters the AVP and CRF signaling, which may be responsible for its effect on the HPA axis and anxiety-like behavior.
Review
Endocrinology & Metabolism
You Lee Son, Takayoshi Ubuka, Kazuyoshi Tsutsui
Summary: Under stressful conditions, the GnIH neuropeptide may play a key role in regulating reproductive function. Different types and durations of stress can modulate the GnIH system, impacting the activity of the HPG axis. GnIH appears to be a potential novel mediator responsible for stress-induced reproductive dysfunction.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Irene Cimino, Hanna Kim, Y. C. Loraine Tung, Kent Pedersen, Debra Rimmington, John A. Tadross, Sara N. Kohnke, Ana Neves-Costa, Andre Barros, Stephanie Joaquim, Don Bennett, Audrey Melvin, Samuel M. Lockhart, Anthony J. Rostron, Jonathan Scott, Hui Liu, Keith Burling, Peter Barker, Menna R. Clatworthy, E-Chiang Lee, A. John Simpson, Giles S. H. Yeo, Luis F. Moita, Kendra K. Bence, Sebastian Beck Jorgensen, Anthony P. Coll, Danna M. Breen, Stephen O'Rahilly
Summary: GDF15 plays a crucial role in activating the hypothalamic-pituitary-adrenal (HPA) axis; It is essential for the protective HPA response to toxins that do not induce a substantial cytokine response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Feiye Wu, Jing Zhu, Yang Wan, Subinuer Kurexi, Jia Zhou, Ke Wang, Tongyu Chen
Summary: This study aimed to investigate the effects of electroacupuncture (EA) on the hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis and its potential mechanisms. The results showed that EA treatment effectively inhibited the hyperactivity of the HPA axis and promoted postoperative recovery by activating the oxytocin/oxytocin receptor (OXT/OXTR) signaling pathway.
NEUROCHEMICAL RESEARCH
(2023)
Article
Neurosciences
Mario F. Juruena, Martha Bourne, Allan H. Young, Anthony J. Cleare
Summary: Evidence suggests that early life stress can disrupt the functioning of the HPA axis, leading to potential mental health disorders in adulthood. Dysregulation in hormone binding to receptors crucial for maintaining homeostasis may result in illness. The response of the HPA axis to stress plays a critical role in an individual's vulnerability to diseases related to psychological stress.
NEUROSCIENCE LETTERS
(2021)
Article
Allergy
Wisdom Alemya Akurugu, Carel Jacobus Van Heerden, Nicola Mulder, Ekkehard Werner Zollner
Summary: This study found that some SNPs of the CRHR1 and NR3C1 genes are associated with HPAS in asthmatic children, with the C allele of rs41423247 potentially having a protective effect on HPAS, and the CC genotype being associated with the highest PMTP ACTH response.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Psychology, Multidisciplinary
Qian Liu, Jianhui Wu, Liang Zhang, Xiaofang Sun, Qing Guan, Zhuxi Yao
Summary: This study found that, for the same level of stress, the subjective perceived level of control in young adults can influence the activation of the hypothalamic-pituitary-adrenal axis.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Endocrinology & Metabolism
Wrivu N. Martin, Carol A. Wang, Stephen J. Lye, Stephen G. Matthews, Rebecca M. Reynolds, Carly E. McLaughlin, Roger Smith, Craig E. Pennell
Summary: The study found an inverse linear relationship between fetal growth and HPA-A function at age 18, with no consistent quadratic relationships identified. Removal of anticipatory responders from the models substantially attenuated the observed relationships. This suggests altered adrenal sensitivity may underlie the relationship.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Wrivu N. Martin, Carol A. Wang, Stephen J. Lye, Stephen G. Matthews, Rebecca M. Reynolds, Carly E. McLaughlin, Roger Smith, Craig E. Pennell
Summary: A study found an inverse linear relationship between fetal growth and HPA-A function at the age of 18, which may be related to altered adrenal sensitivity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Jacinda C. Li, Molly A. Hall, Idan Shalev, Hannah M. C. Schreier, Tomas Gonzalez Zarzar, Isabel Marcovici, Frank W. Putnam, Jennie G. Noll
Summary: This study suggests a mechanistic association between HPA axis attenuation and obesity, with the attenuated cortisol growth rate mediating the effects of childhood sexual abuse on accelerated BMI accumulation and elevated adulthood obesity rates.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Emmet M. Power, Karl J. Iremonger
