Article
Food Science & Technology
Julen Sanz-Serrano, Ariane Vettorazzi, Damian Muruzabal, Amaya Azqueta, Adela Lopez de Cerain
Summary: This article provides a complete in vitro genotoxicity assessment of three nutrients widely used in the European market, demonstrating that they did not show genotoxicity in any of the conditions tested. This study contributes to the limited evidence available and complements EFSA recommendations for in vitro genotoxicity testing of nutrients.
Review
Pharmacology & Pharmacy
Niels Hadrup, Jorid B. Sorli, Anoop K. Sharma
Summary: Molybdenum, lithium, and tungsten are constituents of many products and exposure to these elements potentially occurs at work. Dose descriptors for inhalation toxicity were identified and the potential for genotoxicity and carcinogenicity was assessed.
Article
Environmental Sciences
Sardar Khan, Zahir Qamar, Ajmal Khan, Muhammad Waqas, Javed Nawab, Muhmmmad Khisroon, Ajmal Khan
Summary: This study investigated the genotoxic effects of polycyclic aromatic hydrocarbons (PAHs) present in vehicle-wash wastewater (VWW) on fish and freshwater mussels. The results showed that the genotoxicity of VWW on both fish and mussels increased with the duration of exposure, indicating the high genotoxicity of VWW and the need for treatment before discharge into aquatic ecosystems.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Felipe de Araujo Nascimento, Daniela de Melo e Silva, Thays Millena Alves Pedroso, Jheneffer Sonara Aguiar Ramos, Michelle Rocha Parise
Summary: Occupational exposure to pesticides in farmers results in significant DNA damage, showing a notable impact and variability in the studies. Smokers who are occupationally exposed to pesticides have slightly reduced DNA damage compared to non-smokers, indicating some genetic toxicity. The study demonstrates a higher risk of occupationally exposed rural workers developing related diseases due to the genotoxic effect of pesticides.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Sergey Petrovich Kukla, Victor Pavlovich Chelomin, Andrey Alexandrovich Mazur, Valentina Vladimirovna Slobodskova
Summary: This study compared the effects of zinc ions and zinc oxide nanoparticles on the sperm of marine organisms. The results showed that both pollutants caused an increase in DNA damage, and the increase in DNA damage varied with the concentration of pollutants in different experimental groups.
Article
Pharmacology & Pharmacy
Giselle S. Meireles, Rafaela Aires, Larissa Z. Coco, Edgar H. Kampke, Maria E. S. Barroso, Elisardo C. Vasquez, Thiago M. C. Pereira, Silvana S. Meyrelles, Bianca P. Campagnaro
Summary: This study found that renovascular hypertension can cause oxidative damage and impaired DNA repair in bone marrow cells, leading to compromised hematopoiesis. It provides new insights into the influence of hypertension on bone marrow homeostasis.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Chemistry, Medicinal
Zeineb Marzougui, Sylvie Huet, Anne-Louise Blier, Ludovic Le Hegarat, Haifa Tounsi-Kettiti, Riadh Kharrat, Riadh Marrouchi, Valerie Fessard
Summary: In this study, the in vivo genotoxic effects of C17-sphinganine analog mycotoxin (C17-SAMT) were evaluated using comet assays and micronucleus assay. The results showed that C17-SAMT induced DNA damage in the duodenum and spleen, but had no significant effect on chromosome and genome damage in the bone marrow. Microscopic observations of the liver revealed increased mitosis and hepatocytes' cytoplasm clarification.
Article
Environmental Sciences
Luiza Flavia Veiga Francisco, Debora da Silva Baldivia, Bruno do Amaral Crispim, Syla Maria Farias Ferraz Klafke, Pamella Fukuda de Castilho, Lucilene Finoto Viana, Edson Lucas dos Santos, Kelly Mari Pires de Oliveira, Alexeia Barufatti
Summary: The study found that high concentrations of aluminum and manganese exhibit cytotoxic and genotoxic effects on cell lines, but do not show a clear mutagenic response.
