Review
Environmental Sciences
Helle Raun Andersen, Loic Rambaud, Margaux Riou, Jurgen Buekers, Sylvie Remy, Tamar Berman, Eva Govarts
Summary: Urinary concentrations of pesticides are useful biomarkers for integrated exposure, but there are regional differences and inconsistencies in studies. The general EU population shows widespread exposure to these pesticides, indicating the need for harmonization of methods and reporting.
Article
Environmental Sciences
Wojciech Rodzaj, Malwina Wilenska, Anna Klimowska, Emila Dziewirska, Joanna Jurewicz, Renata Walczak-Jedrzejowska, Jolanta Slowikowska-Hilczer, Wojciech Hanke, Bartosz Wielgomas
Summary: Pyrethroid insecticides are widely used and may pose a threat to human health. A study in Lodz, Poland found that non-dietary factors such as owning a dog, using pesticides on household pets, and dietary sources like seeds and nuts can significantly contribute to pyrethroid exposure in young men.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Yan Li, Xianyu Wang, Jean Feary McKenzie, Andreat Mannetje, Soo Cheng, Chang He, Janet Leathem, Neil Pearce, Jordi Sunyer, Brenda Eskenazi, Ruby Yeh, Lesa L. Aylward, Geoffrey Donovan, Jochen F. Mueller, Jeroen Douwes
Summary: This study aimed to assess pesticide exposure and its determinants in children aged 5-14 years. The study found that New Zealand children had relatively high exposures to chlorpyrifos/triclopyr and pyrethroids, and factors such as season, area of residence, diet, in-home pest control, and pets were associated with exposure.
ENVIRONMENT INTERNATIONAL
(2022)
Review
Environmental Sciences
Antonio J. Signes-Pastor, Enrique Gutierrez-Gonzalez, Miguel Garcia-Villarino, Francisco D. Rodriguez-Cabrera, Jorge J. Lopez-Moreno, Elena Varea-Jimenez, Roberto Pastor-Barriuso, Marina Pollan, Ana Navas-Acien, Beatriz Perez-Gomez, Margaret R. Karagas
Summary: This systematic review highlights the reliability of toenail arsenic concentrations as biomarkers of long-term exposure, showing influences from geographic locations and sources of arsenic contamination. Notably, toenail arsenic levels correlate with concentrations in hair, fingernails, and urine, suggesting its potential as an indicator of long-term internal dose-exposure.
ENVIRONMENTAL RESEARCH
(2021)
Review
Environmental Sciences
Henriqueta Louro, Bruno Costa Gomes, Anne Thoustrup Saber, Anna Laura Iamiceli, Thomas Goen, Kate Jones, Andromachi Katsonouri, Christiana M. Neophytou, Ulla Vogel, Celia Ventura, Axel Oberemm, Radu Corneliu Duca, Mariana F. Fernandez, Nicolas Olea, Tiina Santonen, Susana Viegas, Maria Joao Silva
Summary: This comprehensive review aims to provide regulators and policymakers with a comprehensive overview of occupational exposure to polycyclic aromatic hydrocarbons (PAHs), including the use of exposure and effect biomarkers, as well as the knowledge needs for regulation. The review highlights the importance of advancing harmonized approaches in data and sample collection, as well as the use of appropriate biomarkers in occupational studies to obtain reliable and comparable data on PAH exposure.
Review
Environmental Sciences
Mostafa Hadei, Abbas Shahsavani, Philip K. Hopke, Simin Naseri, Ahmadreza Yazdanbakhsh, Mohsen Sadani, Alireza Mesdaghinia, Maryam Yarahmadi, Masoumeh Rahmatinia, Sevda Fallah, Bahaaran Emam, Majid Kermani, Nemat Jaafarzadeh, Mohammadreza Alipour, Vajihe Hassanzadeh, Shahriyar Bazzazpour, Seyed Saeed Hashemi Nazari
Summary: This study systematically reviewed biomonitoring studies on carcinogen environmental pollutants in Iran, finding high concentrations of cadmium and arsenic in breast milk. The results highlighted the need for comprehensive action plans to reduce population exposure to these environmental contaminants.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Environmental Sciences
Inmaculada Salcedo-Bellido, Enrique Gutierrez-Gonzalez, Esther Garcia-Esquinas, Nerea Fernandez de Larrea-Baz, Ana Navas-Acien, Maria Tellez-Plaza, Roberto Pastor-Barriuso, Virginia Lope, Jose Luis Gomez-Ariza, Tamara Garcia-Barrera, Marina Pollan, Jose Juan Jimenez Moleon, Beatriz Perez-Gomez
Summary: Toenails have been used as biomarkers of exposure to toxic metals, but their validity is still unclear and needs further research. Different toxic metals may have varying levels of validity as biomarkers in toenails. Lack of standardization and conflicting results among studies make it difficult to conclude whether toenails are a reliable biomarker of exposure to toxic metals.
