Review
Immunology
Jonathan Howard DeLong, Sarah Naomi Ohashi, Kevin Charles O'Connor, Lauren Hachmann Sansing
Summary: Ischemic stroke triggers an immune response that affects neuronal loss and tissue repair outside of the central nervous system. While specific aspects of this response have been addressed in recent reviews, it has been several years since a high-level review has summarized the overall state of the field. This review aims to provide an unbiased summary of recent research advances, highlighting valuable discoveries and identifying knowledge gaps that have the potential to improve our understanding of the disease and patient outcomes.
SEMINARS IN IMMUNOPATHOLOGY
(2022)
Article
Engineering, Biomedical
A. Kirschbaum, Th. M. Surowiec, A. Pehl, Th. Wiesmann, D. K. Bartsch, N. Mirow
Summary: The study investigated the potential air leakage following non-anatomical lung parenchyma resection with a Nd:YAG laser, finding that additional coagulation can reduce air leakage and increase the thickness of the coagulation layers.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Endocrinology & Metabolism
Ruslan Rust, Mea M. Holm, Matteo Egger, Oliver Weinmann, Danielle van Rossum, Fruzsina R. Walter, Ana Raquel Santa-Maria, Lisa Gronnert, Michael A. Maurer, Simon Kraler, Alexander Akhmedov, Rose Cideciyan, Thomas F. Luscher, Maria A. Deli, Inge K. Herrmann, Martin E. Schwab
Summary: Nogo-A is a protein with multiple functions in the central nervous system, and it can be secreted by neuronal and glial cells in association with extracellular vesicles. These Nogo-A-containing vesicles can inhibit fibroblast spreading. Additionally, Nogo-A concentrations in the blood are elevated after acute stroke lesions, and Nogo-A active peptides can decrease blood-brain barrier integrity and increase dye permeability in peripheral organs.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Kun Zhang, Shaoqiang Lian, Xiaoyang Shen, Xinhao Zhao, Weidong Zhao, Chunli Li
Summary: This study explores the immunomodulatory activity and mechanisms of recombinant pBD2 against Escherichia coli infection. The results show that pBD2 can reduce the adhesion of E. coli to cells and restore the abnormal expression of ZO-1 and occludin. Additionally, pBD2 can also reduce cell apoptosis and inflammatory responses, acting through the TAK1-NF-κB signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Infectious Diseases
Cordilia Himwaze, Luchenga Adam Mucheleng'anga, Victor Telendiy, Amos Hamukale, John Tembo, Nathan Kapata, Francine Ntoumi, Alimuddin Zumla
Summary: Cysticercosis is a neglected human zoonosis with significant impact on sudden and unexpected deaths in the community, especially cardiac cysticercosis. This study identified nine cases of cysticercosis in Lusaka, Zambia, with most patients having cardiac cysticercosis, highlighting the potential issue of undiagnosed communicable diseases leading to death.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Food Science & Technology
Shen Zhuang, Ke Ming, Ning Ma, Jinrui Sun, Dehai Wang, Mingxing Ding, Yi Ding
Summary: A specific polysaccharide fraction (POPZ) from Portulaca oleracea L. was found to inhibit LPS-induced barrier injury and inflammatory responses in porcine intestinal epithelial monolayer, possibly through inactivating TLR4/NF-κB pathway and activating EGF/EGFR pathway.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Virology
Jingbo Hu, Chenxi Li, Yanyang Zhou, Jingjing Ding, Xiangdong Li, Yanhua Li
Summary: Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly significant pathogen in the swine industry with no approved antiviral drug for its control. This study demonstrates that allicin, a compound found in garlic, exhibits antiviral activity against PRRSV by inhibiting viral entry, replication, and assembly. Allicin also alleviates the inflammatory response induced by PRRSV infection, making it a promising candidate for anti-PRRSV therapy.
Article
Endocrinology & Metabolism
Liyin Zhang, Sherif Rashad, Yuan Zhou, Kuniyasu Niizuma, Teiji Tominaga
Summary: RNF213 gene mutations are found to be responsible for Moyamoya disease, a rare cerebrovascular occlusive disease. This study investigated the function of RNF213 in the vascular system by performing gene knockdown experiments in vascular cells. The results showed that RNF213 knockdown disrupted angiogenesis in HUVEC cells and sensitized them to inflammation. The study also revealed extensive changes in mRNA splicing and alterations in cytoskeletal organization and function in vSMCs after RNF213 knockdown. Furthermore, RNF213 knockdown disrupted endothelial-to-vSMCs communication in co-culture models.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Multidisciplinary Sciences
Koichi Inoue, Hiroyuki Morimoto, Masahiro Ohgidani, Takatoshi Ueki
Summary: Reactive microglia are thought to be involved in neurological disorders, and the administration of fractalkine (FKN) can modify LPS-induced microglial activation. By reducing CX3CR1, the FKN signal is attenuated, partially modulating the inflammatory response of microglial cells.