Article
Plant Sciences
Francisco Laerte Lopes da Silva, Amanda Souza Scotti, Ana Leticia Hilario Garcia, Maria Luiza Brodt Lemes, Ivana Grivicich, Gabriela Mendonca dos Reis, Johnny Ferraz Dias, Fernanda Briao Menezes Boaretto, Jaqueline Nascimento Picada, Juliana da Silva, Alexandre de Barros Falcao Ferraz
Summary: The present study aimed to determine the chemical composition, cytotoxic, genotoxic, mutagenic potential, and antioxidant activity of an aqueous extract of Aloysia gratissima leaves. Results showed that the extract contained terpenoids, flavonoids, and phenolic acids, and exhibited cytotoxic activities against various cancer cells, as well as DNA damage and mutations. Therefore, caution should be exercised when using this plant preparation, despite its pharmacological potential.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Environmental Sciences
Claudia Castro, Ana Carvalho, Isabel Gaivao, Jose Lima-Brito
Summary: The study evaluated the tolerance of four wine-producing varieties to different concentrations of Cu by treating V. vinifera cuttings with Cu-rich hydroponic solutions. It was found that 50μM Cu treatment increased DNA damage, with 'Tinto Cao' being the most sensitive variety. Comet-FISH analysis revealed partial damage on rDNA and telomeric DNA in response to Cu treatment.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Cell Biology
Nasrin Ghassemi-Barghi, Zeynab Ehsanfar, Omid Mohammadrezakhani, Sorour Ashari, Shamim Ghiabi, Zahra Bayrami
Summary: ARA290 has been found to exert a protective effect against cisplatin-induced nephrotoxicity by anti-apoptotic, anti-inflammatory, and antioxidant mechanisms, suggesting its potential as a new therapeutic approach for acute kidney injury patients.
Article
Environmental Sciences
Ronan Adler Tavella, Caroline Lopes Feijo Fernandes, Lucia Emanueli Schimith, Lisiane Martins Volcao, Marina dos Santos, Flavio Manoel Rodrigues da Silva Junior
Summary: Socioeconomic and demographic factors, lifestyle, and cultural characteristics may have an important impact on genetic damage. This study analyzed the association between a set of factors and genetic damage by studying populations in southern Brazil. The results showed that age had a weak association with genetic damage, while factors such as skin color, occupational exposure, drug use, exposure to radiation, and the cultural habit of consuming chimarrao were found to be associated with genetic damage. Yerba mate consumption was identified as a confounding factor in cytogenetic studies in the southern region of South America.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Food Science & Technology
Concepcion Medrano-Padial, Maria Puerto, Ana Isabel Prieto, Nahum Ayala, Pauline Beaumont, Caroline Rouger, Stephanie Krisa, Silvia Pichardo
Summary: This study investigated the in vivo genotoxic effects of rats orally exposed to different doses of ST-99 and found no genotoxicity in the cells isolated from stomach, liver, and blood. Analytical studies confirmed the presence of stilbenes and their metabolites in plasma and tissues, supporting the safety profile of ST-99 for potential application as a preservative in the wine industry.
Article
Biochemistry & Molecular Biology
Galina N. Chelomina, Sergey P. Kukla, Viktor P. Chelomin, Pham N. Doanh
Summary: Parasite infection can lead to DNA damage, potentially involving oxidative stress and cancer development; these research findings are important for understanding the pathogenesis mechanisms of parasitic diseases.
Article
Chemistry, Multidisciplinary
Adriana Rodriguez-Garraus, Maria Alonso-Jauregui, Ana-Gloria Gil, Inigo Navarro-Blasco, Adela Lopez de Cerain, Amaya Azqueta
Summary: A new material composed of kaolin base with silver nanoparticles was developed as an alternative to antibiotics in animal feed. In an in vivo geno-toxicological evaluation in rats, the material showed no adverse effects when administered orally at a dose of 2000 mg/kg b.w. for 28 days. The material did not induce micronuclei or DNA damage in various tissues, and silver content in target organs confirmed the negative results.
