Article
Pharmacology & Pharmacy
Linhu Ye, Lei Cheng, Yan Deng, Sen Wang, Xinyu Wu, Shuiping Ou, Qi Chang, Xinqian Zhao, Wen Zhou, Jinghua Yu, Zuqiang Wu
Summary: Licorice (Glycyrrhiza uralensis Fisch) is widely used in China as a food and herbal medication. The present study investigated the pharmacokinetic profile of Glycycoumarin (GCM), a major coumarin in licorice, in rats. The results showed that GCM was rapidly absorbed and transformed into its conjugated metabolites, with low bioavailability and widespread distribution in various tissues except the brain.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Plant Sciences
Genbei Wang, Ruijia Hao, Yu Liu, Yu Wang, Shuli Man, Wenyuan Gao
Summary: The study aimed to investigate the metabolism and distribution of Paris polyphylla var yunnanensis saponins in rats. Through LC-MS/MS analysis and various experimental methods, the concentration distribution of metabolites in different tissues and the characteristics of permeability and recovery were determined. The results provided a theoretical basis for the future application of this medicinal plant.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Ye Zhang, Chizumi Abe, Koji Ochiai, Toshiro Matsui
Summary: This study clarified the distribution of glyceollins in rat organs, finding that they accumulated in circulatory organs in intact and conjugated forms with a specific preference order. Glyceollin I showed higher accumulation compared to III, while daidzein and hydroxy equol were detected only in the liver and kidneys at lower concentrations.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemical Research Methods
Kusuma Kumari Garikapati, Ravi Kiran V. V. V. Ammu, Praveen Thaggikuppe Krishnamurthy, S. T. Narenderan, B. Babu, Krishnaveni Nagappan
Summary: This article describes a validated bioanalytical method for quantifying rosiglitazone in rat plasma and tissues using LC-MS/MS. The method showed good accuracy and sensitivity, with a good correlation coefficient in the calibration curve. The developed method can be used for measuring rosiglitazone in plasma and tissue samples, and may also be applicable for validating specific organ-targeting delivery systems of rosiglitazone.
BIOMEDICAL CHROMATOGRAPHY
(2022)
Article
Pharmacology & Pharmacy
Zhihua Liu, Yu Feng, Hang Zhao, Jinping Hu, Yanmin Chen, Dongdong Liu, Hongliang Wang, Xiangyang Zhu, Hongzhen Yang, Zhufang Shen, Xuejun Xia, Jun Ye, Yuling Liu
Summary: Ramulus Mori (Sangzhi) alkaloids (SZ-A) derived from mulberry twigs have been approved for the treatment of type 2 diabetes mellitus. SZ-A not only has hypoglycemic effects, but also protects pancreatic B-cell function and alleviates hepatic steatosis. Pharmacokinetic studies showed that SZ-A is rapidly absorbed, exhibits dose-linear pharmacokinetics, and is widely distributed in glycolipid metabolism-related tissues.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Applied
Yu Hu, Jianxin Li, Alan K. Chang, Yanan Li, Xia Tao, Wenbao Liu, Zhina Wang, Weiping Su, Zehao Li, Xiao Liang
Summary: In this study, six xanthones from mangosteen were found to inhibit the activity of PTP1B, with garcinone E being the most effective inhibitor. These compounds were distributed in eleven tissues, and mangosteen could be a promising source of natural compounds with high PTP1B inhibitory activity.
Article
Pharmacology & Pharmacy
Jing-Ze Lu, Dan-Dan Hong, Dan Ye, Sheng Mu, Rong Shi, Yu Song, Chu Feng, Bing-Liang Ma
Summary: A liquid chromatography-tandem mass spectrometry method was developed and applied to analyze the distribution and pharmacokinetic properties of oral GQD in mice. The results showed that different constituents of GQD had different concentrations in the liver and colon, indicating their potential efficacy in treating liver and colon-related diseases. Furthermore, the study revealed the pharmacokinetic properties of GQD as a whole, including its accumulation in the colon.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Ying Li, Hang Su, Zhong-Ping Yin, Jing-En Li, En Yuan, Qing-Feng Zhang
Summary: This study investigated the metabolism, tissue distribution, and excretion of taxifolin in rats after oral administration of taxifolin encapsulated zein-caseinate nanoparticles (TZP). Isomerization of taxifolin was found in the rat's small intestine and colon. UPLC-QTOF-MS analysis identified 16 metabolites of taxifolin in rat feces, plasma, and urine. Taxifolin underwent hydration, dehydration, and ring fission metabolism in the colon through gut microflora. The main metabolites detected in plasma and urine were sulfated, glucuronidated, and/or methylated products of taxifolin. The dynamic variation of taxifolin and its metabolites in tissues and urine were quantified using UPLC-QqQ-MS/MS. Taxifolin and its metabolites were rapidly absorbed and distributed in tissues, with lower concentrations found in the heart and brain. Feces excretion of taxifolin was determined by HPLC, and the total excretion within 24 hours was 2.83 +/- 0.80% of the given dose, with the highest excretion occurring during 8-10 hours post administration. Compared to feces, the excretion of taxifolin and its metabolites in urine was much faster, with a total excretion of 1.96 +/- 0.23% within 12 hours.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Kunqian Mu, Kaiwen Jiang, Yue Wang, Zihan Zhao, Song Cang, Kaishun Bi, Qing Li, Ran Liu
Summary: A LC-MS/MS method was developed to study the in vivo fate of beta-cyclodextrin. The results showed that beta-cyclodextrin has a wide distribution in rats' bodies and is rapidly excreted, indicating low accumulation and good safety.
