Article
Biochemistry & Molecular Biology
Shuai Wang, Zhonghao Cui, Jian Zhu, Peng Zhou, Xianjiao Cao, Xiaolei Li, Yunhan Ma, Qingqing He
Summary: Colchicine can inhibit the proliferation and promote the apoptosis of papillary thyroid carcinoma (PTC) cells likely due to its inhibitory effect on histone deacetylase 1 (HDAC1). This finding implies that colchicine may be helpful for therapeutic intervention in PTC and that HDAC1 may be a promising clinical therapeutic target.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Di Zhang, Lei Li, Jun Li, YunLei Wei, Jian Tang, Xiaohua Man, Feng Liu
Summary: Colchicine treatment mitigates the severity of SAP-ALI in rats by inhibiting inflammation, oxidative stress, and cell apoptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
Mayank, Ashutosh Singh, Kumar Udit Saumya, Mayank Joshi, Navneet Kaur, Neha Garg, Narinder Singh
Summary: 4H-Chromene derivatives are potential anticancer compounds that bind to the colchicine binding site of tubulin protein. The 2-amino-4-phenyl-4H-benzo[h]chromene-3-carbonitrile-based 4H-chromenes scaffold has a significant impact on tubulin proteins. Understanding the interaction pattern of these compounds against various tubulin isoforms is important for selective targeting of cancer cells. Structural modification can potentially enhance the selective targeting ability of these molecules.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Plant Sciences
Jiana Lin, Bingnan Zhang, Jintuo Zou, Zhen Luo, Hao Yang, Peng Zhou, Xiaoyang Chen, Wei Zhou
Summary: This study investigated the induction effect of colchicine on tetraploid Broussonetia papyrifera. Results showed that the best induction effect was achieved when the leaves of B. papyrifera were treated in liquid MS medium containing 450 mgL-1 colchicine for 3 days. The tetraploid B. papyrifera exhibited larger ground diameter, stomata, and leaf cell structures, as well as higher chlorophyll content and photosynthetic rates compared to its diploid counterpart.
Article
Biochemistry & Molecular Biology
Yongpeng Shi, Jiande Li, Ji Wang, Hanwen Cao, Huanbing Tian, FeiFei Yu, Lan Gao
Summary: This study investigated the mechanism of COL-induced diarrhea by exposing mice to COL. The results showed that COL exposure disrupted intestinal metabolic homeostasis, resulting in accumulation or depletion of various metabolites. Certain core metabolites were found to be closely related to COL-induced diarrhea and could be used as biomarkers. Changes in metabolic pathways and abnormal bile secretion were identified as important factors in COL-induced diarrhea.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Plant Sciences
Worasitikulya Taratima, Khoirista Noor Rohmah, Kongtong Plaikhuntod, Pitakpong Maneerattanarungroj, Attachai Trunjaruen
Summary: This study investigated the induction of polyploidy in Cymbidium aloifolium using colchicine and found that colchicine effectively induced the formation of tetraploid plants. However, higher concentrations and longer durations of treatment resulted in decreased survival and growth performance. Tetraploid plants exhibited the largest stomatal and epidermal cell sizes but decreased densities compared to diploid plants. This study provides valuable information for the cultivation of high-quality ornamental plants and pharmaceutical raw materials.
Article
Biochemistry & Molecular Biology
Myriam Gonzalez, Younes Ellahioui, Laura Gallego, Alba Vicente-Blazquez, Raquel Alvarez, Manuel Medarde, Rafael Pelaez
Summary: We have designed new A ring analogs with chameleonic masked polar amino groups to increase aqueous solubility and behave as non-polar through intramolecular hydrogen bonds when bound to tubulin. Some of these compounds showed improved aqueous solubility and nanomolar anti-proliferative potencies against human cancer cell lines, with the most favorable substituent being a 3-methylamino group. The antiproliferative effect is related to tubulin inhibition and cell cycle arrest in G2/M, leading to apoptosis.