Article
Chemistry, Physical
Joao Angelo Lima Perini, Kallyni Irikura, Lilian D. Moura Torquato, Jader Barbosa da S. Flor, Maria V. Boldrin Zanoni
Summary: This study investigates the synergic effect of gold nanoparticles as a co-catalyst on TiO2 nanotubes in an aqueous medium containing an ionic liquid, providing a good strategy for enhancing CO2 conversion into value-added products.
JOURNAL OF CATALYSIS
(2022)
Article
Chemistry, Analytical
Maisa Azevedo Beluomini, Nelson Ramos Stradiotto, Maria Valnice Boldrin Zanoni
Summary: This paper reports the preparation of three-dimensional nanostructured porous platinum (3DnpPt) on a screen-printed electrode using a simple electrochemical method. The prepared electrode shows good electrocatalytic activity and selectivity for the simultaneous determination of hesperidin and narirutin in residual water from the citrus industry.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Physical
Maria Valnice Boldrin Zanoni, Kallyni Irikura, Joao Angelo Lima Perini, Guilherme G. Bessegato, Miguel A. Sandoval, Ricardo Salazar
Summary: This review summarizes recent advances in photo-electrocatalysis of pesticides, including fundamentals, photoanode preparation, and their application in degrading pesticides in different types of water. The effect of the chemical nature of the photoanodes on enhancing electrolysis and photolysis processes is discussed. The use of various semiconductors for pesticide degradation under different experimental conditions is described, serving as a basis for future real-world applications. Outlooks and perspectives are provided and discussed.
CURRENT OPINION IN ELECTROCHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Thais Caroline Almeida da Silva, Leonardo Marchiori, Bianca Oliveira Mattos, Sajjad Ullah, Hernane da Silva Barud, Rafael Romano Domeneguetti, Hernan Dario Rojas-Mantilla, Maria Valnice Boldrin Zanoni, Ubirajara Pereira Rodrigues-Filho, Elias Paiva Ferreira-Neto, Sidney Jose Lima Ribeiro
Summary: This study designs flexible, self-standing, porous, and recyclable BC@SiO2-TiO2 hybrid organic-inorganic aerogel membranes for effective in-flow photo-assisted removal of organic pollutants. The optimized BC@SiO2-TiO2 hybrid aerogel shows increased surface area and higher photocatalytic activity, outperforming most supported-titania materials reported earlier. These hybrid aerogels also demonstrate potential for water purification by successfully removing the model emergent contaminant sertraline drug from aqueous solution.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Instruments & Instrumentation
Sergio L. C. Ferreira, Ravena S. A. Azevedo, Jucelino B. da Silva Jr, Leonardo S. G. Teixeira, Ivanice. F. F. dos Santos, Walter N. L. dos Santos, Antonio F. S. Queiroz, Olivia M. C. de Oliveira, Lilian L. N. Guarieiro, Jeancarlo P. dos Anjos, Maria V. B. Zanoni, Ricardo B. da Silva, Carla Palma, Vanessa Morgado, Victor Cerda, Vanessa Hatje, Rodrigo M. A. Pedreira
Summary: This review discusses the sources, adverse effects, and quantification of emerging contaminants, including chemical elements used in medicine, microplastics in water bodies, and pharmaceuticals, illicit drugs, and their metabolites in wastewater and sewage sludge. It also addresses the pollution caused by these contaminants in urban areas. The main analytical methods for determining these contaminants are briefly reported.
