Article
Biochemistry & Molecular Biology
Stephane Fraga de Oliveira Tosta, Mariana Santana Passos, Rodrigo Kato, Alvaro Salgado, Joilson Xavier, Arun Kumar Jaiswal, Siomar C. Soares, Vasco Azevedo, Marta Giovanetti, Sandeep Tiwari, Luiz Carlos Junior Alcantara
Summary: Yellow fever is a re-emerging major health issue causing recent outbreaks with high mortality rates, mainly affecting tropical countries in Africa and South America. The development of a multi-epitope vaccine for Yellow fever virus using immunoinformatics approaches shows potential in stimulating both humoral and cellular immune responses, making it a candidate for further experimental validation.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Chemistry, Analytical
Ana Carolina Ferreira Balleste Ajorio, Vinicius Pessanha Rhodes, Anderson Peclat Rodrigues, Filipe Merces Moreira, Vanessa Alvaro Diniz, Josiane Machado Vieira Mattoso, Igor Barbosa da Silva, Daniel da Silva Guedes Junior, Marcelo Luiz Lima Brandao
Summary: This study evaluated the inactivation performance of hydrogen peroxide on the yellow fever virus, showing promising results in reducing virus titre at different concentrations and exposure times. Hydrogen peroxide could be a potential disinfectant for yellow fever virus elimination, with varying optimum concentration and contact time depending on the application type.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Review
Medicine, Research & Experimental
Wen-Hung Wang, Aspiro Nayim Urbina, Chih-Yen Lin, Zih-Syuan Yang, Wanchai Assavalapsakul, Arunee Thitithanyanont, Po-Liang Lu, Yen-Hsu Chen, Sheng-Fan Wang
Summary: The development of dengue vaccines is crucial in preventing and controlling the global health threat caused by Dengue virus. Current approved vaccines have demonstrated low efficacy in certain populations, leading to ongoing investigation and development of novel strategies for dengue vaccines.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Bharti Bhatia, Tsing-Lee Tang-Huau, Friederike Feldmann, Patrick W. Hanley, Rebecca Rosenke, Carl Shaia, Andrea Marzi, Heinz Feldmann
Summary: This study demonstrates the efficacy of a VSV-based vaccine in providing protection against KFDV and related diseases, and inducing cross-reactive immune responses.
Article
Biotechnology & Applied Microbiology
David W. Hawman, Kimberly Meade-White, Shanna Leventhal, Sofia Appelberg, Gustaf Ahlen, Negin Nikouyan, Chad Clancy, Brian Smith, Patrick Hanley, Jamie Lovaglio, Ali Mirazimi, Matti Sallberg, Heinz Feldmann
Summary: Crimean-Congo hemorrhagic fever virus (CCHFV) is widely distributed and can cause severe disease. Currently, there are no widely approved vaccines for CCHFV. However, a DNA-based vaccine has shown significant efficacy in cynomolgus macaques, providing protection with a two-dose regimen.
Article
Microbiology
Michael P. Doyle, Joseph R. Genualdi, Adam L. Bailey, Nurgun Kose, Christopher Gainza, Jessica Rodriguez, Kristen M. Reeder, Christopher A. Nelson, Prashant N. Jethva, Rachel E. Sutton, Robin G. Bombardi, Michael L. Gross, Justin G. Julander, Daved H. Fremont, Michael S. Diamond, James E. Crowe
Summary: Yellow fever virus (YFV) is a mosquito-borne virus that occasionally causes outbreaks of severe infection in South America and sub-Saharan Africa. Effective vaccines have been developed, but recent production and distribution issues have left many people vulnerable. This study aimed to isolate an antibody from individuals who had received the YFV vaccine for future use as a biologic drug. The most powerful antiviral antibody was found to be effective in animal models of human infection. These studies provide insights into the human immune response to YFV and offer a potential therapeutic antibody candidate for inhibiting highly virulent strains of the virus.