BIOORGANIC CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Ruiquan Dong, Yi Pei, Lingyan Hong, Jiangli Nie, Yuhang Chen, Huili Yan, Yanjun Liu
Summary: By using artificial polyploid induction, new varieties of horticultural crops with better quality can be generated. In this study, mixed culture was used to induce polyploidy of black currant. The best condition for polyploid induction of black currant was found, and the ploidy of seedlings was verified. Additionally, the morphological differences and stomatal characteristics of tetraploid plants and diploid plants were compared, and differentially expressed genes were identified through transcriptome sequencing analysis. This study enriched the germplasm resources of black currant and provided a new way for black currant breeding.
PLANT CELL TISSUE AND ORGAN CULTURE
(2023)
Article
Plant Sciences
A. Suma, K. Joseph John, Kangila Venkataramana Bhat, Madhavan Latha, Chakkamadathil Jayasundaran Lakshmi, Mottaiyan Pitchaimuthu, V. A. M. Nissar, Polavakkalipalayam Palanisamy Thirumalaisamy, Chitra Devi Pandey, Sushil Pandey, Ashok Kumar, Raj Kumar Gautam, Gyanendra Pratap Singh
Summary: The transfer of tolerance genes from wild Abelmoschus species to cultivated okra through wide hybridization can enrich the genetic diversity and improve the crop's resistance.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Clara Mueller, Louisa Sroka, Marie-Lena Hass, Sabine Aboling, Anja These, Ingrid Vervuert
Summary: The study aimed to observe the rejection behavior of horses towards hay contaminated with meadow saffron, with results showing that most horses ingested meadow saffron initially, but some also rejected it at later stages. The conclusion suggests that hay contaminated with meadow saffron should be avoided for feeding equids.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2022)
Review
Biotechnology & Applied Microbiology
Rupa Sanyal, Saheli Nandi, Sharmila Pandey, Tuyelee Das, Prabhjot Kaur, Merinashwari Konjengbam, Nishi Kant, Md Habibur Rahman, Avinash Mundhra, Mafatlal M. Kher, Uttpal Anand, Radha, Manoj Kumar, Niraj Kumar Jha, Saurabh Kumar Jha, Mahipal S. Shekhawat, Devendra Kumar Pandey, Abhijit Dey
Summary: Gloriosa superba, commonly known as gloriosa lily, is a medicinal plant used in African and Southeast Asian cultures. Due to its high market demand, improper harvesting, and low seed setting, scientists are studying micropropagation techniques and in vitro optimization methods to promote its growth and medicinal properties.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yuanjun Tang, Chenyang Shi, Yingyi Qin, Shuowen Wang, Hui Pan, Ming Chen, Xuemei Yu, Yuefen Lou, Guorong Fan
Summary: Through network pharmacology and experimental verification, the study suggests that colchicine may treat myocardial ischemia reperfusion injury by inhibiting apoptotic signaling pathway and protecting H9C2 cells from Hypoxia/Reoxygenation (H/R) injury through activating the PI3K/AKT/eNOS pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Yanbin Wen, Hongjiu Liu, Huanwen Meng, Lijun Qiao, Guoqing Zhang, Zhihui Cheng
Summary: In this study, efficient and reliable in vitro induction protocols of autotetraploid garlic were established. The obtained autotetraploid garlic exhibited stable and remarkable dwarfness effect and other morphological and cytological changes. Furthermore, the level of phytohormones was significantly lower in autotetraploids, while organosulfur compounds accumulated a higher content significantly. These findings are of great importance for artificial polyploid breeding and investigation into the consequences of whole-genome doubling.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
K. C. Nicolaou, Ruocheng Yu, Zhaoyong Lu, G. Fernando Alvarez
Summary: Researchers have successfully synthesized a complex natural tropolonoid compound, gukulenin B, which is a challenging target for synthesis. They used a series of site-selective aromatic C-H bond functionalizations and C-C bond formations to successfully construct the tropolone nucleus. This study is of great significance for further synthesis and biological research, and provides new insights for the development of tropolone functionalization methods.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Medicinal