ENVIRONMENTAL RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Yelian Marc Bossou, Jonathan Cote, Eloise Morin, Etienne Dumais, Clara Bianchi, Michele Bouchard
Summary: This study aimed to assess the impact of combined exposure to two pesticides on the levels of pyrethroid pesticide biomarkers in agricultural workers. The results showed that coexposure did not significantly affect the urinary levels of the biomarkers, while the occupational task and time variability were important predictors.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Review
Food Science & Technology
Kristina Habschied, Gabriella Kanizai Saric, Vinko Krstanovic, Kresimir Mastanjevic
Summary: Mycotoxins are secondary metabolites produced by fungi that have a toxic effect on human and animal health. Biomonitoring of mycotoxins in plasma, serum, urine, and blood samples has become a common method for determining exposure, with novel techniques aiming toward simultaneous determination of multiple mycotoxins. Liquid chromatography (LC) methodologies coupled with tandem mass spectrometry (MS/MS) or high-resolution mass spectrometry (HRMS) are now the most reliable method for determining mycotoxin exposure.
Article
Toxicology
Kuen-Yuh Wu, Chia-Fang Wu, Yu-Syuan Luo, Yu-Fang Huang, Shi-Nian Uang, Yen-Yi Lee, Su-Yin Chiang
Summary: This study assessed the potential biomarkers of acrylonitrile (AN) exposure by analyzing urinary mercapturic acids (CEMA, CHEMA, HEMA) and cotinine in AN-exposed and non-exposed factory workers. The results showed that urinary CEMA and CHEMA levels were linearly correlated with AN exposure, suggesting their potential as chemically-specific biomarkers for AN exposure. Additionally, cotinine was found to be a biomarker of cigarette smoke exposure for non-exposed workers.
TOXICOLOGY LETTERS
(2023)
Article
Environmental Sciences
Camila L. Bastolla, Miguel Saldana-Serrano, Daina Lima, Jaco J. Mattos, Carlos H. A. M. Gomes, Herculano Cella, Barbara P. H. Righetti, Clarissa P. Ferreira, Flavia L. Zacchi, Marcia C. Bicego, Satie Taniguchi, Afonso C. D. Bainy
Summary: This study investigated the molecular responses of oysters in potentially contaminated areas of oyster farming in Santa Catarina Island, Brazil. The results suggest that human-derived contaminants are affecting the oyster metabolism in some farming areas.
Article
Food Science & Technology
Barbara De Santis, Francesca Debegnach, Piero Toscano, Alfonso Crisci, Paola Battilani, Carlo Brera
Summary: This study revealed the exposure scenario to mycotoxins of adult population throughout Europe, with a concern for public health about AFM1, FBs, T2/HT2, and NIV. OTA and DON were prevalent in Northern countries, while ZEN was higher in Southern countries.
Article
Toxicology
Yelian Marc Bossou, Jonathan Cote, Louiza Mahrouche, Marc Mantha, Naima El Majidi, Alexandra Furtos, Michele Bouchard
Summary: Limited literature data on the impact of coexposure on the toxicokinetics of pesticides in agricultural workers are available. This study investigated the individual temporal profiles of biomarkers of exposure to a pyrethroid (lambda-cyhalothrin) and a fungicide (captan) in strawberry field workers. The results suggested that coexposure was not a major determinant of variability in exposure biomarker levels.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Environmental Sciences
Borja Peris-Camarasa, Olga Pardo, Sandra F. Fernandez, Pablo Dualde, Clara Coscolla
Summary: AA is a potentially carcinogenic chemical compound found in processed foods and tobacco smoke. It is primarily eliminated from the body through urine, and its metabolites serve as biomarkers for exposure. The study found that smoking and consumption of fried potato products, biscuits, and pastries were significant predictors of AA exposure.
