期刊
TOXICOLOGY LETTERS
卷 224, 期 1, 页码 141-146出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2013.10.018
关键词
BFR; NBFR; TBB; TBCO; TBPH; In vitro steroidogenesis
类别
资金
- Natural Science and Engineering Research Council of Canada [406497]
- Canada Foundation for Infrastructure
- Canada Research Chair program
- State Key Laboratory in Marine Pollution, City University of Hong Kong, The Einstein Professor Program of the Chinese Academy of Sciences
Brominated flame retardants are chemicals with fire quenching properties which are extensively used in manufacturing. Historically, less regulated use of legacy brominated flame retardants (BFRs) for a number of years has resulted in ubiquitous contamination of the environment. As a result, some of the more persistent BFRs have been phased out and are being replaced by a next generation of brominated compounds for which there is little toxicological data. The study investigated effects of 2-ethylhexyl tetrabromobenzoate (TBB), 1,2,5,6-tetrabromocyclooctane (TBCO), and bis-(2-ethylhexyl) tetrabromophthalate (TBPH) on steroidogenesis in a porcine primary testicular cell model. TBB did not affect sex-steroid production in this cell model; rather the data suggest a flux towards synthesis of aldosterone and cortisol via up-regulation of CYP21A2. At the greatest concentrations of TBCO and TBPH tested greater production of sex hormones testosterone (T) and estradiol (E2) was observed. Effects were mediated by regulation of multiple molecular targets in the steroidogenesis pathway; CYP11A in the case of TBPH and CYP17A1 in the case of TBCO. This investigation is the first of its kind to use a testicular mixed population cell model to investigate mechanism( s) of action of three chemically diverse compounds currently used in commercial fire retardants. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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