Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors

Activation Route of the Schistosoma mansoni Cathepsin B1 Drug Target: Structural Map with a Glycosaminoglycan Switch

(2014) Adéla Jílková et al.   STRUCTURE

Trypsin- and Chymotrypsin-Like Serine Proteases in Schistosoma mansoni – ‘The Undiscovered Country’

(2014) Martin Horn et al.   PLoS Neglected Tropical Diseases

Parasite Prolyl Oligopeptidases and the Challenge of Designing Chemotherapeuticals for Chagas Disease, Leishmaniasis and African Trypanosomiasis

(2013) I. Bastos et al.   CURRENT MEDICINAL CHEMISTRY

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

(2013) Neil D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

Whole-genome sequence of Schistosoma haematobium

(2012) Neil D Young et al.   NATURE GENETICS

Investigation of the Proteolytic Functions of an Expanded Cercarial Elastase Gene Family in Schistosoma mansoni

(2012) Jessica R. Ingram et al.   PLoS Neglected Tropical Diseases

A Systematically Improved High Quality Genome and Transcriptome of the Human Blood Fluke Schistosoma mansoni

(2012) Anna V. Protasio et al.   PLoS Neglected Tropical Diseases

Mapping the Pro-Peptide of theSchistosoma mansoniCathepsin B1 Drug Target: Modulation of Inhibition by Heparin and Design of Mimetic Inhibitors

(2011) Martin Horn et al.   ACS Chemical Biology

Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke,Schistosoma mansoni

(2011) Adéla Jílková et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitors of Prolyl Oligopeptidases for the Therapy of Human Diseases: Defining Diseases and Inhibitors

(2010) Janice Lawandi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prolyl oligopeptidase of Trypanosoma brucei hydrolyzes native collagen, peptide hormones and is active in the plasma of infected mice

(2010) Izabela M.D. Bastos et al.   MICROBES AND INFECTION

RNA Interference in Schistosoma mansoni Schistosomula: Selectivity, Sensitivity and Operation for Larger-Scale Screening

(2010) Saša Štefanić et al.   PLoS Neglected Tropical Diseases

The Schistosoma japonicum genome reveals features of host–parasite interplay

(2009)   NATURE

The genome of the blood fluke Schistosoma mansoni

(2009) Matthew Berriman et al.   NATURE

Immunopathogenesis of human schistosomiasis

(2009) M. L. BURKE et al.   PARASITE IMMUNOLOGY

Reduced Susceptibility to Praziquantel among Naturally Occurring Kenyan Isolates of Schistosoma mansoni

(2009) Sandra D. Melman et al.   PLoS Neglected Tropical Diseases

Drug Discovery for Schistosomiasis: Hit and Lead Compounds Identified in a Library of Known Drugs by Medium-Throughput Phenotypic Screening

(2009) Maha-Hamadien Abdulla et al.   PLoS Neglected Tropical Diseases

Structure, Function and Biological Relevance of Prolyl Oligopeptidase

(2008) Laszlo Polgar et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

The generalized Born/volume integral implicit solvent model: Estimation of the free energy of hydration using London dispersion instead of atomic surface area

(2008) Paul Labute   JOURNAL OF COMPUTATIONAL CHEMISTRY