期刊
TOXICOLOGY LETTERS
卷 184, 期 2, 页码 126-133出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2008.10.028
关键词
1-Nitropyrene; Inflammation; Oxidative stress; BEAS-2B cells
类别
Nitropyrene (1-NP) is classified as Group 2B carcinogen and is one of the main components of diesel exhaust particles (DEP), which are generated from incomplete combustion of automobile engines to cause human cancer or inflammatory diseases. Although many reports on the mutagenesis or carcinogenesis of 1-NP have been released. non-carcinogenic toxicities of 1-NP have not been widely studied. In this study, induction of pro-inflammatory signals by 1-NP was investigated using cultured human bronchial epithelial cells, BEAS-2B. By using microarray analysis and RT-PCR technique, it was found that 1-NP induced the expression of genes related to the pro-inflammatory responses Such as pentaxin, IL-1 beta, IL-6, IL-8, C-X-C motif ligand 2 (CXCL2), and TNF-alpha. 1-NP was also found to induce ROS generation and intracellular GSH decrease. It suggested that 1-NP may be a pivotal component of DEP to cause inflammatory diseases. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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