Article
Chemistry, Medicinal
Xiuqing Gao, Robert Y. L. Tsai, Jing Ma, Yang Wang, Xiaohua Liu, Dong Liang, Huan Xie
Summary: In this study, a specific, sensitive, and reproducible LC-MS/MS method was developed and validated for the quantification of oxaliplatin (OXP) in rat plasma and tongue tissue. The method showed good linearity, precision, and accuracy. It was successfully used in pharmacokinetic studies and tissue distribution analysis.
Article
Pharmacology & Pharmacy
Haihua Shang, Xiaohan Dai, Mi Li, Yueyi Kai, Zerong Liu, Min Wang, Quansheng Li, Yuan Gu, Changxiao Liu, Duanyun Si
Summary: This study provides the first systematic elucidation of the absorption and distribution characteristics of Rotundic acid (RA) in rats, which can provide valuable information for the further development and evaluation of RA in drug metabolism and pharmacokinetic studies.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2022)
Article
Pharmacology & Pharmacy
Chengjiang Lin, Donghu Zhang, Shanshan Sun, Yue Shi, Chengda Yan, Jianyang Lin
Summary: The study investigated the pharmacokinetics and tissue distribution of ZCY-15 in rats using a LC-MS/MS method, revealing higher concentrations and lower clearance rates of ZCY-15 in female rats compared to male rats. ZCY-15 was found to pass through the blood-brain barrier and accumulate significantly in the hippocampus.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Plant Sciences
Yin-Feng Tan, Rui-Qi Wang, Wen-Ting Wang, Ying Wu, Ning Ma, Wei-Ying Lu, Yong Zhang, Xiao-Po Zhang
Summary: This study established a simple, rapid and accurate LC-MS/MS method to determine laurolitsine in different rat samples, and successfully applied it in a pharmacokinetic study. The results described the pharmacokinetics, bioavailability, tissue distribution, and excretion of laurolitsine.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Environmental Sciences
Dongxia Ren, Yulin Li, Ying Xue, Xiaoyue Tang, Li Yong, Yun Li
Summary: The study demonstrated that oral exposure to iron oxide nanoparticles can induce lipid metabolism disorders in the liver of rats, potentially increasing risks related to safety and potential hazards.
Article
Chemistry, Analytical
Yang Song, Kefei Wang, Xiaoyi Wei, Tongyuan Wei, Tianhao Xiao, Minjie Wei
Summary: A method for quantifying palmatine in rat plasma and tissue samples was developed, showing that the liver and kidney may be the targeting organs of palmatine, and the plasma binding rate of palmatine is higher in humans than in rats.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Medicine, Legal
Toshime Igarashi, Hideki Serizawa, Katsumi Kobayashi, Hiroshi Suzuki, Mariko Matsumoto, Takako Iso, Tomoko Kawamura, Kaoru Inoue, Atsushi Ono, Takashi Yamada, Akihiko Hirose
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2018)
Article
Chemistry, Medicinal
Dongping Liao, Qiqi Wang, Jiali He, David B. Alexander, Mohamed Abdelgied, Ahmed M. El-Gazzar, Mitsuru Futakuchi, Masumi Suzui, Jun Kanno, Akihiko Hirose, Jiegou Xu, Hiroyuki Tsuda
CHEMICAL RESEARCH IN TOXICOLOGY
(2018)
Article
Toxicology
Ahmed M. El-Gazzar, Mohamed Abdelgied, David B. Alexander, William T. Alexander, Takamasa Numano, Masaaki Iigo, Aya Naiki, Satoru Takahashi, Hiroshi Takase, Akihiko Hirose, Jun Kannno, Osama Saeid Elokle, Ashraf Mohamed Nazem, Hiroyuki Tsuda
ARCHIVES OF TOXICOLOGY
(2019)
Article
Toxicology