APPLIED SPECTROSCOPY REVIEWS
(2023)
Article
Toxicology
Tais S. Viana, Diana Campos, Mariana Bartilotti, Fernanda G. Leite, Maria Valnice Zanoni, Daniel J. Dorta, Danielle P. Oliveira, Joao L. T. Pestana
Summary: Produced water (PW) generated by oil companies is a highly impacting waste that contains chemicals such as metals and organic and inorganic compounds. Conventional treatments have limited efficiency in removing PW toxicity, so alternative approaches must be developed and standardized. Treatment with magnetized vermiculite (VMT-mag) shows potential in reducing PW toxicity to aquatic biota.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Electrochemistry
Lilian Danielle de Moura Torquato, Rosa Maria Matteucci, Paolo Stufano, Danilo Vona, Gianluca M. Farinola, Massimo Trotta, Maria Valnice Boldrin Zanoni, Matteo Grattieri
Summary: The metabolic versatility of purple non-sulphur bacteria makes them suitable for developing photobioelectrochemical systems in contaminated environments. The effects of 2,4 dinitrophenol, a common contaminant, on purple bacteria photobioelectrocatalysis were investigated. The results showed that the aromatic contaminant significantly affected the current generation, with enhanced photocurrent at low dinitrophenol concentrations, while higher concentrations resulted in a gradual decrease.
Editorial Material
Electrochemistry
Lilian Danielle de Moura Torquato, Rosa Maria Matteucci, Paolo Stufano, Danilo Vona, Gianluca M. Farinola, Massimo Trotta, Maria Valnice Boldrin Zanoni, Matteo Grattieri
Summary: Invited for this issue's Front Cover is an international collaborative team consisting of researchers from Universita degli Studi di Bari Aldo Moro (Italy), SAo Paulo State University (UNESP, Brasil), and Consiglio Nazionale delle Ricerche (Italy). The cover picture showcases purple bacterial cells that exhibit photo-induced electrons hitting or missing their target electrode depending on the concentration of dinitrophenol. The research article can be accessed at 10.1002/celc.202300013.
Editorial Material
Chemistry, Analytical
Maria Valnice Boldrin Zanoni
BRAZILIAN JOURNAL OF ANALYTICAL CHEMISTRY
(2023)
Article
Environmental Sciences
Bianca de Arruda Leite, Gabriela Meireles, Flavia Renata Abe, Carlos Gravato, Daniel Junqueira Dorta, Danielle P. de Oliveira
Summary: Some dyes used by industries such as textile, pharmaceutical, food, cosmetic, and photographic have been found to be toxic and mutagenic to aquatic life. These dyes resist degradation in wastewater treatment processes, potentially creating more toxic by-products. However, research on the toxicity of these dyes is limited. This study evaluated the effects of Disperse Red 60, 73, and 78 on the zebrafish model, revealing behavioral and developmental alterations that suggest potential environmental and human health hazards.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Multidisciplinary Sciences
Alexandre de Oliveira Jorgetto, Maria Valnice Boldrin Zanoni, Marcelo Ornaghi Orlandi
Summary: Microporous Sn2+-containing SnO2 material with microrod morphology and a relatively large surface area has been synthesized. The material exhibits superior photoactivity due to the presence of Sn2+ states in its band structure. The internal crystalline structure analysis reveals a mesocrystalline structure at the nanoscale level.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Taisa Carla Rizzi Rialto, Renan Vieira Marino, Flavia Renata Abe, Daniel Junqueira Dorta, Danielle Palma Oliveira
Summary: This study assessed and compared the toxicity of BDE-47 and ALPI to zebrafish by analyzing various parameters. The results showed that BDE-47 was more toxic than ALPI.
Article
Electrochemistry
Maisa Azevedo Beluomini, Yu Wang, Lina Wang, Mariolino Carta, Neil B. McKeown, Simon M. Wikeley, Tony D. James, Pablo Lozano-Sanchez, Marco Caffio, Nelson Ramos Stradiotto, Maria Valnice Boldrin Zanoni, Frank Marken
Summary: 3D-graphene foam electrodes immersed in a phosphate buffer solution of pH 7 generate hydrogen peroxide at a significantly faster rate in the presence of nanoparticulate polymer PIM-1. The release of oxygen from PIM-1 at the electrode-solution interface quadruples H2O2 production.
