Review
Food Science & Technology
Seyedeh-Masomeh Derakhshandeh-Rishehri, Saeed Ghobadi, Masoumeh Akhlaghi, Shiva Faghih
Summary: Calcium supplement intake is associated with a significant reduction in low density lipoprotein cholesterol level, especially in individuals without dyslipidemia, higher calcium intakes, and longer period of consumption.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Environmental Sciences
Axel G. Andersson, Anna Lundgren, Yiyi Xu, Christel Nielsen, Christian H. Lindh, Daniela Pineda, Julia Cederlund, Elisavet Pataridou, Sandra Sogaard Tottenborg, Kajsa Ugelvig Petersen, Tony Fletcher, Martin Lagging, Mats Bemark, Kristina Jakobsson, Ying Li
Summary: This study aimed to evaluate the association between PFAS exposure levels and antibody responses after SARS-CoV-2 vaccination in adults. The results showed no negative correlation between PFAS exposure and antibody levels 5 weeks and 6 months after COVID-19 vaccination.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Article
Engineering, Biomedical
Detlef H. Krieter, Jarline Jeyaseelan, Marieke Ruth, Horst-Dieter Lemke, Christoph Wanner, Christiane Drechsler
Summary: This study investigated the impact of different membrane materials on white blood cell, platelet, complement factor C5a, and thrombin-antithrombin III concentrations in double-filtration lipoprotein apheresis patients. The results showed that PES membranes caused less leukocyte and complement system activation compared to EVAL membranes, with the same treatment efficacy.
Review
Environmental Sciences
Soon Hoe Ho, Stacy Xin Hui Soh, Min Xian Wang, Janet Ong, Annabel Seah, Yvonne Wong, Zhanxiong Fang, Shuzhen Sim, Jue Tao Lim
Summary: This systematic review examines the associations between perfluoroalkyl substances (PFAS) and lipid concentrations in human populations. The results suggest that PFAS exposure is associated with higher levels of LDL, HDL, and TC, while the association with TG tends to be negative. Additionally, the study indicates a positive relationship between PFAS concentrations and cholesterol-related health outcomes. Further research is needed to investigate the effects of less-studied PFAS on human health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Hao Zhao, Wei Gui, Xin Tan, Ying Chen, Yao Ning, Xin Wang
Summary: This study investigated the relationship between neonicotinoid insecticides (NNIs) and their metabolites in urine with serum lipid profiles in adults. The results showed a significant positive correlation between N-desmethyl-acetamiprid and total cholesterol (TC) levels, especially in participants aged over 46 years. Body mass index (BMI) also modified the association between N-desmethyl-acetamiprid and LDL-C and Apo-B levels.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Yuan Kong, Yong-Jia Yi, Xiao-Qing Liu, Pan Yu, Lin-Guo Zhao, Dong-Dong Li
Summary: In this study, a series of berberine analogs were synthesized and evaluated for their lipid-lowering activities. Compound 1m was found to exhibit potent cholesterol inhibitory activity and had significant effects on LDLC and HDLC levels. The results suggest that 1m has the potential to be a new lipid-lowering agent.
BIOORGANIC CHEMISTRY
(2022)
Article
Clinical Neurology
Pierre C. Amarenco, Philippa S. Lavallee, Jong Kim, Julien Labreuche, Hugo Charles, Maurice Giroud, Byung-Chul Lee, Marie-Helene Mahagne, Elena Meseguer, Norbert Nighoghossian, Philippe Gabriel Steg, Eric Vicaut, Eric Bruckert, Treat Stroke Target Invest
Summary: This study investigated the effects of two different strategies for reducing low-density lipoprotein (LDL) cholesterol on reducing cardiovascular risk. The results showed that among patients with a target LDL cholesterol level of <70 mg/dL, a reduction in LDL cholesterol of >50% from baseline significantly reduced the risk of the primary outcome.