Article
Chemistry, Multidisciplinary
Sahily Reyes-Esteves, Jia Nong, Patrick M. Glassman, Serena Omo-Lamai, Sarah Ohashi, Jacob W. Myerson, Marco E. Zamora, Xiaonan Ma, Scott E. Kasner, Lauren Sansing, Vladimir R. Muzykantov, Oscar A. Marcos-Contreras, Jacob S. Brenner
Summary: Intracerebral hemorrhage (ICH) is a common cause of deadly stroke without specific drug therapies. Passive intravenous (IV) delivery fails to deliver drugs to the area around the hemorrhage, while targeted delivery via IV monoclonal antibodies (mAbs) shows promising results in accumulating drugs in the brain endothelium.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Oncology
Chad A. Arledge, William N. Crowe, Lulu Wang, John Daniel Bourland, Umit Topaloglu, Amyn A. Habib, Dawen Zhao
Summary: The study established a PK model for DCE MRI images and applied a trained model to another small animal brain metastasis model through transfer learning. The results showed that this method accurately assessed vascular permeability and detected permeability changes induced by radiotherapy. The importance of this study lies in providing a fast and accurate method for evaluating vascular permeability and treatment response in brain tumor models.
Article
Cell Biology
Qiang Qu, Kyoungmin Park, Kevin Zhou, Drew Wassel, Rafal Farjo, Tracy Criswell, Jian-xing Ma, Yuanyuan Zhang
Summary: The level of PEDF in the vitreous is found to be associated with diabetic retinopathy. A 34-mer peptide of PEDF encapsulated in nanoparticles can provide prolonged therapeutic effects and have potential in treating retinal inflammation and vascular leakage.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Scott R. Burks, Cymon N. Kersch, Jaclyn A. Witko, Michael A. Pagel, Maggie Sundby, Leslie L. Muldoon, Edward A. Neuwelt, Joseph A. Frank
Summary: Intracarotid arterial hyperosmolar mannitol (ICAHM) is effective and safe for treating central nervous system malignancies by disrupting the blood-brain barrier, but it can induce a transient neuroinflammatory response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Yukiko Takahashi, Takeshi Kawasaki, Hironori Sato, Yoshinori Hasegawa, Steven M. Dudek, Osamu Ohara, Koichiro Tatsumi, Takuji Suzuki
Summary: The study found that CD26/DPP4 plays important roles in regulating inflammation, barrier function, and regenerative processes in HLMVECs, and may mediate injury in pulmonary endothelial cells. Reduction of CD26/DPP4 via siRNA affects inflammation, barrier function, and regenerative processes in HLMVECs.
Article
Chemistry, Multidisciplinary
Chih-Wei Chiu, Chih-Hao Yang, Jie-Heng Tsai, Cheng-Ying Hsieh, Shih-Yi Huang
Summary: The study found that platonin has inhibitory effects on inflammatory VSMCs, reducing the expression of inducible nitric oxide synthetase and interleukin-1 beta, suppressing NF-kappa B activation, decreasing MCP-1 production, preventing lipid accumulation, and demonstrating potent anti-inflammatory and vascular protective properties.
APPLIED SCIENCES-BASEL
(2021)
Article
Parasitology
Miguel A. Orrego, Manuela R. Verastegui, Carlos M. Vasquez, Hector H. Garcia, Theodore E. Nash
Summary: The study reveals that the proliferative growth of the bladder wall in racemose neurocysticercosis is associated with the insulin receptor-mediated MAPK signaling pathway. It is found that metformin inhibits this pathway, reducing cell proliferation and parasite growth. This discovery offers a new therapeutic approach for racemose neurocysticercosis.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2022)
Correction
Food Science & Technology
X. Fernandez-Cassi, N. Timoneda, E. Gonzales-Gustavson, J. F. Abril, S. Bofill-Mas, R. Girones
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Letter
Pathology
Yonghu Lu, Vidiya Ramachandran, Siddhartha Mahanty, William D. Rawlinson
Correction
Engineering, Environmental
Eloy Gonzales-Gustavson, Marta Rusinol, Gertjan Medema, Miquel Calvo, Rosina Girones
Article
Multidisciplinary Sciences
Daniel A. Andrade-Mogrovejo, Eloy Gonzales-Gustavson, Ana C. Ho-Palma, Joaquin M. Prada, Gabrielle Bonnet, Francesco Pizzitutti, Luis A. Gomez-Puerta, Gianfranco Arroyo, Seth E. O'Neal, Hector H. Garcia, Javier Guitian, Armando Gonzalez
Summary: This study systematically reviewed and analyzed pig infection experiments to evaluate the accuracy of dose-response models for Taenia solium cyst development. The exact beta-Poisson model was found to be the best fit for the data, providing important parameters for future experimental infections and transmission simulation models.