Article
Immunology
William C. Wilson, Bonto Faburay, Jessie D. Trujillo, Izabela Ragan, Sun-Young Sunwoo, Igor Morozov, Vinay Shivanna, Aaron Balogh, Kinga Urbaniak, D. Scott McVey, Dashzeveg Bold, Natasha N. Gaudreault, Erin E. Schirtzinger, Wenjun Ma, Juergen A. Richt
Summary: RVFV is a mosquito-borne virus that causes diseases in animals and humans in Africa, with no licensed vaccine available for humans. However, a vaccine based on Gn and Gc glycoproteins has shown promising results in protecting cattle from the virus in experimental studies.
Article
Immunology
Muhammad Tahir Ul Qamar, Saba Ismail, Sajjad Ahmad, Muhammad Usman Mirza, Sumra Wajid Abbasi, Usman Ali Ashfaq, Ling-Ling Chen
Summary: Crimean-Congo hemorrhagic fever (CCHF) is a severe viral disease with high mortality caused by CCHFV. A study proposed a multi-epitope vaccine (MEV) that covers 99.74% of the world population, showing high antigenic potential and no toxicity. The vaccine exhibited excellent binding affinity with immune receptors TLR2 and TLR3, suggesting potential for specific immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jolynne Mokaya, Derick Kimathi, Teresa Lambe, George M. Warimwe
Summary: Yellow fever remains a global health threat, with efforts to eliminate it by vaccinating one billion people at risk by 2026. The current vaccine provides good protection, but production challenges limit its use, leading to exploration of alternative dosing strategies. Understanding immune responses to vaccination and exploring antibody characteristics and cell-mediated immunity are important for developing a comprehensive understanding of protective immunity.
Article
Immunology
Nicola Douglass, Ruzaiq Omar, Henry Munyanduki, Akiko Suzuki, Warren de Moor, Paidamwoyo Mutowembwa, Alri Pretorius, Tshifhiwa Nefefe, Antoinette van Schalkwyk, Pravesh Kara, Livio Heath, Anna-Lise Williamson
Summary: Dual vaccines against lumpy skin disease (LSD) and bovine ephemeral fever (BEF) were constructed and tested in rabbit and cattle models, showing safety and efficacy in inducing neutralizing and T cell responses, providing protection against LSDV and BEFV.
Review
Immunology
Tong Chen, Zhe Ding, Jiaming Lan, Gary Wong
Summary: Increased human activities and rural development have raised the risk of human-wildlife contact, leading to zoonotic outbreaks of bunyaviruses. Development of vaccines for these pathogens has been limited by the scarcity of BSL-4 laboratories. However, innovative technologies like mRNA vaccines and bioinformatics-based antigen design offer potential solutions. This article summarizes current vaccine developments for Crimean-Congo Hemorrhagic Fever Virus, Rift Valley Fever Virus, and Hantaan virus, and provides perspectives for future advances.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Tianwen Lin, Jing Xing, Xiaoqian Tang, Xiuzhen Sheng, Heng Chi, Wenbin Zhan
Summary: In this study, a bicistronic DNA vaccine targeting the interferon regulatory factor 3 (IRF3) of pearl gentian grouper was successfully constructed. The vaccine expressed both capsid protein (CP) and IRF3 and elicited cellular, humoral, and local immune responses in the grouper, providing effective protection against NNV infection.
Article
Immunology
J. Xiang, Q. Chang, J. H. McLinden, N. Bhattarai, J. L. Welch, T. M. Kaufman, Jack T. Stapleton
Summary: Live attenuated vaccines such as the yellow fever virus vaccine can modulate immune functions, but they may also have off-target effects on T-cell receptor signaling, which could impact clinical outcomes.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Fabienne Piras-Douce, Karine Broudic, Emilie Chautard, Franck Raynal, Virginie Courtois, Sylviane Gautheron, Nathalie Mantel
Summary: The increased demand for yellow fever vaccines has led to global shortages. A new live-attenuated vaccine candidate called vYF, cloned from YF-17D vaccine substrain adapted for growth in Vero cells, showed safety and immunogenicity in cynomolgus macaques. vYF provided effective protection against wild-type YFV Asibi, similar to the currently marketed YF-17D vaccines.