Mohamed Abdelgied, Ahmed M. El-Gazzar, David B. Alexander, William T. Alexander, Takamasa Numano, Masaaki Iigou, Aya Naiki-Ito, Hiroshi Takase, Khaled Abbas Abdou, Akihiko Hirose, Yuhji Taquahashi, Jun Kanno, Mona Abdelhamid, Hiroyuki Tsuda, Satoru Takahashi
ARCHIVES OF TOXICOLOGY
(2019)
Article
Oncology
Takamasa Numano, Hitomi Higuchi, David B. Alexander, William T. Alexander, Mohamed Abdelgied, Ahmed M. El-Gazzar, Dina Saleh, Hiroshi Takase, Akihiko Hirose, Aya Naiki-Ito, Shugo Suzuki, Satoru Takahashi, Hiroyuki Tsuda
Article
Toxicology
Mohamed Abdelgied, Ahmed M. El-Gazzar, William T. Alexander, Takamasa Numano, Masaaki Iigou, Aya Naiki-Ito, Hiroshi Takase, Akihiko Hirose, Yuhji Taquahashi, Jun Kanno, Mona Abdelhamid, Khaled Abbas Abdou, Satoru Takahashi, David B. Alexander, Hiroyuki Tsuda
PARTICLE AND FIBRE TOXICOLOGY
(2019)
Article
Medicine, Legal
Toshime Igarashi, Hiroshi Suzuki, Kazuo Ushida, Mariko Matsumoto, Kaoru Inoue, Takuya Kanno, Yoshihisa Miwa, Takahiro Ishii, Takahiko Nagase, Yoshihiro Katsumata, Akihiko Hirose
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2020)
Review
Pharmacology & Pharmacy
Shihori Tanabe, Akihiko Hirose, Maurice Whelan, Takashi Yamada
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2020)
Review
Pharmacology & Pharmacy
Takashi Yamada, Takao Ashikaga, Hajime Kojima, Akihiko Hirose
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2020)
Article
Mathematical & Computational Biology
Keita Yoshii, Hiroshi Nishiura, Kaoru Inoue, Takayuki Yamaguchi, Akihiko Hirose
THEORETICAL BIOLOGY AND MEDICAL MODELLING
(2020)
Article
Toxicology
Dina Mourad Saleh, William T. Alexander, Takamasa Numano, Omnia Hosny Mohamed Ahmed, Sivagami Gunasekaran, David B. Alexander, Mohamed Abdelgied, Ahmed M. El-Gazzar, Hiroshi Takase, Jiegou Xu, Aya Naiki-Ito, Satoru Takahashi, Akihiko Hirose, Makoto Ohnishi, Jun Kanno, Hiroyuki Tsuda
PARTICLE AND FIBRE TOXICOLOGY
(2020)
Article
Oncology
Shihori Tanabe, Sabina Quader, Ryuichi Ono, Horacio Cabral, Kazuhiko Aoyagi, Akihiko Hirose, Hiroshi Yokozaki, Hiroki Sasaki
Article
Oncology
Motoki Hojo, Yukio Yamamoto, Yoshimitsu Sakamoto, Ai Maeno, Aya Ohnuki, Jin Suzuki, Akiko Inomata, Takako Moriyasu, Yuhji Taquahashi, Jun Kanno, Akihiko Hirose, Dai Nakae
Summary: A rat model of mesothelioma development caused by peritoneal injection of multiwalled carbon nanotubes was established, with detailed histological analysis revealing early mesothelioma characteristics and the potential involvement of altered apolipoprotein profiles in underlying mechanisms.
Article
Medicine, Legal
Mariko Matsumoto, Masao Takano, Michihito Takabe, Noriko Yamaguchi, Takako Iso, Yoshiyuki Shigeta, Yasumasa Murata, Nozomu Hirose, Kaoru Inoue, Akihiko Hirose
Summary: Ethyl(dimethyl)(tetradecyl)ammonium ethyl sulfate is classified as a priority assessment chemical substance for environmental effects, with insufficient toxicity data for human health. Testing showed no reproductive and developmental toxicity.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hongyan Cui, Keisuke Soga, Norimasa Tamehiro, Reiko Adachi, Akiko Hachisuka, Akihiko Hirose, Kazunari Kondo, Tomoko Nishimaki-Mogami
Summary: Studies show that statins can inhibit the production and release of IL-1 beta induced by crystals and nanoneedles by preventing the internalization of crystals by macrophages, thereby exerting anti-inflammatory effects.
BIOCHEMICAL PHARMACOLOGY
(2021)