Article
Biochemical Research Methods
Gabrielle Bonnet, Francesco Pizzitutti, Eloy A. A. Gonzales-Gustavson, Sarah Gabriel, William K. K. Pan, Hector H. H. Garcia, Javier A. A. Bustos, Percy Vilchez, Seth E. E. O'Neal
Summary: This paper presents CystiHuman, the first model of human neurocysticercosis, a parasitic disease that is responsible for a large proportion of epilepsy cases in developing countries and also contributes to intracranial hypertension, hydrocephalus, and death. The model suggests that short-term interventions that successfully reduce parasite transmission to a small fraction of its original level, but are followed by a rapid recuperation in transmission levels, will likely fail to produce a substantial reduction in neurocysticercosis prevalence.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Veterinary Sciences
Karina Bardales-Ortiz, L. Raul Enriquez, H. Cesar Sedano, Saul J. Santivanez S, Z. Armando Gonzalez
Summary: The study evaluated the use of the enzyme-linked immunoelectrotransfer blot test (EITB) for serological diagnosis of ovine hydatidosis. The EITB showed low sensitivity and high specificity in comparison to necropsy as the gold standard. Although the EITB had high sensitivity in identifying active cystic lesions, there was no significant difference in the results statistically.
REVISTA DE INVESTIGACIONES VETERINARIAS DEL PERU
(2022)
Article
Biochemistry & Molecular Biology
Miguel A. Orrego, Carlos M. Vasquez, Kayla Togneri, Juan P. Laclette, Hector H. Garcia, Theodore E. Nash
Summary: Iron deposits were detected in the bladder wall of racemose cysts but not in univesicular cysts, and the genes for iron-binding proteins and ribonucleotide reductase were significantly overexpressed in racemose cysts compared to univesicular cysts.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
(2022)
Article
Multidisciplinary Sciences
Francesco Pizzitutti, Gabrielle Bonnet, Eloy Gonzales-Gustavson, Sarah Gabriel, William K. Pan, Ian W. Pray, Armando E. Gonzalez, Hector H. Garcia, Seth E. O'Neal
Summary: The paper presents a new agent-based model and calibration approach for the transmission of pork tapeworm. The calibrated model accurately reproduces observed prevalences and can be transferred within an endemic region. This finding expands the potential applications of the model and informs future control interventions.
Editorial Material
Immunology
Miguel A. Orrego, Manuela R. Verastegui, Hector H. Garcia
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Veterinary Sciences
Linda Gallegos, Juan Calcina, Eliana Icochea, Eloy Gonzales, Luis A. Gomez-Puerta, Armando E. Gonzalez
Summary: The aim of this study was to develop a stochastic simulation model to estimate the implementation costs of porcine cysticercosis control programs. The study found that the dosing strategy with oxfendazole (OFZ) was the least expensive alternative among the proposed scenarios.
REVISTA DE INVESTIGACIONES VETERINARIAS DEL PERU
(2022)
Article
Immunology
Carla Cangalaya, Susanne Wegmann, Weilun Sun, Lisa Diez, Anna Gottfried, Karin Richter, Stoyan Stoyanov, Janelle Pakan, Klaus-Dieter Fischer, Alexander Dityatev
Summary: Remodeling of synapses by microglia is critical for synaptic plasticity in the brain. In neuro-inflammation and neurodegenerative diseases, microglia can cause excessive synaptic loss, and this study investigated the underlying mechanisms by observing microglia-synapse interactions under inflammatory conditions. The findings showed that inflammatory stimuli prolonged microglia-neuron contacts, decreased surveillance of synapses, and promoted synaptic remodeling through the elimination of spines tagged by synaptic filopodia.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Parasitology
Luis A. Gomez-Puerta, Ana Vargas-Calla, Madeline Garcia-Leandro, Javier Jara-Vila, Wendy Rojas-Anticona, Joel I. Pacheco, Jose M. Angulo-Tisoc, Walter Silva, Armando E. Gonzalez
Summary: This study assessed the occurrence of Hydatigera taeniaeformis metacestodes in various species of wild rodents from Peru. Five rodents were found to be infected with H. taeniaeformis metacestodes, and the molecular analysis confirmed the presence of H. taeniaeformis in these new intermediate hosts. This study also provided the first molecular contribution for H. taeniaeformis from Peru.
PARASITOLOGY RESEARCH
(2023)
Article
Microbiology
Eloy Gonzales-Gustavson, Ian W. Pray, Ricardo Gamboa, Claudio Muro, Percy Vilchez, Luis Gomez-Puerta, Ana Vargas-Calla, Gabrielle Bonnet, Francesco Pizzitutti, Hector H. Garcia, Armando E. Gonzalez, Seth E. O'Neal
Summary: The study examined the risk of porcine cysticercosis associated with exposure to human feces, dung beetles, and flies in an endemic community setting. Results showed that pig ingestion of human feces is not the only mode of transmission for Taenia solium. Dung beetles and flies were found to have no significant role in the infection.
Article
Environmental Sciences
Cesar A. Valdivia-Carrera, Ana C. Ho-Palma, Astrid Munguia-Mercado, Karoll Gonzalez-Pizarro, Claudia Ibacache-Quiroga, Alejandro Dinamarca, Milan Stehlik, Marta Rusinol, Rosina Girones, Maria T. Lopez-Urbina, Anani Basaldua Galarzacj, Eloy Gonzales-Gustavson
Summary: Wastewater-based epidemiology is shown to be an excellent tool for monitoring and anticipating outbreaks of infectious diseases in low- and middle-income countries.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)