Review
Immunology
Kerstin Kling, Cristina Domingo, Christian Bogdan, Steven Duffy, Thomas Harder, Jeremy Howick, Jos Kleijnen, Kevin McDermott, Ole Wichmann, Annelies Wilder-Smith, Robert Wolff
Summary: The duration of protection after a single dose of yellow fever vaccine is a topic of debate. A systematic literature review and meta-analysis revealed that the seroprotection rates after single vaccination dose were close to 100% within 3 months and remained high in adults for 5 to 10 years. However, the seroprotection rate for children vaccinated before age 2 years was 52% within 5 years after primary vaccination. Immunodeficient persons showed relevant waning of seroprotection. The extent of waning depends on age and immune status at primary vaccination.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Vanderlan Nogueira Holanda, Elton Marlon de Araujo Lima, Welson Vicente da Silva, Rafael Trindade Maia, Rafael de Lima Medeiros, Arabinda Ghosh, Vera Lucia de Menezes Lima, Regina Celia Bressan Queiroz de Figueiredo
Summary: This study aimed to identify 1,2,3-triazole-phthalimide derivatives as potential drug candidates against SARS-CoV-2 through in silico screening, docking, and molecular dynamics. Among 101 derivatives investigated, compounds with poor pharmacokinetic properties or toxicity were filtered out, and seven selected compounds showed promising interactions with multiple target proteins of SARS-CoV-2, indicating their potential as antiviral agents for COVID-19 treatment or prevention.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Virology
Iracema J. A. A. Jacques, Leila Katz, Marilia A. Sena, Ana B. G. Guimaraes, Yasmim L. Silva, Gabriela D. M. Albuquerque, Raisa O. Pereira, Camila A. M. C. de Albuquerque, Maria Almerice L. Silva, Paula A. S. Oliveira, Maria de Fatima P. M. Albuquerque, Marli T. Cordeiro, Ernesto T. A. Marques, Rafael F. O. Franca, Celina M. T. Martelli, Priscila M. S. Castanha, Cynthia Braga
Summary: This study focused on the diagnosis of arbovirus-related obstetric complications in high-risk pregnancy and childbirth care, particularly in a hospital in Brazil affected by Zika outbreak. The research found that a high percentage (93.1%) of pregnant women had previous DENV exposure, and 16.6% had recent ZIKV, CHIKV, and/or DENV infections, highlighting the importance of screening for arboviral infections in pregnant women with obstetrical complications.
Article
Infectious Diseases
Ricardo Arraes de Alencar Ximenes, Democrito de Barros Miranda-Filho, Ulisses Ramos Montarroyos, Celina Maria Turchi Martelli, Thalia Velho Barreto de Araujo, Elizabeth Brickley, Maria de Fatima Pessoa Militao de Albuquerque, Wayner Vieira Souza, Liana O. Ventura, Camila V. Ventura, Adriana L. Gois, Mariana C. Leal, Danielle Maria da Silva Oliveira, Sophie Helena Eickmann, Maria Durce C. G. Carvalho, Paula F. S. da Silva, Maria Angela Wanderley Rocha, Regina Coeli Ferreira Ramos, Sinval Pinto Brandao-Filho, Marli Tenorio Cordeiro, Luciana Caroline Albuquerque Bezerra, George Dimech, Sandra Valongueiro, Pedro Pires, Priscila Mayrelle da Silva Castanha, Rafael Dhalia, Ernesto Torres Azevedo Marques-Junior, Laura C. Rodrigues
Summary: This study delves into the risks and outcomes of Zika virus infection during pregnancy, using a variety of diagnostic methods to identify cases and finding that the infection can lead to various abnormalities in children.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Infectious Diseases
Ivonne Morales, Kerstin D. Rosenberger, Tereza Magalhaes, Clarice N. L. Morais, Cynthia Braga, Ernesto T. A. Marques, Guilherme Amaral Calvet, Luana Damasceno, Patricia Brasil, Ana Maria Bispo de Filippis, Sarah Bethencourt, Adriana Tami, Mayling Alvarez, Pedro A. Martinez, Maria G. Guzman, Bruno Souza Benevides, Andrea Caprara, Nguyen Thanh Ha Quyen, Cameron Simmons, Bridget Wills, Xavier de Lamballerie, Jan Felix Drexler, Thomas Jaenisch