ENVIRONMENTAL POLLUTION
(2023)
Article
Agriculture, Multidisciplinary
Dawei Chen, Jingguang Li, Yunfeng Zhao, Yongning Wu
Summary: This article summarizes potential human exposures to Fipronil and results of human biomonitoring studies, emphasizing the importance of such studies for assessing Fipronil exposure and human health risks.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemical Research Methods
Martyna Piotrowska, Krzesimir Ciura, Michalina Zalewska, Marta Dawid, Bruna Correia, Paulina Sawicka, Bogdan Lewczuk, Joanna Kasprzyk, Laura Sola, Wojciech Piekoszewski, Bartosz Wielgomas, Krzysztof Waleron, Szymon Dziomba
JOURNAL OF CHROMATOGRAPHY A
(2020)
Article
Pharmacology & Pharmacy
Dominika Krenczkowska, Krystyna Mojsiewicz-Pienkowska, Bartosz Wielgomas, Dagmara Bazar, Zbigniew Jankowski
Article
Environmental Sciences
Pawel Radwan, Bartosz Wielgomas, Michal Radwan, Rafal Krasinski, Anna Klimowska, Radoslaw Zajdel, Dorota Kaleta, Joanna Jurewicz
Summary: This study examined the association between urinary concentration of triclosan and in vitro reproductive outcomes among women undergoing IVF treatment, finding that urinary concentrations of triclosan were associated with a decrease in implantation rate but not with other examined IVF outcomes. Studies among larger and more diverse population are needed to confirm the results, as this is one of the first studies on this topic.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Reproductive Biology
Pawel Radwan, Bartosz Wielgomas, Michal Radwan, Rafal Krasinski, Anna Klimowska, Dorota Kaleta, Joanna Jurewicz
REPRODUCTIVE TOXICOLOGY
(2020)
Article
Chemistry, Analytical
Aleksandra Pawelec, Bartosz Wielgomas
Summary: This study aimed to develop and validate a method for analyzing fragrance allergens in aromas for e-cigarettes. Thirteen fragrance allergens were detected using gas chromatography, showing that concentrations of fragrances in aromas for e-cigarettes can be high and varies among products.
JOURNAL OF SEPARATION SCIENCE
(2021)
Article
Nutrition & Dietetics
Aleksandra Medza, Katarzyna Kazmierska, Bartosz Wielgomas, Lucyna Konieczna, Ilona Oledzka, Agnieszka Szlagatys-Sidorkiewicz, Katarzyna Sznurkowska
Summary: This study aimed to compare the nutritional status between deltaF508 CFTR heterozygous and homozygous paediatric patients with cystic fibrosis. The results showed no significant differences in serum vitamins or erythrocyte membrane fatty acid profiles between the two patient groups, and there were also no significant differences in height, weight, and BMI percentiles. Patients with cystic fibrosis, whether heterozygous or homozygous, had similar nutritional statuses.
Article
Biochemical Research Methods
Szymon Dziomba, Magdalena Wysocka, Joanna Jonca, Laura Sola, Aleksandra Stec, Krzysztof Waleron, Bartosz Wielgomas
Summary: The study evaluated the impact of selected parameters of CZE method on OMVs isolate analysis, finding that extending the sample injection plug length significantly improves the detectability of macromolecular aggregates in CZE, with negligible adsorption of OMVs to capillary walls. Additionally, the relaxation effect and deformation/polarization of vesicles were shown to affect OMVs electrophoretic mobility.
