Article
Biochemistry & Molecular Biology
Ching-Yao Yang, Shing-Hwa Liu, Chin-Chuan Su, Kai-Min Fang, Tsung-Yuan Yang, Jui-Ming Liu, Ya-Wen Chen, Kai-Chih Chang, Haw-Ling Chuang, Cheng-Tien Wu, Kuan- Lee, Chun-Fa Huang
Summary: Methylmercury exposure leads to cytotoxicity in pancreatic beta-cells, affecting insulin secretion and cell viability. The mechanism involves activation of mitochondrial and endoplasmic reticulum stress pathways, resulting in apoptosis. Additionally, methylmercury induces JNK activation and reactive oxygen species generation, exacerbating cell damage and insulin secretion dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Gobichettipalayam Balasubramaniam Maadurshni, Ganeshmurthy Kanniamal Tharani, Inbamani Udayakumar, Manigandan Nagarajan, Jeganathan Manivannan
Summary: Recent evidences have shown that the release of aluminum oxide nanoparticles (Al2O3-NPs) may pose a risk to the environment and cause adverse effects on living organisms. This study investigated the hepatotoxic effects of Al2O3-NPs on developing chicken embryos and cell cultures. The results revealed that exposure to Al2O3-NPs caused abnormal liver histology, increased tissue damage markers, oxidative stress, impaired antioxidant enzyme function, abnormal red blood cell morphology, and enhanced apoptosis. Additionally, novel mechanisms and prevention strategies were explored.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Food Science & Technology
Linlin Qu, Rongzhan Fu, Xiaoxuan Ma, Daidi Fan
Summary: The study demonstrated that protopanaxatriol-type saponin (PTS) effectively protected against acetaminophen (APAP)-induced liver injury by reducing inflammation, oxidative stress, and hepatic apoptosis, and reversing histological changes. Additionally, PTS showed potential as a novel therapeutic agent for APAP-induced liver injury through the ROS-mediated JNK pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Environmental Sciences
Yuanxu Li, Gaolong Zhong, Ting He, Jinwen Quan, Siying Liu, Zhonghua Liu, Zhaoxin Tang, Wenlan Yu
Summary: The exposure to arsenic and copper can activate the Nrf2 antioxidant pathway to reduce oxidative stress and induce kidney cell pyroptosis and apoptosis. Knocking out Nrf2 decreases antioxidant capacity and leads to more severe apoptosis, pyroptosis, and nephrotoxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Li Zhou, Chaoqin Zhang, Yu Qiang, Min Huang, Xiangmei Ren, Yuanhong Li, Jihong Shao, Lichun Xu
Summary: The study demonstrated that APSP can protect against lead-induced reproductive toxicity in male mice by attenuating testicular injury, improving sperm count and motility, reducing sperm abnormality rate, restoring antioxidant levels, inhibiting lipid peroxidation, and modulating the JNK signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Huan Li, Qin Yang, Zhen Huang, Cui Liang, Dian-Hong Zhang, Hui-Ting Shi, Jia-Qi Du, Bin-Bin Du, Yan-Zhou Zhang
Summary: Diabetic cardiomyopathy (DCM) is a heart dysfunction that occurs in patients with diabetes mellitus (DM). This study found that dual-specificity phosphatase 12 (DUSP12) plays an important role in DCM. Overexpression of DUSP12 worsens cardiac dysfunction and increases oxidative stress and apoptosis, while DUSP12 deficiency exacerbates these effects. The study also found that DUSP12 interacts with a specific signaling pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Fisheries
Linming Li, Ruoxuan Wang, Ziping Zhang
Summary: Copper can cause oxidative stress and damage the health of farmed fish. The Nrf2 signaling pathway is an important pathway related to oxidative stress in vertebrates. This study explored the effect of copper on the Nrf2 signaling pathway in fish hepatocytes and provided theoretical data for toxicological research.
Article
Toxicology
Jae Eun Park, Ji Sook Han
Summary: This study found that scopoletin can protect INS-1 pancreatic beta cells from apoptosis and oxidative stress caused by high glucose. It does so by reducing ROS, TBARS, and NO levels, increasing antioxidant enzyme activities, and influencing the apoptosis pathway. These findings suggest that scopoletin has the potential to be used as a pharmaceutical material to protect pancreatic beta cells.