Summary: This study evaluated three commercially available immunoassays for detecting ZIKV antibodies, with the IgAM test showing the best performance in detecting infections. The study was conducted in two different American countries with endemic arboviruses, and sequential blood samples allowed for evaluation of test performance over time. The IgAM assay exhibited superior sensitivity in detecting ZIKV infections compared to IgG and IgM assays, making it a promising candidate for serological monitoring in future ZIKV outbreaks.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Chemistry, Analytical
Barbara V. M. Silva, Marli T. Cordeiro, Marco A. B. Rodrigues, Ernesto T. A. Marques, Rosa F. Dutra
Summary: Zika virus (ZIKV) is a mosquito-borne infection associated with congenital disabilities, for which no vaccine is currently available. A new immunosensor utilizing NS2B for early diagnosis shows promise in differentiating ZIKV infection from dengue virus (DENV) infection.
Article
Biochemical Research Methods
Priscila D. Mendonca, Lorenna K. B. Santos, Marcos Foguel, Marco A. B. Rodrigues, Marli T. Cordeiro, Luis M. Goncalves, Ernesto T. A. Marques, Rosa F. Dutra
Summary: The incidence of dengue virus infection has grown dramatically worldwide, affecting 128 countries. The diagnosis is challenging due to similarities with other viruses such as Zika, and the underreporting of cases leads to potentially higher numbers of affected people. An immunosensor using carbon nanotube-ethylenediamine for NS1 detection shows promising results for diagnosis of dengue and Zika viruses.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Immunology
Jana L. Jacobs, William Bain, Asma Naqvi, Brittany Staines, Priscila M. S. Castanha, Haopu Yang, Valerie F. Boltz, Simon Barratt-Boyes, Ernesto T. A. Marques, Stephanie L. Mitchell, Barbara Methe, Tolani F. Olonisakin, Ghady Haidar, Thomas W. Burke, Elizabeth Petzold, Thomas Denny, Chris W. Woods, Bryan J. McVerry, Janet S. Lee, Simon C. Watkins, Claudette M. St Croix, Alison Morris, Mary F. Kearney, Mark S. Ladinsky, Pamela J. Bjorkman, Georgios D. Kitsios, John W. Mellors
Summary: This study found that SARS-CoV-2 vRNA was detected in the plasma of COVID-19 patients, with the highest rates in ICU patients. Higher levels of vRNA were associated with more severe disease, patient outcomes, and specific inflammatory biomarkers.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Deyzi Caroline da Silva Barbosa, Vanderlan Nogueira Holanda, Arabinda Ghosh, Rafael Trindade Maia, Welson Vicente da Silva, Vera Lucia de Menezes Lima, Marcia Vanusa da Silva, Maria Tereza dos Santos Correia, Regina Celia Bressan Queiroz de Figueiredo
Summary: The essential oil from Myrciaria floribunda fruits peel showed moderate cytotoxicity for Vero cells and macrophages, with potential as a Leishmania inhibitor. The major compound delta-Cadinene may be an effective inhibitor of TreR and C14DM enzymes, with favorable affinity energy values.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Immunology
Joao P. M. Brainer-Lima, Bruno H. S. Leite, Catarina M. C. S. de Araujo, Rafael Dhalia, Danilo F. Coelho, Franciane M. E. Teixeira, Anna Claudia C. C. Branco, Maria N. Sato, Ernesto T. A. Marques, Roberto D. Lins, Isabelle F. T. Viana
Summary: ZIKV infection may lead to NMOSD, but research suggests that it is not due to cross-reacting antibodies. However, persistent viral replication in eye tissue may be the cause of NMOSD symptoms.
