Article
Pharmacology & Pharmacy
Zhihui Liu, Bendong Shi, Yu Wang, Qingyang Xu, Hongxin Gao, Jun Ma, Xiaowen Jiang, Wenhui Yu
Summary: Curcumin has been shown to alleviate aristolochic acid I-induced renal injury in rats by activating the SIRT1/Nrf2/HO-1 signaling pathway.
Article
Biochemistry & Molecular Biology
Ruiran Wei, Yueqin Zhao, Juan Wang, Xu Yang, Shunlin Li, Yinyuan Wang, Xingzhi Yang, Jimin Fei, Xiaojiang Hao, Yuhan Zhao, Liming Gui, Xiao Ding
Summary: Colorectal cancer (CRC) is a common malignant tumor and traditional treatments have limited efficacy. Ferroptosis, a form of regulated cell death dependent on iron and reactive oxygen species (ROS), has been studied as a promising way to fight against resistant cancers. This study explored the mechanism of action of tagitinin C (TC), a natural product, as a novel ferroptosis inducer in CRC cells, showing that TC induces ferroptosis through ER stress-mediated activation of the PERK-Nrf2-HO-1 signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Juan Chen, Lijun Xiao, Ying Chen, Wei Li, Yinan Liu, Fang Yi, Ying Zhou, Hong Tan
Summary: This study assessed the effects of butylphthalide on cognitive deficiencies caused by sleep deprivation. The results showed that butylphthalide improved cognitive decline, reduced neuronal degeneration, apoptosis, and inflammation in the hippocampus. Activation of the Nrf2/HO-1 pathway was involved in the protective effects of butylphthalide.
Article
Immunology
Sameh S. Zaghlool, Nashwa Abdelaal, Ehab A. M. El-Shoura, Nesreen I. Mahmoud, Yasmin M. Ahmed
Summary: This study found that sulforaphane (SFN) has a protective effect against folic acid-induced acute renal injury through its antioxidant, anti-inflammatory, and anti-apoptotic activities, thus providing a potential therapeutic strategy for preventing such injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Environmental Sciences
Dan Wang, Jieyu Liu, Hong Jiang
Summary: Triclosan (TCS), a broad-spectrum antimicrobial agent, is recognized as an environmental endocrine disruptor causing pollution and potential threat to human health. This study found that TCS-induced oxidative damage in HT-22 neurons is associated with the activation of the PI3K/Akt/JNK/Nrf2/HO-1 signaling cascade.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Immunology
Aya Khaleel, Ahmed R. El-Sheakh, Ghada M. Suddek
Summary: This study aimed to explore the possible protective effect of celecoxib, a cyclooxygenase-2 inhibitor, on immunological responses elicited in a mouse model of autoimmune hepatitis. Results showed that celecoxib significantly protected the liver from ConA-induced damage, improved antioxidant capacity, and inhibited inflammation and apoptosis. Moreover, celecoxib modulated multiple signaling pathways, leading to liver protection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Xin Wang, Tingbo Ye, Bingqian Xue, Meihua Yang, Rui Li, Xiaohui Xu, Xin Zeng, Na Tian, Liming Bao, Yi Huang
Summary: Deficiency of GRIM-19 correlates with poor survival outcomes in GC patients, and DNA hypermethylation is associated with downregulation of GRIM-19. GRIM-19 deficiency promotes GC metastasis through aberrant oxidative stress and ROS-dependent activation of the NRF2-HO-1 axis.
Article
Biochemistry & Molecular Biology
Sariya Meephat, Patoomporn Prasatthong, Prapassorn Potue, Sarawoot Bunbupha, Poungrat Pakdeechote, Putcharawipa Maneesai
Summary: Diosmetin demonstrated a reduction in blood pressure and alleviation of vascular abnormalities in experimentally hypertensive rats by exerting antioxidant and anti-inflammatory effects, and modulating the expression of Nrf2/HO1 and p-JNK/NF-kappa B proteins.
