Article
Biochemistry & Molecular Biology
Lukasz Boguszewicz, Agata Bielen, Mateusz Ciszek, Jacek Wendykier, Krzysztof Szczepanik, Agnieszka Skorupa, Jolanta Mrochem-Kwarciak, Krzysztof Skladowski, Maria Sokol
Summary: This study analyzed the nuclear magnetic resonance (NMR) blood serum metabolic profiles of 106 head and neck squamous cell carcinoma (HNSCC) patients during radio- and concurrent radio-chemotherapy, finding that seven metabolites were significantly altered by radiotherapy. The influence of irradiated volume on metabolic profile was weak, mainly correlating with inflammatory markers, creatinine, lymphocyte count, and branched-chain amino acids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Chongyang Huang, Hehua Lei, Chaoyang Liu, Yulan Wang
Summary: In this study, the metabolic effects of Cyadox were evaluated using comprehensive methods. The results showed dose-dependent alterations in the metabolism of urine, kidney, plasma, and liver. Gene expressions in the liver were also affected by high dose Cyadox treatment, with differentially expressed genes involved in xenobiotic metabolism, lipid metabolism, energy metabolism, nucleic acid metabolism, inflammatory response, and oxidative stress.
Article
Environmental Sciences
Ting Qi, Lele Wu, Jiachen Yu, Zongcheng Song, Feng Liu, Jun Li, Xiefa Song, Xian Li
Summary: This study found that low-dose phosphate had negative effects on the metabolism of juvenile turbot, leading to cell structure damage and signal recognition disorder. It also induced oxidative stress and immunotoxicity in fish, affecting the expression of certain genes. Additionally, all phosphate-treated groups showed lesions on gill tissue. These findings are important for controlling phosphate accumulation in fish farming and protecting species diversity and marine ecosystems.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Polymer Science
Abeer Aljubailah, Saad M. S. Alqahtani, Tahani Saad Al-Garni, Waseem Sharaf Saeed, Abdelhabib Semlali, Taieb Aouak
Summary: Poly(2-hydroxyethylmethacrylate)/Naproxen (NPX/pHEMA) and poly (2-hydroxypropyl methacrylate)/Naproxen (NPX/pHPMA) composites with different NPX content were prepared using free radical photopolymerization. The performance of the drug release dynamics and the solubility of Naproxen were studied. It was found that pHEMA showed the best performance in drug release dynamics, and the solubility of NPX was significantly improved in pH1 and pH7 media.
Article
Biochemical Research Methods
Susanta Das, Kiyoto Aramis Tanemura, Laleh Dinpazhoh, Mithony Keng, Christina Schumm, Lydia Leahy, Carter K. Asef, Markace Rainey, Arthur S. Edison, Facundo M. Fernandez, Kenneth M. Merz
Summary: This study developed an efficient CCS computational workflow using a machine learning model and standard DFT methods, and validated the workflow through Traveling Wave IM-MS experiments. It provided accurate structural predictions and insights into the preferred conformation of metabolites analyzed using IM-MS experiments. The workflow is significant for computing CCS values of conformationally flexible metabolites with complex molecular structures.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2022)
Article
Biochemical Research Methods
Susanta Das, Kiyoto Aramis Tanemura, Laleh Dinpazhoh, Mithony Keng, Christina Schumm, Lydia Leahy, Carter K. Asef, Markace Rainey, Arthur S. Edison, Facundo M. Fernandez, Kenneth M. Merz
Summary: In this study, an efficient CCS computational workflow was developed to accurately predict unknown structures using a machine learning model and standard DFT methods. TWIMS experiments were performed to validate the experimental values and assess uncertainties. The workflow yielded accurate structural predictions and provided unique insights into preferred conformations.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2022)
Article
Environmental Sciences
Sonia Torres, Sara Samino, Pere Rafols, Manuela Martins-Green, Xavier Correig, Noelia Ramirez
Summary: This study investigated the metabolic disorders caused by thirdhand smoke (THS) exposure in the liver of male mice and the effects of antioxidant treatment. Results showed that THS exposure altered 88 metabolites, including amino acids, nucleotides, and various lipids, affecting pathways related to oxidative stress and lipid metabolism. Antioxidant treatment reduced lipid accumulation but did not fully reverse metabolic alterations, indicating THS as a new factor for liver steatosis.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Plant Sciences
Lingyu Ruan, Wenli Zhao, Buzha-xi Luo, Qi Zheng, Zhichao Liu, Wenya Liu, Daji-deng Ba, Jiage Zhong, Hui Luo, Junsong Wang, Xin Feng
Summary: High-dose HR caused hepatotoxicity and nephrotoxicity in rats, while low-dose ESP showed advantages in reducing toxicity. ESP may induce hepatotoxicity and nephrotoxicity, with HR being the main potential source of nephrotoxicity in ESP.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Environmental Sciences
Andrea Liliana Moreno Rios, Karol Gutierrez-Suarez, Zenen Carmona, Claudete Gindri Ramos, Luis Felipe Silva Oliveira
Summary: This article provides an overview of the behavior and risks associated with naproxen (NP) in the environment, highlighting the importance of understanding the behavior of its original compounds, metabolites, and transformation products.