Article
Clinical Neurology
Lu Xu, Kai Wang, Shengfeng Wang, Lili Liu, Xiaozhen Lv, Yongfeng Song
Summary: This study revealed that high levels of triglycerides increased the risk of depressive symptoms in men, especially in individuals without hypertension and diabetes.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Medicine, General & Internal
Xiaoqi Wang, Yingqing Feng, Li Yang, Guohui Zhang, Xiaoyuan Tian, Qianhui Ling, Jiangshan Tan, Jun Cai
Summary: Baseline LDL-C and non-HDL-C concentrations have a J-shaped association with cardiovascular disease outcomes. The effects of intensive SBP control on cardiovascular disease outcomes are not influenced by baseline LDL-C and non-HDL-C concentrations.
CHINESE MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Rahul Aggarwal, Deepak L. Bhatt, Fatima Rodriguez, Robert W. Yeh, Rishi K. Wadhera
Summary: Lipid concentrations improved among US adults over the past decade, while rates of lipid control did not significantly change among adults receiving statin therapy. There were improvements in lipid control among certain racial and ethnic groups, but disparities remained between genders and races.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Medicine, General & Internal
Jamal S. Rana, Salim S. Virani, Howard H. Moffet, Jennifer Y. Liu, Landis A. Coghlan, Jitesh Vasadia, Christie M. Ballantyne, Andrew J. Karter
Summary: The study aimed to evaluate the association between outpatient LDL-C testing and subsequent statin adherence and intensification in patients after an ASCVD event. The results showed that LDL-C testing was associated with improved statin adherence and higher rates of treatment intensification.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
C. J. MacDonald, A. L. Madika, G. Severi, A. Fournier, M. C. Boutron-Ruault
Summary: The study found that non-O blood groups, particularly the A group, are associated with an increased risk of dyslipidaemia. Current smokers have a 30% higher risk of dyslipidaemia compared to never-smokers. These results could be useful for personalized approaches to preventing cardiovascular risk factors.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
Mehran Nouri, Mohammad Ali Mohsenpour, Niki Katsiki, Saeed Ghobadi, Alireza Jafari, Shiva Faghih, Maciej Banach, Mohsen Mazidi
Summary: In this meta-analysis, the relationship between serum lipid profile and breast cancer risk was investigated. The results showed a negative association between high-density lipoprotein cholesterol (HDL-C) level and breast cancer risk, while other indicators such as TG, TC, ApoA and LDL-C were not associated with breast cancer development.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Immunology
Jiahui Yan, Sisi Yang, Liang Han, Xin Ba, Pan Shen, Weiji Lin, Tingting Li, Ruiyuan Zhang, Ying Huang, Yao Huang, Kai Qin, Yu Wang, Shenghao Tu, Zhe Chen
Summary: This article describes the unique lipid profile of RA, explores the mechanisms underlying lipid changes, and investigates the impact of lipid changes on cardiovascular disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Cathy J. Sun, Christopher McCudden, Diane Brisson, Julie Shaw, Daniel Gaudet, Teik C. Ooi
Summary: Switching from the Friedewald equation to the Martin-Hopkins or Sampson-National Institutes of Health equations for LDLC calculation can lead to reclassification of patients into different cardiovascular disease risk categories. There is a strong correlation between the calculated LDLC values using these different equations, but the difference is greater with higher triglyceride levels and lower LDLC levels. Clinical laboratories are recommended to report results using either the Martin-Hopkins or Sampson-National Institutes of Health equations, but the latter should not be used in patients with familial hypercholesterolemia until further studies are conducted.