Article
Environmental Sciences
Wojciech Rodzaj, Malwina Wilenska, Anna Klimowska, Emila Dziewirska, Joanna Jurewicz, Renata Walczak-Jedrzejowska, Jolanta Slowikowska-Hilczer, Wojciech Hanke, Bartosz Wielgomas
Summary: Pyrethroid insecticides are widely used and may pose a threat to human health. A study in Lodz, Poland found that non-dietary factors such as owning a dog, using pesticides on household pets, and dietary sources like seeds and nuts can significantly contribute to pyrethroid exposure in young men.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Ewelina Czubacka, Bartosz Wielgomas, Anna Klimowska, Michal Radwan, Pawel Radwan, Anetta Karwacka, Pawel Kaluzny, Joanna Jurewicz
Summary: This study found a negative association between BPA exposure and women's ovarian reserve parameters (AMH and AFC), with no relationship with other parameters (FSH, E2). These findings suggest that BPA exposure may have an impact on ovarian reserve, but further confirmation is needed.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Environmental Sciences
Malgorzata Waclawik, Wojciech Rodzaj, Bartosz Wielgomas
Summary: Researchers have shown an increasing interest in tracking personal exposure to multiple chemicals over time. Silicone wristbands have emerged as a valuable tool for assessing chemical risks in various environments. However, there is a lack of detailed information on the methods and a comprehensive comparison with other approaches. This review summarizes the current research using silicone wristbands as passive samplers, discusses the steps involved in obtaining exposure data, compares the characteristics of wristbands with other matrices for exposure assessment, and highlights the future research needs.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Aleksandra Stec, Joanna Jonca, Krzysztof Waleron, Malgorzata Waleron, Agata Ploska, Leszek Kalinowski, Bartosz Wielgomas, Szymon Dziomba
Summary: This study isolated EVs from Pectobacterium zantedeschiae culture media using different ultracentrifugation techniques and characterized them using BCA, NTA, and CE. The results showed that there was a satisfactory correlation between quantitative results obtained with BCA, NTA, and CE only for isolates obtained with the IDGUC. Moreover, NTA was found to be unable to provide reliable information on EVs quantity in samples isolated with UC and ICUC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Anna Klimowska, Evelien Wynendaele, Bartosz Wielgomas
Summary: The aim of this study was to develop an analytical method for quantifying and assessing the stability of 26 phenolic and acidic biomarkers of environmental pollutants in human urine. The method involved solid-phase extraction coupled with gas chromatography and tandem mass spectrometry (SPE-GC/MS/MS). The results showed satisfactory accuracy, precision, and limits of quantification for the biomarkers, and the method was successfully used for quantification in 38 urine samples.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Anna Hering, Justyna Stefanowicz-Hajduk, Magdalena Gucwa, Bartosz Wielgomas, Jadwiga Renata Ochocka
Summary: This study investigated the biological effects of fermented honeybush extracts, which are derived from an African shrub known for its high polyphenol content. The extracts were found to inhibit certain enzymes responsible for skin malfunction and aging, such as collagenase, elastase, tyrosinase, and hyaluronidase. The extracts also demonstrated potential for wound healing and sun protection, as well as strong antioxidant properties. These findings highlight the potential of honeybush extracts as anti-aging, anti-inflammatory, and skin-protective agents.
Article
Chemistry, Multidisciplinary
Hannah Hirmz, Frederick Verbeke, Bartosz Wielgomas, Christophe Furman, Emmanuelle Lipka, Bart De Spiegeleer, Evelien Wynendaele
Summary: Green chemistry initially focused on organic synthetic approaches, and now green analytics is also seeking ways to reduce volumes, cost, and ecotoxicity of analytically used chemicals and lower energy usage. The current emphasis is on techniques like miniaturization, on-line spectroscopy, and chemicals used in the analytical process. However, little attention has been given to the production and use of analytical reagents in greening analytics.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Article
Engineering, Environmental
Ivan Liakh, Darya Harshkova, Pavel Hrouzek, Katerina Bisova, Anna Aksmann, Bartosz Wielgomas
Summary: The use of unicellular algae for removing xenobiotics from wastewaters is a rapidly developing field in environmental protection. Efficient phycoremediation requires biosorption, bioaccumulation, and biotransformation. However, the potential toxicity of biotransformation products and the resistance of analyzed algae strains to the mixture of compounds need to be considered. In this study, Chlamydomonas reinhardtii showed promise in removing diclofenac, a non-steroidal anti-inflammatory drug, through biosorption, bioaccumulation, and biotransformation processes.
JOURNAL OF HAZARDOUS MATERIALS
(2023)