Summary: Research shows that the excitability of CRH neurons is regulated over the estrous cycle, with peak excitability in proestrus and lowest in estrus. Additionally, the relationship between I-A currents and excitability is opposite, and blocking I-A currents can equalize excitability across cycle stages, indicating a role for I-A in mediating plasticity in stress circuit function over the female estrous cycle.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Leticia Diez-Quijada, Concepcion Medrano-Padial, Maria Llana-Ruiz-Cabello, Giorgiana M. Catunescu, Rosario Moyano, Maria A. Risalde, Ana M. Camean, Angeles Jos
Article
Food Science & Technology
Leticia Diez-Quijada, Rosario Moyano, Veronica Molina-Hernandez, Ana M. Camean, Angeles Jos
Summary: The 28-day repeated dose oral study on rats with Cylindrospermopsin (CYN) showed mild toxic effects with no toxicity relevance in male rats, while slight changes in biochemical parameters and organ weights were observed in female rats without toxicological significance. This suggests the need for longer oral toxicity studies to define the potential consequences of long-term CYN exposure.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Food Science & Technology
Antonio Cascajosa-Lira, Maria Puerto, Ana I. Prieto, Silvia Pichardo, Leticia Diez-Quijada Jimenez, Alberto Banos, Enrique Guillamon, Rosario Moyano, Veronica Molina-Hernandez, Angeles Jos, Ana M. Camean
Summary: This study confirmed the lack of in vivo genotoxicity of PTS at the doses tested, indicating that it is a promising natural alternative in animal feed without adverse effects on genetic material.
Article
Marine & Freshwater Biology
Maria A. Risalde, Ana Ma Molina, Antonio J. Lora, Nahum Ayala, Jose C. Gomez-Villamandos, Ma Rosario Moyano
Summary: This study evaluated the expression of cyp19a aromatase in zebrafish after exposure to different concentrations of BPA, finding that these aromatases are overexpressed and could be good biomarkers for identifying early effects of low BPA concentrations. The study is the first to localize and quantify the expression of cyp19a1a and cyp19a1b in the cells of brain and ovary after fish exposure to BPA.
AQUATIC TOXICOLOGY
(2021)
Article
Food Science & Technology
Ana M. Molina, Nieves Abril, Antonio J. Lora, Paula Huertas-Abril, Nahum Ayala, Carmen Blanco, M. Rosario Moyano
Summary: The study suggests that short-term exposure to low concentrations of BPA can have effects on ovarian follicular development in zebrafish at both histopathological and proteomic levels. Even inadvertent exposure to small amounts of BPA could lead to alterations in essential biological processes.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Juan Carlos Fernandez-Martin, Ana Maria Espinosa-Oliva, Irene Garcia-Dominguez, Isaac Rosado-Sanchez, Yolanda M. Pacheco, Rosario Moyano, Jose G. Monterde, Jose Luis Venero, Rocio M. de Pablos
Summary: This study investigates the role of galectin-3 (Gal3) in the development of endotoxemia and sepsis. The absence of Gal3 reduces mortality and tissue damage in a murine model of endotoxemia. Gal3 levels decrease in immune cells, particularly monocytes, after LPS injection, and Gal3 is up-regulated in peripheral organs. These findings suggest that Gal3 plays a significant role in systemic inflammation and may provide potential therapeutic options for sepsis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Lilian de Paula Goncalves Reis, Antonio Jesus Lora-Benitez, Ana Ma Molina-Lopez, Rafael Mora-Medina, Nahum Ayala-Soldado, Ma del Rosario Moyano-Salvago
Summary: This study assessed the toxic effects of BPA on reproduction and embryonic development in zebrafish. The results showed that embryos from fish exposed to BPA exhibited signs of embryotoxicity, and histopathological alterations were observed in the reproductive organs of the exposed fish. These findings suggest that BPA has a significant impact on fertility and viability of offspring.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Agriculture, Dairy & Animal Science
Francisca Bujalance-Reyes, Ana M. Molina-Lopez, Nahum Ayala-Soldado, Antonio Lora-Benitez, Rafael Mora-Medina, Rosario Moyano-Salvago
Summary: Bisphenol A (BPA) is a common environmental and food pollutant that both animals and humans are exposed to. By analyzing blood biochemistry and reproductive parameters, this study found that changes in glucose, total proteins, and albumin could potentially serve as early indicators of health issues caused by prolonged exposure to low doses of BPA.
