Article
Biochemistry & Molecular Biology
Ivanildo Inacio da Silva Jr, Niely Priscila Correia da Silva, James A. Marrs, Pabyton Goncalves Cadena
Summary: This study evaluated the effects of lemongrass, thyme, and oregano essential oils on zebrafish embryos and larvae, and found that these oils can influence the development and cause morphological defects and behavioral changes in the embryos and larvae. Essential oil exposure may have neurodevelopmental toxicity on zebrafish. Therefore, careful use of essential oils, especially during pregnancy, should be considered.
Article
Environmental Sciences
Jinze Ma, Ping Jiang, Yong Huang, Chen Lu, Guiyou Tian, Xiaoping Xiao, Yunlong Meng, Xiaoqiang Xiong, Bo Cheng, Di Wang, Huiqiang Lu
Summary: The herbicide flumioxazin has been found to induce cardiac defects in vertebrates, possibly due to oxidative stress. This study investigated the underlying mechanisms and found that flumioxazin caused cardiac malformations and abnormal gene expression associated with cardiac development. It also led to increased oxidative stress and apoptosis in the zebrafish heart. The antioxidant astaxanthin reversed these effects and protected against flumioxazin-induced cardiotoxicity.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Article
Environmental Sciences
Liqing Zang, Yasuhito Shimada, Hideto Miyake, Norihiro Nishimura
Summary: This study examined the toxicity and safety of UVC exposure in zebrafish embryos and the corresponding molecular mechanisms. The research found that 4.5 mJ/cm(2) was the limit dosage that the internal biodefense system of zebrafish embryos can protect against UVC radiation. Transcriptome analysis revealed the molecular mechanisms underlying the response of zebrafish embryos to UVC irradiation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Multidisciplinary Sciences
Min Luo, Dan Xie, Ziyuan Lin, Huaqin Sun, Yanyan Liu
Summary: The potential risks of hydroxychloroquine (HCQ) treatment include various side effects and potential genetic defects. This study used zebrafish embryos to investigate the effects of HCQ overdose and found that high concentrations can lead to mortality, malformation, and abnormal differentiation of vital organs.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Marta Silva Muniz, Katharina Halbach, Igor Caue Alves Araruna, Rafael Xavier Martins, Bettina Seiwert, Oliver Lechtenfeld, Thorsten Reemtsma, Davi Farias
Summary: Moxidectin exhibited acute toxicity to zebrafish embryos by decreasing hatching rates, altering enzymatic activity, and strongly accumulating in embryos, mainly distributed in the head and eyes.
ENVIRONMENTAL POLLUTION
(2021)
Review
Environmental Sciences
Monica Torres-Ruiz, Antonio De la Vieja, Mercedes de Alba Gonzalez, Marta Esteban Lopez, Argelia Castano Calvo, Ana Isabel Canas Portilla
Summary: Studies on the effects of polystyrene nanoplastics on zebrafish embryo development show that size, concentration, and exposure time do not significantly affect organism responses or cellular responses. Larger nanoplastics mainly accumulate in the gut, while smaller ones can reach internal organs. Effects on locomotion and heart rate are more commonly associated with smaller nanoplastics.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Natalia Abramenko, Gregory Deyko, Evgeny Abkhalimov, Vera Isaeva, Lyubov Pelgunova, Eugeny Krysanov, Leonid Kustov
Summary: Metal-organic frameworks (MOFs) have unique properties with potential applications in drug delivery, catalysis, and gas separation, but their biomedical use may be limited due to unclear interactions with the environment and humans. This study investigated the toxicity of HKUST-1 nanoparticles (Cu-nanoMOF) towards embryos and adult zebrafish, finding that Cu2+ ions had a higher toxic effect compared to Cu-MOF NPs for zebrafish. Both forms of fish were sensitive to HKUST-1 NPs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Weifeng Shen, Guiling Yang, Qi Guo, Lu Lv, Li Liu, Xinquan Wang, Bao Lou, Qiang Wang, Yanhua Wang
Summary: The study revealed the combined toxic effect of myclobutanil and thiamethoxam on zebrafish, showing their synergistic toxicity and impact on biomarkers.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemistry & Molecular Biology