Lun Wang, Yunhua Zheng, Dan Li, Jianhong Yang, Lei Lei, Wei Yan, Wei Zheng, Minghai Tang, Mingsong Shi, Ruijia Zhang, Xiaoying Cai, Hengfan Ni, Xu Ma, Na Li, Feng Hong, Haoyu Ye, Lijuan Chen
Summary: The study identified a potential clinical candidate for cancer therapy by synthesizing and studying derivatives of KX01, with 8a showing significantly improved antitumor effects in several tumor cell lines. The X-ray crystal structure revealed a novel binding mode of 8a, which may contribute to its enhanced anti-proliferative activity.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Toxicology
Kathryn Page, Walter Westerink, Kristie Sullivan, Thomas McDonald, Clive Roper
Summary: This study developed a new method to assess the skin irritation of antimicrobial cleaning products. The method utilized a more human-like model and demonstrated its effectiveness through comparison with in vivo rabbit skin irritation data.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Arupam Patra, Thirukumaran Kandasamy, Siddhartha Sankar Ghosh, Gurvinder Kaur Saini
Summary: This study successfully produced recombinant anisoplin and demonstrated its significant anti-cancer effect and ability to induce apoptosis in breast cancer cells. The activation of related signaling pathways may be the key to cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Thomas Haller, Alexander Jesacher, Alberto Hidalgo, Christina Schmidt
Summary: This study used live cell imaging to observe the accumulation of amiodarone in primary rat alveolar type II cells, and found that it specifically accumulates in lamellar bodies. The uptake is rapid, while storage is persistent. The main mechanisms for intracellular bioaccumulation of amiodarone are proposed to be passive diffusion, ion-trapping, and lipophilic interactions.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Filiz Bakar-Ates, Erva Ozkan
Summary: This study investigated the ferroptotic effect of CuB in breast cancer cells and evaluated its combination with erastin, a ferroptosis inducer. The results showed that the combination treatment significantly activated the ferroptotic pathways and altered the expression of iron-related proteins in breast cancer cells.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Rachel Z. Bennie, Ian C. Shaw
Summary: Estrogen mimics are synthetic and naturally occurring compounds that can interact with estrogen receptors in animals. In vitro transactivation reporter gene assay and in silico molecular modelling can be used to predict the mimicry of these compounds, reducing reliance on animal studies.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Sevda Isik, Semra Cicek
Summary: This study found that high doses of riboflavin can cause cytotoxicity in rainbow trout gonad cells and affect the transcriptional expressions of antioxidant enzymes and growth and reproductive genes, potentially leading to DNA damage and cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Ying Wang, Jie Wu, Mengqi Wan, Dou Yang, Fasheng Liu, Kehao Li, Manxin Hu, Yuanyuan Tang, Huiqiang Lu, Shouhua Zhang, Yuanzhen Xiong
Summary: m-Cresol is commonly used as an intermediate for pesticides and other industrial applications. This study investigated the hepatotoxicity of m-cresol using zebrafish larvae and explored its molecular mechanisms. The results suggest that m-cresol may induce liver damage in zebrafish larvae through oxidative stress and cell apoptosis pathways.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Vincent J. Manna, Shannon Dwyer, Vanessa Pizutelli, Salvatore J. Caradonna
Summary: The widespread use of electronic cigarettes and the emergence of a new illness have raised concerns about the effects of e-cigarette vapor on respiratory tissues. Researchers have developed a simple device to mimic the response of human airway tissue after long-term exposure to e-cigarette vapor, and have identified differences in the effects of different vapor compositions on airway tissue.
TOXICOLOGY IN VITRO
(2024)