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Article
Behavioral Sciences
Frieder Schlunk, Paul Fischer, Hans M. G. Princen, Andre Rex, Vincent Prinz, Marco Foddis, Dieter Luetjohann, Ulrich Laufs, Matthias Endres
Summary: In this mouse study, treatment with anti-PCSK9 antibodies did not lead to differences in behavior or changes in cognition.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Pharmacology & Pharmacy
V. Sashi Gopaul, Elsbet J. Pieterman, Hans M. G. Princen, Linnea Bergenholm, Eva Lundborg, Anders Cavallin, Magnus J. Johansson, Glen Hawthorne, Anders Bjorkbom, Maria Hammarberg, XueQing Li, Annica Jarke, Jonathan Bright, Lena Svensson, Rasmus Jansson-Lofmark, Bertil Abrahamsson, Rahul Agrawal, Eva Hurt-Camejo
Summary: The results in mice and dogs indicate that mineral oil does not affect the pharmacokinetics of atorvastatin or pravastatin, but may cause low-grade inflammation with chronic oral administration, warranting further investigation.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Orthopedics
Y. van Gemert, A. E. Kozijn, M. G. Pouwer, N. N. L. Kruisbergen, M. H. J. van den Bosch, A. B. Blom, E. J. Pieterman, H. Weinans, R. Stoop, H. M. G. Princen, P. L. E. M. van Lent
Summary: The study found that therapeutic cholesterol lowering did not reduce cartilage degradation progression in dyslipidemic mice, suggesting that inflammation is a key feature of the disease and therapeutic cholesterol-lowering strategies may still hold promise.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Multidisciplinary Sciences
Anita M. van den Hoek, Lars Verschuren, Martien P. M. Caspers, Nicole Worms, Aswin L. Menke, Hans M. G. Princen
Summary: The study investigated the response of Elafibranor in APOE*3Leiden.CETP mice, demonstrating its ability to significantly reduce steatosis and hepatic inflammation, and preclude progression of fibrosis. Comparison of disease pathways in the model and NASH patients showed substantial similarity, indicating potential usefulness of Elafibranor in treating human NASH, possibly in combination with other agents.
SCIENTIFIC REPORTS
(2021)
Review
Toxicology
Styliani S. Fragki, Hubert Dirven, Tony Fletcher, Bettina Grasl-Kraupp, Kristine Bjerve Gutzkow, Ron Hoogenboom, Sander Kersten, Birgitte Lindeman, Jochem Louisse, Ad Peijnenburg, Aldert H. Piersma, Hans M. G. Princen, Maria Uhl, Joost Westerhout, Marco J. Zeilmaker, Mirjam Luijten
Summary: The association between PFOS/PFOA and increased blood lipids in humans has been observed, while rodent studies show opposite effects, likely due to different exposure levels. Mechanistic research suggests that PFOS/PFOA activate the PPAR alpha pathway in human liver cells, but the involvement of other nuclear receptors is less clear. Future studies focusing on human-relevant test systems are needed to better understand the implications of PFOS/PFOA exposure on lipid homeostasis and human health.