Article
Plant Sciences
Yanfen Cheng, Xiaoping Wu, Xin Nie, Yihan Wu, Chen Zhang, Simon Ming-Yuen Lee, Kongpeng Lv, George Pak-Heng Leung, Chaomei Fu, Jinming Zhang, Jingjing Li
Summary: Glycyrrhetinic acid (GA) protects against doxorubicin-induced cardiotoxicity by suppressing oxidative stress, mitochondrial dysfunction, and apoptosis via upregulating the Nrf2/HO-1 signaling pathway.
Article
Gastroenterology & Hepatology
Alessio Lepore, Pui Man Choy, Nathan C. W. Lee, Maria Annunziata Carella, Rosy Favicchio, Marco A. Briones-Orta, Shannon S. Glaser, Gianfranco Alpini, Clive D'Santos, Reuben M. Tooze, Mihaela Lorger, Wing-Kin Syn, Athanasios Papakyriakou, Georgios Giamas, Concetta Bubici, Salvatore Papa
Summary: The study found that activation of the JNK pathway promotes ICC cell proliferation by affecting the stability of PIN1, and highlights the JNK-PIN1 regulatory axis as an important factor in ICC growth.
Article
Medicine, Research & Experimental
Emad H. M. Hassanein, Islam M. Ibrahim, Esraa K. Abd-alhameed, Zeina W. Sharawi, Fatima A. Jaber, Hanan S. Althagafy
Summary: Chronic kidney disease (CKD) is a common chronic disease that can lead to kidney failure and death. Renal fibrosis, caused by oxidative stress and inflammation, is a key characteristic of CKD. The activation of Nrf2/HO-1 signal pathway has shown promising results in protecting the kidneys against fibrosis induced by oxidative stress and inflammation. This review summarizes studies on Nrf2/HO-1 and explores potential bioactive compounds that may attenuate renal fibrosis through HO-1 activation.
Article
Immunology
Tianxiang Yu, Xiangwei Xu, Jiajia Wei, Jiachen Xu, Wu Luo, Ankang Li, Guang Liang, Mengyang Wang
Summary: This study evaluated the effects of ginsenoside Rg5 on Ang II-induced cardiac remodeling and heart failure. It was found that Rg5 inhibited cardiac inflammation, myocardial fibrosis, and hypertrophy, and prevented cardiac malfunction in mice challenged with Ang II, through the JNK/AP-1 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Qing Xia, Shuo Gao, Samuel Rajendran Rapael Gnanamuthu, Kaiyan Zhuang, Zhenzhen Song, Yun Zhang, Xue Wang, Pengfei Tu, Jianheng Li, Kechun Liu
Summary: Aconitine (AC) exerts severe toxic effects on zebrafish embryo development, including cardiac, liver, and neurodevelopment impairment, as well as ROS-mediated mitochondrial apoptosis. High-concentration AC exposure results in deficient cardiovascular system and cell apoptosis in the heart and brain regions.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Genetics & Heredity
Jielian Wu, Rong Lv, Linhan Qiu, Shuangping Zhang, He Jiao, Yanrui Wang, Shanshan Luo, Haihong Fang, Chungen Wen
Summary: In response to stress, cells activate the Nrf2/Keap1 pathway to protect against oxidative damage. JNK regulates the Nrf2/ARE signaling pathway and NQO1 plays a vital role in removing peroxide and providing resistance to oxidative injury.
Article
Immunology
Yuan An, Qiang Luo, Donghai Han, Lianyue Guan
Summary: This study found that abietic acid has a protective effect on acetaminophen-induced liver injury by reducing inflammation and ferroptosis. It can inhibit NF-KB activation and increase the expression of Nrf2 and HO-1. The results in Nrf2-/- mice and in vitro experiments confirmed the therapeutic effects of abietic acid.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