TOXICOLOGY IN VITRO
(2023)
Article
Pharmacology & Pharmacy
Qing Xia, Shuo Gao, Samuel Rajendran Rapael Gnanamuthu, Kaiyan Zhuang, Zhenzhen Song, Yun Zhang, Xue Wang, Pengfei Tu, Jianheng Li, Kechun Liu
Summary: Aconitine (AC) exerts severe toxic effects on zebrafish embryo development, including cardiac, liver, and neurodevelopment impairment, as well as ROS-mediated mitochondrial apoptosis. High-concentration AC exposure results in deficient cardiovascular system and cell apoptosis in the heart and brain regions.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wenrong Feng, Shengyan Su, Changyou Song, Fan Yu, Jun Zhou, Jianlin Li, Rui Jia, Pao Xu, Yongkai Tang
Summary: High concentrations of copper pose a threat to aquatic animals, but the response mechanisms of crustaceans to Cu2+ exposure are not well understood. This study investigated the physiological and molecular changes in Chinese mitten crabs after Cu2+ exposure. The results showed that Cu2+ exposure decreased antioxidative capacity and promoted lipid peroxidation in different tissues. It also induced apoptosis and autophagy, and triggered an immune response. The toxicity of Cu2+ may be associated with the activation of ERK, AMPK, and TLR2-MyD88-NF-kappa B pathways.
Article
Cell Biology
Ze-qing Pu, Tian-fu Yu, Dong Liu, Cheng-wen Jin, Esha Sadiq, Xiaofei Qiao, Xiaojie Li, Yuxuan Chen, Jinsong Zhang, Mingzhong Tian, Siying Li, Ru-xing Zhao, Xiang-dong Wang
Summary: The study demonstrates that NR4A1 attenuates JNK phosphorylation incurred by ER-stress or ROS partially by enhancing MKP7 expression, potentially decreases pancreatic beta cell apoptosis induced by ROS or ER-stress.
CELL DEATH DISCOVERY
(2021)
Article
Environmental Sciences
Mingquan Huang, Xingjie Li, Shengjun Jia, Shuang Liu, Li Fu, Xue Jiang, Meng Yang
Summary: The study reveals that BPAF can induce apoptosis of KGN cells in a concentration- and time-dependent manner by increasing the expression of pro-apoptotic proteins and decreasing the expression of anti-apoptotic proteins. Additionally, BPAF exposure leads to a significant increase in intracellular ROS levels, which mediates KGN cell apoptosis through the ROS-ASK1-JNK axis.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemistry & Molecular Biology
Quanwei Li, Jianzhao Liao, Kai Zhang, Zhuoying Hu, Hui Zhang, Qingyue Han, Jianying Guo, Lianmei Hu, Jiaqiang Pan, Ying Li, Yuelong Li, Zhaoxin Tang
Summary: This study investigated the mechanism of copper toxicity in the cardiomyocytes of large mammal pigs. The results showed that excessive copper intake caused oxidative damage, activated antioxidant pathways and endoplasmic reticulum stress, disrupted mitochondrial balance, and induced cell apoptosis.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Environmental Sciences
Wenying Sun, Huanyi Liu, Huijun Zhu, Meichen Gao, Shiwen Xu
Summary: In this experimental study, the mechanism of TBBPA toxicity on Grass carp hepatocytes (L8824 cells) and the antagonistic impact of EUC on TBBPA were investigated. The results showed that TBBPA exposure induced oxidative stress and activated the ASK1/JNK signaling pathway, resulting in apoptosis. Additionally, EUC effectively protected against TBBPA-induced apoptosis and immune dysfunction by regulating the ROS/ASK1/JNK pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Guoxiu Zu, Keyun Sun, Ling Li, Xiuli Zu, Tao Han, Hailiang Huang
Summary: In this study, potential molecular targets of quercetin were identified using bioinformatics methods, and the therapeutic potential of quercetin in type 2 diabetes mellitus and Alzheimer's disease was explored. The study provides insights into potential therapeutic targets and pathways for further clinical research.
SCIENTIFIC REPORTS
(2021)