ELECTROCHEMISTRY COMMUNICATIONS
(2022)
Article
Materials Science, Multidisciplinary
Fabiana Avolio Sayao, Xiao Ma, Maria Valnice Boldrin Zanoni, Abdessadek Lachgar
Summary: The effect of phosphorene as a co-catalyst for CO2 reduction to methanol and water splitting on Ti/TiO2 nanotube electrodes was investigated. Phosphorene acts as a p-type semiconductor with strong photoactivation under visible light. Under specified conditions, CO2 reduction and hydrogen production from water splitting can be achieved.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Review
Chemistry, Multidisciplinary
Luis Henrique Aratijo Grecco, Barbara Camila de Araujo Souza, Maria Valnice Boldrin Zanoni
Summary: EC technology is a well-known wastewater treatment process that applies electric current to remove contaminants without chemical additives. Iron and aluminum electrodes, though conventional, may leave unwanted residues and pose health risks. Research on non-conventional electrodes is essential for more effective wastewater treatment.
Article
Toxicology
Kathryn Page, Walter Westerink, Kristie Sullivan, Thomas McDonald, Clive Roper
Summary: This study developed a new method to assess the skin irritation of antimicrobial cleaning products. The method utilized a more human-like model and demonstrated its effectiveness through comparison with in vivo rabbit skin irritation data.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Arupam Patra, Thirukumaran Kandasamy, Siddhartha Sankar Ghosh, Gurvinder Kaur Saini
Summary: This study successfully produced recombinant anisoplin and demonstrated its significant anti-cancer effect and ability to induce apoptosis in breast cancer cells. The activation of related signaling pathways may be the key to cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Thomas Haller, Alexander Jesacher, Alberto Hidalgo, Christina Schmidt
Summary: This study used live cell imaging to observe the accumulation of amiodarone in primary rat alveolar type II cells, and found that it specifically accumulates in lamellar bodies. The uptake is rapid, while storage is persistent. The main mechanisms for intracellular bioaccumulation of amiodarone are proposed to be passive diffusion, ion-trapping, and lipophilic interactions.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Filiz Bakar-Ates, Erva Ozkan
Summary: This study investigated the ferroptotic effect of CuB in breast cancer cells and evaluated its combination with erastin, a ferroptosis inducer. The results showed that the combination treatment significantly activated the ferroptotic pathways and altered the expression of iron-related proteins in breast cancer cells.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Rachel Z. Bennie, Ian C. Shaw
Summary: Estrogen mimics are synthetic and naturally occurring compounds that can interact with estrogen receptors in animals. In vitro transactivation reporter gene assay and in silico molecular modelling can be used to predict the mimicry of these compounds, reducing reliance on animal studies.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Sevda Isik, Semra Cicek
Summary: This study found that high doses of riboflavin can cause cytotoxicity in rainbow trout gonad cells and affect the transcriptional expressions of antioxidant enzymes and growth and reproductive genes, potentially leading to DNA damage and cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Ying Wang, Jie Wu, Mengqi Wan, Dou Yang, Fasheng Liu, Kehao Li, Manxin Hu, Yuanyuan Tang, Huiqiang Lu, Shouhua Zhang, Yuanzhen Xiong
Summary: m-Cresol is commonly used as an intermediate for pesticides and other industrial applications. This study investigated the hepatotoxicity of m-cresol using zebrafish larvae and explored its molecular mechanisms. The results suggest that m-cresol may induce liver damage in zebrafish larvae through oxidative stress and cell apoptosis pathways.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Vincent J. Manna, Shannon Dwyer, Vanessa Pizutelli, Salvatore J. Caradonna
Summary: The widespread use of electronic cigarettes and the emergence of a new illness have raised concerns about the effects of e-cigarette vapor on respiratory tissues. Researchers have developed a simple device to mimic the response of human airway tissue after long-term exposure to e-cigarette vapor, and have identified differences in the effects of different vapor compositions on airway tissue.
TOXICOLOGY IN VITRO
(2024)