CRITICAL REVIEWS IN TOXICOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Danielle van Keulen, Ian D. van Koeverden, Arjan Boltjes, Hans M. G. Princen, Alain J. van Gool, Gert J. de Borst, Folkert W. Asselbergs, Dennie Tempel, Gerard Pasterkamp, Sander W. van der Laan
Summary: The study found that a genetic variant (rs1316887) in the OSMR locus is associated with increased plaque vulnerability, but not with coronary calcification or cardiovascular disease risk. The precise biological mechanisms through which OSM signaling affects plaque morphology remain unclear.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Miguel Carracedo, Sven-Christian Pawelzik, Gonzalo Artiach, Marianne G. Pouwer, Oscar Plunde, Peter Saliba-Gustafsson, Ewa Ehrenborg, Per Eriksson, Elsbet Pieterman, Leif Stenke, Hans M. G. Princen, Anders Franco-Cereceda, Magnus Back
Summary: This study found that nilotinib can promote aortic valve thickening and valvular interstitial cell calcification, while imatinib does not have this effect. The study also found differential tyrosine kinase expression between healthy and calcified valve tissue. These findings may have important implications for cardiovascular surveillance and personalized medicine in chronic myeloid leukaemia patients.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alexandra K. Suchowerska, Geurt Stokman, James T. Palmer, Phillip A. Coghlan, Elsbet J. Pieterman, Nanda Keijzer, Gilles Lambert, Kevin Chemello, Ali K. Jaafar, Jasneet Parmar, Liping Yan, Yingtao Tong, Lin Mu, Hans M. G. Princen, James Bonnar, Benny J. Evison
Summary: This study reported the discovery of an orally bioavailable small-molecule inhibitor of PCSK9 called NYX-PCSK9i, which demonstrated significant cholesterol-lowering activity in hyperlipidemic APOE*3-Leiden.CETP mice. NYX-PCSK9i has the potential to be a new therapy for hypercholesterolemia and can enhance the lipid-lowering activities of statins.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Orthopedics
Y. van Gemert, N. N. L. Kruisbergen, A. B. Blom, M. H. J. van den Bosch, P. M. van der Kraan, E. J. Pieterman, H. M. G. Princen, P. L. E. M. van Lent
Summary: Inhibition of IL-1 beta combined with cholesterol-lowering therapy can reduce synovial thickening and cartilage degeneration in mice, suggesting its potential benefits for patients with metabolic inflammation.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Biochemistry & Molecular Biology
Jose A. Inia, Geurt Stokman, Elsbet J. Pieterman, Martine C. Morrison, Aswin L. Menke, Lars Verschuren, Martien P. M. Caspers, Martin Giera, J. Wouter Jukema, Anita M. van den Hoek, Hans M. G. Princen
Summary: Patients with metabolic syndrome are often prescribed statins to prevent cardiovascular disease, but their effects on NASH are lacking. This study found that atorvastatin can significantly reduce hepatic steatosis, inflammation, and fibrosis, as well as prevent cholesterol crystal formation and NLRP3 inflammasome activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jose A. Inia, Geurt Stokman, Martine C. Morrison, Nicole Worms, Lars Verschuren, Martien P. M. Caspers, Aswin L. Menke, Louis Petitjean, Li Chen, Mathieu Petitjean, J. Wouter Jukema, Hans M. G. Princen, Anita M. van den Hoek
Summary: Semaglutide, a glucagon-like peptide-1 receptor agonist, has been approved for the treatment of obesity and shows potential for the treatment of non-alcoholic steatohepatitis (NASH). It significantly reduces hepatic steatosis and inflammation, but has limited effects on fibrosis. Combining Semaglutide with other NASH agents may be necessary for the reversal of advanced fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Orthopedics
Y. van Gemert, A. B. Blom, I. Di Ceglie, B. Walgreen, M. Helsen, A. Sloetjes, T. Vogl, J. Roth, N. N. L. Kruisbergen, E. J. Pieterman, H. M. G. Princen, P. M. van der Kraan, P. L. E. M. van Lent, M. H. J. van den Bosch
Summary: The study investigated the effects of intensive cholesterol-lowering treatment on joint inflammation and pathology in a collagenase-induced osteoarthritis model. While the treatment reduced inflammation, it did not significantly impact end-stage disease.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
B. Rolin, H. M. G. Princen, A. M. Van den Hoek, G. Rakipovski, J. F. Lau, P. W. Garibay, C. K. Mogensen
Meeting Abstract
Endocrinology & Metabolism
Paul Fischer, Frieder Schlunk, Hans M. G. Princen, Andre Rex, Vincent Prinz, Marco Foddis, Dieter Lutjohann, Ulrich Laufs, Matthias Endres
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Meeting Abstract
Orthopedics
Y. van Gemert, N. N. Kruisbergen, M. H. van den Bosch, A. B. Blom, P. M. van der Kraan, E. J. Pieterman, H. M. Princen, P. L. van Lent
OSTEOARTHRITIS AND CARTILAGE
(2022)