Article
Environmental Sciences
Siti Norliyana Zubaidi, Wasim S. M. Qadi, Syahida Maarof, Norazlan Mohmad Misnan, Halimatul Saadiah Mohammad Noor, Hamizah Shahirah Hamezah, Syarul Nataqain Baharum, Nurwahyuna Rosli, Faidruz Azura Jam, Ebtesam Al-Olayan, Chuanyi Wang, Khaoula Hellal, Nawal Buzgaia, Ahmed Mediani
Summary: This study used advanced proton nuclear magnetic resonance (H-1 NMR) techniques to evaluate the acute oral toxicity of A. muricata leaf ethanol extract in Sprague Dawley rats. The results showed no significant toxicity at a dose of 2000 mg/kg. The findings suggest that A. muricata leaf ethanol extract can be safely consumed with an LD50 greater than 2000 mg/kg.
Article
Toxicology
Guillermo Quintas, Teresa Martinez-Sena, Isabel Conde, Eugenia Pareja Ibars, Jos Kleinjans, Jose Castell
Summary: DILI, an adverse toxic reaction associated with drug administration, is currently classified based on ALT and ALP values, but lacks accuracy. By integrating metabolomic information, a more accurate evaluation of DILI phenotypes can be achieved.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ewelina Swiatek, Paula Ossowicz-Rupniewska, Ewa Janus, Anna Nowak, Peter Sobolewski, Wiktoria Duchnik, Lukasz Kucharski, Adam Klimowicz
Summary: The paper presents the synthesis, identification, and characterization of new salts-L-proline alkyl ester naproxenates [ProOR][NAP], which showed improved solubility, enhanced absorption through biological membranes, lower lipophilicity, and no additional risk in terms of toxicity compared to the parent naproxen.
Article
Pharmacology & Pharmacy
Qiyuan Shan, Gang Tian, Xin Han, Hui Hui, Mai Yamamoto, Min Hao, Jingwei Wang, Kuilong Wang, Xianan Sang, Luping Qin, Guanqun Chen, Gang Cao
Summary: This study conducted subacute toxicity and metabolomics research on Tetradium ruticarpum (TR). The results showed that rats did not show obvious subacute toxicity when receiving three times the recommended dose of TR, but high doses caused liver damage. Processing could effectively reduce the toxicity of TR, and metabolomics analysis revealed the toxicity metabolic regulatory network. The study is important for understanding the toxicity mechanisms of TR, supporting traditional processing theory, and guiding clinical use.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Karsten Seeger
Summary: A new sample preparation method was proposed to shorten the preparation time of NMR samples, suitable for different sample types. Experimental results showed that this extraction protocol combined with slice-selection NMR experiments can be successfully used for metabolic investigations.
ANALYTICAL CHEMISTRY
(2021)
Article
Engineering, Environmental
Elena Legrand, Amanda L. Bayless, Daniel W. Bearden, Fabio Casu, Michael Edwards, Annie Jacob, W. Edward Johnson, Tracey B. Schock
Summary: This study aimed to expand the knowledge of using metabolic end points in environmental monitoring by investigating the dreissenid mussel metabolome in the field. The results showed that the mussel metabolome had distinct characteristics at different sites and could reflect changes in energy metabolism and amino acids. Furthermore, the data highlighted the importance of considering seasonality and handling effects during sampling.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)