Article
Food Science & Technology
Antonio Cascajosa-Lira, Silvia Pichardo, Alberto Banos, Enrique Guillamon, Veronica Molina-Hernandez, Rosario Moyano, Angeles Jos, Ana M. Camean
Summary: For the first time, acute and subchronic toxicity studies were conducted on the organosulfur compound PTS, demonstrating its safety in rats at certain doses with no significant adverse effects observed.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Veterinary Sciences
Nahum Ayala-Soldado, Antonio Jesus Lora-Benitez, Rafael Mora-Medina, Ana Ma Molina-Lopez, Jose Ignacio Artillo-Guimera, Ma Rosario Moyano-Salvago
Summary: Claviceps paspali is a fungus that parasitises Paspalum dilatatum, causing tremorgenic syndrome in cattle. This study describes a clinical case in a cattle farm in Seville, where the diagnosis was based on clinical inspection and identification of the fungus in paspalum seed heads. No effective treatment is currently available, but supportive treatment and different handling methods led to complete recovery of the animals.
VETERINARNI MEDICINA
(2022)
Article
Veterinary Sciences
Nahum Ayala-Soldado, Rafael Mora-Medina, Antonio Jesus Lora-Benitez, Lilian de Paula Goncalves Reis, Ana M. Molina-Lopez, M. del Rosario Moyano-Salvago
Summary: In animal experiments, measures should be taken to minimize pain and suffering while obtaining accurate experimental results. This study compares the efficacy of eugenol and MS-222 as euthanasia agents in zebrafish and evaluates their effects. Eugenol is found to be a stronger euthanasia agent, but it also causes branchial alterations and nerve tissue changes. MS-222 with a buffer enhances effectiveness and reduces severity of lesions, making it the most effective and safest euthanasia method for zebrafish research.
LABORATORY ANIMALS
(2023)
Article
Environmental Sciences
Antonio Casas-Rodriguez, Rosario Moyano, Veronica Molina-Hernandez, Ana Maria Camean, Angeles Jos
Summary: This study conducted uterotrophic bioassay in ovariectomized rats to investigate the estrogenic properties of MC-LR and CYN. The results showed no changes in uterus growth but potential thyroid disruption effects.
ENVIRONMENTAL RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Rafael Mora-Medina, Antonio Jesus Lora-Benitez, Ana Maria Molina-Lopez, Nahum Ayala-Soldado, Rosario Moyano-Salvago
Summary: In recent years, there has been a growing concern about milk pollution by aflatoxin M1 due to the increasing prevalence of aflatoxins in animal feeding and dairy product consumption. A study was conducted to determine the transfer of aflatoxin B1 into milk and its effects on production and serological parameters in goats. Goats were exposed to different doses of aflatoxin B1 for 31 days and the concentration of aflatoxin M1 in milk was found to significantly increase with the amount of aflatoxin B1 ingested. However, the ingested amount did not affect the aflatoxin M1 carryover, indicating a certain resistance of goats to the effects of aflatoxin B1.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Environmental Sciences
Antonio Cascajosa-Lira, Remedios Guzman-Guillen, Alberto Banos Arjona, Maria Arantzazu Aguinaga-Casanas, Nahum Ayala-Soldado, M. Rosario Moyano-Salvago, Ana Molina, Angeles Jos, Ana M. Camean, Silvia Pichardo
Summary: The organosulfur compound PTSO from Allium cepa has potential applications in the agrifood industry. In vivo study on mice showed that exposure to PTSO did not cause significant reproductive toxicity, confirming its safety for agrifood applications.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Ana M. Molina-Lopez, Francisca Bujalance-Reyes, Maria Teresa Urbano, Antonio Lora-Benitez, Nahum Ayala-Soldado, Rosario Moyano-Salvago
Summary: This study examined the effects of chronic exposure to different doses of BPA on blood biochemistry and tissue histology in mice. The results showed that low doses of BPA could inhibit hepatic gluconeogenesis, leading to hypoglycemia, and induce lipid synthesis, resulting in increased levels of blood lipids and cholesterol. Additionally, it was found that continuous exposure to BPA could potentially cause hepatic and renal dysfunction, indicated by alterations in blood biochemical parameters. However, no histological changes were observed in the pituitary and gonads.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