Chloe Bars, Jente Hoyberghs, Allan Valenzuela, Laura Buyssens, Miriam Ayuso, Chris Van Ginneken, Alain J. Labro, Kenn Foubert, Steven J. Van Cruchten
Summary: Zebrafish embryos and larvae have the potential to bioactivate drugs, but the formation levels are lower compared to mammals. Exposure to carbamazepine and phenytoin may have teratogenic effects in zebrafish.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Modi Bhai, Ambika Binesh, S. A. Shanmugam, Kaliyamurthi Venkatachalam
Summary: In this study, the effects of mercury on zebrafish embryo development were investigated. The results showed that higher concentrations of mercury led to reduced hatching rate, increased morphological abnormalities, and higher mortality. Additionally, developmental abnormalities and changes in larval behaviors were observed. Furthermore, mercury exposure resulted in increased antioxidant enzyme activities and pro-inflammatory cytokine transcription levels.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Moe Nishimura, Hiroyuki Fuchino, Kaoru Takayanagi, Hitomi Kawakami, Hiroko Nakayama, Nobuo Kawahara, Yasuhito Shimada
Summary: The study identified cytotoxic mechanisms of jegosaponin A and B from Styrax japonica Siebold et al. Zuccarini. The active molecules showed toxic effects on zebrafish embryos and exhibited cell membrane disruptive properties. The study highlights the importance of toxicity testing in early stages of drug discovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Victoria McGruer, Philip Tanabe, Sara M. F. Vliet, Subham Dasgupta, Le Qian, David C. Volz, Daniel Schlenk
Summary: PAHs exposure can cause gross morphological abnormalities and cardiotoxicity in developing fish embryos. Changes in cholesterol biosynthetic pathway genes were found, and pretreatment with cholesterol solution partially mitigated the effects on heart rate. Exposure to PAHs also led to an increase in yolk area, indicating impaired lipid transport during development.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2021)
Article
Toxicology
Binjie Wang, Tianyi Chen, Anli Wang, Jiakai Fang, Jiye Wang, Weixuan Yao, Yuanzhao Wu
Summary: This study investigated the toxic effects of anisodamine on zebrafish embryos, showing that exposure to high doses of anisodamine resulted in cranial malformations, abnormal pigmentation, eye development defects, and reduced bone density in the embryos. The toxicity was associated with the functional development of neural crest cells through gene expression. This study provides new evidence of the developmental toxicity of anisodamine and warns of the safe use of this drug in aqueous solutions.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Environmental Sciences
Anne Havermans, Edwin P. Zwart, Hans W. J. M. Cremers, Maarten D. M. van Schijndel, Romy S. Constant, Maja Meskovic, Laura X. Worutowicz, Jeroen L. A. Pennings, Reinskje Talhout, Leo T. M. van der Ven, Harm J. Heusinkveld
Summary: Tobacco use is the main cause of preventable death globally, with nicotine being the primary addictive compound. The zebrafish embryo has shown to be an effective model for studying the effects of nicotine, where acute nicotine exposure decreased ZFE activity in a dose-dependent manner. Pre-treatment with nicotine can reverse this effect and may lead to decreased potency of acute nicotine exposure, indicating the induction of tolerance.
Article
Multidisciplinary Sciences
Yali Ge, Wenjuan Yuan, Wenzhu Jia, Zhongxia Guan, Tianfeng Huang, Yang Zhang, Chengyi Song, Yinggang Xiao, Ju Gao
Summary: General anesthetics can cause neurological damage and long-term behavioral/cognitive impairment in fetal and early postnatal life. This study used zebrafish embryos to investigate the effects of propofol on embryonic and larval growth and development, as well as the apoptotic mechanism. The findings showed that propofol exposure resulted in developmental toxicity in zebrafish embryos and larvae, which correlated with the intrinsic apoptosis pathway and the upregulation of casp3a, casp3b, casp9, and baxb genes.