JOURNAL OF NEUROIMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Ludmila Lobkowicz, Democrito de Barros Miranda-Filho, Ulisses Ramos Montarroyos, Celina Maria Turchi Martelli, Thalia Velho Barreto de Araujo, Wayner Vieira De Souza, Luciana Caroline Albuquerque Bezerra, Rafael Dhalia, Ernesto T. A. Marques, Nuria Sanchez Clemente, Jayne Webster, Aisling Vaughan, Emily L. Webb, Elizabeth B. Brickley, Ricardo Arraes de Alencar Ximenes
Summary: The co-circulation of arthropod-borne viruses, including Zika and Chikungunya, is increasingly common. This study investigated the geographic and temporal distribution of these infections during pregnancy and found that clinical symptoms alone may not be sufficient for differentiating Zika and Chikungunya infections. Laboratory diagnostics remain important in these cases.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Behavioral Sciences
Jose R. de Oliveira-Santos, Regina C. Bressan Queiroz de Figueiredo, Geraldo J. Barbosa de Moura
Summary: This study analysed the defence mechanisms of Leptodactylus vastus, a species of anuran, and found multiple strategies including body puffing, push movement, distress call, hiding, cloacal discharge, and spine aggression. The distress call of this species was found to have no acoustic variation. Understanding the defensive mechanisms of animals is important for identifying antipredatory strategies and conservation efforts for neotropical species.
ETHOLOGY ECOLOGY & EVOLUTION
(2023)
Article
Immunology
Priscila M. S. Castanha, Dylan J. Tuttle, Georgios D. Kitsios, Jana L. Jacobs, Ulisses Braga-Neto, Matthew Duespohl, Sanjay Rathod, Michelle M. Marti, Sarah Wheeler, Asma Naqvi, Brittany Staines, John Mellors, Alison Morris, Bryan J. McVerry, Faraaz Shah, Caitlin Schaefer, Bernard J. C. Macatangay, Barbara Methe, Christian A. Fernandez, Simon M. Barratt-Boyes, Donald Burke, Ernesto T. A. Marques
Summary: This study reveals that the classical pathway mediates complement overactivation in response to increased levels of circulating immune complexes, leading to the severity of COVID-19. Early non-neutralizing IgG responses play a crucial role in complement overactivation.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Franciane Mouradian Emidio Teixeira, Luana de Mendonca Oliveira, Anna Julia Pietrobon, Erika Machado de Salles, Maria Regina D'Imperio Lima, Isabelle Freire Tabosa Viana, Roberto Dias Lins, Paula Ordonhez Rigato, Ernesto Torres de Azevedo Marques, Alberto Jose da Silva Duarte, Maria Notomi Sato
Summary: Neonatal immunization with a LAMP-1/p55Gag DNA vaccine can enhance antibody production and contribute to the development of new vaccine approaches for other emerging pathogens in early life.
Letter
Medicine, General & Internal
Denis Y. Logunov, David M. Livermore, David A. Ornelles, Wibke Bayer, Ernesto Marques, Cecil Czerkinsky, Inna V. Dolzhikova, Hildegund C. J. Ertl
Article
Biochemistry & Molecular Biology
Felix F. Loeffler, Isabelle F. T. Viana, Nico Fischer, Danilo F. Coelho, Carolina S. Silva, Antonio F. Purificacao, Catarina M. C. S. Araujo, Bruno H. S. Leite, Ricardo Duraes-Carvalho, Tereza Magalhaes, Clarice N. L. Morais, Marli T. Cordeiro, Roberto D. Lins, Ernesto T. A. Marques, Thomas Jaenisch
Summary: This study characterized antibody responses in Zika-infected individuals and identified a potential biomarker, the NS2B epitope, for diagnosing and predicting Zika-associated neurological disease. The differential IgG profiles between non-severe and severe infections were confirmed through peptide arrays and multivariate data analysis. The study also computationally engineered an artificial protein to stabilize the NS2B epitope structure and confirmed its absence in samples with Zika-associated microcephaly.
RSC MEDICINAL CHEMISTRY
(2021)